DE3327449A1 - Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung - Google Patents

Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung

Info

Publication number
DE3327449A1
DE3327449A1 DE19833327449 DE3327449A DE3327449A1 DE 3327449 A1 DE3327449 A1 DE 3327449A1 DE 19833327449 DE19833327449 DE 19833327449 DE 3327449 A DE3327449 A DE 3327449A DE 3327449 A1 DE3327449 A1 DE 3327449A1
Authority
DE
Germany
Prior art keywords
cefuroxime axetil
cefuroxime
axetil
highly pure
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19833327449
Other languages
German (de)
English (en)
Inventor
John Charles Eastcote Pinner Middlesex Clayton
Harold Alfred Harrow Weald Middlesex Crisp
Leonard Godfrey Ulverston Cumbria Elliott
Edward McKenzie Penn High Wycombe Buckinghamshire Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10532012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3327449(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE3327449A1 publication Critical patent/DE3327449A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19833327449 1982-07-30 1983-07-29 Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung Withdrawn DE3327449A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8222019 1982-07-30

Publications (1)

Publication Number Publication Date
DE3327449A1 true DE3327449A1 (de) 1984-02-02

Family

ID=10532012

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19833327449 Withdrawn DE3327449A1 (de) 1982-07-30 1983-07-29 Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung
DE8383304405T Expired DE3374010D1 (en) 1982-07-30 1983-07-29 Novel form of cefuroxime ester, process for its preparation and composition containing it

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8383304405T Expired DE3374010D1 (en) 1982-07-30 1983-07-29 Novel form of cefuroxime ester, process for its preparation and composition containing it

Country Status (41)

Country Link
US (4) US4562181A (enExample)
EP (1) EP0107276B1 (enExample)
JP (1) JPH0730084B2 (enExample)
KR (1) KR910000046B1 (enExample)
AT (1) AT382154B (enExample)
AU (1) AU566881B2 (enExample)
BE (1) BE897422A (enExample)
CA (1) CA1240313A (enExample)
CH (1) CH657134A5 (enExample)
CS (1) CS259515B2 (enExample)
CY (1) CY1434A (enExample)
CZ (1) CZ280528B6 (enExample)
DE (2) DE3327449A1 (enExample)
DK (2) DK164507C (enExample)
DO (1) DOP1990004773A (enExample)
EC (1) ECSP941098A (enExample)
ES (1) ES8505689A1 (enExample)
FI (1) FI76093C (enExample)
FR (1) FR2531087B1 (enExample)
GB (1) GB2127401B (enExample)
GR (1) GR79349B (enExample)
HK (1) HK84288A (enExample)
HU (1) HU190603B (enExample)
IE (1) IE55748B1 (enExample)
IL (1) IL69375A (enExample)
IT (1) IT1168206B (enExample)
KE (1) KE3805A (enExample)
LU (1) LU84935A1 (enExample)
MY (1) MY8700058A (enExample)
NL (1) NL8302705A (enExample)
NO (1) NO163897C (enExample)
NZ (1) NZ205083A (enExample)
PL (1) PL156001B1 (enExample)
PT (1) PT77135B (enExample)
SE (1) SE453195B (enExample)
SG (1) SG26088G (enExample)
SK (1) SK403191A3 (enExample)
SU (1) SU1266471A3 (enExample)
YU (1) YU44680B (enExample)
ZA (1) ZA835579B (enExample)
ZW (1) ZW17383A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427859A1 (de) * 1983-07-29 1985-02-14 Glaxo Group Ltd., London Verbesserungen betreffend antibiotika
DE4011956A1 (de) * 1989-04-27 1990-10-31 Parenta Srl Verfahren und vorrichtung zur darstellung von sterilen einspritzbaren antibiotikapulvern
WO1998043980A1 (en) * 1997-03-31 1998-10-08 Daewoong Pharmaceutical Co., Ltd. A process for preparing an amorphous cefuroxime axetil having a low melting point
WO2000071116A1 (en) * 1999-05-25 2000-11-30 Ranbaxy Laboratories Limited Process for the production of amorphous atorvastatin calcium

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
NL193682C (nl) * 1987-05-14 2000-07-04 Glaxo Group Ltd Beklede cefuroximaxetilsamenstelling.
CA1339136C (en) * 1987-07-01 1997-07-29 Sailesh Amilal Varia Amorphous form of aztreonam
GB8810394D0 (en) * 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
AT393955B (de) * 1990-03-30 1992-01-10 Martin Dr Leixnering Einrichtung zur nachbehandlung frischer beugesehnenverletzungen
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (enExample) * 1997-09-29 2001-09-29 Ranbaxy Lab Ltd
GB9726781D0 (en) * 1997-12-19 1998-02-18 Glaxo Group Ltd Pharmaceutical composition
ES2171056T3 (es) * 1998-02-20 2002-08-16 Fako Ilaclari A S Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble.
CA2322432C (en) * 1998-03-03 2005-12-20 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition containing cefuroxime axetil stable for moisture absorption
KR100299356B1 (ko) * 1998-03-03 2001-10-27 윤재승 수분흡수에대해안정한세푸록심악세틸함유제약조성물
CA2239331C (en) * 1998-05-29 1999-11-30 Bernard Charles Sherman Pharmaceutical tablets comprising cefuroxime axetil
US6384213B1 (en) 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
KR100363566B1 (ko) * 1998-11-20 2003-08-19 국제약품공업주식회사 무정형 세푸록심 악세틸의 제조방법
AT413647B (de) * 1998-11-26 2006-04-15 Sandoz Ag Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten
CA2366617A1 (en) 1999-03-19 2000-09-28 Indu Bhushan Process for the preparation of a bioavailable oral dosage form of cefuroxime axetil
IN191492B (enExample) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6930983B2 (en) * 2000-03-15 2005-08-16 Texas Instruments Incorporated Integrated circuits, systems, apparatus, packets and processes utilizing path diversity for media over packet applications
CA2280925A1 (en) 1999-07-29 2001-01-29 Bernard Charles Sherman Stabilized cefuroxime axetil
IN191496B (enExample) * 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
KR100342943B1 (ko) * 1999-08-04 2002-07-02 민경윤 비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물
JP2001131071A (ja) * 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd 非晶質および非晶質を含有する医薬組成物
KR100357816B1 (ko) * 2000-05-09 2002-10-18 보령제약 주식회사 무정형 세푸록심 악세틸의 제조 및 이의 분리방법
IN190849B (enExample) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
KR20020016052A (ko) * 2000-08-24 2002-03-04 최현식 무정형 세푸록심 악세틸의 제조방법
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
KR100399195B1 (ko) * 2001-03-17 2003-09-26 신풍제약주식회사 무정형 세푸록심 악세틸의 제조방법
ITMI20011763A1 (it) * 2001-08-10 2003-02-10 Antibioticos Spa Processo di preparazione di cefuroxime axelite ad elevata purezza
ITMI20011766A1 (it) * 2001-08-10 2003-02-10 A & G Soluzioni Digitali S R L Dispositivo e metodo per la simulazione della presenza di una o piu' sorgenti di suoni in posizioni virtuali nello spazio acustico a tre dim
DK1427397T3 (da) * 2001-09-10 2008-05-26 Hoffmann La Roche Olieagtige thixotrope formuleringer
ITMI20011925A1 (it) * 2001-09-14 2003-03-14 Antibioticos Spa Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
GB2383042A (en) * 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
CZ12993U1 (cs) * 2001-11-23 2003-02-10 Glaxo Group Limited Farmaceutický prostředek
US7034162B2 (en) * 2002-08-12 2006-04-25 Dr. Reddy's Laboratories Limited Amorphous form of 3-[2-(dimethylamino) ethyl]-N-methyl-1H-indole-5-methane sulfonamide succinate (sumatriptan succinate)
US6911441B2 (en) * 2002-12-16 2005-06-28 Akzo Nobel N.V. Prolonged release pharmaceutical composition
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
US20050079213A1 (en) * 2003-06-06 2005-04-14 Unilab Pharmatech Ltd Pharmaceutical compositions
KR100552567B1 (ko) * 2003-08-23 2006-02-15 한국유나이티드제약 주식회사 수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법
US7633033B2 (en) * 2004-01-09 2009-12-15 General Lasertronics Corporation Color sensing for laser decoating
JP2007517864A (ja) * 2004-01-09 2007-07-05 ハンミ ファーム． シーオー．， エルティーディー． セフロキシムアキセチル顆粒及びこの製造方法
CN100448879C (zh) * 2004-07-22 2009-01-07 北京化工大学 一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
US8900637B2 (en) * 2005-12-02 2014-12-02 Lupin Limited Stable taste masked formulations of cephalosporins
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
SE529796C2 (sv) * 2006-02-08 2007-11-27 Optoskand Ab Fiberoptiskt kontaktdon
US10112257B1 (en) 2010-07-09 2018-10-30 General Lasertronics Corporation Coating ablating apparatus with coating removal detection
WO2013024373A1 (en) 2011-08-12 2013-02-21 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
US9895771B2 (en) 2012-02-28 2018-02-20 General Lasertronics Corporation Laser ablation for the environmentally beneficial removal of surface coatings
WO2013151516A1 (en) 2012-04-04 2013-10-10 Mahmut Bilgic Film tablet formulations comprising cefuroxime axetil and clavulanic acid
US10086597B2 (en) 2014-01-21 2018-10-02 General Lasertronics Corporation Laser film debonding method
CN105131016A (zh) * 2015-08-04 2015-12-09 江苏正大清江制药有限公司 一种头孢呋辛酯的制备方法
CN116284050B (zh) * 2022-12-19 2024-04-12 华北制药河北华民药业有限责任公司 一种高效率结晶型头孢呋辛酯转无定型粉体的方法及产品

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US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
US4002748A (en) * 1976-01-19 1977-01-11 Eli Lilly And Company Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration
GB1572993A (en) * 1976-02-16 1980-08-13 Glaxo Operations Ltd Ester derivatives of cefuroxime
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
ES484320A1 (es) * 1978-09-21 1980-10-01 Glaxo Group Ltd Un procedimiento para la preparacion de cefalosporinas
JPS5562714A (en) * 1978-11-01 1980-05-12 Hitachi Ltd Garnet film for magnetic bubble
IL58287A (en) * 1979-04-06 1982-08-31 Glaxo Group Ltd Process for the preparation of 3-carbamoyloxymethyl cephalosporin compounds
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427859A1 (de) * 1983-07-29 1985-02-14 Glaxo Group Ltd., London Verbesserungen betreffend antibiotika
DE4011956A1 (de) * 1989-04-27 1990-10-31 Parenta Srl Verfahren und vorrichtung zur darstellung von sterilen einspritzbaren antibiotikapulvern
WO1998043980A1 (en) * 1997-03-31 1998-10-08 Daewoong Pharmaceutical Co., Ltd. A process for preparing an amorphous cefuroxime axetil having a low melting point
RU2152947C2 (ru) * 1997-03-31 2000-07-20 Дае Вунг Фармасьютикал Ко., Лтд. Способ приготовления аморфного цефуроксима аксетила, имеющего низкую точку плавления
WO2000071116A1 (en) * 1999-05-25 2000-11-30 Ranbaxy Laboratories Limited Process for the production of amorphous atorvastatin calcium
US6528660B1 (en) 1999-05-25 2003-03-04 Ranbaxy Laboratories Limited Process for the production of amorphous atorvastatin calcium

Also Published As

Publication number Publication date
DK68392D0 (da) 1992-05-25
EP0107276B1 (en) 1987-10-07
SE8304208D0 (sv) 1983-07-29
CZ403191A3 (en) 1993-05-12
DK68392A (da) 1992-05-25
FI76093B (fi) 1988-05-31
SE8304208L (sv) 1984-01-31
HU190603B (en) 1986-09-29
ES524590A0 (es) 1985-06-01
DOP1990004773A (es) 1999-02-09
GR79349B (enExample) 1984-10-22
PT77135B (en) 1986-01-24
CA1240313A (en) 1988-08-09
NO832773L (no) 1984-01-31
ES8505689A1 (es) 1985-06-01
CH657134A5 (de) 1986-08-15
CY1434A (en) 1988-09-02
DK349083D0 (da) 1983-07-29
SE453195B (sv) 1988-01-18
NO163897B (no) 1990-04-30
FR2531087B1 (fr) 1985-11-22
FI832757A0 (fi) 1983-07-29
HK84288A (en) 1988-10-28
NO163897C (no) 1990-08-08
JPH0730084B2 (ja) 1995-04-05
US4820833A (en) 1989-04-11
CS568783A2 (en) 1988-03-15
DE3374010D1 (en) 1987-11-12
SU1266471A3 (ru) 1986-10-23
CZ280528B6 (cs) 1996-02-14
AT382154B (de) 1987-01-26
FI76093C (fi) 1988-09-09
MY8700058A (en) 1987-12-31
NZ205083A (en) 1986-03-14
US4994567A (en) 1991-02-19
US5013833A (en) 1991-05-07
IL69375A0 (en) 1983-11-30
BE897422A (fr) 1984-01-30
DK164507B (da) 1992-07-06
SK277896B6 (en) 1995-07-11
ECSP941098A (es) 1995-01-16
FR2531087A1 (fr) 1984-02-03
IL69375A (en) 1986-12-31
JPS5944391A (ja) 1984-03-12
AU566881B2 (en) 1987-11-05
ATA276783A (de) 1986-06-15
IT8348789A0 (it) 1983-07-29
IT1168206B (it) 1987-05-20
EP0107276A3 (en) 1985-03-06
KR840005454A (ko) 1984-11-12
IE831804L (en) 1984-01-30
KE3805A (en) 1988-06-03
GB2127401B (en) 1986-04-16
DK164507C (da) 1992-11-23
GB8320518D0 (en) 1983-09-01
NL8302705A (nl) 1984-02-16
GB2127401A (en) 1984-04-11
PL243228A1 (en) 1984-08-27
PT77135A (en) 1983-08-01
LU84935A1 (fr) 1983-11-23
CS259515B2 (en) 1988-10-14
FI832757L (fi) 1984-01-31
YU44680B (en) 1990-12-31
ZW17383A1 (en) 1983-10-26
DK349083A (da) 1984-01-31
YU155883A (en) 1986-04-30
AU1741783A (en) 1984-02-02
IT8348789A1 (it) 1985-01-29
IE55748B1 (en) 1991-01-02
ZA835579B (en) 1984-09-26
SG26088G (en) 1988-07-15
US4562181A (en) 1985-12-31
KR910000046B1 (ko) 1991-01-19
EP0107276A2 (en) 1984-05-02
SK403191A3 (en) 1995-07-11
PL156001B1 (pl) 1992-01-31

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