BR112016028884A2 - ácidos graxos e seu uso em conjugação a biomoléculas - Google Patents

ácidos graxos e seu uso em conjugação a biomoléculas

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Publication number
BR112016028884A2
BR112016028884A2 BR112016028884A BR112016028884A BR112016028884A2 BR 112016028884 A2 BR112016028884 A2 BR 112016028884A2 BR 112016028884 A BR112016028884 A BR 112016028884A BR 112016028884 A BR112016028884 A BR 112016028884A BR 112016028884 A2 BR112016028884 A2 BR 112016028884A2
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Prior art keywords
disease
conjugate
fatty acid
metabolic disorders
diseases
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BR112016028884A
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English (en)
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BR112016028884B1 (pt
Inventor
Kanter Aaron
Richardson Usera Aimee
Marshall Bruce Alexandra
Duttaroy Alokesh
Bose Avirup
Lou Changgang
Ibebunjo Chikwendu
Weninger Barnes David
Zecri Frédéric
Yuan Jun
Yamada Ken
Clare Kirman Louise
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Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112016028884A2 publication Critical patent/BR112016028884A2/pt
Publication of BR112016028884B1 publication Critical patent/BR112016028884B1/pt

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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/22—Hormones
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    • C07—ORGANIC CHEMISTRY
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Abstract

a presente invenção refere-se a um conjugado compreendendo uma biomolécula ligada a um ácido graxo através de um ligante onde o ácido graxo tem a fórmula a1, a2 ou a3 que segue: onde r1, r2, r3, r4, ak, n, m e p são aqui definidos. a invenção refere-se também a um método para fabricação do conjugado da invenção tal como conjugado de gdf15 e seus usos terapêuticos tal como trata-mento ou prevenção de distúrbios ou doenças metabólicas, diabetes mellitus tipo 2, obesidade, pancreatite, dislipidemia, doença hepática gordurosa alcoólica e não alcoólica/esteatoepatite e outras doenças hepáticas progressivas, resistência à insulina, hiperinsulinemia, intole-rância à glicose, hiperglicemia, síndrome metabólica, hipertensão, do-ença cardiovascular, aterosclerose, doença arterial periférica, acidente vascular cerebral, falência cardíaca, doença cardíaca coronária, com-plicações diabéticas (incluindo, mas não limitado a, doença renal crô-nica), neuropatia, gastroparese e outros distúrbios metabólicos. a pre-sente invenção provê ainda uma combinação de agentes farmacologi-camente ativos e uma composição farmacêutica.
BR112016028884-0A 2014-06-23 2015-06-18 Conjugado compreendendo uma biomolécula ligada a um ácido graxo, seu uso, mistura, combinação, composição farmacêutica, e composto BR112016028884B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US62/015,862 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US62/082,327 2014-11-20
US201562107016P 2015-01-23 2015-01-23
US62/107,016 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules

Publications (2)

Publication Number Publication Date
BR112016028884A2 true BR112016028884A2 (pt) 2017-10-31
BR112016028884B1 BR112016028884B1 (pt) 2023-07-04

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CN107073130B (zh) 2021-11-16
JP6823696B2 (ja) 2021-02-03
PL3157571T3 (pl) 2022-03-28
SG11201609704TA (en) 2017-01-27
US20180326079A1 (en) 2018-11-15
AP2016009585A0 (en) 2016-11-30
GT201600263A (es) 2019-07-19
JP2020203934A (ja) 2020-12-24
RS62907B1 (sr) 2022-03-31
HRP20220152T1 (hr) 2022-04-15
CN107073130A (zh) 2017-08-18
WO2015200078A1 (en) 2015-12-30

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