MX2021005366A - Metodos y combinaciones para el tratamiento y modulacion de celulas t. - Google Patents

Metodos y combinaciones para el tratamiento y modulacion de celulas t.

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Publication number
MX2021005366A
MX2021005366A MX2021005366A MX2021005366A MX2021005366A MX 2021005366 A MX2021005366 A MX 2021005366A MX 2021005366 A MX2021005366 A MX 2021005366A MX 2021005366 A MX2021005366 A MX 2021005366A MX 2021005366 A MX2021005366 A MX 2021005366A
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Mexico
Prior art keywords
methods
cell therapy
cells
compositions
involving
Prior art date
Application number
MX2021005366A
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English (en)
Inventor
Michael Pourdehnad
Michael Ports
Melissa Works
Yue Jiang
Stanley R Frankel
Jens Hasskarl
Heidi Jessup
Jim Shi Xiang Qin
Neha Soni
Original Assignee
Juno Therapeutics Inc
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Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021005366A publication Critical patent/MX2021005366A/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

La presente descripción se refiere en algunos aspectos a métodos, composiciones y usos que implican inmunoterapias, tal como terapia celular adoptiva, por ejemplo, terapia de células T, y un compuesto inmunomodulador, tal como un análogo estructural o funcional o derivado de talidomida y/o un inhibidor de E3-ubiquitina ligasa. Los métodos, composiciones y usos proporcionados incluyen aquellos para terapias de combinación que implican la administración o el uso de uno o más compuestos inmunomoduladores en conjunto con una terapia de células T, tal como una terapia de células T genéticamente modificadas que implica células modificadas con un receptor recombinante, tal como células T que expresan receptor de antígeno quimérico (CAR). También se proporcionan composiciones, métodos de administración a sujetos, artículos de fabricación y kits para el uso en los métodos. En algunos aspectos, las características de los métodos y células proporcionan actividad, eficacia, persistencia, expansión y/o proliferación incrementada o mejorada de células T para terapia celular adoptiva o células T endógenas reclutadas por agentes inmunoterapéuticos.
MX2021005366A 2018-11-08 2019-11-07 Metodos y combinaciones para el tratamiento y modulacion de celulas t. MX2021005366A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862757755P 2018-11-08 2018-11-08
US201962826928P 2019-03-29 2019-03-29
PCT/US2019/060367 WO2020097403A1 (en) 2018-11-08 2019-11-07 Methods and combinations for treatment and t cell modulation

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MX2021005366A true MX2021005366A (es) 2021-09-10

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US (1) US20220008477A1 (es)
EP (1) EP3876958A1 (es)
JP (1) JP2022512971A (es)
KR (1) KR20210111247A (es)
CN (1) CN113573719A (es)
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