DE59803108D1 - 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren - Google Patents

2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren

Info

Publication number
DE59803108D1
DE59803108D1 DE59803108T DE59803108T DE59803108D1 DE 59803108 D1 DE59803108 D1 DE 59803108D1 DE 59803108 T DE59803108 T DE 59803108T DE 59803108 T DE59803108 T DE 59803108T DE 59803108 D1 DE59803108 D1 DE 59803108D1
Authority
DE
Germany
Prior art keywords
phenyl
phosphodiesterase inhibitors
substituted imidazotriazinone
imidazotriazinone
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59803108T
Other languages
German (de)
English (en)
Inventor
Ulrich Niewoehner
Mazen Es-Sayed
Helmut Haning
Thomas Schenke
Karl-Heinz Schlemmer
Joerg Keldenich
Erwin Bischoff
Elisabeth Perzborn
Klaus Dembowsky
Peter Serno
Marc Nowakowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27217917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE59803108(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19750085A external-priority patent/DE19750085A1/de
Priority claimed from DE1998112462 external-priority patent/DE19812462A1/de
Priority claimed from DE1998140289 external-priority patent/DE19840289A1/de
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE59803108T priority Critical patent/DE59803108D1/de
Application granted granted Critical
Publication of DE59803108D1 publication Critical patent/DE59803108D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE59803108T 1997-11-12 1998-10-31 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren Expired - Lifetime DE59803108D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59803108T DE59803108D1 (de) 1997-11-12 1998-10-31 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19750085A DE19750085A1 (de) 1997-11-12 1997-11-12 2-Phenyl-substituierte Imidazotriazinone
DE1998112462 DE19812462A1 (de) 1998-03-23 1998-03-23 2-[2-Ethoxy-5(4-ethyl-piperazin-1-sulfonyl) -phenyl]-5-methyl-7-prophyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on Dihydrochlorid
DE1998140289 DE19840289A1 (de) 1998-09-04 1998-09-04 2-Phenyl-substituierte Imidazotriazinone
DE59803108T DE59803108D1 (de) 1997-11-12 1998-10-31 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren
PCT/EP1998/006910 WO1999024433A1 (de) 1997-11-12 1998-10-31 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren

Publications (1)

Publication Number Publication Date
DE59803108D1 true DE59803108D1 (de) 2002-03-21

Family

ID=27217917

Family Applications (3)

Application Number Title Priority Date Filing Date
DE59803108T Expired - Lifetime DE59803108D1 (de) 1997-11-12 1998-10-31 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren
DE19881732A Expired - Lifetime DE19881732C1 (de) 1997-11-12 1998-10-31 2-Phenyl-substituierte Imidazotriazinone
DE19881732D Expired - Lifetime DE19881732D2 (de) 1997-11-12 1998-10-31 2-Phenyl-substituierte Imidazotriazinone als Phoshodiesterase Inhibitoren

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE19881732A Expired - Lifetime DE19881732C1 (de) 1997-11-12 1998-10-31 2-Phenyl-substituierte Imidazotriazinone
DE19881732D Expired - Lifetime DE19881732D2 (de) 1997-11-12 1998-10-31 2-Phenyl-substituierte Imidazotriazinone als Phoshodiesterase Inhibitoren

Country Status (43)

Country Link
US (9) US6362178B1 (enExample)
EP (3) EP1174431B1 (enExample)
JP (2) JP3356428B2 (enExample)
KR (2) KR100548120B1 (enExample)
CN (2) CN100430396C (enExample)
AR (2) AR013759A1 (enExample)
AT (1) ATE213246T1 (enExample)
AU (1) AU738675B2 (enExample)
BG (1) BG65257B1 (enExample)
BR (2) BR9812785A (enExample)
CA (2) CA2309332C (enExample)
CH (1) CH693954A5 (enExample)
CO (1) CO4980861A1 (enExample)
CU (1) CU23063A3 (enExample)
CY (1) CY1112949T1 (enExample)
CZ (1) CZ301911B6 (enExample)
DE (3) DE59803108D1 (enExample)
DK (3) DK1049695T3 (enExample)
EE (1) EE04781B1 (enExample)
ES (3) ES2172945T3 (enExample)
FI (1) FI113772B (enExample)
GB (1) GB2346877B (enExample)
HN (1) HN1998000175A (enExample)
HR (2) HRP20000292B1 (enExample)
HU (3) HU230154B1 (enExample)
ID (1) ID25871A (enExample)
IL (3) IL135462A0 (enExample)
IN (1) IN188419B (enExample)
LU (1) LU90561B1 (enExample)
MY (1) MY138535A (enExample)
NO (2) NO314940B1 (enExample)
NZ (1) NZ504436A (enExample)
PE (1) PE131799A1 (enExample)
PL (2) PL194801B1 (enExample)
PT (2) PT1174431E (enExample)
SE (1) SE522809C2 (enExample)
SI (2) SI1049695T1 (enExample)
SK (1) SK287161B6 (enExample)
TR (1) TR200001338T2 (enExample)
TW (2) TWI229081B (enExample)
UA (1) UA46166C2 (enExample)
UY (2) UY25246A1 (enExample)
WO (1) WO1999024433A1 (enExample)

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CN1434825A (zh) * 1999-12-24 2003-08-06 拜尔公司 咪唑并[1,3,5]三嗪酮及其应用
IL158738A0 (en) 2001-05-09 2004-05-12 Bayer Healthcare Ag Novel use of 2-phenyl-substituted imidazotriazinones
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel

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HK1031730A1 (en) 2001-06-22
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Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, 1335, DE