SG11202110512WA - Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection - Google Patents
Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injectionInfo
- Publication number
- SG11202110512WA SG11202110512WA SG11202110512WA SG11202110512WA SG11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA
- Authority
- SG
- Singapore
- Prior art keywords
- variant
- drug
- pharmaceutical composition
- subcutaneous injection
- human hyaluronidase
- Prior art date
Links
- 101001041117 Homo sapiens Hyaluronidase PH-20 Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000010254 subcutaneous injection Methods 0.000 title 1
- 239000007929 subcutaneous injection Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20190033880 | 2019-03-25 | ||
| PCT/KR2020/003975 WO2020197230A1 (en) | 2019-03-25 | 2020-03-24 | Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202110512WA true SG11202110512WA (en) | 2021-10-28 |
Family
ID=72611090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202110512WA SG11202110512WA (en) | 2019-03-25 | 2020-03-24 | Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20210363270A1 (en) |
| EP (1) | EP3785701A4 (en) |
| JP (3) | JP7295150B2 (en) |
| KR (3) | KR20230037691A (en) |
| CN (3) | CN117100867A (en) |
| AU (2) | AU2020248612B9 (en) |
| BR (1) | BR112021019076A2 (en) |
| CA (1) | CA3131052A1 (en) |
| CL (1) | CL2021002464A1 (en) |
| CO (1) | CO2021012380A2 (en) |
| CR (1) | CR20210489A (en) |
| DO (1) | DOP2021000197A (en) |
| EA (1) | EA202192588A1 (en) |
| EC (1) | ECSP21070640A (en) |
| IL (1) | IL286539A (en) |
| JO (1) | JOP20210262A1 (en) |
| MX (1) | MX2021011278A (en) |
| NI (1) | NI202100085A (en) |
| PE (1) | PE20220283A1 (en) |
| SG (1) | SG11202110512WA (en) |
| WO (1) | WO2020197230A1 (en) |
| ZA (2) | ZA202108027B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201403714TA (en) | 2011-12-30 | 2014-07-30 | Halozyme Inc | Ph20 polypeptide variants, formulations and uses thereof |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| EP3790532A1 (en) | 2018-05-10 | 2021-03-17 | Regeneron Pharmaceuticals, Inc. | High concentration vegf receptor fusion protein containing formulations |
| AU2019311658B2 (en) * | 2018-07-25 | 2022-10-20 | Alteogen, Inc | Novel hyaluronidase variants and pharmaceutical composition comprising the same |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| MX2022008060A (en) * | 2020-01-23 | 2022-07-27 | Alteogen Inc | Novel hyaluronic acid-hydrolyzing enzyme variant having improved stability and pharmaceutical composition comprising same. |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| EP4267172A1 (en) | 2020-12-28 | 2023-11-01 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
| AU2021411486A1 (en) | 2020-12-28 | 2023-06-29 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| AU2022322077A1 (en) | 2021-08-02 | 2024-02-08 | argenx BV | Subcutaneous unit dosage forms |
| IL311429A (en) | 2021-09-14 | 2024-05-01 | Takeda Pharmaceuticals Co | Facilitated delivery of concentrated antibody formulations using hyaluronidase |
| AU2022376750A1 (en) * | 2021-10-29 | 2024-05-16 | Alteogen Inc. | Pharmaceutical composition comprising human hyaluronidase ph20 and drug |
| WO2023168305A1 (en) | 2022-03-01 | 2023-09-07 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
| WO2023169986A1 (en) * | 2022-03-07 | 2023-09-14 | Mabxience Research, S.L. | Stable formulations for antibodies |
| WO2023204554A1 (en) * | 2022-04-20 | 2023-10-26 | 주식회사 알토스바이오로직스 | Pharmaceutical composition comprising ocrelizumab and use thereof |
| WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| TW202405176A (en) * | 2022-06-22 | 2024-02-01 | 南韓商阿特根公司 | N-terminal and/or c-terminal cleaved soluble ph20 polypeptide and use thereof |
| WO2024005502A1 (en) * | 2022-06-29 | 2024-01-04 | 주식회사 오디스젠 | Hyaluronidase hyal1 variant exhibiting activity in neutral ph |
| KR20240038901A (en) * | 2022-09-16 | 2024-03-26 | (주)피앤피바이오팜 | Novel hyaluronidase PH20 mutant and uses thereof |
| KR102554775B1 (en) * | 2023-02-07 | 2023-07-12 | 한국코러스 주식회사 | Hyaluronidase formulation and which contains stabilizer for hyaluronidase |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG177008A1 (en) * | 2003-03-05 | 2012-01-30 | Halozyme Inc | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| RU2008123518A (en) | 2005-11-10 | 2009-12-20 | Ресептор Байолоджикс, Инк. (Us) | METHODS FOR PRODUCING ISOFORM OF RECEPTORS AND LIGANDS |
| TWI489994B (en) * | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | Combinations and methods for subcutaneous administration of immune globulin and hyaluronidase |
| EP3192525A1 (en) * | 2008-04-14 | 2017-07-19 | Halozyme, Inc. | Modified hyaluronidases for use in treating hyaluronan-associated diseases and conditions |
| EP3037529B1 (en) * | 2008-12-09 | 2019-03-27 | Halozyme, Inc. | Extended soluble ph20 polypeptides and uses thereof |
| US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| SG11201403714TA (en) * | 2011-12-30 | 2014-07-30 | Halozyme Inc | Ph20 polypeptide variants, formulations and uses thereof |
| TW201534726A (en) | 2013-07-03 | 2015-09-16 | Halozyme Inc | Thermally stable PH20 hyaluronidase variants and uses thereof |
| US20170218382A1 (en) * | 2014-07-31 | 2017-08-03 | National University Corporation Kobe University | Secretion Signal Peptide, And Protein Secretory Production And Cell Surface Display Using Said Secretion Signal Peptide |
| EP3186281B1 (en) * | 2014-08-28 | 2019-04-10 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
| JP2020500863A (en) * | 2016-11-30 | 2020-01-16 | メモリアル スローン ケタリング キャンサー センター | Inhibitor-functionalized ultra-small nanoparticles and methods thereof |
| KR20230144110A (en) * | 2017-03-02 | 2023-10-13 | 제넨테크, 인크. | Adjuvant treatment of her2-positive breast cancer |
| AU2019311658B2 (en) * | 2018-07-25 | 2022-10-20 | Alteogen, Inc | Novel hyaluronidase variants and pharmaceutical composition comprising the same |
-
2020
- 2020-03-24 KR KR1020237007559A patent/KR20230037691A/en active Search and Examination
- 2020-03-24 SG SG11202110512WA patent/SG11202110512WA/en unknown
- 2020-03-24 PE PE2021001563A patent/PE20220283A1/en unknown
- 2020-03-24 CA CA3131052A patent/CA3131052A1/en active Pending
- 2020-03-24 CN CN202310758097.1A patent/CN117100867A/en active Pending
- 2020-03-24 CR CR20210489A patent/CR20210489A/en unknown
- 2020-03-24 US US17/052,952 patent/US20210363270A1/en active Pending
- 2020-03-24 KR KR1020207030248A patent/KR102650991B1/en active IP Right Grant
- 2020-03-24 EP EP20776465.5A patent/EP3785701A4/en active Pending
- 2020-03-24 KR KR1020227016935A patent/KR102507853B1/en active IP Right Grant
- 2020-03-24 WO PCT/KR2020/003975 patent/WO2020197230A1/en active Application Filing
- 2020-03-24 CN CN202080003052.8A patent/CN112203642A/en active Pending
- 2020-03-24 EA EA202192588A patent/EA202192588A1/en unknown
- 2020-03-24 AU AU2020248612A patent/AU2020248612B9/en active Active
- 2020-03-24 BR BR112021019076A patent/BR112021019076A2/en unknown
- 2020-03-24 CN CN202310416462.0A patent/CN116870164A/en active Pending
- 2020-03-24 MX MX2021011278A patent/MX2021011278A/en unknown
- 2020-03-24 JP JP2020569741A patent/JP7295150B2/en active Active
- 2020-03-24 JO JOP/2021/0262A patent/JOP20210262A1/en unknown
-
2021
- 2021-09-19 IL IL286539A patent/IL286539A/en unknown
- 2021-09-22 DO DO2021000197A patent/DOP2021000197A/en unknown
- 2021-09-22 CL CL2021002464A patent/CL2021002464A1/en unknown
- 2021-09-22 EC ECSENADI202170640A patent/ECSP21070640A/en unknown
- 2021-09-22 CO CONC2021/0012380A patent/CO2021012380A2/en unknown
- 2021-09-22 NI NI202100085A patent/NI202100085A/en unknown
- 2021-10-20 ZA ZA2021/08027A patent/ZA202108027B/en unknown
-
2022
- 2022-04-18 JP JP2022068166A patent/JP7166478B2/en active Active
- 2022-05-13 US US17/744,575 patent/US20220289864A1/en active Pending
- 2022-08-22 ZA ZA2022/09369A patent/ZA202209369B/en unknown
-
2023
- 2023-02-24 JP JP2023026863A patent/JP2023078146A/en active Pending
-
2024
- 2024-02-23 AU AU2024201238A patent/AU2024201238A1/en active Pending
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