CA2239331C - Pharmaceutical tablets comprising cefuroxime axetil - Google Patents
Pharmaceutical tablets comprising cefuroxime axetil Download PDFInfo
- Publication number
- CA2239331C CA2239331C CA 2239331 CA2239331A CA2239331C CA 2239331 C CA2239331 C CA 2239331C CA 2239331 CA2239331 CA 2239331 CA 2239331 A CA2239331 A CA 2239331A CA 2239331 C CA2239331 C CA 2239331C
- Authority
- CA
- Canada
- Prior art keywords
- cefuroxime axetil
- carbonate
- tablet
- bicarbonate
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 title claims abstract description 22
- 229960002620 cefuroxime axetil Drugs 0.000 title claims abstract description 22
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 11
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 10
- 239000007884 disintegrant Substances 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229960000913 crospovidone Drugs 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 2
- 239000008109 sodium starch glycolate Substances 0.000 claims description 2
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 2
- 239000003826 tablet Substances 0.000 description 21
- 238000010521 absorption reaction Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- 230000002496 gastric effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 229960001668 cefuroxime Drugs 0.000 description 1
- JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- -1 for example Polymers 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical tablet comprising cefuroxime axetil and a carbonate or bicarbonate.
Description
PHARMACEUTICAL TABLETS COMPRISING
CEFUROXIME AXETIL
BACKGROUND
Cefuroxime axetil is an antibiotic effective against a wide spectrum of microorganisms. Antibiotics for oral administration should be in a form which provides high bioavailability, whereby absorption into the bloodstream from the gastro-intestinal tract is maximized.
For cefuroxime axetil, the prior art discloses substantial difficulties in making compositions for oral administration providing high bioavailability.
Pure cefuroxime axetil can be produced in crystalline form or amorphous form. U.S. patent 4820833 discloses that the pure amorphous form is more soluble in water than the pure crystalline form and gives higher bioavailability upon oral administration.
U.S. patent 4897270 further discloses that film coated tablets comprising cefuroxime axetil (even in amorphous form) give low levels of absorption into the blood stream unless the tablets are formulated such that, when the tablet is ingested, the film coating ruptures very rapidly and the core then disintegrates immediately.
U.S. patent 5677433 discloses a new ~ crystalline form which purports to have good bioavailability characteristics.
Taken together, U.S. patents 4820833 and 4897270 teach that good absorption from tablets comprising cefuroxime axetil can be achieved only if the cefuroxime axetil used in the formulation is in pure amorphous form and the tablets contain sufficient disintegrant to cause them to disintegrate immediately in gastro-intestinal fluid.
Copending Canadian patent application 2,209,868 discloses that the need to use cefuroxime axetil in pure amorphous form can be overcome by making a co-precipitate of cefuroxime axetil and a water-soluble excipient.
However, even when a co-precipitate is used, because of the tendency of cefuroxime axetil to form a gel in water, even when the cefuroxime axetil is in a co-precipitate, the tablets still must contain a substantial amount of disintegrant to cause them to disintegrate sufficiently rapidly to enable satisfactory absorption after ingestion.
It is the object of the present invention to overcome this limitation disclosed in the prior art; that is to say, to enable satisfactory absorption with a lesser amount of disintegrant in the tablet than required in prior art formulations.
BRIEF SUMMARY OF THE INVENTION
It has been found that the rate of disintegration of the tablets in gastric fluid can be enhanced by including in the tablet a carbonate or bicarbonate.
DETAILED DESCRIPTION OF THE INVENTION
As aforesaid, because of the tendency of cefuroxime axetil to form a gel in water, prior art tablets have required inclusion of a relatively large amount of disintegrant to cause the tablets to disintegrate sufficiently rapidly to enable satisfactory absorption after ingestion.
CEFUROXIME AXETIL
BACKGROUND
Cefuroxime axetil is an antibiotic effective against a wide spectrum of microorganisms. Antibiotics for oral administration should be in a form which provides high bioavailability, whereby absorption into the bloodstream from the gastro-intestinal tract is maximized.
For cefuroxime axetil, the prior art discloses substantial difficulties in making compositions for oral administration providing high bioavailability.
Pure cefuroxime axetil can be produced in crystalline form or amorphous form. U.S. patent 4820833 discloses that the pure amorphous form is more soluble in water than the pure crystalline form and gives higher bioavailability upon oral administration.
U.S. patent 4897270 further discloses that film coated tablets comprising cefuroxime axetil (even in amorphous form) give low levels of absorption into the blood stream unless the tablets are formulated such that, when the tablet is ingested, the film coating ruptures very rapidly and the core then disintegrates immediately.
U.S. patent 5677433 discloses a new ~ crystalline form which purports to have good bioavailability characteristics.
Taken together, U.S. patents 4820833 and 4897270 teach that good absorption from tablets comprising cefuroxime axetil can be achieved only if the cefuroxime axetil used in the formulation is in pure amorphous form and the tablets contain sufficient disintegrant to cause them to disintegrate immediately in gastro-intestinal fluid.
Copending Canadian patent application 2,209,868 discloses that the need to use cefuroxime axetil in pure amorphous form can be overcome by making a co-precipitate of cefuroxime axetil and a water-soluble excipient.
However, even when a co-precipitate is used, because of the tendency of cefuroxime axetil to form a gel in water, even when the cefuroxime axetil is in a co-precipitate, the tablets still must contain a substantial amount of disintegrant to cause them to disintegrate sufficiently rapidly to enable satisfactory absorption after ingestion.
It is the object of the present invention to overcome this limitation disclosed in the prior art; that is to say, to enable satisfactory absorption with a lesser amount of disintegrant in the tablet than required in prior art formulations.
BRIEF SUMMARY OF THE INVENTION
It has been found that the rate of disintegration of the tablets in gastric fluid can be enhanced by including in the tablet a carbonate or bicarbonate.
DETAILED DESCRIPTION OF THE INVENTION
As aforesaid, because of the tendency of cefuroxime axetil to form a gel in water, prior art tablets have required inclusion of a relatively large amount of disintegrant to cause the tablets to disintegrate sufficiently rapidly to enable satisfactory absorption after ingestion.
The disintegrant is an ingredient which absorbs water and swells to cause the tablet to disintegrate when immersed in gastro-intestinal fluid. Preferred disintegrants are water-insoluble cross-linked polymers, including, for example, croscarmellose sodium, sodium starch glycolate, and crospovidone.
It has now been found that, for tablets containing cefuroxime axetil, the tendency to form a gel in water can be alleviated and the required quantity of disintegrant that is needed can thus be reduced by including in the tablet a carbonate or bicarbonate.
The carbonate and bicarbonate that may be used within the scope of the invention may be any carbonate or bicarbonate that is sufficiently non-toxic to be suitable for use as a pharmaceutical excipient, including for example sodium bicarbonate, sodium carbonate, calcium carbonate, potassium carbonate, and magnesium carbonate.
Preferred carbonates and bicarbonates are sodium bicarbonate, sodium carbonate and calcium carbonate.
Gastric fluid is acidic. Hence, when a tablet containing a carbonate or bicarbonate is ingested and immersed in gastric fluid, the acid in the gastric fluid will react with the carbonate or bicarbonate. The reaction causes release of carbon dioxide, and thus effervescence.
In the case of cefuroxime axetil tablets, it has been found that this e~er\,escence helps inhibit gel formation and thus enables disintegration of the tablet with less disintegrant than otherwise required to achieve the desired rate of disintegration, and have the consequent desired dissolution and absorption. Compositions within the scope of the present invention are thus pharmaceutical tablets that comprise cefuroxime axetil and a carbonate or bicarbonate.
~
It has now been found that, for tablets containing cefuroxime axetil, the tendency to form a gel in water can be alleviated and the required quantity of disintegrant that is needed can thus be reduced by including in the tablet a carbonate or bicarbonate.
The carbonate and bicarbonate that may be used within the scope of the invention may be any carbonate or bicarbonate that is sufficiently non-toxic to be suitable for use as a pharmaceutical excipient, including for example sodium bicarbonate, sodium carbonate, calcium carbonate, potassium carbonate, and magnesium carbonate.
Preferred carbonates and bicarbonates are sodium bicarbonate, sodium carbonate and calcium carbonate.
Gastric fluid is acidic. Hence, when a tablet containing a carbonate or bicarbonate is ingested and immersed in gastric fluid, the acid in the gastric fluid will react with the carbonate or bicarbonate. The reaction causes release of carbon dioxide, and thus effervescence.
In the case of cefuroxime axetil tablets, it has been found that this e~er\,escence helps inhibit gel formation and thus enables disintegration of the tablet with less disintegrant than otherwise required to achieve the desired rate of disintegration, and have the consequent desired dissolution and absorption. Compositions within the scope of the present invention are thus pharmaceutical tablets that comprise cefuroxime axetil and a carbonate or bicarbonate.
~
The invention will be further illustrated by the following example, which is intended to be illustrative but not limiting of the scope of the invention.
EXAMPLE
4.5 kg of cefuroxime axetil together with 0.5 kg of sorbitol were dissolved in a mixture of 20.0 kg of acetone and 5.0 kg of water. The solution was spray-dried to obtain a co-precipitate comprising by weight 90% cefuroxime axetil and 10% sorbitol. About 0.4% by weight magnesium stearate, as a lubricant, and 0.1 % by weight colloidal silicon dioxide, as glidant, were added to this Co-precipitate and the mixture was then compacted to increase its density and then ground up into granules. The following were then mixed together:
granules 3500 g crospovidone 1470 g sodium bicarbonate 700 g magnesium stearate 20 g colloidal silicon dioxide 10 g Total : 5700 g This mixture was then compressed into tablets of weight 1140 mg.
In view of the proportions of ingredients as aforesaid, each tablet contained of about 627 mg of cefuroxime axetil, which in turn is equivalent to about 500 mg of cefuroxime.
The tablets were also tested for dissolution as set out in the United States Pharmacoepia, 23rd edition, page 316. The result was over 75% in 45 minutes, which exceeds the lower limit set in the United States Pharmacoepia, and is sufficient to ensure good absorption.
EXAMPLE
4.5 kg of cefuroxime axetil together with 0.5 kg of sorbitol were dissolved in a mixture of 20.0 kg of acetone and 5.0 kg of water. The solution was spray-dried to obtain a co-precipitate comprising by weight 90% cefuroxime axetil and 10% sorbitol. About 0.4% by weight magnesium stearate, as a lubricant, and 0.1 % by weight colloidal silicon dioxide, as glidant, were added to this Co-precipitate and the mixture was then compacted to increase its density and then ground up into granules. The following were then mixed together:
granules 3500 g crospovidone 1470 g sodium bicarbonate 700 g magnesium stearate 20 g colloidal silicon dioxide 10 g Total : 5700 g This mixture was then compressed into tablets of weight 1140 mg.
In view of the proportions of ingredients as aforesaid, each tablet contained of about 627 mg of cefuroxime axetil, which in turn is equivalent to about 500 mg of cefuroxime.
The tablets were also tested for dissolution as set out in the United States Pharmacoepia, 23rd edition, page 316. The result was over 75% in 45 minutes, which exceeds the lower limit set in the United States Pharmacoepia, and is sufficient to ensure good absorption.
Claims (5)
1. A pharmaceutical tablet comprising cefuroxime axetil and a carbonate or bicarbonate.
2. A tablet as in Claim 1 further comprising a disintegrant.
3. A tablet as in Claim 1 or 2 wherein the carbonate or bicarbonate is selected from the group consisting of sodium bicarbonate, sodium carbonate, calcium carbonate, potassium carbonate and magnesium carbonate.
4. A tablet as in Claim 2 wherein the disintegrant is selected from the group consisting of croscarmellose sodium, sodium starch glycolate, and crospovidone.
5. A tablet as in any Claims 1 to 4 which comprises a co-precipitate of cefuroxime axetil and a water-soluble excipient.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2239331 CA2239331C (en) | 1998-05-29 | 1998-05-29 | Pharmaceutical tablets comprising cefuroxime axetil |
| AU38074/99A AU3807499A (en) | 1998-05-29 | 1999-05-18 | Pharmaceutical tablets comprising cefuroxime axetil |
| PCT/CA1999/000446 WO1999062559A1 (en) | 1998-05-29 | 1999-05-18 | Pharmaceutical tablets comprising cefuroxime axetil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2239331 CA2239331C (en) | 1998-05-29 | 1998-05-29 | Pharmaceutical tablets comprising cefuroxime axetil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2239331C true CA2239331C (en) | 1999-11-30 |
Family
ID=4162505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2239331 Expired - Fee Related CA2239331C (en) | 1998-05-29 | 1998-05-29 | Pharmaceutical tablets comprising cefuroxime axetil |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3807499A (en) |
| CA (1) | CA2239331C (en) |
| WO (1) | WO1999062559A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT413647B (en) * | 1998-11-26 | 2006-04-15 | Sandoz Ag | USE OF A COPOLYMERISATE OF 1-VINYL-2-PYRROLIDONE AND VINYL ACETATE FOR THE PREPARATION OF CEFUROXIMAXETIL-SUBJECTED TABLETS |
| DE60221787T2 (en) * | 2002-03-04 | 2008-06-05 | Orbus Pharma Inc. | Fast release compositions containing cefuroxime axetil |
| WO2005002540A2 (en) * | 2003-07-01 | 2005-01-13 | Ranbaxy Laboratories Limited | Dry powder pharmaceutical suspension compositions of cefuroxime axetil |
| KR100552567B1 (en) * | 2003-08-23 | 2006-02-15 | 한국유나이티드제약 주식회사 | Composition and preparation method for tablets containing cefuroxime axetyl that is stable to moisture absorption and rapidly disintegrates |
| GB0400971D0 (en) * | 2004-01-16 | 2004-02-18 | Sandoz Ag | Pharmaceutical compositions |
| CN104230957B (en) * | 2013-06-09 | 2017-02-08 | 广东立国制药有限公司 | Preparing method of cefuroxime acid and method of removing DCC lactone in preparation process of the cefuroxime acid |
| CN106109433A (en) * | 2016-08-10 | 2016-11-16 | 瑞阳制药有限公司 | CEFUROXIME AXETIL Film coated tablets and preparation method thereof |
| CN114191375B (en) * | 2021-12-20 | 2022-07-26 | 广东金城金素制药有限公司 | Cefuroxime sodium for injection and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
| ES8502863A1 (en) * | 1982-09-10 | 1985-02-01 | Glaxo Group Ltd | Pharmaceutical compositions containing beta -lactam antibiotics |
| GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| CA2209868C (en) * | 1997-08-15 | 2001-08-14 | Bernard Charles Sherman | Pharmaceutical compositions comprising cefuroxime axetil |
-
1998
- 1998-05-29 CA CA 2239331 patent/CA2239331C/en not_active Expired - Fee Related
-
1999
- 1999-05-18 WO PCT/CA1999/000446 patent/WO1999062559A1/en not_active Ceased
- 1999-05-18 AU AU38074/99A patent/AU3807499A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999062559A1 (en) | 1999-12-09 |
| AU3807499A (en) | 1999-12-20 |
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