MX2016017395A - Acidos grasos novedosos y su uso en la conjugacion con biomoleculas. - Google Patents

Acidos grasos novedosos y su uso en la conjugacion con biomoleculas.

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Publication number
MX2016017395A
MX2016017395A MX2016017395A MX2016017395A MX2016017395A MX 2016017395 A MX2016017395 A MX 2016017395A MX 2016017395 A MX2016017395 A MX 2016017395A MX 2016017395 A MX2016017395 A MX 2016017395A MX 2016017395 A MX2016017395 A MX 2016017395A
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MX
Mexico
Prior art keywords
disease
conjugate
fatty acid
metabolic disorders
diseases
Prior art date
Application number
MX2016017395A
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English (en)
Other versions
MX367520B (es
Inventor
Yuan Jun
Yamada Ken
Zecri Frederic
Weninger Barnes David
Marshall Bruce Alexandra
Kanter Aaron
Lou Changgang
Richardson Usera Aimee
Ibebunjo Chikwendu
Duttaroy Alokesh
Clare Kirman Louise
Bose Avirup
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2016017395A publication Critical patent/MX2016017395A/es
Publication of MX367520B publication Critical patent/MX367520B/es

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Abstract

La invención proporciona un conjugado, el cual comprende una biomolécula enlazada a un ácido graso por medio de un enlazador, en donde el ácido graso tiene las siguientes fórmulas A1, A2 o A3: (ver Fórmula) en donde R1, R2, R3, R4, Ak, n, m y p se definen en la presente. La invención también se refiere a un método para la elaboración del conjugado de la invención tal como el conjugado de GDF15, y a sus usos terapéuticos, tales como el tratamiento o la prevención de trastornos o enfermedades metabólicas, diabetes mellitus tipo 2, obesidad, pancreatitis, dislipidemia, enfermedad de hígado graso alcohólico y no alcohólico/esteatohepatitis y otras enfermedades progresivas del hígado, resistencia a la insulina, hiperinsulinemia, intolerancia a la glucosa, hiperglucemia, síndrome metabólico, hípertensión, enfermedad cardiovascular, ateroesclerosis, enfermedad de arterias periféricas, embolia, insuficiencia cardíaca, enfermedad cardiaca coronaria, complicaciones diabéticas (incluyendo, pero no limitándose a, enfermedad crónica del riñón), neuropatía, gastroparesis y otros trastornos metabólicos. La presente invención Proporciona además una combinación de los agentes farmacológicamente activos y una composición farmacéutica.
MX2016017395A 2014-06-23 2015-06-18 Ácidos grasos novedosos y su uso en la conjugación con biomoléculas. MX367520B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules

Publications (2)

Publication Number Publication Date
MX2016017395A true MX2016017395A (es) 2017-05-01
MX367520B MX367520B (es) 2019-08-26

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EP (2) EP3988170A1 (es)
JP (5) JP6636959B2 (es)
KR (2) KR102559975B1 (es)
CN (3) CN114099693A (es)
AP (1) AP2016009585A0 (es)
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CR (1) CR20160596A (es)
CU (1) CU24455B1 (es)
CY (1) CY1125006T1 (es)
DK (1) DK3157571T3 (es)
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Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
WO2012138919A2 (en) 2011-04-08 2012-10-11 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
PL3027642T3 (pl) 2013-07-31 2021-01-11 Amgen Inc. Konstrukty czynnika różnicowania wzrostu 15 (GDF-15)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
EA201791238A1 (ru) 2014-12-04 2018-02-28 Новартис Аг Способы и композиции, в которых используются варианты полипептидов klotho
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
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