BR112016021910A2 - Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina - Google Patents

Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina

Info

Publication number
BR112016021910A2
BR112016021910A2 BR112016021910A BR112016021910A BR112016021910A2 BR 112016021910 A2 BR112016021910 A2 BR 112016021910A2 BR 112016021910 A BR112016021910 A BR 112016021910A BR 112016021910 A BR112016021910 A BR 112016021910A BR 112016021910 A2 BR112016021910 A2 BR 112016021910A2
Authority
BR
Brazil
Prior art keywords
pyridin
phenyl
aminocyclobutyl
imidazo
amine
Prior art date
Application number
BR112016021910A
Other languages
English (en)
Inventor
Bates Craig
Chen Jian-Xie
Mao Jianmin
P Reed David
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of BR112016021910A2 publication Critical patent/BR112016021910A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO DE PREPARAÇÃO DE 3-(3-(4-(1-AMINOCICLOBUTIL)FENIL)-5-FENIL-3H-IMIDAZO[4,5-B]PIRIDIN-2-IL)PIRIDIN-2-AMINA. A presente invenção é dirigida a um processo para a síntese de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3H-imidazo[4,5-b]piridin-2-il)piridin-2-amina: fórmula (7).
BR112016021910A 2014-03-24 2015-03-24 Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina BR112016021910A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461969546P 2014-03-24 2014-03-24
PCT/US2015/022177 WO2015148464A1 (en) 2014-03-24 2015-03-24 Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

Publications (1)

Publication Number Publication Date
BR112016021910A2 true BR112016021910A2 (pt) 2017-08-15

Family

ID=54141455

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016021910A BR112016021910A2 (pt) 2014-03-24 2015-03-24 Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina

Country Status (16)

Country Link
US (2) US9464083B2 (pt)
EP (1) EP3122748B1 (pt)
JP (1) JP6578298B2 (pt)
KR (1) KR20160135234A (pt)
CN (1) CN106459036B (pt)
AU (1) AU2015236273B2 (pt)
BR (1) BR112016021910A2 (pt)
CA (1) CA2938923A1 (pt)
DK (1) DK3122748T3 (pt)
ES (1) ES2692243T3 (pt)
IL (2) IL247480A (pt)
MX (1) MX367267B (pt)
RU (1) RU2677478C2 (pt)
TW (1) TWI662033B (pt)
WO (1) WO2015148464A1 (pt)
ZA (1) ZA201605598B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
WO2019027855A1 (en) * 2017-08-02 2019-02-07 Merck Sharp & Dohme Corp. NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
WO2019027856A1 (en) * 2017-08-02 2019-02-07 Merck Sharp & Dohme Corp. NOVEL SUBSTITUTED PYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
WO2023168291A1 (en) * 2022-03-02 2023-09-07 Terremoto Biosciences, Inc. Covalent modifiers of akt1 and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
KR100830859B1 (ko) * 2000-04-27 2008-05-21 아스텔라스세이야쿠 가부시키가이샤 이미다조피리딘 유도체 및 이를 함유하는 의약 조성물
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
CN1839132A (zh) * 2003-08-21 2006-09-27 Osi制药公司 作为c－kit抑制剂的n3－取代的咪唑并吡啶衍生物
AU2007231577B2 (en) * 2006-03-22 2012-07-19 Vertex Pharmaceuticals Incorporated c-MET protein kinase inhibitors for the treatment of proliferative disorders
US8501770B2 (en) * 2009-12-30 2013-08-06 Arqule, Inc. Substituted imidazopyridinyl-aminopyridine compounds
JP5959330B2 (ja) * 2011-06-17 2016-08-02 田辺三菱製薬株式会社 新規抗血小板薬
ES2579855T3 (es) 2011-06-24 2016-08-17 Arqule, Inc. Compuestos de imidazopiridinil-aminopiridina sustituidos
US8815854B2 (en) 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
WO2013078254A1 (en) * 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors

Also Published As

Publication number Publication date
IL253239A0 (en) 2017-08-31
IL247480A (en) 2017-07-31
MX367267B (es) 2019-08-12
ZA201605598B (en) 2018-12-19
CA2938923A1 (en) 2015-10-01
TW201623301A (zh) 2016-07-01
EP3122748A4 (en) 2017-09-27
US9834556B2 (en) 2017-12-05
US9464083B2 (en) 2016-10-11
US20160376270A1 (en) 2016-12-29
EP3122748A1 (en) 2017-02-01
US20150266876A1 (en) 2015-09-24
TWI662033B (zh) 2019-06-11
RU2677478C2 (ru) 2019-01-17
IL253239B (en) 2018-04-30
JP6578298B2 (ja) 2019-09-18
RU2016141426A3 (pt) 2018-11-19
MX2016012485A (es) 2016-12-16
AU2015236273A1 (en) 2016-08-25
EP3122748B1 (en) 2018-09-26
RU2016141426A (ru) 2018-04-25
ES2692243T3 (es) 2018-11-30
WO2015148464A1 (en) 2015-10-01
CN106459036A (zh) 2017-02-22
DK3122748T3 (en) 2018-11-05
CN106459036B (zh) 2021-07-16
JP2017516749A (ja) 2017-06-22
KR20160135234A (ko) 2016-11-25
AU2015236273B2 (en) 2019-03-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 471/04 , C07D 401/04 , C07D 403/04

Ipc: C07D 471/04 (2006.01), C07D 401/04 (2006.01), C07D

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time