CA2410662C - Novel peptides as ns3-serine protease inhibitors of hepatitis c virus - Google Patents

Novel peptides as ns3-serine protease inhibitors of hepatitis c virus Download PDF

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Publication number
CA2410662C
CA2410662C CA2410662A CA2410662A CA2410662C CA 2410662 C CA2410662 C CA 2410662C CA 2410662 A CA2410662 A CA 2410662A CA 2410662 A CA2410662 A CA 2410662A CA 2410662 C CA2410662 C CA 2410662C
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CA
Canada
Prior art keywords
compound
mmol
alkyl
solution
concentrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2410662A
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English (en)
French (fr)
Other versions
CA2410662A1 (en
Inventor
Anil K. Saksena
Viyyoor Moopil Girijavallabhan
Raymond G. Lovey
Edwin E. Jao
Frank Bennett
Jinping L. Mc Cormick
Haiyan Wang
Russell E. Pike
Stephane L. Bogen
Tin-Yau Chan
Yi-Tsung Liu
Zhaoning Zhu
F. George Njoroge
Ashok Arasappan
Tejal N. Parekh
Ashit K. Ganguly
Kevin X. Chen
Srikanth Venkatraman
Henry A. Vaccaro
Patrick A. Pinto
Bama Santhanam
Wanli Wu
Siska Hendrata
Yuhua Huang
Scott Jeffrey Kemp
Odile Esther Levy
Marguerita Lim-Wilby
Susan Y. Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendreon Corp
Merck Sharp and Dohme LLC
Original Assignee
Dendreon Corp
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22822095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2410662(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dendreon Corp, Merck Sharp and Dohme LLC filed Critical Dendreon Corp
Publication of CA2410662A1 publication Critical patent/CA2410662A1/en
Application granted granted Critical
Publication of CA2410662C publication Critical patent/CA2410662C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2410662A 2000-07-21 2001-07-19 Novel peptides as ns3-serine protease inhibitors of hepatitis c virus Expired - Fee Related CA2410662C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22010800P 2000-07-21 2000-07-21
US60/220,108 2000-07-21
PCT/US2001/022678 WO2002008244A2 (en) 2000-07-21 2001-07-19 Peptides as ns3-serine protease inhibitors of hepatitis c virus

Publications (2)

Publication Number Publication Date
CA2410662A1 CA2410662A1 (en) 2002-01-31
CA2410662C true CA2410662C (en) 2012-09-18

Family

ID=22822095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2410662A Expired - Fee Related CA2410662C (en) 2000-07-21 2001-07-19 Novel peptides as ns3-serine protease inhibitors of hepatitis c virus

Country Status (31)

Country Link
US (4) US7012066B2 (enExample)
EP (1) EP1385870B1 (enExample)
JP (3) JP4298289B2 (enExample)
KR (2) KR100904788B1 (enExample)
CN (3) CN102206247B (enExample)
AR (2) AR033985A1 (enExample)
AT (1) ATE461207T1 (enExample)
AU (2) AU2001276988B2 (enExample)
BR (1) BR0112540A (enExample)
CA (1) CA2410662C (enExample)
CY (2) CY1112267T1 (enExample)
CZ (1) CZ303213B6 (enExample)
DE (2) DE60141608D1 (enExample)
DK (1) DK1385870T3 (enExample)
EC (1) ECSP034438A (enExample)
ES (1) ES2341534T3 (enExample)
HU (1) HU229997B1 (enExample)
IL (2) IL153670A0 (enExample)
LU (1) LU91910I2 (enExample)
MX (1) MXPA03000627A (enExample)
MY (2) MY143322A (enExample)
NO (2) NO332329B1 (enExample)
NZ (1) NZ523782A (enExample)
PL (1) PL206255B1 (enExample)
PT (1) PT1385870E (enExample)
RU (2) RU2355700C9 (enExample)
SI (1) SI1385870T1 (enExample)
SK (1) SK288064B6 (enExample)
TW (1) TWI324611B (enExample)
WO (1) WO2002008244A2 (enExample)
ZA (1) ZA200210312B (enExample)

Families Citing this family (273)

* Cited by examiner, † Cited by third party
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