JOP20210262A1 - تركيبة صيدلانية، تشمل متغير ودواء هيالورونيداز ph20 البشرى، للحقن تحت الجلد - Google Patents

تركيبة صيدلانية، تشمل متغير ودواء هيالورونيداز ph20 البشرى، للحقن تحت الجلد

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Publication number
JOP20210262A1
JOP20210262A1 JOP/2021/0262A JOP20210262A JOP20210262A1 JO P20210262 A1 JOP20210262 A1 JO P20210262A1 JO P20210262 A JOP20210262 A JO P20210262A JO P20210262 A1 JOP20210262 A1 JO P20210262A1
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pharmaceutical composition
human
variant
present disclosure
drug
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JOP/2021/0262A
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English (en)
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Jae Park Soon
Joo Lee Seung
Seok NAM Ki
KIM Kyuwan
Byun Minsoo
Chung Hye-Shin
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Alteogen Inc
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Publication of JOP20210262A1 publication Critical patent/JOP20210262A1/ar

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    • C12N9/14—Hydrolases (3)
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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Abstract

يتعلق الكشف الحالي بتركيبة صيدلانية تشمل (أ) دواء و(ب) متغير PH20 بشري. يشتمل متغير PH20 البشري الموجود في التركيبة الصيدلانية وفقًا للكشف الحالي على بديل (بدائل) متخلفات الحمض الأميني في منطقة أو أكثر مختارة من منطقة alpha-helix 8 (S347 إلى C381) ومنطقة رابط (A333 إلى R346) بين alpha-helix 7 وalpha-helix 8 في PH20 البشري من النوع البري الذي يحتوي على سلسلة الأحماض الأمينية لمتوالية برقم تعريف: 1، حيث يتم شق متخلف (متخلفات) الأحماض الأمينية الموجود في الطرف N أو الطرف C بشكل انتقائي. بالإضافة إلى ذلك، يمكن أيضًا أن تشتمل التركيبة الصيدلانية وفقًا للكشف الحالي على مادة مضافة مقبولة صيدلانيًا، خاصة مادة مثبتة. يمكن للتركيبة الصيدلانية وفقًا للكشف الحالي أن تزيد من التأثير العلاجي للدواء المستخدم في توليفة معه، نظرًا لتأثير متغيرات PH20 البشرية.
JOP/2021/0262A 2019-03-25 2020-03-24 تركيبة صيدلانية، تشمل متغير ودواء هيالورونيداز ph20 البشرى، للحقن تحت الجلد JOP20210262A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190033880 2019-03-25
PCT/KR2020/003975 WO2020197230A1 (ko) 2019-03-25 2020-03-24 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물

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JOP20210262A1 true JOP20210262A1 (ar) 2023-01-30

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US (2) US20210363270A1 (ar)
EP (1) EP3785701A4 (ar)
JP (3) JP7295150B2 (ar)
KR (3) KR102507853B1 (ar)
CN (3) CN116870164A (ar)
AU (2) AU2020248612B9 (ar)
BR (1) BR112021019076A2 (ar)
CA (1) CA3131052A1 (ar)
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BR112021019076A2 (pt) 2021-11-30
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JP2023078146A (ja) 2023-06-06
CA3131052A1 (en) 2020-10-01
AU2024201238A1 (en) 2024-03-14

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