SG11202103990QA - Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof - Google Patents
Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereofInfo
- Publication number
- SG11202103990QA SG11202103990QA SG11202103990QA SG11202103990QA SG11202103990QA SG 11202103990Q A SG11202103990Q A SG 11202103990QA SG 11202103990Q A SG11202103990Q A SG 11202103990QA SG 11202103990Q A SG11202103990Q A SG 11202103990QA SG 11202103990Q A SG11202103990Q A SG 11202103990QA
- Authority
- SG
- Singapore
- Prior art keywords
- gdf15
- glp1
- glucagon
- peptide
- fusion proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862748603P | 2018-10-22 | 2018-10-22 | |
| PCT/IB2019/059029 WO2020084496A1 (en) | 2018-10-22 | 2019-10-22 | Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202103990QA true SG11202103990QA (en) | 2021-05-28 |
Family
ID=70330680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202103990QA SG11202103990QA (en) | 2018-10-22 | 2019-10-22 | Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US11713345B2 (en) |
| EP (1) | EP3870211A4 (en) |
| JP (1) | JP2022513363A (en) |
| KR (1) | KR20210081389A (en) |
| CN (1) | CN113226351A (en) |
| AU (1) | AU2019368816A1 (en) |
| BR (1) | BR112021007376A2 (en) |
| CA (1) | CA3116983A1 (en) |
| CL (1) | CL2021000987A1 (en) |
| CO (1) | CO2021005051A2 (en) |
| CR (1) | CR20210193A (en) |
| DO (1) | DOP2021000075A (en) |
| EA (1) | EA202191105A1 (en) |
| EC (1) | ECSP21028914A (en) |
| IL (1) | IL282297A (en) |
| JO (1) | JOP20210084A1 (en) |
| MX (1) | MX2021004665A (en) |
| PE (1) | PE20211078A1 (en) |
| PH (1) | PH12021550885A1 (en) |
| SG (1) | SG11202103990QA (en) |
| WO (1) | WO2020084496A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| JOP20210111A1 (en) * | 2018-11-20 | 2023-01-30 | Janssen Pharmaceutica Nv | Gdf15 analogs and methods for use in decreasing body weight and/or reducing food intake |
| CN115260313B (en) | 2019-12-31 | 2023-07-18 | 北京质肽生物医药科技有限公司 | Fusion proteins of GLP-1 and GDF15 and conjugates thereof |
| US20210371488A1 (en) * | 2020-05-27 | 2021-12-02 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| US20240124541A1 (en) * | 2021-04-12 | 2024-04-18 | University of Florida Research Foundation, Incorprated | Compositions and methods for treating obesity |
| EP4351628A1 (en) * | 2021-05-21 | 2024-04-17 | Yuhan Corporation | Composition for preventing or treating non-alcoholic fatty liver disease or non-alcoholic steatohepatitis comprising growth differentiation factor-15 variant |
| AU2022276998A1 (en) * | 2021-05-21 | 2023-12-07 | Yuhan Corporation | Composition for combination therapy comprising growth differentiation factor-15 variant and glucagon-like peptide-1 receptor agonist |
| WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2434237C (en) * | 2000-12-07 | 2012-05-15 | Eli Lilly And Company | Glp-1 fusion proteins |
| EP2049567A2 (en) | 2006-07-18 | 2009-04-22 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
| JP2011520961A (en) * | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | Scaffold domain protein based on multivalent fibronectin |
| CN102307994A (en) | 2009-02-06 | 2012-01-04 | 先正达参股股份有限公司 | Modification of multidomain enzyme for expression in plants |
| AU2011353197B2 (en) | 2010-12-27 | 2017-04-20 | Apo-T B.V. | A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis |
| SI2922872T1 (en) * | 2012-11-21 | 2019-01-31 | Janssen Biotech, Inc., | Bispecific egfr/c-met antibodies |
| KR101993714B1 (en) * | 2013-01-30 | 2019-06-28 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | Compositions and methods of use in treating metabolic disorders |
| KR20160021183A (en) | 2013-06-20 | 2016-02-24 | 노보 노르디스크 에이/에스 | Glp-1 derivatives and uses thereof |
| UA116665C2 (en) | 2013-07-31 | 2018-04-25 | Емджен Інк. | Growth differentiation factor 15 (gdf-15) constructs |
| GB201403794D0 (en) * | 2014-03-04 | 2014-04-16 | Univ Manchester | Novel antimicrobial peptides |
| US20170204149A1 (en) | 2014-06-23 | 2017-07-20 | Novartis Ag | Hsa-gdf-15 fusion polypeptide and use thereof |
| US10588980B2 (en) * | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| JP2019510739A (en) | 2016-02-29 | 2019-04-18 | イーライ リリー アンド カンパニー | GFRAL receptor therapy |
| US10336812B2 (en) | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
-
2019
- 2019-10-22 CR CR20210193A patent/CR20210193A/en unknown
- 2019-10-22 EP EP19875615.7A patent/EP3870211A4/en active Pending
- 2019-10-22 CA CA3116983A patent/CA3116983A1/en active Pending
- 2019-10-22 CN CN201980085401.2A patent/CN113226351A/en active Pending
- 2019-10-22 BR BR112021007376-0A patent/BR112021007376A2/en unknown
- 2019-10-22 US US17/309,114 patent/US11713345B2/en active Active
- 2019-10-22 JO JOP/2021/0084A patent/JOP20210084A1/en unknown
- 2019-10-22 WO PCT/IB2019/059029 patent/WO2020084496A1/en active Application Filing
- 2019-10-22 AU AU2019368816A patent/AU2019368816A1/en active Pending
- 2019-10-22 PE PE2021000543A patent/PE20211078A1/en unknown
- 2019-10-22 KR KR1020217015121A patent/KR20210081389A/en active Search and Examination
- 2019-10-22 MX MX2021004665A patent/MX2021004665A/en unknown
- 2019-10-22 JP JP2021546056A patent/JP2022513363A/en active Pending
- 2019-10-22 SG SG11202103990QA patent/SG11202103990QA/en unknown
- 2019-10-22 EA EA202191105A patent/EA202191105A1/en unknown
-
2021
- 2021-04-13 IL IL282297A patent/IL282297A/en unknown
- 2021-04-19 CL CL2021000987A patent/CL2021000987A1/en unknown
- 2021-04-20 CO CONC2021/0005051A patent/CO2021005051A2/en unknown
- 2021-04-21 DO DO2021000075A patent/DOP2021000075A/es unknown
- 2021-04-21 PH PH12021550885A patent/PH12021550885A1/en unknown
- 2021-04-22 EC ECSENADI202128914A patent/ECSP21028914A/en unknown
-
2023
- 2023-06-09 US US18/332,690 patent/US20230322888A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019368816A1 (en) | 2021-05-13 |
| WO2020084496A1 (en) | 2020-04-30 |
| CO2021005051A2 (en) | 2021-04-30 |
| CN113226351A (en) | 2021-08-06 |
| CA3116983A1 (en) | 2020-04-30 |
| MX2021004665A (en) | 2021-08-24 |
| PE20211078A1 (en) | 2021-06-09 |
| KR20210081389A (en) | 2021-07-01 |
| IL282297A (en) | 2021-05-31 |
| US20230322888A1 (en) | 2023-10-12 |
| EP3870211A1 (en) | 2021-09-01 |
| US20220089669A1 (en) | 2022-03-24 |
| CR20210193A (en) | 2021-06-15 |
| EA202191105A1 (en) | 2021-08-03 |
| ECSP21028914A (en) | 2021-05-31 |
| PH12021550885A1 (en) | 2022-02-21 |
| BR112021007376A2 (en) | 2021-08-10 |
| JP2022513363A (en) | 2022-02-07 |
| DOP2021000075A (en) | 2021-12-15 |
| CL2021000987A1 (en) | 2021-09-10 |
| JOP20210084A1 (en) | 2023-01-30 |
| EP3870211A4 (en) | 2022-08-10 |
| US11713345B2 (en) | 2023-08-01 |
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