IT1392908B1 - Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative - Google Patents

Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative

Info

Publication number
IT1392908B1
IT1392908B1 ITMI2008A001720A ITMI20081720A IT1392908B1 IT 1392908 B1 IT1392908 B1 IT 1392908B1 IT MI2008A001720 A ITMI2008A001720 A IT MI2008A001720A IT MI20081720 A ITMI20081720 A IT MI20081720A IT 1392908 B1 IT1392908 B1 IT 1392908B1
Authority
IT
Italy
Prior art keywords
histone
philadelphia
care
negative
deacetylase inhibitors
Prior art date
Application number
ITMI2008A001720A
Other languages
English (en)
Inventor
Tiziano Barbui
Tiziano Oldoni
Paolo Mascagni
Alessandro Rambaldi
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2008A001720A priority Critical patent/IT1392908B1/it
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to KR1020177031565A priority patent/KR20170124640A/ko
Priority to KR1020167020675A priority patent/KR20160096721A/ko
Priority to BRPI0913699A priority patent/BRPI0913699A2/pt
Priority to EP09783251.3A priority patent/EP2344253B1/en
Priority to PT97832513T priority patent/PT2344253E/pt
Priority to DK09783251.3T priority patent/DK2344253T3/da
Priority to PL09783251T priority patent/PL2344253T3/pl
Priority to ES09783251.3T priority patent/ES2478827T3/es
Priority to CA2738081A priority patent/CA2738081C/en
Priority to CN2009801382462A priority patent/CN102164638A/zh
Priority to JP2011528301A priority patent/JP2012504112A/ja
Priority to KR1020117008487A priority patent/KR20110069075A/ko
Priority to SI200930963T priority patent/SI2344253T1/sl
Priority to PCT/EP2009/062214 priority patent/WO2010034693A1/en
Publication of ITMI20081720A1 publication Critical patent/ITMI20081720A1/it
Priority to US13/064,450 priority patent/US20110294892A1/en
Application granted granted Critical
Publication of IT1392908B1 publication Critical patent/IT1392908B1/it
Priority to US14/047,391 priority patent/US9522127B2/en
Priority to HRP20140499AT priority patent/HRP20140499T1/hr
Priority to SM201400087T priority patent/SMT201400087B/it
Priority to CY20141100514T priority patent/CY1115255T1/el
Priority to US15/346,926 priority patent/US20170049740A1/en
Priority to US17/149,794 priority patent/US20210128512A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ITMI2008A001720A 2008-09-29 2008-09-29 Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative IT1392908B1 (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI2008A001720A IT1392908B1 (it) 2008-09-29 2008-09-29 Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
JP2011528301A JP2012504112A (ja) 2008-09-29 2009-09-21 フィラデルフィア陰性骨髄増殖性症候群のケアのためのヒストンデアセチラーゼ阻害剤の使用
BRPI0913699A BRPI0913699A2 (pt) 2008-09-29 2009-09-21 inibidores de histona desacetilase para o tratamento de síndromes mieloproliferativas negativas para filadélfia
EP09783251.3A EP2344253B1 (en) 2008-09-29 2009-09-21 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes
PT97832513T PT2344253E (pt) 2008-09-29 2009-09-21 Utilização de inibidores de histona-desacetilase para o cuidado de sindromas mieloproliferativos filadélfia-negativos
DK09783251.3T DK2344253T3 (da) 2008-09-29 2009-09-21 Anvendelse af histon-deacetylase-inhibitorer til pleje af philadelphia-negative myeloproliferative syndromer
PL09783251T PL2344253T3 (pl) 2008-09-29 2009-09-21 Zastosowanie inhibitorów deacetylazy histonowej do leczenia zespołów mieloproliferacyjnych Philadelphia-ujemnych
ES09783251.3T ES2478827T3 (es) 2008-09-29 2009-09-21 Uso de inhibidores de histona desacetilasa para el tratamiento de síndromes mieloproliferativos Filadelfia negativos
CA2738081A CA2738081C (en) 2008-09-29 2009-09-21 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes
KR1020167020675A KR20160096721A (ko) 2008-09-29 2009-09-21 필라델피아 염색체-음성 골수증식 증후군의 관리를 위한 히스톤 디아세틸라아제 억제제의 용도
KR1020177031565A KR20170124640A (ko) 2008-09-29 2009-09-21 필라델피아 염색체-음성 골수증식 증후군의 관리를 위한 히스톤 디아세틸라아제 억제제의 용도
CN2009801382462A CN102164638A (zh) 2008-09-29 2009-09-21 组蛋白脱乙酰酶抑制剂在治疗费城-阴性骨髓增生综合征中的用途
KR1020117008487A KR20110069075A (ko) 2008-09-29 2009-09-21 필라델피아 염색체-음성 골수증식 증후군의 관리를 위한 히스톤 디아세틸라아제 억제제의 용도
PCT/EP2009/062214 WO2010034693A1 (en) 2008-09-29 2009-09-21 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes
SI200930963T SI2344253T1 (sl) 2008-09-29 2009-09-21 Uporaba inhibitorjev histon deacetilaze za terapijo philadelphia- negativnih mieloproliferativnih sindromov
US13/064,450 US20110294892A1 (en) 2008-09-29 2011-03-25 Use of histone deacetylase inhibitors for the care of Philadephia-negative myeloproliferative syndromes
US14/047,391 US9522127B2 (en) 2008-09-29 2013-10-07 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes
HRP20140499AT HRP20140499T1 (hr) 2008-09-29 2014-05-30 Upotreba inhibitora histonske deacetilaze u lijeäśenju filadelfija-negativnih mijeloproliferativnih sindroma
SM201400087T SMT201400087B (it) 2008-09-29 2014-07-07 Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
CY20141100514T CY1115255T1 (el) 2008-09-29 2014-07-09 Χρηση αναστολεων αποακετυλασης ιστονων για την φροντιδα philadelphia-αρνητικων μυελοπολλαπλασιαστικων συνδρομων
US15/346,926 US20170049740A1 (en) 2008-09-29 2016-11-09 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes
US17/149,794 US20210128512A1 (en) 2008-09-29 2021-01-15 Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001720A IT1392908B1 (it) 2008-09-29 2008-09-29 Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative

Publications (2)

Publication Number Publication Date
ITMI20081720A1 ITMI20081720A1 (it) 2010-03-30
IT1392908B1 true IT1392908B1 (it) 2012-04-02

Family

ID=40810309

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001720A IT1392908B1 (it) 2008-09-29 2008-09-29 Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative

Country Status (17)

Country Link
US (4) US20110294892A1 (it)
EP (1) EP2344253B1 (it)
JP (1) JP2012504112A (it)
KR (3) KR20170124640A (it)
CN (1) CN102164638A (it)
BR (1) BRPI0913699A2 (it)
CA (1) CA2738081C (it)
CY (1) CY1115255T1 (it)
DK (1) DK2344253T3 (it)
ES (1) ES2478827T3 (it)
HR (1) HRP20140499T1 (it)
IT (1) IT1392908B1 (it)
PL (1) PL2344253T3 (it)
PT (1) PT2344253E (it)
SI (1) SI2344253T1 (it)
SM (1) SMT201400087B (it)
WO (1) WO2010034693A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217079B2 (en) * 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
WO2015165975A1 (en) * 2014-04-29 2015-11-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating myeloid neoplasias
US20180127386A1 (en) 2016-10-20 2018-05-10 Forma Therapeutics, Inc. Methods using hdac11 inhibitors
JP7098640B2 (ja) * 2017-02-20 2022-07-11 ダウ シリコーンズ コーポレーション 室温硬化性シリコーン組成物及び電気／電子機器
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
IT1283637B1 (it) 1996-05-14 1998-04-23 Italfarmaco Spa Composti ad attivita' antinfiammatoria ed immunosoppressiva
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
US8034831B2 (en) * 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
ITMI20030063A1 (it) * 2003-01-17 2004-07-18 Italfarmaco Spa Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.
ITMI20030064A1 (it) * 2003-01-17 2004-07-18 Italfarmaco Spa Uso dei derivati dell'acido idrossamico per la preparazione
US7244751B2 (en) 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
EP1819669A2 (en) * 2004-12-09 2007-08-22 Kalypsys, Inc. Novel inhibitors of histone deacetylase for the treatment of disease
AR056682A1 (es) * 2005-07-29 2007-10-17 Kalypsys Inc COMPUESTOS MULTICíCLICOS DERIVADOS DE LA SULFONAMIDA COMO INHIBIDORES DE LA HISTONA DESACETILASA Y COMPOSICIoN FARMACÉUTICA
JP2009518438A (ja) 2005-12-09 2009-05-07 マサチューセッツ・インスティテュート・オブ・テクノロジー 核形態に基づく腫瘍幹細胞の同定および標的のための方法
US20080242648A1 (en) * 2006-11-10 2008-10-02 Syndax Pharmaceuticals, Inc., A California Corporation COMBINATION OF ERa+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
US20110104177A1 (en) * 2006-12-28 2011-05-05 The Johns Hopkins University Histone deacetylase inhibitors, combination therapies and methods of use

Also Published As

Publication number Publication date
US20210128512A1 (en) 2021-05-06
JP2012504112A (ja) 2012-02-16
DK2344253T3 (da) 2014-06-16
CA2738081A1 (en) 2010-04-01
CA2738081C (en) 2017-11-07
US20140039059A1 (en) 2014-02-06
CN102164638A (zh) 2011-08-24
HRP20140499T1 (hr) 2014-07-04
BRPI0913699A2 (pt) 2017-06-13
KR20170124640A (ko) 2017-11-10
KR20110069075A (ko) 2011-06-22
SI2344253T1 (sl) 2014-08-29
SMT201400087B (it) 2014-09-08
EP2344253A1 (en) 2011-07-20
US20170049740A1 (en) 2017-02-23
US9522127B2 (en) 2016-12-20
ES2478827T3 (es) 2014-07-23
PL2344253T3 (pl) 2014-09-30
CY1115255T1 (el) 2017-01-04
KR20160096721A (ko) 2016-08-16
PT2344253E (pt) 2014-07-16
ITMI20081720A1 (it) 2010-03-30
US20110294892A1 (en) 2011-12-01
WO2010034693A1 (en) 2010-04-01
EP2344253B1 (en) 2014-04-23

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