DE69717831T3 - Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels - Google Patents
Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels Download PDFInfo
- Publication number
- DE69717831T3 DE69717831T3 DE69717831.5T DE69717831T DE69717831T3 DE 69717831 T3 DE69717831 T3 DE 69717831T3 DE 69717831 T DE69717831 T DE 69717831T DE 69717831 T3 DE69717831 T3 DE 69717831T3
- Authority
- DE
- Germany
- Prior art keywords
- dioxopiperidin
- oxo
- mixture
- mmol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08690258 US5635517B1 (en) | 1996-07-24 | 1996-07-24 | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US690258 | 1996-07-24 | ||
| US08/701,494 US5798368A (en) | 1996-08-22 | 1996-08-22 | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US701494 | 1996-08-22 | ||
| US4827897P | 1997-05-30 | 1997-05-30 | |
| US48278P | 1997-05-30 | ||
| EP97936295.1A EP0925294B3 (en) | 1996-07-24 | 1997-07-24 | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
| PCT/US1997/013375 WO1998003502A1 (en) | 1996-07-24 | 1997-07-24 | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
Publications (4)
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| DE69717831D1 DE69717831D1 (de) | 2003-01-23 |
| DE69717831T2 DE69717831T2 (de) | 2003-08-28 |
| DE69717831C5 DE69717831C5 (de) | 2008-03-20 |
| DE69717831T3 true DE69717831T3 (de) | 2018-08-30 |
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| DE69740140T Expired - Lifetime DE69740140D1 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide und Oxoisoindoline und Verfahren zur Verringerung der TNF-Alpha-Stufen |
| DE69739802T Expired - Lifetime DE69739802D1 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-Dioxopiperidine-3-yl)-phthalimide -1-oxoisoindoline und Verfahren zur Reduzierung des TNF-alpha Spiegels |
| DE200712000079 Active DE122007000079I2 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels |
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| DE69740140T Expired - Lifetime DE69740140D1 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide und Oxoisoindoline und Verfahren zur Verringerung der TNF-Alpha-Stufen |
| DE69739802T Expired - Lifetime DE69739802D1 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-Dioxopiperidine-3-yl)-phthalimide -1-oxoisoindoline und Verfahren zur Reduzierung des TNF-alpha Spiegels |
| DE200712000079 Active DE122007000079I2 (de) | 1996-07-24 | 1997-07-24 | Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels |
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| GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
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| US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| DE4422237A1 (de) * | 1994-06-24 | 1996-01-04 | Gruenenthal Gmbh | Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe |
| PL195916B1 (pl) * | 1996-07-24 | 2007-11-30 | Celgene Corp | Izomery optyczne podstawionej 1-okso-izoindoliny i 1,3-diokso-izoindoliny, kompozycje farmaceutyczne je zawierające oraz ich zastosowanie |
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
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Representative=s name: KEBEKUS, U., DIPL.-BIOCHEM. DR.RER.NAT., PAT.-ANW. |
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Free format text: PRODUCT NAME: LENALIDOMID, 1-OXO-(2,6-DIOXOPIPERIDIN-3-YL)-4-AMINOISOINDOLIN UND SAEUREADDITIONSSALZE SOWIE DERIVATE DAVON, WIE IM STAMMPATENT BESCHRIEBEN; REGISTRATION NO/DATE: EU/1/07/391/001 - EU/1/07/391/004; 20070614 Spc suppl protection certif: 12 2007 000 079 Filing date: 20071119 |
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Free format text: PRODUCT NAME: LENALIDOMID, 1-OXO-(2,6-DIOXOPIPERIDIN-3-YL)-4-AMINOISOINDOLIN UND SAEUREADDITIONSSALZE SOWIE DERIVATE DAVON, WIE IM STAMMPATENT BESCHRIEBEN; REGISTRATION NO/DATE: EU/1/07/391/001 - EU/1/07/391/004; 20070614 Spc suppl protection certif: 12 2007 000 079 Filing date: 20071119 |
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Free format text: PRODUCT NAME: LENALIDOMID, 1-OXO-(2,6-DIOXOPIPERIDIN-3-YL)-4-AMINOISOINDOLIN UND SAEUREADDITIONSSALZE SOWIE DERIVATE DAVON, WIE IM STAMMPATENT BESCHRIEBEN; REGISTRATION NO/DATE: EU/1/07/391/001 - EU/1/07/391/004; 20070614 Spc suppl protection certif: 12 2007 000 079 Filing date: 20071119 |