MA40278A - Acides gras et leur utilisation dans la conjugaison de biomolécules - Google Patents

Acides gras et leur utilisation dans la conjugaison de biomolécules

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Publication number
MA40278A
MA40278A MA040278A MA40278A MA40278A MA 40278 A MA40278 A MA 40278A MA 040278 A MA040278 A MA 040278A MA 40278 A MA40278 A MA 40278A MA 40278 A MA40278 A MA 40278A
Authority
MA
Morocco
Prior art keywords
biomolecules
conjugation
fatty acids
fatty acid
linker
Prior art date
Application number
MA040278A
Other languages
English (en)
Inventor
David Weninger Barnes
Avirup Bose
Alexandra Marshall Bruce
Alokesh Duttaroy
Chikwendu Ibebunjo
Aaron Kanter
Louise Clare Kirman
Changgang Lou
Aimee Richardson Usera
Ken Yamada
Jun Yuan
Frederic Zecri
Original Assignee
David Weninger Barnes
Avirup Bose
Alexandra Marshall Bruce
Alokesh Duttaroy
Chikwendu Ibebunjo
Aaron Kanter
Louise Clare Kirman
Changgang Lou
Novartis Ag
Aimee Richardson Usera
Ken Yamada
Jun Yuan
Frederic Zecri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53491695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40278(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by David Weninger Barnes, Avirup Bose, Alexandra Marshall Bruce, Alokesh Duttaroy, Chikwendu Ibebunjo, Aaron Kanter, Louise Clare Kirman, Changgang Lou, Novartis Ag, Aimee Richardson Usera, Ken Yamada, Jun Yuan, Frederic Zecri filed Critical David Weninger Barnes
Publication of MA40278A publication Critical patent/MA40278A/fr

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/22—Tricarboxylic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
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    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)

Abstract

L'invention concerne un conjugué comprenant une biomolécule liée à un acide gras par l'intermédiaire d'un lieur, les formules de l'acide gras étant les suivantes : a1, a2 ou a3 dans lesquelles r
MA040278A 2014-06-23 2015-06-18 Acides gras et leur utilisation dans la conjugaison de biomolécules MA40278A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23

Publications (1)

Publication Number Publication Date
MA40278A true MA40278A (fr) 2017-04-26

Family

ID=53491695

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040278A MA40278A (fr) 2014-06-23 2015-06-18 Acides gras et leur utilisation dans la conjugaison de biomolécules

Country Status (37)

Country Link
US (4) US10588980B2 (fr)
EP (2) EP3988170A1 (fr)
JP (5) JP6636959B2 (fr)
KR (2) KR102559975B1 (fr)
CN (3) CN114133443A (fr)
AP (1) AP2016009585A0 (fr)
AU (1) AU2015280351C1 (fr)
CA (1) CA2953480A1 (fr)
CL (1) CL2016003281A1 (fr)
CR (1) CR20160596A (fr)
CU (1) CU24455B1 (fr)
CY (1) CY1125006T1 (fr)
DK (1) DK3157571T3 (fr)
EA (1) EA039074B1 (fr)
EC (1) ECSP17004665A (fr)
ES (1) ES2905479T3 (fr)
GT (1) GT201600263A (fr)
HK (1) HK1232160A1 (fr)
HR (1) HRP20220152T1 (fr)
HU (1) HUE057845T2 (fr)
IL (1) IL248990B (fr)
JO (1) JO3813B1 (fr)
LT (1) LT3157571T (fr)
MA (1) MA40278A (fr)
MX (1) MX367520B (fr)
MY (1) MY193993A (fr)
PE (1) PE20171095A1 (fr)
PH (1) PH12016502294A1 (fr)
PL (1) PL3157571T3 (fr)
PT (1) PT3157571T (fr)
RS (1) RS62907B1 (fr)
SG (2) SG11201609704TA (fr)
SI (1) SI3157571T1 (fr)
TN (1) TN2016000558A1 (fr)
TW (3) TWI701048B (fr)
UY (1) UY36186A (fr)
WO (1) WO2015200078A1 (fr)

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US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
JP5977814B2 (ja) 2011-04-08 2016-08-24 アムジエン・インコーポレーテツド 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
EP3027642B1 (fr) 2013-07-31 2020-08-19 Amgen Inc. Constructions contenant le facteur 15 de différentiation de croissance (gdf-15)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
CN107810201A (zh) 2014-12-04 2018-03-16 诺华股份有限公司 使用klotho变体多肽的方法和组合物
KR20170103970A (ko) 2015-01-23 2017-09-13 노파르티스 아게 개선된 반감기를 갖는 합성 아펠린 지방산 접합체
CN108367053A (zh) * 2015-12-22 2018-08-03 诺华股份有限公司 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法
CA3011894A1 (fr) 2016-01-31 2017-08-03 University Of Massachusetts Oligonucleotides ramifies
MX2018014023A (es) 2016-05-24 2019-04-04 Novo Nordisk As Compuestos de citocina inhibidora de macrofagos 1 (mic-1) y uso de estos.
KR101727506B1 (ko) * 2016-07-14 2017-05-04 충남대학교 산학협력단 Gdf15 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 지방간의 예방 또는 치료용 약학적 조성물
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