CY1116110T1 - ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ - Google Patents
ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝInfo
- Publication number
- CY1116110T1 CY1116110T1 CY20151100105T CY151100105T CY1116110T1 CY 1116110 T1 CY1116110 T1 CY 1116110T1 CY 20151100105 T CY20151100105 T CY 20151100105T CY 151100105 T CY151100105 T CY 151100105T CY 1116110 T1 CY1116110 T1 CY 1116110T1
- Authority
- CY
- Cyprus
- Prior art keywords
- shasegp
- neutral
- glypro
- procedure
- pharmaceutical compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 title 1
- KZNQNBZMBZJQJO-YFKPBYRVSA-N glyclproline Chemical compound NCC(=O)N1CCC[C@H]1C(O)=O KZNQNBZMBZJQJO-YFKPBYRVSA-N 0.000 title 1
- 108010077515 glycylproline Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000007935 neutral effect Effects 0.000 abstract 3
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract 2
- 102000001974 Hyaluronidases Human genes 0.000 abstract 2
- 229960002773 hyaluronidase Drugs 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 238000003307 slaughter Methods 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Η εφεύρεση αναφέρεται στην ανακάλυψη καινοτόμων διαλυτών ουδέτερων δραστικών Γλυκοπρωτεϊνών Υαλουρονιδάσης (sHASEGP's), μεθόδους για την κατασκευή τους, και στην χρήση τους στην διευκόλυνση της χορήγησης άλλων μορίων ή στην ανακούφιση παθολογικών καταστάσεων που σχετίζονται με τις γλυκοσαμινογλυκάνες. Ελάχιστα δραστικά τμήματα πολυπεπτιδίων των διαλυτών, ουδέτερων δραστικών πεδίων των sHASEGP περιγράφονται, τα οποία περιλαμβάνουν τμήματα σακχάρων που είναι συνδεδεμένα σε ασπαραγινικό που απαιτούνται για ένα λειτουργικό ουδέτερο δραστικό πεδίο υαλουρονιδάσης. Περιλαμβάνονται τροποποιημένες αμινοτελικά καθοδηγητικά πεπτίδια τα οποία ενισχύουν την έκκριση των sHASEGP. Η εφεύρεση περιλαμβάνει επιπλέον σιαλιλυλοποιημένες και πεγκυλιωμένες μορφές μιας ανασυνδυασμένης sHASEGP προκειμένου να ενισχυθεί η σταθερότητα και η φαρμακοκινητική στον ορό στα φυσικώς υπάρχοντα ένζυμα σφαγείου. Περιγράφονται επιπλέον κατάλληλες συνθέσεις μιας σημαντικά καθαρής ανασυνδυασμένης sHASEGP γλυκοπρωτεΐνης που προέρχεται από ένα ευκαρυωτικό κύτταρο που παράγει την κατάλληλη γλυκοσυλίωση που απαιτείται για την οπτική δραστηριότητα της.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US45236003P | 2003-03-05 | 2003-03-05 | |
EP09012669.9A EP2177620B1 (en) | 2003-03-05 | 2004-03-05 | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
Publications (1)
Publication Number | Publication Date |
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CY1116110T1 true CY1116110T1 (el) | 2017-02-08 |
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
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CY20101100068T CY1109750T1 (el) | 2003-03-05 | 2010-01-22 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY20151100105T CY1116110T1 (el) | 2003-03-05 | 2015-02-02 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY20151100333T CY1116370T1 (el) | 2003-03-05 | 2015-04-07 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY2015033C CY2015033I2 (el) | 2003-03-05 | 2015-07-21 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY20161100267T CY1117358T1 (el) | 2003-03-05 | 2016-03-31 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY2016024C CY2016024I2 (el) | 2003-03-05 | 2016-07-06 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
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CY20151100333T CY1116370T1 (el) | 2003-03-05 | 2015-04-07 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY2015033C CY2015033I2 (el) | 2003-03-05 | 2015-07-21 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY20161100267T CY1117358T1 (el) | 2003-03-05 | 2016-03-31 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
CY2016024C CY2016024I2 (el) | 2003-03-05 | 2016-07-06 | ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ |
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EP (7) | EP2330213A1 (el) |
JP (3) | JP4464395B2 (el) |
KR (4) | KR20050118273A (el) |
CN (2) | CN102943067B (el) |
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AU (2) | AU2004218354B2 (el) |
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CA (1) | CA2517145C (el) |
CY (6) | CY1109750T1 (el) |
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PL (4) | PL2177620T3 (el) |
PT (3) | PT2163643E (el) |
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KR20210023798A (ko) | 2018-07-25 | 2021-03-04 | (주)알테오젠 | 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물 |
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