ES8505689A1 - Un procedimiento para preparar el ester-1-acetoxietilico de cefuroxima, altamente puro, en forma sustancialmente amorfa. - Google Patents

Un procedimiento para preparar el ester-1-acetoxietilico de cefuroxima, altamente puro, en forma sustancialmente amorfa.

Info

Publication number
ES8505689A1
ES8505689A1 ES524590A ES524590A ES8505689A1 ES 8505689 A1 ES8505689 A1 ES 8505689A1 ES 524590 A ES524590 A ES 524590A ES 524590 A ES524590 A ES 524590A ES 8505689 A1 ES8505689 A1 ES 8505689A1
Authority
ES
Spain
Prior art keywords
product
cefuroxime
preparation
composition containing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524590A
Other languages
English (en)
Other versions
ES524590A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10532012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8505689(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES524590A0 publication Critical patent/ES524590A0/es
Publication of ES8505689A1 publication Critical patent/ES8505689A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR EL ESTER 1-ACETOXIETILICO DE CEFUROXIMA ALTAMENTE PURO EN FORMA SUSTANCIALMENTE AMORFA.COMPRENDE PREPARAR UNA DISOLUCION QUE CONTIENE 1 A 30 EN MASA/MASA DEL ESTER 1-ACETOXIETILICO DE CEFUROXIMA EN UN DISOLVENTE ORGANICO O EN UNA MEZCLA HOMOGENEA DE DISOLVENTES ORGANICOS O EN UNA MEZCLA HOMOGENEA DE UNO O MAS DISOLVENTE ORGANICOS Y AGUA, Y SOMETER LA DISOLUCION A UN SECADO POR ATOMIZACION EMPLEANDO AIRE O UN GAS DE SECADO INERTE, A UNA TEMPERATURA DE ENTRADA DEL GAS DE 50 A 140JC Y A UNA TEMPERATURA DE SALIDA DEL GAS DE 45 A 100JC.
ES524590A 1982-07-30 1983-07-29 Un procedimiento para preparar el ester-1-acetoxietilico de cefuroxima, altamente puro, en forma sustancialmente amorfa. Expired ES8505689A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8222019 1982-07-30

Publications (2)

Publication Number Publication Date
ES524590A0 ES524590A0 (es) 1985-06-01
ES8505689A1 true ES8505689A1 (es) 1985-06-01

Family

ID=10532012

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524590A Expired ES8505689A1 (es) 1982-07-30 1983-07-29 Un procedimiento para preparar el ester-1-acetoxietilico de cefuroxima, altamente puro, en forma sustancialmente amorfa.

Country Status (41)

Country Link
US (4) US4562181A (es)
EP (1) EP0107276B1 (es)
JP (1) JPH0730084B2 (es)
KR (1) KR910000046B1 (es)
AT (1) AT382154B (es)
AU (1) AU566881B2 (es)
BE (1) BE897422A (es)
CA (1) CA1240313A (es)
CH (1) CH657134A5 (es)
CS (1) CS259515B2 (es)
CY (1) CY1434A (es)
CZ (1) CZ280528B6 (es)
DE (2) DE3374010D1 (es)
DK (2) DK164507C (es)
DO (1) DOP1990004773A (es)
EC (1) ECSP941098A (es)
ES (1) ES8505689A1 (es)
FI (1) FI76093C (es)
FR (1) FR2531087B1 (es)
GB (1) GB2127401B (es)
GR (1) GR79349B (es)
HK (1) HK84288A (es)
HU (1) HU190603B (es)
IE (1) IE55748B1 (es)
IL (1) IL69375A (es)
IT (1) IT1168206B (es)
KE (1) KE3805A (es)
LU (1) LU84935A1 (es)
MY (1) MY8700058A (es)
NL (1) NL8302705A (es)
NO (1) NO163897C (es)
NZ (1) NZ205083A (es)
PL (1) PL156001B1 (es)
PT (1) PT77135B (es)
SE (1) SE453195B (es)
SG (1) SG26088G (es)
SK (1) SK403191A3 (es)
SU (1) SU1266471A3 (es)
YU (1) YU44680B (es)
ZA (1) ZA835579B (es)
ZW (1) ZW17383A1 (es)

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GB8810394D0 (en) * 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
IT1230095B (it) * 1989-04-27 1991-10-05 Parenta Srl Procedimento per la preparazione di forme sterili di polveri iniettabili di antibiotici.
AT393955B (de) * 1990-03-30 1992-01-10 Martin Dr Leixnering Einrichtung zur nachbehandlung frischer beugesehnenverletzungen
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
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KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
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EP0937727B1 (de) * 1998-02-20 2002-01-30 Fako Ilaclari A.S. Verfahren zur Herstellung vom löslichen kristallinen Cefuroxim axetil
KR100299356B1 (ko) * 1998-03-03 2001-10-27 윤재승 수분흡수에대해안정한세푸록심악세틸함유제약조성물
JP2002505290A (ja) * 1998-03-03 2002-02-19 ダエウン ファーマシューティカル カンパニー リミテッド 水分吸収に対して安定であるセフロキシムアクセチルを含む医薬組成物
CA2239331C (en) * 1998-05-29 1999-11-30 Bernard Charles Sherman Pharmaceutical tablets comprising cefuroxime axetil
US6384213B1 (en) 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
KR100363566B1 (ko) * 1998-11-20 2003-08-19 국제약품공업주식회사 무정형 세푸록심 악세틸의 제조방법
AT413647B (de) * 1998-11-26 2006-04-15 Sandoz Ag Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten
PT1165051E (pt) * 1999-03-19 2003-11-28 Ranbaxy Lab Ltd Processo para a preparacao de uma forma de dosagem oral biodisponivel de cefuroxima axetil
IN191492B (es) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
IN191236B (es) * 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
US6930983B2 (en) * 2000-03-15 2005-08-16 Texas Instruments Incorporated Integrated circuits, systems, apparatus, packets and processes utilizing path diversity for media over packet applications
CA2280925A1 (en) 1999-07-29 2001-01-29 Bernard Charles Sherman Stabilized cefuroxime axetil
IN191496B (es) 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
KR100342943B1 (ko) * 1999-08-04 2002-07-02 민경윤 비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물
JP2001131071A (ja) * 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd 非晶質および非晶質を含有する医薬組成物
KR100357816B1 (ko) * 2000-05-09 2002-10-18 보령제약 주식회사 무정형 세푸록심 악세틸의 제조 및 이의 분리방법
IN190849B (es) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
KR20020016052A (ko) * 2000-08-24 2002-03-04 최현식 무정형 세푸록심 악세틸의 제조방법
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
KR100399195B1 (ko) * 2001-03-17 2003-09-26 신풍제약주식회사 무정형 세푸록심 악세틸의 제조방법
ITMI20011766A1 (it) * 2001-08-10 2003-02-10 A & G Soluzioni Digitali S R L Dispositivo e metodo per la simulazione della presenza di una o piu' sorgenti di suoni in posizioni virtuali nello spazio acustico a tre dim
ITMI20011763A1 (it) * 2001-08-10 2003-02-10 Antibioticos Spa Processo di preparazione di cefuroxime axelite ad elevata purezza
DK1427397T3 (da) * 2001-09-10 2008-05-26 Hoffmann La Roche Olieagtige thixotrope formuleringer
ITMI20011925A1 (it) * 2001-09-14 2003-03-14 Antibioticos Spa Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
CZ12993U1 (cs) * 2001-11-23 2003-02-10 Glaxo Group Limited Farmaceutický prostředek
US7034162B2 (en) * 2002-08-12 2006-04-25 Dr. Reddy's Laboratories Limited Amorphous form of 3-[2-(dimethylamino) ethyl]-N-methyl-1H-indole-5-methane sulfonamide succinate (sumatriptan succinate)
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US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
US20050079213A1 (en) * 2003-06-06 2005-04-14 Unilab Pharmatech Ltd Pharmaceutical compositions
KR100552567B1 (ko) * 2003-08-23 2006-02-15 한국유나이티드제약 주식회사 수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법
JP2007517864A (ja) * 2004-01-09 2007-07-05 ハンミ ファーム． シーオー．， エルティーディー． セフロキシムアキセチル顆粒及びこの製造方法
US7633033B2 (en) * 2004-01-09 2009-12-15 General Lasertronics Corporation Color sensing for laser decoating
CN100448879C (zh) * 2004-07-22 2009-01-07 北京化工大学 一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
US8900637B2 (en) * 2005-12-02 2014-12-02 Lupin Limited Stable taste masked formulations of cephalosporins
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US10112257B1 (en) 2010-07-09 2018-10-30 General Lasertronics Corporation Coating ablating apparatus with coating removal detection
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Also Published As

Publication number Publication date
SK277896B6 (en) 1995-07-11
JPH0730084B2 (ja) 1995-04-05
PT77135B (en) 1986-01-24
YU44680B (en) 1990-12-31
IE831804L (en) 1984-01-30
NO163897B (no) 1990-04-30
GB8320518D0 (en) 1983-09-01
AU1741783A (en) 1984-02-02
DK68392D0 (da) 1992-05-25
KR840005454A (ko) 1984-11-12
CH657134A5 (de) 1986-08-15
HU190603B (en) 1986-09-29
DK349083A (da) 1984-01-31
DK164507C (da) 1992-11-23
FI76093C (fi) 1988-09-09
IL69375A0 (en) 1983-11-30
IT8348789A0 (it) 1983-07-29
ES524590A0 (es) 1985-06-01
ZW17383A1 (en) 1983-10-26
DOP1990004773A (es) 1999-02-09
FR2531087A1 (fr) 1984-02-03
NZ205083A (en) 1986-03-14
AU566881B2 (en) 1987-11-05
US4994567A (en) 1991-02-19
US4562181A (en) 1985-12-31
SE8304208D0 (sv) 1983-07-29
DE3327449A1 (de) 1984-02-02
NO163897C (no) 1990-08-08
SU1266471A3 (ru) 1986-10-23
SG26088G (en) 1988-07-15
FI832757A0 (fi) 1983-07-29
CZ280528B6 (cs) 1996-02-14
US5013833A (en) 1991-05-07
PL156001B1 (pl) 1992-01-31
DE3374010D1 (en) 1987-11-12
ATA276783A (de) 1986-06-15
FI832757A (fi) 1984-01-31
KE3805A (en) 1988-06-03
DK68392A (da) 1992-05-25
CA1240313A (en) 1988-08-09
DK349083D0 (da) 1983-07-29
CS568783A2 (en) 1988-03-15
EP0107276A2 (en) 1984-05-02
DK164507B (da) 1992-07-06
PT77135A (en) 1983-08-01
SE453195B (sv) 1988-01-18
CZ403191A3 (en) 1993-05-12
SE8304208L (sv) 1984-01-31
PL243228A1 (en) 1984-08-27
IL69375A (en) 1986-12-31
IE55748B1 (en) 1991-01-02
US4820833A (en) 1989-04-11
ZA835579B (en) 1984-09-26
YU155883A (en) 1986-04-30
NL8302705A (nl) 1984-02-16
IT1168206B (it) 1987-05-20
HK84288A (en) 1988-10-28
BE897422A (fr) 1984-01-30
CY1434A (en) 1988-09-02
EP0107276A3 (en) 1985-03-06
FI76093B (fi) 1988-05-31
AT382154B (de) 1987-01-26
EP0107276B1 (en) 1987-10-07
FR2531087B1 (fr) 1985-11-22
SK403191A3 (en) 1995-07-11
NO832773L (no) 1984-01-31
GB2127401A (en) 1984-04-11
JPS5944391A (ja) 1984-03-12
GB2127401B (en) 1986-04-16
GR79349B (es) 1984-10-22
CS259515B2 (en) 1988-10-14
KR910000046B1 (ko) 1991-01-19
MY8700058A (en) 1987-12-31
LU84935A1 (fr) 1983-11-23
ECSP941098A (es) 1995-01-16

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