DE69740159D1 - Benzamid-Derivate, verwendbar als Zelldifferenzierungsinduktoren - Google Patents
Benzamid-Derivate, verwendbar als ZelldifferenzierungsinduktorenInfo
- Publication number
- DE69740159D1 DE69740159D1 DE69740159T DE69740159T DE69740159D1 DE 69740159 D1 DE69740159 D1 DE 69740159D1 DE 69740159 T DE69740159 T DE 69740159T DE 69740159 T DE69740159 T DE 69740159T DE 69740159 D1 DE69740159 D1 DE 69740159D1
- Authority
- DE
- Germany
- Prior art keywords
- cell differentiation
- derivatives useful
- benzamide derivatives
- differentiation inducers
- inducers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
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- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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US6822267B1 (en) * | 1997-08-20 | 2004-11-23 | Advantest Corporation | Signal transmission circuit, CMOS semiconductor device, and circuit board |
US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
US6503949B1 (en) | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
CN1356977A (zh) * | 1999-05-17 | 2002-07-03 | 诺沃挪第克公司 | 胰高血糖素拮抗剂/反向激动剂 |
JP2001064177A (ja) * | 1999-08-16 | 2001-03-13 | Schering Ag | ベンズアミド誘導体を有効成分とする製剤 |
AU6936500A (en) * | 1999-08-24 | 2001-03-19 | Regents Of The University Of California, The | Non-quinoline inhibitors of malaria parasites |
JP2001081031A (ja) * | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
CA2391952C (en) | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
CZ20024105A3 (cs) * | 2000-06-23 | 2003-05-14 | Novo Nordisk A/S | Glukagonoví antagonisté/inverzní agonisté |
UA75093C2 (en) | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
US6902881B2 (en) * | 2000-10-13 | 2005-06-07 | President And Fellows Of Harvard College | Compounds and methods for regulating cell differentiation |
DE60207399T2 (de) | 2001-03-02 | 2006-08-03 | F. Hoffmann-La Roche Ag | Alkoxycarbonylaminobenzoesäure- oder alkoxycarbonylaminotetrazolylphenylderivate als ip-antagonisten |
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WO2019019130A1 (zh) * | 2017-07-28 | 2019-01-31 | 杭州领业医药科技有限公司 | 含恩替诺特的化合物,其化合物晶型及其制备方法和药物组合物 |
CN107459480A (zh) * | 2017-09-05 | 2017-12-12 | 镇江斯格派医疗器械有限公司 | 一种双芳基脲类组蛋白去乙酰化酶抑制剂 |
EP3461488A1 (de) | 2017-09-27 | 2019-04-03 | Onxeo | Kombination aus einem dbait-molekül und einem hdac-inhibitor zur behandlung von krebs |
EP3461480A1 (de) | 2017-09-27 | 2019-04-03 | Onxeo | Kombination von checkpoint-hemmern des dna-schädigungsantwort-zellzyklus und belinostat zur behandlung von krebs |
US20220265669A1 (en) * | 2019-02-25 | 2022-08-25 | Albert Einstein College Of Medicine | Compounds useful for inhibiting raf dimers |
EP3997209A4 (de) * | 2019-07-08 | 2023-06-07 | Mayo Foundation for Medical Education and Research | Wnt-aktivatoren und verwendungsverfahren |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CA3176748A1 (en) | 2020-04-30 | 2021-11-04 | Jia-Shiong Chen | Histone deacetylase inhibitors for immunomodulation in tumor microenvironment |
CN113200908B (zh) * | 2021-04-09 | 2022-07-19 | 南华大学 | 一种含叔胺的邻氨基苯甲酰胺类化合物及其制备与应用 |
CN113185454B (zh) * | 2021-04-09 | 2022-07-05 | 南华大学 | 一种基于恩替诺特骨架的邻氨基苯甲酰胺类化合物及其制备与应用 |
KR20240019100A (ko) * | 2021-05-10 | 2024-02-14 | 맥파란 스미스 리미티드 | 엔티노스타트의 신규 형태 |
WO2023041805A1 (en) | 2021-09-20 | 2023-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
WO2023194441A1 (en) | 2022-04-05 | 2023-10-12 | Istituto Nazionale Tumori Irccs - Fondazione G. Pascale | Combination of hdac inhibitors and statins for use in the treatment of pancreatic cancer |
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PL157443B1 (en) * | 1988-12-22 | 1992-05-29 | Univ Mikolaja Kopernika | Method for preparation of the new, n-phenylcarbamyle derivatives of difurylethane and difurylvinylchloride |
CA2056911C (en) | 1990-12-11 | 1998-09-22 | Yuuichi Nagano | Hiv protease inhibitors |
GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
JPH06179622A (ja) | 1992-12-15 | 1994-06-28 | Taisho Pharmaceut Co Ltd | 分化誘導剤 |
JPH06192073A (ja) | 1992-12-24 | 1994-07-12 | Eisai Co Ltd | 細胞分化誘導剤 |
JP3593350B2 (ja) | 1993-03-05 | 2004-11-24 | エーザイ株式会社 | 細胞分化誘導剤 |
JPH06316520A (ja) | 1993-03-11 | 1994-11-15 | Eisai Co Ltd | 非環状ポリイソプレノイド系細胞分化誘導剤 |
JPH06305955A (ja) | 1993-04-27 | 1994-11-01 | Eisai Co Ltd | キノン系細胞分化誘導剤 |
JPH07206765A (ja) | 1993-12-27 | 1995-08-08 | Medicine Inst Chinese Acad Medical Science | 安息香酸誘導体 |
JPH07258100A (ja) | 1994-03-24 | 1995-10-09 | Osamu Michioka | サツマイモに分布するガン細胞の増殖抑制および分化を促進することで抗がん作用を示す糖脂質およびその精製方法 |
GB9408185D0 (en) | 1994-04-25 | 1994-06-15 | Fujisawa Pharmaceutical Co | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
JP2978967B2 (ja) | 1995-01-11 | 1999-11-15 | 三進製藥株式會社 | 新規ピペラジン誘導体、その製造方法及びそれを含有する組成物 |
GB9526560D0 (en) * | 1995-12-27 | 1996-02-28 | Bayer Ag | Use of 2-Amino-Heterocycles |
US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
-
1997
- 1997-09-26 US US08/935,087 patent/US6174905B1/en not_active Ceased
- 1997-09-30 EP EP04008185A patent/EP1437346B9/de not_active Expired - Lifetime
- 1997-09-30 DE DE69729626T patent/DE69729626T2/de not_active Expired - Lifetime
- 1997-09-30 EP EP97307679A patent/EP0847992B1/de not_active Expired - Lifetime
- 1997-09-30 DE DE69740159T patent/DE69740159D1/de not_active Expired - Lifetime
- 1997-09-30 ES ES04008185T patent/ES2359564T3/es not_active Expired - Lifetime
- 1997-09-30 ES ES97307679T patent/ES2218645T3/es not_active Expired - Lifetime
-
2006
- 2006-10-03 US US11/542,043 patent/USRE40703E1/en not_active Expired - Lifetime
-
2007
- 2007-11-14 US US11/984,206 patent/US7687525B2/en not_active Expired - Fee Related
-
2010
- 2010-03-11 US US12/721,843 patent/US8026239B2/en not_active Expired - Fee Related
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EP0847992A1 (de) | 1998-06-17 |
EP1437346A1 (de) | 2004-07-14 |
ES2359564T3 (es) | 2011-05-24 |
US8026239B2 (en) | 2011-09-27 |
EP0847992B1 (de) | 2004-06-23 |
USRE40703E1 (en) | 2009-04-28 |
ES2218645T3 (es) | 2004-11-16 |
EP1437346B9 (de) | 2011-09-28 |
US6174905B1 (en) | 2001-01-16 |
US7687525B2 (en) | 2010-03-30 |
US20100256201A1 (en) | 2010-10-07 |
DE69729626T2 (de) | 2005-07-28 |
EP1437346B1 (de) | 2011-03-30 |
DE69729626D1 (de) | 2004-07-29 |
US20080188489A1 (en) | 2008-08-07 |
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