CY1125006T1 - Λιπαρα οξεα και η χρηση τους σε συνδυασμο με βιομορια - Google Patents
Λιπαρα οξεα και η χρηση τους σε συνδυασμο με βιομοριαInfo
- Publication number
- CY1125006T1 CY1125006T1 CY20221100152T CY221100152T CY1125006T1 CY 1125006 T1 CY1125006 T1 CY 1125006T1 CY 20221100152 T CY20221100152 T CY 20221100152T CY 221100152 T CY221100152 T CY 221100152T CY 1125006 T1 CY1125006 T1 CY 1125006T1
- Authority
- CY
- Cyprus
- Prior art keywords
- disease
- conjugate
- fatty acid
- combination
- metabolic disorders
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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Abstract
Η εφεύρεση παρέχει ένα σύζευγμα που αποτελείται από ένα βιομόριο συνδεδεμένο με ένα λιπαρό οξύ μέσω ενός συνδέτη όπου το λιπαρό οξύ έχει τους ακόλουθους Τύπους Α1, Α2 ή A3: όπου τα R1, R2, R3, R4, Ak, n, m και p ορίζονται στο παρόν. Η εφεύρεση αναφέρεται επίσης σε μια μέθοδο για την παρασκευή του συζεύγματος της εφεύρεσης, όπως του συζεύγματος GDF15, και στις θεραπευτικές του χρήσεις όπως η θεραπευτική αγωγή ή πρόληψη μεταβολικών διαταραχών ή ασθενειών, σακχαρώδη διαβήτη τύπου 2, παχυσαρκίας, παγκρεατίτιδας, δυσλιπιδαιμίας, αλκοολικής και μη αλκοολικής λιπώδους ηπατικής νόσου/στεατοηπατίτιδας και άλλων προοδευτικών ηπατικών ασθενειών, αντίστασης στην ινσουλίνη, υπερινσουλιναιμίας, δυσανεξίας στη γλυκόζη, υπεργλυκαιμίας, μεταβολικού συνδρόμου, υπέρτασης. καρδιαγγειακής νόσου, αθηροσκλήρωσης, περιφερικής αρτηριοπάθειας, εγκεφαλικού επεισοδίου, καρδιακής ανεπάρκειας, στεφανιαίας καρδιακής νόσου, διαβητικών επιπλοκών (που περιλαμβάνει, ενδεικτικά, χρόνια νεφρική νόσο), νευροπάθειας, γαστροπάρεσης και άλλων μεταβολικών διαταραχών. Η παρούσα εφεύρεση παρέχει περαιτέρω έναν συνδυασμό φαρμακολογικώς δραστικών παραγόντων και μιας φαρμακευτικής σύνθεσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462015862P | 2014-06-23 | 2014-06-23 | |
US201462082327P | 2014-11-20 | 2014-11-20 | |
US201562107016P | 2015-01-23 | 2015-01-23 | |
PCT/US2015/036328 WO2015200078A1 (en) | 2014-06-23 | 2015-06-18 | Fatty acids and their use in conjugation to biomolecules |
Publications (1)
Publication Number | Publication Date |
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CY1125006T1 true CY1125006T1 (el) | 2023-01-05 |
Family
ID=53491695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20221100152T CY1125006T1 (el) | 2014-06-23 | 2022-02-22 | Λιπαρα οξεα και η χρηση τους σε συνδυασμο με βιομορια |
Country Status (37)
Country | Link |
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US (4) | US10588980B2 (el) |
EP (2) | EP3157571B1 (el) |
JP (5) | JP6636959B2 (el) |
KR (2) | KR20230056796A (el) |
CN (3) | CN107073130B (el) |
AP (1) | AP2016009585A0 (el) |
AU (1) | AU2015280351C1 (el) |
CA (1) | CA2953480A1 (el) |
CL (1) | CL2016003281A1 (el) |
CR (1) | CR20160596A (el) |
CU (1) | CU24455B1 (el) |
CY (1) | CY1125006T1 (el) |
DK (1) | DK3157571T3 (el) |
EA (1) | EA039074B1 (el) |
EC (1) | ECSP17004665A (el) |
ES (1) | ES2905479T3 (el) |
GT (1) | GT201600263A (el) |
HK (1) | HK1232160A1 (el) |
HR (1) | HRP20220152T1 (el) |
HU (1) | HUE057845T2 (el) |
IL (1) | IL248990B (el) |
JO (1) | JO3813B1 (el) |
LT (1) | LT3157571T (el) |
MA (1) | MA40278A (el) |
MX (1) | MX367520B (el) |
MY (1) | MY193993A (el) |
PE (1) | PE20171095A1 (el) |
PH (1) | PH12016502294B1 (el) |
PL (1) | PL3157571T3 (el) |
PT (1) | PT3157571T (el) |
RS (1) | RS62907B1 (el) |
SG (2) | SG10201912965TA (el) |
SI (1) | SI3157571T1 (el) |
TN (1) | TN2016000558A1 (el) |
TW (3) | TWI701048B (el) |
UY (1) | UY36186A (el) |
WO (1) | WO2015200078A1 (el) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
EP2694092B1 (en) | 2011-04-08 | 2017-01-04 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
PT3027642T (pt) | 2013-07-31 | 2020-10-30 | Amgen Inc | Construtos do fator 15 de diferenciação de crescimento (gdf-15) |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
WO2016088059A1 (en) | 2014-12-04 | 2016-06-09 | Novartis Ag | Methods and compositions using klotho variant polypeptides |
SG11201704758XA (en) * | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
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