HK1232160A1 - 脂肪酸及其於共軛至生物分子之用途 - Google Patents
脂肪酸及其於共軛至生物分子之用途Info
- Publication number
- HK1232160A1 HK1232160A1 HK17105974.0A HK17105974A HK1232160A1 HK 1232160 A1 HK1232160 A1 HK 1232160A1 HK 17105974 A HK17105974 A HK 17105974A HK 1232160 A1 HK1232160 A1 HK 1232160A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- biomolecules
- conjugation
- fatty acids
- fatty
- acids
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
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- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462015862P | 2014-06-23 | 2014-06-23 | |
US201462082327P | 2014-11-20 | 2014-11-20 | |
US201562107016P | 2015-01-23 | 2015-01-23 | |
PCT/US2015/036328 WO2015200078A1 (en) | 2014-06-23 | 2015-06-18 | Fatty acids and their use in conjugation to biomolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1232160A1 true HK1232160A1 (zh) | 2018-01-05 |
Family
ID=53491695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK17105974.0A HK1232160A1 (zh) | 2014-06-23 | 2017-06-15 | 脂肪酸及其於共軛至生物分子之用途 |
Country Status (37)
Country | Link |
---|---|
US (4) | US10588980B2 (zh) |
EP (2) | EP3988170A1 (zh) |
JP (5) | JP6636959B2 (zh) |
KR (2) | KR102559975B1 (zh) |
CN (3) | CN114099693A (zh) |
AP (1) | AP2016009585A0 (zh) |
AU (1) | AU2015280351C1 (zh) |
CA (1) | CA2953480A1 (zh) |
CL (1) | CL2016003281A1 (zh) |
CR (1) | CR20160596A (zh) |
CU (1) | CU24455B1 (zh) |
CY (1) | CY1125006T1 (zh) |
DK (1) | DK3157571T3 (zh) |
EA (1) | EA039074B1 (zh) |
EC (1) | ECSP17004665A (zh) |
ES (1) | ES2905479T3 (zh) |
GT (1) | GT201600263A (zh) |
HK (1) | HK1232160A1 (zh) |
HR (1) | HRP20220152T1 (zh) |
HU (1) | HUE057845T2 (zh) |
IL (1) | IL248990B (zh) |
JO (1) | JO3813B1 (zh) |
LT (1) | LT3157571T (zh) |
MA (1) | MA40278A (zh) |
MX (1) | MX367520B (zh) |
MY (1) | MY193993A (zh) |
PE (1) | PE20171095A1 (zh) |
PH (1) | PH12016502294A1 (zh) |
PL (1) | PL3157571T3 (zh) |
PT (1) | PT3157571T (zh) |
RS (1) | RS62907B1 (zh) |
SG (2) | SG11201609704TA (zh) |
SI (1) | SI3157571T1 (zh) |
TN (1) | TN2016000558A1 (zh) |
TW (3) | TWI750725B (zh) |
UY (1) | UY36186A (zh) |
WO (1) | WO2015200078A1 (zh) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
WO2012138919A2 (en) | 2011-04-08 | 2012-10-11 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
PL3027642T3 (pl) | 2013-07-31 | 2021-01-11 | Amgen Inc. | Konstrukty czynnika różnicowania wzrostu 15 (GDF-15) |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EA201791238A1 (ru) | 2014-12-04 | 2018-02-28 | Новартис Аг | Способы и композиции, в которых используются варианты полипептидов klotho |
SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
EP3393494A1 (en) * | 2015-12-22 | 2018-10-31 | Novartis Ag | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
EP3408391A4 (en) | 2016-01-31 | 2019-08-28 | University of Massachusetts | BRANCHED OLIGONUCLEOTIDES |
KR101727506B1 (ko) * | 2016-07-14 | 2017-05-04 | 충남대학교 산학협력단 | Gdf15 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 지방간의 예방 또는 치료용 약학적 조성물 |
US11753638B2 (en) | 2016-08-12 | 2023-09-12 | University Of Massachusetts | Conjugated oligonucleotides |
WO2018136702A1 (en) | 2017-01-23 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof |
AU2018219283B2 (en) | 2017-02-08 | 2022-05-19 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
CN110325649A (zh) | 2017-04-11 | 2019-10-11 | 雷杰纳荣制药公司 | 用于筛选羟基类固醇(17-β)脱氢酶(HSD17B)家族成员的调节剂的活性的测定法 |
BR112019023990A2 (pt) * | 2017-05-18 | 2020-06-16 | Regeneron Pharmaceuticals, Inc. | Bis-octa-hidrofenantreno carboxamidas e conjugados de proteína das mesmas |
TWI710377B (zh) * | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Mic-1化合物及其用途 |
CA3078883A1 (en) | 2017-10-11 | 2019-04-18 | Regeneron Pharmaceuticals, Inc. | Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation |
TWI811280B (zh) * | 2017-12-22 | 2023-08-11 | 瑞士商諾華公司 | 用fgf21變體治療代謝障礙之方法 |
WO2019179494A1 (zh) * | 2018-03-23 | 2019-09-26 | 深圳市塔吉瑞生物医药有限公司 | 取代的十五烷二酸化合物及药物组合物及其用途 |
CN111954537A (zh) | 2018-04-09 | 2020-11-17 | 美国安进公司 | 生长分化因子15融合蛋白 |
CR20200571A (es) | 2018-06-01 | 2021-01-18 | Novartis Ag | Moléculas de únion contra bcma y usos de las mismas |
WO2020031149A2 (en) | 2018-08-10 | 2020-02-13 | Novartis Ag | Gfral extracellular domains and methods of use |
KR20210093227A (ko) | 2018-08-10 | 2021-07-27 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 변형된 올리고뉴클레오티드 |
CA3116983A1 (en) * | 2018-10-22 | 2020-04-30 | Janssen Pharmaceutica Nv | Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof |
US20220025344A1 (en) | 2018-11-26 | 2022-01-27 | Novartis Ag | Lpl-gpihbp1 fusion polypeptides |
TW202337914A (zh) * | 2019-04-23 | 2023-10-01 | 南韓商Lg化學股份有限公司 | 融合多肽及其用途與製備方法、核酸分子、重組載體、重組細胞以及用於增強生長/分化因子15或其功能變體的活體內穩定性的方法 |
CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
EP3972998A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Cd19 binding molecules and uses thereof |
US20230071196A1 (en) | 2019-05-21 | 2023-03-09 | Novartis Ag | Variant cd58 domains and uses thereof |
EP3999103A4 (en) | 2019-07-19 | 2023-11-22 | Inari Agriculture Technology, Inc. | GENOMIC EDITING FOR ENHANCED HOMOLOGY-DIRECTED REPAIR |
WO2021067655A1 (en) | 2019-10-04 | 2021-04-08 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
JP2023500763A (ja) | 2019-11-04 | 2023-01-11 | フェリング ベスローテン フェンノートシャップ | 泌乳の改善のためのメロトシンの鼻腔内投与 |
EP4065172A1 (en) * | 2019-11-26 | 2022-10-05 | DTX Pharma, Inc. | Compound comprising a nucleic acid and a half-life extension motif |
WO2021126990A1 (en) * | 2019-12-16 | 2021-06-24 | The Scripps Research Institute | Oxytocin derivatives with improved properties |
CN115260313B (zh) | 2019-12-31 | 2023-07-18 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
CN115243727A (zh) * | 2020-01-13 | 2022-10-25 | 西纳福克斯股份有限公司 | 经由环加成的双侧官能化抗体 |
CN115666656A (zh) * | 2020-01-13 | 2023-01-31 | 西纳福克斯股份有限公司 | 通过环加成双侧功能化抗体 |
EP4090377A1 (en) * | 2020-01-13 | 2022-11-23 | Synaffix B.V. | Conjugates of antibodies an immune cell engagers |
CA3199095A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
KR102543789B1 (ko) * | 2021-03-08 | 2023-06-20 | 주식회사 온코크로스 | 토르세미드 및 크로몰린을 포함하는 대사질환 예방 또는 치료용 조성물 |
WO2022219495A1 (en) | 2021-04-12 | 2022-10-20 | Novartis Ag | 2-((4-((s)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-imidazole derivatives as activators of the glp1 receptor for the treatment of obesity |
TW202304500A (zh) | 2021-04-21 | 2023-02-01 | 瑞士商諾華公司 | 升糖素樣肽化合物 |
AU2022278933A1 (en) * | 2021-05-21 | 2023-12-07 | Yuhan Corporation | Composition for preventing or treating non-alcoholic fatty liver disease or non-alcoholic steatohepatitis comprising growth differentiation factor-15 variant |
TW202315943A (zh) | 2021-06-23 | 2023-04-16 | 麻薩諸塞大學 | 用於治療子癇前症及其它血管新生病症的最佳化抗flt1寡核苷酸化合物 |
WO2023039522A1 (en) * | 2021-09-10 | 2023-03-16 | Guardian Therapeutics, Llc | Fatty acid conjugates of nucleic acids |
CN113582832B (zh) * | 2021-09-13 | 2024-01-26 | 深圳瑞德林生物技术有限公司 | 一种长链二酸的制备方法 |
TW202342014A (zh) | 2022-02-10 | 2023-11-01 | 瑞士商諾華公司 | 1,3-苯并二氧戊環衍生物 |
WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
CN114740105B (zh) * | 2022-03-17 | 2023-11-07 | 重庆医药高等专科学校 | 一种脯氨酸和n-甲基脯氨酸的液相色谱分离检测方法及其应用 |
WO2023196754A2 (en) * | 2022-04-08 | 2023-10-12 | University Of North Texas Health Science Center At Fort Worth | Treatment for reducing or preventing tissue fibrosis |
CN114891086B (zh) * | 2022-06-01 | 2024-03-26 | 恺佧生物科技(上海)有限公司 | 一种生物素标记的gdf15的复性方法 |
WO2024030367A2 (en) * | 2022-08-01 | 2024-02-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fatty acid-d-amino acid peptides conjugates as anaplerotic compounds for use in treating propionic acidemia, methylmalonic acidurias, and energy metabolic disorders |
CN116466010B (zh) * | 2023-06-15 | 2023-08-25 | 四川普锐特药业有限公司 | 一种用于脂质纳米粒中多种脂质组分定量检测的方法 |
Family Cites Families (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3043871A (en) * | 1956-09-03 | 1962-07-10 | Ruhrchemie Ag | Production of heptadecanedicarboxylic acid-1, 17 |
EP0112344A1 (en) | 1982-06-11 | 1984-07-04 | National Research Development Corporation | Amphipathic compounds |
US4517105A (en) | 1983-03-07 | 1985-05-14 | Aluminum Company Of America | Metalworking lubricant composition containing a novel substituted malonic acid diester |
US4582927A (en) | 1984-04-04 | 1986-04-15 | Frito-Lay, Inc. | Synthetic cooking oils containing dicarboxylic acid esters |
US5175191A (en) | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5296439A (en) | 1990-12-26 | 1994-03-22 | Ricoh Company, Ltd. | Reversible thermosensitive coloring recording medium, recording method, and image display apparatus using the recording medium |
WO1996018730A1 (en) | 1994-12-15 | 1996-06-20 | Human Genome Sciences, Inc. | Prostatic growth factor |
US6521227B1 (en) | 1999-11-18 | 2003-02-18 | Peter L. Hudson | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
US5994102A (en) | 1994-12-15 | 1999-11-30 | Human Genome Sciences, Inc. | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
FR2735131B1 (fr) | 1995-06-12 | 1997-08-22 | Rech De Pathologie Appliquee S | Conjugues d'msh avec un acide gras, leur procede de preparation et leur utilisation a titre de medicament |
CA2225377C (en) | 1995-06-22 | 2013-08-13 | St. Vincent's Hospital Sydney Limited | Novel tgf-.beta. like cytokine |
US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
NZ334592A (en) | 1996-09-11 | 2000-10-27 | Ortho Mcneil Pharm Inc | Protein growth factor related to TNF-beta and coupled with a toxic moiety for use in treating prostate cancer |
AU8591198A (en) | 1997-07-31 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-15 |
CN1283228A (zh) | 1997-12-24 | 2001-02-07 | 武田药品工业株式会社 | 多肽、其生产方法及应用 |
US6974684B2 (en) | 2001-08-08 | 2005-12-13 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
US6297400B1 (en) | 1999-07-02 | 2001-10-02 | The Clorox Company | Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol |
AU2001247899A1 (en) | 2000-04-06 | 2001-10-23 | Genetics Institute, Llc | Polynucleotides encoding novel secreted proteins |
AU5018201A (en) | 2000-04-20 | 2001-11-07 | St Vincents Hospital Sydney Lt | Diagnostic assay and method of treatment involving macrophage inhibitory cytokine -1 (mic-1) |
JP2005502322A (ja) | 2001-04-19 | 2005-01-27 | ザ スクリップス リサーチ インスティテュート | 非天然アミノ酸のインビボ組込み |
US20030166903A1 (en) | 2001-04-27 | 2003-09-04 | Anna Astromoff | Genes associated with vascular disease |
CA2466034C (en) | 2001-11-08 | 2012-12-18 | Protein Design Labs, Inc. | Stable aqueous pharmaceutical formulations of daclizumab antibodies |
TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
US7157235B2 (en) | 2002-06-17 | 2007-01-02 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
ATE442365T1 (de) | 2003-05-20 | 2009-09-15 | Novartis Pharma Gmbh | N-acyl stickstoffheterocyclen als liganden von peroxisom-proliferator-aktivierten rezeptoren |
BRPI0414539B8 (pt) | 2003-09-19 | 2021-05-25 | Novo Nordisk As | composto, composição farmacêutica, e, uso de um composto |
AU2005205595A1 (en) | 2004-01-14 | 2005-07-28 | Janssen Pharmaceutica N.V. | Methods of using peroxisome proliferator-activated receptor alpha target genes |
PL2929891T3 (pl) | 2004-04-13 | 2020-08-24 | St Vincent's Hospital Sydney Limited | Sposób modulowania apetytu |
US20070207120A1 (en) | 2004-04-14 | 2007-09-06 | Sarah Drayton | Selective Killing Of Cancer Cells By Induction Of Acetyltransferase Via Tnf-Alpha And Il-6 |
US8431558B2 (en) | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
US20090142338A1 (en) * | 2005-03-04 | 2009-06-04 | Curedm, Inc. | Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions |
KR20120089475A (ko) * | 2005-04-29 | 2012-08-10 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 결핵균 감염을 예방 또는 치료하기 위한 신규한 방법 |
US20110319324A1 (en) | 2005-05-27 | 2011-12-29 | Five Prime Therapeutics, Inc. | Methods of and compositions for stimulation of glucose uptake into muscle cells and treatment of diseases |
US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
CA2632095A1 (en) | 2005-11-30 | 2007-06-07 | Ambrilia Biopharma Inc. | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
BRPI0622256A2 (pt) | 2005-12-20 | 2011-08-09 | Bristol-Myers Squibb Company | formulações estáveis adequadas para administração subcutánea compreendendo moléculas de ctla4ig |
CN101002945B (zh) * | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
US20100278843A1 (en) | 2007-08-16 | 2010-11-04 | St. Vincent's Hospital Sydney Limited | Agents and methods for modulating macrophage inhibitory cytokine (mic-1) activity |
WO2009042798A1 (en) | 2007-09-26 | 2009-04-02 | Cold Spring Harbor Laboratory | Methods for treating fibrosis by modulating cellular senescence |
US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
US8673841B2 (en) | 2008-03-31 | 2014-03-18 | Ferring B.V. | Oxytocin analogues |
CN102264697B (zh) | 2008-10-24 | 2015-09-09 | Irm责任有限公司 | 生物合成产生的吡咯啉-羧基-赖氨酸以及通过吡咯啉-羧基-赖氨酸和吡咯赖氨酸残基化学衍生化的位点特异性蛋白修饰 |
CA2741921A1 (en) * | 2008-11-05 | 2010-05-14 | F. Hoffmann-La Roche Ag | Neuropeptide-2-receptor (y-2r) agonists and uses thereof |
EP2209003A1 (en) | 2009-01-16 | 2010-07-21 | F. Hoffmann-Roche AG | Means and methods for differentiating between fibrosis and cirrhosis |
EP2211182A1 (en) | 2009-01-16 | 2010-07-28 | Roche Diagnostics GmbH | Method for the assessment of severity of liver cirrhosis |
EP2261662B1 (en) * | 2009-06-10 | 2014-01-22 | Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften | Novel synthetic blocking reagents |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
EP2521446A2 (en) | 2010-01-06 | 2012-11-14 | The University of North Carolina At Chapel Hill | Fatty acid derivatives and analogs of drugs |
CN101852804B (zh) | 2010-03-29 | 2013-06-12 | 中国医学科学院病原生物学研究所 | Gdf15蛋白的抗体的新用途 |
US8859629B2 (en) | 2010-04-27 | 2014-10-14 | Synaffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
US8691771B2 (en) | 2010-05-21 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins for tissue repair |
GB201018518D0 (en) * | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
WO2012138919A2 (en) | 2011-04-08 | 2012-10-11 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
US9480751B2 (en) | 2011-04-11 | 2016-11-01 | Yeda Research And Development Co. Ltd. | Albumin binding probes and drug conjugates thereof |
US9394343B2 (en) | 2011-07-05 | 2016-07-19 | The Regents Of The University Of California | Appetite stimulating protein |
WO2013027191A1 (en) | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
CA2862516C (en) | 2012-03-27 | 2023-02-14 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
US8921307B2 (en) | 2012-11-20 | 2014-12-30 | Novartis Ag | Synthetic linear apelin mimetics for the treatment of heart failure |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
ES2732574T3 (es) | 2012-11-30 | 2019-11-25 | Novartis Ag | Métodos para preparar conjugados a partir de proteínas que contienen disulfuro |
ES2791183T3 (es) | 2012-12-21 | 2020-11-03 | Aveo Pharmaceuticals Inc | Anticuerpos anti-GDF15 |
PT2935312T (pt) | 2012-12-21 | 2018-10-26 | Hoffmann La Roche | Péptidos enquanto agonistas da oxitocina |
WO2014120619A2 (en) | 2013-01-30 | 2014-08-07 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
SG10201800800YA (en) | 2013-05-06 | 2018-03-28 | Scholar Rock Inc | Compositions and methods for growth factor modulation |
WO2015003122A2 (en) | 2013-07-03 | 2015-01-08 | Alder Biopharmaceuticals, Inc. | Regulation of glucose metabolism using anti-cgrp antibodies |
CA2918076A1 (en) | 2013-07-11 | 2015-01-15 | Novartis Ag | Site-specific chemoenzymatic protein modifications |
EP3024847A1 (en) | 2013-07-25 | 2016-06-01 | Novartis AG | Disulfide cyclic polypeptides for the treatment of heart failure |
EP3024492A2 (en) | 2013-07-25 | 2016-06-01 | Novartis AG | Bioconjugates of synthetic apelin polypeptides |
AU2014293386B2 (en) | 2013-07-25 | 2016-11-17 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
US9908919B2 (en) | 2013-07-25 | 2018-03-06 | Novartis Ag | Cyclic apelin derivatives for the treatment of heart failure |
PL3027642T3 (pl) | 2013-07-31 | 2021-01-11 | Amgen Inc. | Konstrukty czynnika różnicowania wzrostu 15 (GDF-15) |
US10172948B2 (en) | 2013-11-26 | 2019-01-08 | Novartis Ag | Methods for oxime conjugation to ketone-modified polypeptides |
AU2015213721B2 (en) | 2014-02-07 | 2021-05-20 | Effector Therapeutics, Inc. | Methods for treating fibrotic disease |
CN106461830B (zh) | 2014-05-01 | 2019-08-27 | 富士胶片株式会社 | 红外线传感器、近红外线吸收组合物、感光性树脂组合物、化合物及其应用 |
CA2947967A1 (en) | 2014-05-06 | 2015-11-12 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
JP6721572B2 (ja) | 2014-05-23 | 2020-07-15 | ノバルティス アーゲー | ジスルフィド含有タンパク質からコンジュゲートを作製するための方法 |
MX2016016826A (es) | 2014-06-20 | 2017-08-28 | Aveo Pharmaceuticals Inc | Tratamiento de la enfermedad renal cronica y otra disfuncion renal utilizando un modulador gdf15. |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EP3157947A1 (en) | 2014-06-23 | 2017-04-26 | Novartis AG | Hsa-gdf-15 fusion polypeptide and use thereof |
ES2818109T3 (es) | 2014-06-23 | 2021-04-09 | Novartis Ag | Modificaciones de proteínas específicas para un sitio |
MX2016016063A (es) | 2014-06-24 | 2017-03-10 | Novo Nordisk As | Proteinas de fusion de citocina-1 inhibidora de macrofagos (mic-1) y usos de las mismas. |
CN106573966B (zh) | 2014-07-30 | 2022-03-01 | Ngm生物制药有限公司 | 用于治疗代谢异常的组合物和方法 |
WO2016069925A1 (en) | 2014-10-30 | 2016-05-06 | Acceleron Pharma Inc. | Methods and compositions using gdf15 polypeptides for increasing red blood cells |
CA2961587A1 (en) | 2014-10-31 | 2016-05-06 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
US20170334971A1 (en) | 2014-12-22 | 2017-11-23 | Novo Nordisk A/S | Alpha-1-Antitrypsin (A1AT) Fusion Proteins and Uses Thereof |
SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
CN107849114B (zh) | 2015-04-06 | 2021-08-20 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
KR20180002661A (ko) | 2015-04-06 | 2018-01-08 | 악셀레론 파마 인코포레이티드 | ALK7:ActRIIB 이형다합체와 이의 용도 |
WO2017066525A1 (en) | 2015-10-14 | 2017-04-20 | The Johns Hopkins University | Protein bioconjugation method |
EP3393494A1 (en) | 2015-12-22 | 2018-10-31 | Novartis Ag | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
EP3184106A1 (en) | 2015-12-23 | 2017-06-28 | Sanofi-Aventis Deutschland GmbH | Growth differentiation factor 15 as biomarker for metformin |
US11105818B2 (en) | 2016-01-15 | 2021-08-31 | Novo Nordisk A/S | MIC-1 receptor and uses thereof |
JP2019510739A (ja) | 2016-02-29 | 2019-04-18 | イーライ リリー アンド カンパニー | Gfral受容体療法 |
AU2017228489A1 (en) | 2016-03-04 | 2018-09-06 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for modulating body weight |
KR101727506B1 (ko) | 2016-07-14 | 2017-05-04 | 충남대학교 산학협력단 | Gdf15 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 지방간의 예방 또는 치료용 약학적 조성물 |
MA50141A (fr) | 2017-04-20 | 2020-07-29 | Novo Nordisk As | Procédés de purification de protéines de fusion d'albumine |
TWI710377B (zh) | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Mic-1化合物及其用途 |
JP2020533302A (ja) | 2017-09-10 | 2020-11-19 | ノヴォ ノルディスク アー/エス | 肥満の治療において使用するためのmic−1およびglp−1 |
CA3131912A1 (en) | 2019-03-08 | 2020-09-17 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
WO2021067655A1 (en) | 2019-10-04 | 2021-04-08 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
CN115260313B (zh) | 2019-12-31 | 2023-07-18 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
BR112022020809A2 (pt) | 2020-04-15 | 2023-02-23 | Theradaptive Inc | Composições e métodos para entrega terapêutica direcionada ao osso |
WO2022092915A1 (ko) | 2020-10-30 | 2022-05-05 | 가톨릭대학교 산학협력단 | Gdf15를 유효성분으로 함유하는 면역질환의 예방 및 치료용 조성물 |
-
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