CN1498224A - 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 - Google Patents

用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 Download PDF

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Publication number
CN1498224A
CN1498224A CNA018131115A CN01813111A CN1498224A CN 1498224 A CN1498224 A CN 1498224A CN A018131115 A CNA018131115 A CN A018131115A CN 01813111 A CN01813111 A CN 01813111A CN 1498224 A CN1498224 A CN 1498224A
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China
Prior art keywords
compound
alkyl
conhch
exist
mmol
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Pending
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CNA018131115A
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English (en)
Chinese (zh)
Inventor
Ak
A·K·萨克塞纳
V·M·吉里亚瓦拉班
ά
R·G·洛维
Ң
E·E·尧
F·本尼特
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J·L·麦克科尔米克
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H·王
R·E·皮克
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S·L·伯根
覃天佑
刘怡宗
����˹���ʹ�˾
朱昭宁
F·G·恩约罗格
A·阿拉萨潘
ƽ
T·N·帕雷克
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A·K·甘古利
陈新海
S·文卡特拉曼
H·A·瓦卡罗
�-ά��˹
P·A·平托
B·桑塔纳姆
W·吴
S·亨德拉塔
Y·黄
S·J·坎普
O·E·莱维
M·利姆-维尔比
S·Y·塔穆拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Covas International
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22822095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1498224(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Covas International, Schering Corp filed Critical Covas International
Publication of CN1498224A publication Critical patent/CN1498224A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNA018131115A 2000-07-21 2001-07-19 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 Pending CN1498224A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22010800P 2000-07-21 2000-07-21
US60/220,108 2000-07-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2011100651916A Division CN102206247B (zh) 2000-07-21 2001-07-19 一种具有HCV NS3/NS4a蛋白酶抑制活性的化合物
CN2011102287110A Division CN102372764A (zh) 2000-07-21 2001-07-19 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽

Publications (1)

Publication Number Publication Date
CN1498224A true CN1498224A (zh) 2004-05-19

Family

ID=22822095

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA018131115A Pending CN1498224A (zh) 2000-07-21 2001-07-19 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
CN2011102287110A Pending CN102372764A (zh) 2000-07-21 2001-07-19 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
CN2011100651916A Expired - Fee Related CN102206247B (zh) 2000-07-21 2001-07-19 一种具有HCV NS3/NS4a蛋白酶抑制活性的化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2011102287110A Pending CN102372764A (zh) 2000-07-21 2001-07-19 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
CN2011100651916A Expired - Fee Related CN102206247B (zh) 2000-07-21 2001-07-19 一种具有HCV NS3/NS4a蛋白酶抑制活性的化合物

Country Status (31)

Country Link
US (4) US7012066B2 (enExample)
EP (1) EP1385870B1 (enExample)
JP (3) JP4298289B2 (enExample)
KR (2) KR100904788B1 (enExample)
CN (3) CN1498224A (enExample)
AR (2) AR033985A1 (enExample)
AT (1) ATE461207T1 (enExample)
AU (2) AU2001276988B2 (enExample)
BR (1) BR0112540A (enExample)
CA (1) CA2410662C (enExample)
CY (2) CY1112267T1 (enExample)
CZ (1) CZ303213B6 (enExample)
DE (2) DE60141608D1 (enExample)
DK (1) DK1385870T3 (enExample)
EC (1) ECSP034438A (enExample)
ES (1) ES2341534T3 (enExample)
HU (1) HU229997B1 (enExample)
IL (2) IL153670A0 (enExample)
LU (1) LU91910I2 (enExample)
MX (1) MXPA03000627A (enExample)
MY (2) MY143322A (enExample)
NO (2) NO332329B1 (enExample)
NZ (1) NZ523782A (enExample)
PL (1) PL206255B1 (enExample)
PT (1) PT1385870E (enExample)
RU (2) RU2355700C9 (enExample)
SI (1) SI1385870T1 (enExample)
SK (1) SK288064B6 (enExample)
TW (1) TWI324611B (enExample)
WO (1) WO2002008244A2 (enExample)
ZA (1) ZA200210312B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883590A (zh) * 2007-09-14 2010-11-10 先灵公司 治疗丙型肝炎患者的方法

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