JO3813B1 - أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية - Google Patents
أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيويةInfo
- Publication number
- JO3813B1 JO3813B1 JOP/2015/0150A JOP20150150A JO3813B1 JO 3813 B1 JO3813 B1 JO 3813B1 JO P20150150 A JOP20150150 A JO P20150150A JO 3813 B1 JO3813 B1 JO 3813B1
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- Prior art keywords
- disease
- conjugate
- fatty acid
- metabolic disorders
- diseases
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Abstract
يوفر الاختراع متقارن يشتمل على جزئ حيوي مرتبط بحمض دهني من خلال رابط حيث يكون للحمض الدهني الصيغ التالية A1، A2 أو A3: A1 A2 أو A3 1) حيث تكون R1, R2, R3, R4, Ak, n, m وp معرفة هنا. يتعلق الاختراع أيضاً بطريقة لتصنيع متقارن الاختراع مثل متقارن GDF15، واستخداماته العلاجية مثل علاج أو الوقاية من اضطرابات أو أمراض أيضية، النوع الثاني من داء السكري، السمنة، التهاب البنكرياس، عسر شحميات الدم، مرض الكبد الدهني الكحولي وغير الكحولي/التهاب الكبد الدهني وغيرها من أمراض الكبد التقدمية، مقاومة الأنسولين، فرط الانسولينية، الحساسية المفرطة تجاه الجلوكوز، ارتفاع السكر في الدم، المتلازمة الأيضية، ارتفاع ضغط الدم، أمراض القلب والأوعية الدموية، تصلب الشرايين، أمراض الشرايين الطرفية، السكتة الدماغية، هبوط القلب، مرض القلب التاجي، مضاعفات السكري (تتضمن لكنها لا تقتصر على مرض الكلى المزمن)، اعتلال الأعصاب، خزل المعدة واضطرابات أيضية أخرى. يوفر الاختراع الحالي كذلك توليفة من عوامل نشطة صيدلية وتركيبة صيدلية.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462015862P | 2014-06-23 | 2014-06-23 | |
US201462082327P | 2014-11-20 | 2014-11-20 | |
US201562107016P | 2015-01-23 | 2015-01-23 |
Publications (1)
Publication Number | Publication Date |
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JO3813B1 true JO3813B1 (ar) | 2021-01-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JOP/2015/0150A JO3813B1 (ar) | 2014-06-23 | 2015-06-21 | أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية |
Country Status (37)
Country | Link |
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US (4) | US10588980B2 (ar) |
EP (2) | EP3988170A1 (ar) |
JP (5) | JP6636959B2 (ar) |
KR (2) | KR20230056796A (ar) |
CN (3) | CN107073130B (ar) |
AP (1) | AP2016009585A0 (ar) |
AU (1) | AU2015280351C1 (ar) |
CA (1) | CA2953480A1 (ar) |
CL (1) | CL2016003281A1 (ar) |
CR (1) | CR20160596A (ar) |
CU (1) | CU24455B1 (ar) |
CY (1) | CY1125006T1 (ar) |
DK (1) | DK3157571T3 (ar) |
EA (1) | EA039074B1 (ar) |
EC (1) | ECSP17004665A (ar) |
ES (1) | ES2905479T3 (ar) |
GT (1) | GT201600263A (ar) |
HK (1) | HK1232160A1 (ar) |
HR (1) | HRP20220152T1 (ar) |
HU (1) | HUE057845T2 (ar) |
IL (1) | IL248990B (ar) |
JO (1) | JO3813B1 (ar) |
LT (1) | LT3157571T (ar) |
MA (1) | MA40278A (ar) |
MX (1) | MX367520B (ar) |
MY (1) | MY193993A (ar) |
PE (1) | PE20171095A1 (ar) |
PH (1) | PH12016502294A1 (ar) |
PL (1) | PL3157571T3 (ar) |
PT (1) | PT3157571T (ar) |
RS (1) | RS62907B1 (ar) |
SG (2) | SG10201912965TA (ar) |
SI (1) | SI3157571T1 (ar) |
TN (1) | TN2016000558A1 (ar) |
TW (3) | TWI792596B (ar) |
UY (1) | UY36186A (ar) |
WO (1) | WO2015200078A1 (ar) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
CN103533951B (zh) | 2011-04-08 | 2017-04-19 | 安姆根有限公司 | 使用生长分化因子15(gdf‑15)治疗或改善代谢障碍的方法 |
MA38873B1 (fr) | 2013-07-31 | 2018-11-30 | Amgen Inc | Constructions contenant le facteur 15 de différentiation de croissance (gdf-15) |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EP3227319B1 (en) | 2014-12-04 | 2019-11-27 | Novartis AG | Methods and compositions using klotho variant polypeptides |
CR20170338A (es) * | 2015-01-23 | 2017-09-12 | Novartis Ag | Conjugados de ácidos grasos y apelina sintética con mayor vida media |
CN108367053A (zh) * | 2015-12-22 | 2018-08-03 | 诺华股份有限公司 | 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法 |
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