MX2023004707A - Combinacion de celulas t y un inhibidor de tirosina cinasa de bruton (btk) y su uso en terapia. - Google Patents

Combinacion de celulas t y un inhibidor de tirosina cinasa de bruton (btk) y su uso en terapia.

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Publication number
MX2023004707A
MX2023004707A MX2023004707A MX2023004707A MX2023004707A MX 2023004707 A MX2023004707 A MX 2023004707A MX 2023004707 A MX2023004707 A MX 2023004707A MX 2023004707 A MX2023004707 A MX 2023004707A MX 2023004707 A MX2023004707 A MX 2023004707A
Authority
MX
Mexico
Prior art keywords
cells
methods
cell therapy
compositions
therapy
Prior art date
Application number
MX2023004707A
Other languages
English (en)
Inventor
Michael Ports
Ruth Amanda Salmon
Oleksandr Baturevych
Heidi Gillenwater
Jim Qin
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2023004707A publication Critical patent/MX2023004707A/es

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Abstract

Se proporcionan en la presente métodos, composiciones y usos que implican inmunoterapias, tal como terapia celular adoptiva, por ejemplo, terapia de células T, e inhibidores de una cinasa de la familia TEK, tal como BTK o ITK. Los métodos proporcionados, composiciones y usos incluyen aquellos para terapias de combinación que implican la administración o uso de uno o más de estos inhibidores en conjunción con otro agente, tal como un agente inmunoterapéutico que fija como objetivo célula T, tal como un anticuerpo terapéutico, por ejemplo, un anticuerpo multiespecífico (por ejemplo, de acoplamiento a células T), y/o células T genéticamente modificadas, tal como células T que expresan el receptor de antígeno quimérico (CAR). También se proporcionan métodos para fabricar células T modificada, composiciones, métodos de la administración a sujetos, ácidos nucleicos, artículos de manufactura y equipos para el uso en los métodos. En algunos aspectos, las características de los métodos y células proporcionan actividad incrementada o mejorada, eficacia, persistencia, expansión y/o proliferación de células T para terapia de células adoptivas o células T endógenas reclutadas por agentes inmunoterapéuticos.
MX2023004707A 2016-11-03 2019-04-29 Combinacion de celulas t y un inhibidor de tirosina cinasa de bruton (btk) y su uso en terapia. MX2023004707A (es)

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JP2019532997A (ja) 2019-11-14
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US20190298772A1 (en) 2019-10-03
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