ITMI20030063A1 - Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. - Google Patents

Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.

Info

Publication number
ITMI20030063A1
ITMI20030063A1 IT000063A ITMI20030063A ITMI20030063A1 IT MI20030063 A1 ITMI20030063 A1 IT MI20030063A1 IT 000063 A IT000063 A IT 000063A IT MI20030063 A ITMI20030063 A IT MI20030063A IT MI20030063 A1 ITMI20030063 A1 IT MI20030063A1
Authority
IT
Italy
Prior art keywords
hydroxicarbammoyl
diethylaminomethy
naftalen
fenyl
ester
Prior art date
Application number
IT000063A
Other languages
English (en)
Inventor
Paolo Mascagni
Massimo Pinori
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to IT000063A priority Critical patent/ITMI20030063A1/it
Priority to PCT/IT2004/000003 priority patent/WO2004065355A1/en
Priority to EP04700754A priority patent/EP1583737B1/en
Priority to ES04700754T priority patent/ES2372280T3/es
Priority to JP2006500386A priority patent/JP4425906B2/ja
Publication of ITMI20030063A1 publication Critical patent/ITMI20030063A1/it
Priority to US11/149,548 priority patent/US7329689B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT000063A 2003-01-17 2003-01-17 Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. ITMI20030063A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT000063A ITMI20030063A1 (it) 2003-01-17 2003-01-17 Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.
PCT/IT2004/000003 WO2004065355A1 (en) 2003-01-17 2004-01-08 Monohydrate hydrochloride of the 4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylaminomethyl-naphtalen-2-yl) ester
EP04700754A EP1583737B1 (en) 2003-01-17 2004-01-08 Monohydrate hydrochloride of the 4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylaminomethyl-naphtalen-2-yl) ester
ES04700754T ES2372280T3 (es) 2003-01-17 2004-01-08 Clorhidrato monohidratado del éster (6-dietilaminometil-naftalen-2-ílico) del ácido (4-hidroxicarbamoil-fenil)-carbámico.
JP2006500386A JP4425906B2 (ja) 2003-01-17 2004-01-08 ４−ヒドロキシカルバモイルフェニル）−カルバミン酸（６−ジエチルアミノメチル−ナフタレン−２−イル）エステルの塩酸一水和物
US11/149,548 US7329689B2 (en) 2003-01-17 2005-06-10 Monohydrate hydrochloride of the 4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylaminomethyl-naphtalen-2-yl) ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000063A ITMI20030063A1 (it) 2003-01-17 2003-01-17 Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.

Publications (1)

Publication Number Publication Date
ITMI20030063A1 true ITMI20030063A1 (it) 2004-07-18

Family

ID=32750475

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000063A ITMI20030063A1 (it) 2003-01-17 2003-01-17 Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.

Country Status (6)

Country Link
US (1) US7329689B2 (it)
EP (1) EP1583737B1 (it)
JP (1) JP4425906B2 (it)
ES (1) ES2372280T3 (it)
IT (1) ITMI20030063A1 (it)
WO (1) WO2004065355A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1392908B1 (it) 2008-09-29 2012-04-02 Italfarmaco Spa Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
IT1396915B1 (it) 2009-10-23 2012-12-20 Italfarmaco Spa Dietil-[6-(4-idrossicarbamoil-fenil-carbamoilossimetil)-naftalen-2-il-metil]-ammonio cloruro ed altri derivati della n-idrossi-benzammide per l'uso nel trattamento di infezioni da hiv.
IT1397912B1 (it) * 2010-01-28 2013-02-04 Chemi Spa Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.
US8217079B2 (en) 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
JP2015512869A (ja) 2012-02-03 2015-04-30 イタルファルマコ ソシエタ ペル アチオニＩｔａｌｆａｒｍａｃｏ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 筋ジストロフィーの治療に用いられるジエチル−［６−（４−ヒドロキシカルバモイル−フェニル−カルバモイルオキシ−メチル）−ナフタレン−２−イル−メチル］−アンモニウムクロリド
ITUB20155193A1 (it) * 2015-11-03 2017-05-03 Italfarmaco Spa Sospensioni orali di Givinostat fisicamente e chimicamente stabili
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
IT201900003281A1 (it) * 2019-03-06 2020-09-06 Chemi Spa Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza
WO2022088047A1 (zh) * 2020-10-30 2022-05-05 中国科学院深圳先进技术研究院 Itf2357在制备预防和治疗冠状病毒的药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283637B1 (it) * 1996-05-14 1998-04-23 Italfarmaco Spa Composti ad attivita' antinfiammatoria ed immunosoppressiva

Also Published As

Publication number Publication date
JP4425906B2 (ja) 2010-03-03
JP2006515028A (ja) 2006-05-18
EP1583737A1 (en) 2005-10-12
EP1583737B1 (en) 2011-08-24
WO2004065355A1 (en) 2004-08-05
US7329689B2 (en) 2008-02-12
US20050245604A1 (en) 2005-11-03
ES2372280T3 (es) 2012-01-18

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