CN1427707A - 皮肤外用剂和增白剂 - Google Patents
皮肤外用剂和增白剂 Download PDFInfo
- Publication number
- CN1427707A CN1427707A CN01808871A CN01808871A CN1427707A CN 1427707 A CN1427707 A CN 1427707A CN 01808871 A CN01808871 A CN 01808871A CN 01808871 A CN01808871 A CN 01808871A CN 1427707 A CN1427707 A CN 1427707A
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- CN
- China
- Prior art keywords
- acid
- acceptable salt
- crataegolic
- physiological acceptable
- uvaol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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Abstract
Description
评估 | 详述 |
++ | 增白程度高于当加入450μg/mL维生素C-磷酸镁时观察到的增白程度 |
+ | 增白程度几乎与当加入450μg/mL维生素C-磷酸镁时观察到的增白程度相同 |
± | 增白程度不高于当加入450μg/mL维生素C-磷酸镁时观察到的增白程度,但高于从对照观察到的增白程度 |
- | 增白程度几乎与从对照观察到的相同 |
试验样品 | 浓度(ppm) | |||||||
2 | 4 | 6 | 8 | 10 | 15 | 25 | 50 | |
纯化的山楂酸1 | ± | + | ++ | ++ | ++ | |||
纯化的山楂酸2 | ± | + | ++ | ++ | ++ | |||
高根二醇 | ± | ± | ± | ± | ± | ± | + | + |
乌苏醇 | - | - | - | ± | + | + | + | + |
桦木酸 | - | ± | ± | ± | + | + | + | + |
桦木脑 | - | - | ± | ± | ± | + | + | + |
合成1的化合物 | ± | + | ++ | ++ | ++ | |||
合成2的化合物 | ± | ± | + | ++ | ++ | ++ | ||
合成3的化合物 | - | ± | ± | + | + | + | + | + |
合成4的化合物 | ± | ± | + | ++ | ++ | ++ | ||
合成5的化合物 | ± | ± | ± | ± | ± | ± | + | + |
合成6的化合物 | - | - | - | ± | + | + | + | + |
合成7的化合物 | - | ± | ± | ± | + | + | + | + |
合成8的化合物 | - | - | ± | ± | ± | + | + | + |
试验样品 | 浓度(ppm) | |||||||
10 | 15 | 25 | 50 | 100 | 200 | 300 | 450 | |
熊果苷 | - | - | - | ± | ± | + | ++ | ++ |
曲酸 | - | - | - | ± | ± | + | ++ | ++ |
试验样品 | 浓度(ppm) | |||||||||
2 | 4 | 6 | 8 | 10 | 15 | 25 | 50 | 100 | 200 | |
纯化的山楂酸1 | 100 | 100 | 100 | 79 | 57 | |||||
纯化的山楂酸2 | 100 | 100 | 100 | 88 | 69 | |||||
高根二醇 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 97 | 85 | 72 |
乌苏醇 | 100 | 100 | 100 | 100 | 100 | 100 | 90 | 82 | 71 | 61 |
桦木酸 | 100 | 100 | 100 | 100 | 99 | 83 | 76 | 69 | 60 | 51 |
桦木脑 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
合成1的化合物 | 100 | 100 | 100 | 77 | 54 | |||||
合成2的化合物 | 100 | 100 | 100 | 99 | 80 | 59 | ||||
合成3的化合物 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 94 | ||
合成4的化合物 | 100 | 100 | 100 | 100 | 82 | 60 | ||||
合成5的化合物 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 95 | 81 |
合成6的化合物 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 91 | 80 | 69 |
合成7的化合物 | 100 | 100 | 100 | 100 | 98 | 81 | 72 | 60 | 52 | |
合成8的化合物 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
试验样品 | 浓度(ppm) | |||||||
10 | 15 | 25 | 50 | 100 | 200 | 300 | 450 | |
熊果苷 | 100 | 100 | 100 | 86 | 69 | 56 | 41 | 16 |
曲酸 | 100 | 100 | 100 | 100 | 100 | 93 | 80 | 66 |
组分(%) | 本发明的产物 | ||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
(1)蜂蜡 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | |
(2)鲸蜡醇 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | |
(3)还原羊毛脂 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | |
(4)角鲨烷 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | |
(5)甘油mono | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | |
(6)亲脂性甘油一硬脂酸酯 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | |
(7)POE脱水山梨糖醇一-月桂酸酯(20E.O.) | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | |
(8)纯化的山楂酸1 | 0.01 | ||||||||
(9)纯化的山楂酸2 | 0.01 | ||||||||
(9)纯化的山楂酸2 | 0.001 | ||||||||
(10)高根二醇 | 0.01 | ||||||||
(11)乌苏醇 | 0.01 | ||||||||
(12)桦木酸 | 0.01 | ||||||||
(13)桦木脑 | 0.01 | ||||||||
(14)合成1的化合物 | 0.01 | ||||||||
(20)防腐剂 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | |
(21)香料 | 适量(足够即可) | ||||||||
(22)纯水 | 余量 | ||||||||
增白作用 | 有效 | 13 | 14 | 10 | 12 | 13 | 13 | 12 | 14 |
略微有效 | 2 | 1 | 4 | 3 | 1 | 1 | 3 | 1 | |
无效 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
组分(%) | 发明的产物 | 参比产品 | ||||||
9 | 10 | 11 | 1 | 2 | 3 | 4 | ||
(1)蜂蜡 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | |
(2)鲸蜡醇 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | |
(3)还原羊毛脂 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | |
(4)角鲨烷 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | |
(5)甘油一硬脂酸酯 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | |
(6)亲脂性甘油一硬脂酸酯 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | |
(7)POE脱水山梨糖醇一-月桂酸酯(20E.O.) | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | |
(15)合成2的化合物 | 0.01 | |||||||
(16)合成3的化合物 | 0.01 | |||||||
(17)合成4的化合物 | 0.01 | |||||||
(18)维生素C-磷酸镁 | 0.01 | |||||||
(19)曲酸 | 0.01 | |||||||
(19)曲酸 | 0.001 | |||||||
(20)防腐剂 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | |
(21)香料 | 适量(足够即可) | |||||||
(22)纯水 | 余量 | |||||||
增白作用 | 有效 | 13 | 13 | 13 | 3 | 12 | 5 | 0 |
略微有效 | 2 | 2 | 2 | 8 | 3 | 6 | 1 | |
无效 | 0 | 0 | 0 | 4 | 0 | 4 | 14 |
等级 | 描述 |
有效 | 试验样本使皮肤的变黑和消光不明显 |
略微有效 | 试验样本使皮肤的变黑和消光有一定程度上不明显 |
无效 | 皮肤的状况几乎与涂敷试验样本之前观察到的相同 |
配方 | (%) |
(1)甘油 | 5.0 |
(2)1,3-丁二醇 | 6.5 |
(3)聚氧乙烯(POE;20E.O.)脱水山梨糖醇一月桂酸酯 | 1.2 |
(4)乙醇 | 8.0 |
(5)纯化的山楂酸1 | 0.2 |
(6)防腐剂 | 适量 |
(7)香料 | 适量 |
(8)纯水 | 余量 |
配方 | (%) |
(1)POE(10E.O.)脱水山梨糖醇一硬脂酸酯 | 1.0 |
(2)POE(60E.O.)山梨糖醇四油酸酯 | 0.5 |
(3)甘油一硬脂酸酯 | 1.0 |
(4)硬脂酸 | 0.5 |
(5)山嵛醇 | 0.5 |
(6)角鲨烷 | 8.0 |
(7)纯化的山楂酸2 | 0.01 |
(8)生育酚乙酸酯 | 1.0 |
(9)防腐剂 | 0.1 |
(10)羧乙烯基聚合物 | 0.1 |
(11)氢氧化钠 | 0.05 |
(12)乙醇 | 5.0 |
(13)纯水 | 余量 |
(14)香料 | 适量 |
配方 | (%) |
(1)聚乙烯醇 | 20.0 |
(2)乙醇 | 20.0 |
(3)甘油 | 5.0 |
(4)高岭土 | 6.0 |
(5)纯化的山楂酸1 | 0.05 |
(6)防腐剂 | 适量 |
(7)香料 | 适量 |
(8)纯水 | 余量 |
配方 | (%) |
(1)羊毛脂 | 7.0 |
(2)液体石蜡 | 5.0 |
(3)硬脂酸 | 2.0 |
(4)鲸蜡醇 | 1.0 |
(5)甘油 | 5.0 |
(6)三乙醇胺 | 1.0 |
(7)羧甲基纤维素 | 0.7 |
(8)纯水 | 余量 |
(9)云母 | 15.0 |
(10)滑石 | 6.0 |
(11)氧化钛 | 3.0 |
(12)着色颜料 | 6.0 |
(13)纯化的山楂酸2 | 0.01 |
(14)对甲氧基肉桂酸乙酯(Ethyl p-methoxy-silicate) | 适量 |
(15)香料 | 适量 |
配方 | (%) |
(1)硬脂酸 | 2.0 |
(2)鲸蜡醇 | 1.0 |
(3)聚氧乙烯脱水山梨糖醇(20E.O.)一油酸酯 | 0.5 |
(4)脱水山梨糖醇倍半油酸酯 | 0.5 |
(5)对甲氧基肉桂酸2-乙基己酯 | 8.0 |
(6)2-乙基己酸鲸蜡酯 | 12.0 |
(7)1,3-丁二醇 | 10.0 |
(8)羧乙烯基聚合物 | 0.2 |
(9)三乙醇胺 | 0.5 |
(10)纯化的山楂酸2 | 0.01 |
(11)纯水 | 余量 |
(12)防腐剂 | 适量 |
(13)氧化钛 | 3.0 |
(14)香料 | 适量 |
制剂 | (%) |
(1)羧乙烯基聚合物 | 1.0 |
(2)三乙醇胺 | 1.0 |
(3)1,3-丁二醇 | 10.0 |
(4)纯化的山楂酸2 | 0.01 |
(5)纯水 | 余量 |
配方 | (%) |
(1)POE(10E.O.)脱水山梨糖醇一硬脂酸酯 | 1.0 |
(2)POE(60E.O.)山梨糖醇四油酸酯 | 0.5 |
(3)甘油一硬脂酸酯 | 1.0 |
(4)硬脂酸 | 0.5 |
(5)山嵛醇 | 0.5 |
(6)角鲨烷 | 8.0 |
(7)合成2的化合物 | 0.01 |
(8)生育酚乙酸酯 | 1.0 |
(9)防腐剂 | 0.1 |
(10)羧乙烯基聚合物 | 0.1 |
(11)氢氧化钠 | 0.05 |
(12)乙醇 | 5.0 |
(13)纯水 | 余量 |
(14)香料 | 适量 |
配方 | (%) |
(1)硬脂酸 | 2.0 |
(2)鲸蜡醇 | 1.0 |
(3)聚氧乙烯脱水山梨糖醇一油酸酯(20E.O.) | 0.5 |
(4)脱水山梨糖醇倍半油酸酯 | 0.5 |
(5)对甲氧基肉桂酸2-乙基己酯 | 8.0 |
(6)2-乙基己酸鲸蜡酯 | 12.0 |
(7)1,3-丁二醇 | 10.0 |
(8)羧乙烯基聚合物 | 0.2 |
(9)三乙醇胺 | 0.5 |
(10)合成7的化合物 | 0.01 |
(11)纯水 | 余量 |
(12)防腐剂 | 适量 |
(13)氧化钛 | 3.0 |
(14)香料 | 适量 |
配方 | (%) |
(1)甘油 | 5.0 |
(2)1,3-丁二醇 | 6.5 |
(3)聚氧乙烯(20E.O.)脱水山梨糖醇一月桂酸酯 | 1.2 |
(4)乙醇 | 8.0 |
(5)3-O-β-D-吡喃葡糖基-山楂酸 | 0.2 |
(6)防腐剂 | 适量 |
(7)香料 | 适量 |
(8)纯水 | 余量 |
Claims (33)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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JP97428/2000 | 2000-03-31 | ||
JP2000097428 | 2000-03-31 | ||
JP258995/2000 | 2000-08-29 | ||
JP2000258995 | 2000-08-29 | ||
JP2000403353 | 2000-12-28 | ||
JP403353/2000 | 2000-12-28 |
Publications (1)
Publication Number | Publication Date |
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CN1427707A true CN1427707A (zh) | 2003-07-02 |
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Application Number | Title | Priority Date | Filing Date |
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CN01808871A Pending CN1427707A (zh) | 2000-03-31 | 2001-03-30 | 皮肤外用剂和增白剂 |
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US (1) | US20030133958A1 (zh) |
EP (1) | EP1295587A1 (zh) |
JP (1) | JP3958968B2 (zh) |
KR (1) | KR20030005252A (zh) |
CN (1) | CN1427707A (zh) |
AU (1) | AU4468201A (zh) |
CA (1) | CA2404012A1 (zh) |
WO (1) | WO2001072265A1 (zh) |
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-
2001
- 2001-03-30 AU AU4468201A patent/AU4468201A/xx active Pending
- 2001-03-30 CA CA002404012A patent/CA2404012A1/en not_active Abandoned
- 2001-03-30 CN CN01808871A patent/CN1427707A/zh active Pending
- 2001-03-30 JP JP2001570227A patent/JP3958968B2/ja not_active Expired - Fee Related
- 2001-03-30 EP EP01917726A patent/EP1295587A1/en not_active Withdrawn
- 2001-03-30 WO PCT/JP2001/002787 patent/WO2001072265A1/ja not_active Application Discontinuation
- 2001-03-30 KR KR1020027013053A patent/KR20030005252A/ko not_active Application Discontinuation
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100459970C (zh) * | 2004-01-15 | 2009-02-11 | 株式会社太平洋 | 具有协同增白作用的皮肤增白组合物 |
CN106730012A (zh) * | 2017-02-08 | 2017-05-31 | 于晓兵 | 一种胶原基可降解脊柱融合器及其制备方法 |
CN111032009A (zh) * | 2017-08-23 | 2020-04-17 | 一丸自然美建有限公司 | 美白剂、美白用皮肤外用剂以及皮肤的美白方法 |
Also Published As
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EP1295587A1 (en) | 2003-03-26 |
US20030133958A1 (en) | 2003-07-17 |
JPWO2001072265A1 (ja) | 2004-03-18 |
WO2001072265A1 (fr) | 2001-10-04 |
KR20030005252A (ko) | 2003-01-17 |
AU4468201A (en) | 2001-10-08 |
CA2404012A1 (en) | 2001-10-04 |
JP3958968B2 (ja) | 2007-08-15 |
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