DE60031793T2 - Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung - Google Patents
Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung Download PDFInfo
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- DE60031793T2 DE60031793T2 DE60031793T DE60031793T DE60031793T2 DE 60031793 T2 DE60031793 T2 DE 60031793T2 DE 60031793 T DE60031793 T DE 60031793T DE 60031793 T DE60031793 T DE 60031793T DE 60031793 T2 DE60031793 T2 DE 60031793T2
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| PCT/US2000/033276 WO2001049698A1 (en) | 1999-12-29 | 2000-12-19 | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
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| DE60031793D1 DE60031793D1 (de) | 2006-12-21 |
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| WO2004087097A2 (en) * | 2003-03-31 | 2004-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer |
| CR20120384A (es) | 2003-05-14 | 2016-12-02 | Immunogen Inc | Composición de farmaco conjugado |
| WO2005042002A2 (en) * | 2003-10-30 | 2005-05-12 | Entelos, Inc. | Treatment of rhematoid arthritis with flip antagonists |
| US20070287680A1 (en) * | 2004-05-10 | 2007-12-13 | University Of Utah Research Foundation | Combined Active and Passive Targeting of Biologically Active Agents |
| BRPI0510909A2 (pt) | 2004-05-19 | 2008-12-16 | Medarex Inc | composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor |
| RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
| GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
| DE69028610T2 (de) * | 1989-12-19 | 1997-02-06 | Pharmacia S.P.A., Mailand/Milano | Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte |
| US5304687A (en) | 1989-12-19 | 1994-04-19 | Farmitalia Carlo Erba S.R.L. | Morpholinyl derivatives of doxorubicin and process for their preparation |
| GB2296495B (en) * | 1994-12-23 | 1998-04-15 | Erba Carlo Spa | Anthracycline derivatives |
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
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2000
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- 2000-12-19 AU AU29066/01A patent/AU767394C/en not_active Ceased
- 2000-12-19 DK DK00993714T patent/DK1242438T3/da active
- 2000-12-19 EP EP00993714A patent/EP1242438B1/en not_active Expired - Lifetime
- 2000-12-19 CA CA002395660A patent/CA2395660A1/en not_active Abandoned
- 2000-12-19 ES ES00993714T patent/ES2274823T3/es not_active Expired - Lifetime
- 2000-12-19 WO PCT/US2000/033276 patent/WO2001049698A1/en active IP Right Grant
- 2000-12-19 NZ NZ518764A patent/NZ518764A/en not_active IP Right Cessation
- 2000-12-19 PT PT00993714T patent/PT1242438E/pt unknown
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- 2000-12-19 DE DE60031793T patent/DE60031793T2/de not_active Expired - Lifetime
- 2000-12-21 US US09/740,991 patent/US6630579B2/en not_active Expired - Fee Related
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| EP1242438B1 (en) | 2006-11-08 |
| US20010036923A1 (en) | 2001-11-01 |
| NZ518764A (en) | 2004-02-27 |
| US6630579B2 (en) | 2003-10-07 |
| CA2395660A1 (en) | 2001-07-12 |
| AU2906601A (en) | 2001-07-16 |
| AU767394B2 (en) | 2003-11-06 |
| DK1242438T3 (da) | 2007-02-12 |
| JP2003531821A (ja) | 2003-10-28 |
| AU767394C (en) | 2005-04-21 |
| ATE344801T1 (de) | 2006-11-15 |
| WO2001049698A1 (en) | 2001-07-12 |
| DE60031793D1 (de) | 2006-12-21 |
| ES2274823T3 (es) | 2007-06-01 |
| EP1242438A1 (en) | 2002-09-25 |
| PT1242438E (pt) | 2007-02-28 |
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