JP4447466B2 - メラノサイトのデンドライト伸長抑制剤及びそれを含有する皮膚外用剤 - Google Patents
メラノサイトのデンドライト伸長抑制剤及びそれを含有する皮膚外用剤 Download PDFInfo
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- JP4447466B2 JP4447466B2 JP2004556862A JP2004556862A JP4447466B2 JP 4447466 B2 JP4447466 B2 JP 4447466B2 JP 2004556862 A JP2004556862 A JP 2004556862A JP 2004556862 A JP2004556862 A JP 2004556862A JP 4447466 B2 JP4447466 B2 JP 4447466B2
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- 239000010497 wheat germ oil Substances 0.000 description 1
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
1)ヨモギ属の植物に含まれ、アレルギー性疾患の治療に有用であること。(特許文献6)
2)抗癌作用を有すること。(特許文献7)
3)ヤグルマギク属の植物に含まれていること。(非特許文献1)
(3)メラニン産生量が寄与しない色素異常症の改善用であることを特徴とする、(2)に記載の皮膚外用剤。
本発明のメラノサイトのデンドライト伸長抑制剤は、センタウレイジン(Centaureidin)及び/又はその塩からなる。
などで液液抽出したり、クロロホルム−メタノールなどを溶出溶媒とするシリカゲルカラムクロマトグラフィー等で精製したりすることにより、前記のセンタウレイジン(Centaureidin)及び/又はその塩を単離することが出来る。
キク科セイヨウノコギリソウの地上部の乾燥物10Kgを細切し、エタノール501を加えて、3時間加熱還流した。室温まで冷却した後、減圧濃縮し、これに11の酢酸エチルと水を加え、液液抽出を行い、酢酸エチル相をとり、減圧濃縮し、エキスを得た。残渣をクロロホルムにとかし、シリカゲルカラムクロマトグラフィーにチャージし、溶出溶媒クロロホルム:メタノール=100:1→70:30で精製し、化合物1を211.5mg得た。この構造はX線解析により決定した。
本発明の皮膚外用剤は、センタウレイジン(Centaureidin)及び/又はその塩を、皮膚外用剤全量に対して0.001〜10重量%、好ましくは0.005〜5重量%含有することを特徴とする。本発明に言う、皮膚外用剤とは、皮膚に外用で適用される組成物の総称を意味し、医薬部外品を含む化粧料、皮膚外用医薬、皮膚外用雑貨等が例示できる。これらの内、特に好ましいものは化粧料である。これは、前記本発明のメラノサイトのデンドライト伸長抑制剤が優れた安全性を有しているため、化粧料のように連日、習慣的に使用することができ、その様な使用形態で美白作用をより遺憾なく発揮するためである。
ソルビタンセスキオレート、ソルビタンモノオレート、ソルビタントリオレート、ソルビタンセスキステアレート、ソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンステアレート、ポリオキシエチレンオレート、ポリオキシエチレングリセリル脂肪酸エステル、ポリエキシエチレンアルキルエーテル、ポリオキシエチレン硬化ヒマシ油等の非イオン界面活性剤類、ソジウムラウリルステアレート、ポリオキシエチレンアルキル硫酸塩
、スルホコハク酸エステル塩などのアニオン界面活性剤類、4級アルキルアンモニウム塩等のカチオン界面活性剤類、アルキルベタイン等の両性界面活性剤類、
結晶セルロースや架橋型メチルポリシロキサン、ポリエチレン粉末、アクリル樹脂粉体等の有機粉体類、タルク、マイカ、セリサイト、炭酸マグネシウム、炭酸カルシウム、二酸化チタン、酸化鉄、紺青、群青、チタンマイカ、チタンセリサイト、シリカ等の表面処理されていても良い粉体類、
アクリル酸・メタクリル酸アルキルコポリマー及び/又はその塩、カルボキシビニルポリマー及び/又はその塩、キサンタンガムやヒドロキシプロピルセルロースなどの増粘剤、
レチノール、レチノイン酸、トコフェロール、リボフラビン、ピリドキシン、アスコルビン酸、アスコルビン酸リン酸エステル塩などのビタミンやグリチルリチン酸塩、グリチルレチン、ウルソール酸、オレアノール酸などのテルペン類、エストラジオール、エチニルエストラジオール、エストリオールなどのステロイド類などの有効成分、
フェノキシエタノール、パラベン類、ヒビテングルコネート、塩化ベンザルコニウム等の防腐剤、ジメチルアミノ安息香酸エステル類、桂皮酸エステル類、ベンゾフェノン類などの紫外線吸収剤などが好ましく例示できる。
[実施例1]
以下に示す方法に従って、ヒトメラノサイトを用いて、デンドライトの伸長抑制作用を調べた。
(試薬類)細胞・基礎培地・増殖添加剤は倉敷紡績(株)より購入した。
(細胞)正常ヒトメラノサイト
(培地)基礎培地(Medium 154S)に下記の試薬を添加したもの。
(試薬)増殖添加剤:ウシ脳下垂体抽出液(BPE)(培地中の最終濃度0.4%v/v)、ウシ胎児血清(FBS)(培地中の最終濃度0.5%v/v)、ヒト組換え型塩基性繊維芽細胞増殖因子(rFGF−B)(培地中の最終濃度3ng/ml)、ハイドロコーチゾン(培地中の最終濃度0.18μg/ml)、インスリン(培地中の最終濃度5μg/ml)、トランスフェリン(培地中の最終濃度5μg/ml)、ホルボール 12−ミリスタート 13−アセタート(PMA)(培地中の最終濃度10ng/ml)、ヘパリン(培地中の最終濃度3μg/ml)、PSA溶液(ペニシリン濃度50,000Unit/ml、ストレプトマイシン濃度50μg/ml、アンフォテリシンB濃度12.5μg/mlの混合溶液。培地500mlに対して1ml添加。)
・前記製造例で得たセイヨウノコギリソウエキスおよび化合物1(センタウレイジン)を、濃度として100μg/mlとなるように基礎培地で希釈しサンプル溶液を作製した。なお、コントロールは基礎培地のみの溶液である。
・正常ヒトメラノサイトを48穴マイクロプレートに播種し(3000cells/well,200μl培地)、37℃で培養した。
・24時間後にサンプル溶液50μlを添加した。
・サンプル添加24時間後にデンドライト伸長抑制を観察した。
結果を、デンドライトの長さとして、表1に示す。コントロールでは増殖因子の添加効果によってデンドライトが伸長しているが、センタウレイジン添加群では伸長が抑制されていることがわかる。
下記に示す処方に従って、本発明の皮膚外用剤である化粧料を作製した。即ち、イ、ロ、ハの成分をそれぞれ70℃に加熱し、ロをハで中和し、攪拌しながらイを徐々に加えて乳化し、ホモジナイザーで均質化した後、攪拌冷却して乳液を得た。このものの化合物1をスクワランに置換した比較例1を作製し、通常のメラニン産生抑制用の化粧料では改善しない色黒に悩む人10人1群、計20名を用いて、朝晩2回、連日30日使用の使用テストで色黒の改善度を調べた。改善度は、30日使用後に、スコア5:著しい改善、スコア4:明らかな改善、スコア3:改善、スコア2:やや改善、スコア1:改善せずのスコアで評価してもらった。結果を表2に示す。これより、本発明の皮膚外用剤である化粧料は、優れた美白効果を有することがわかる。
スクワラン 10 重量部
ソルビタンセスキステアレート 2 重量部
化合物1 0.05重量部
ブチルパラベン 0.1 重量部
ロ
1,3−ブタンジオール 5 重量部
キサンタンガム 0.1 重量部
アクリル酸・メタクリル酸アルキル(C10〜30) 0.4 重量部
メチルパラベン 0.1 重量部
水 50 重量部
ハ
水酸化カリウム 0.2 重量部
水 32.05重量部
実施例2と同様に化合物1の量を変えて皮膚外用剤(化粧料)を作製し、10名の同様のパネラーを用い、同様に評価した。この皮膚外用剤においても同様な効果が認められた。
スクワラン 10 重量部
ソルビタンセスキステアレート 2 重量部
化合物1 0.1重量部
ブチルパラベン 0.1重量部
ロ
1,3−ブタンジオール 5 重量部
キサンタンガム 0.1重量部
アクリル酸・メタクリル酸アルキル(C10〜30) 0.4重量部
メチルパラベン 0.1重量部
水 50 重量部
ハ
水酸化カリウム 0.2重量部
水 32.0重量部
下記に示す処方に従って、実施例2、3同様に皮膚外用剤(化粧料)を作製し、同様のパネラーを用いて、同様に評価を行った。比較例2として、化合物1をアルブチンに置換したものを作製し、同様に評価した。結果を表4に示す。これより、パネラーにおいてチロシナーゼ阻害剤の美白効果があまり認められないこと、その様なパネラーでも本発明のメラノサイトのデンドライト伸長抑制剤は有効に作用することが認められた。
スクワラン 10 重量部
ソルビタンセスキステアレート 2 重量部
化合物1 1 重量部
ブチルパラベン 0.1重量部
ロ
1,3−ブタンジオール 5 重量部
キサンタンガム 0.1重量部
アクリル酸・メタクリル酸アルキル(C10〜30) 0.4重量部
メチルパラベン 0.1重量部
水 50 重量部
ハ
水酸化カリウム 0.2重量部
水 31.1重量部
Claims (3)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2002350733 | 2002-12-03 | ||
JP2002350733 | 2002-12-03 | ||
PCT/JP2003/015267 WO2004050054A1 (ja) | 2002-12-03 | 2003-11-28 | メラノサイトのデンドライト伸長抑制剤及びそれを含有する皮膚外用剤 |
Publications (2)
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JPWO2004050054A1 JPWO2004050054A1 (ja) | 2006-03-30 |
JP4447466B2 true JP4447466B2 (ja) | 2010-04-07 |
Family
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JP2004556862A Expired - Lifetime JP4447466B2 (ja) | 2002-12-03 | 2003-11-28 | メラノサイトのデンドライト伸長抑制剤及びそれを含有する皮膚外用剤 |
Country Status (8)
Country | Link |
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US (1) | US8183283B2 (ja) |
EP (1) | EP1570838B1 (ja) |
JP (1) | JP4447466B2 (ja) |
KR (1) | KR101156970B1 (ja) |
CN (1) | CN1324021C (ja) |
AU (1) | AU2003284491A1 (ja) |
ES (1) | ES2427142T3 (ja) |
WO (1) | WO2004050054A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN100496452C (zh) * | 2003-12-15 | 2009-06-10 | 可乐丽股份有限公司 | 皮肤外用剂 |
JP4499543B2 (ja) * | 2003-12-15 | 2010-07-07 | 株式会社クラレ | 皮膚外用剤 |
JP4663265B2 (ja) * | 2004-07-16 | 2011-04-06 | ポーラ化成工業株式会社 | 肌荒れ改善作用を有する皮膚外用剤 |
FR2998793B1 (fr) | 2012-11-30 | 2014-11-28 | Oreal | Composition cosmetique sous forme d'emulsion huile-dans-eau |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55111411A (en) | 1979-02-19 | 1980-08-28 | Sansho Seiyaku Kk | Cosmetic for making fair skin |
US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
FR2558196A2 (fr) * | 1983-01-24 | 1985-07-19 | Attali Freddy | Dispositif de fixation reglable de liteaux sur une structure |
FR2628317B1 (fr) | 1988-03-09 | 1991-11-08 | Lvmh Rech | Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de scutellaria, ou au moins un flavonoide tel que baicaleine ou baicaline et composition cosmetique ou pharmaceutique, notamment dermatologique, a activite anti-allergique, anti-inflammatoire ou anti-vieillissement, l'incorporant |
JPH02172907A (ja) | 1988-12-26 | 1990-07-04 | Lion Corp | 毛髪化粧料 |
JP3415200B2 (ja) | 1993-06-30 | 2003-06-09 | 三省製薬株式会社 | 皮膚外用剤 |
JP3660692B2 (ja) | 1993-11-18 | 2005-06-15 | 株式会社ノエビア | チロシナーゼ生合成阻害剤及びこれを配合して成る美白剤 |
JPH10287544A (ja) * | 1997-04-11 | 1998-10-27 | Yakult Honsha Co Ltd | 色素沈着防止剤並びに皮膚化粧料および皮膚外用剤 |
US8039026B1 (en) * | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
JPH11246336A (ja) | 1998-02-27 | 1999-09-14 | Ichimaru Pharcos Co Ltd | 活性酸素消去剤及び美肌化粧料組成物 |
JPH11246339A (ja) | 1998-03-05 | 1999-09-14 | Shiseido Co Ltd | 皮膚外用剤 |
JPH11246347A (ja) | 1998-03-05 | 1999-09-14 | Shiseido Co Ltd | 美白用皮膚外用剤 |
JPH11349435A (ja) | 1998-06-03 | 1999-12-21 | Noevir Co Ltd | 紫外線による色素沈着症状の防止,改善に有効な皮膚外用剤 |
US6750229B2 (en) | 1998-07-06 | 2004-06-15 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin pigmentation |
JP2001199866A (ja) | 2000-01-24 | 2001-07-24 | Pola Chem Ind Inc | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
KR100833805B1 (ko) * | 2000-04-19 | 2008-05-30 | 니치유 가부시키가이샤 | 화장품 조성물 |
JP2002154920A (ja) | 2000-11-14 | 2002-05-28 | Pola Chem Ind Inc | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
SE517738C2 (sv) * | 2000-11-22 | 2002-07-09 | Denovastella Ab | Preparat för behandling av allergiska symptom innehållande oljor från Artemisia samt förfarande för dess framställning |
-
2003
- 2003-11-28 US US10/537,320 patent/US8183283B2/en not_active Expired - Fee Related
- 2003-11-28 ES ES03775960T patent/ES2427142T3/es not_active Expired - Lifetime
- 2003-11-28 KR KR1020057009916A patent/KR101156970B1/ko not_active IP Right Cessation
- 2003-11-28 WO PCT/JP2003/015267 patent/WO2004050054A1/ja active Application Filing
- 2003-11-28 CN CNB2003801048296A patent/CN1324021C/zh not_active Expired - Lifetime
- 2003-11-28 JP JP2004556862A patent/JP4447466B2/ja not_active Expired - Lifetime
- 2003-11-28 EP EP03775960.2A patent/EP1570838B1/en not_active Expired - Lifetime
- 2003-11-28 AU AU2003284491A patent/AU2003284491A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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EP1570838A1 (en) | 2005-09-07 |
EP1570838A4 (en) | 2009-03-04 |
CN1720020A (zh) | 2006-01-11 |
JPWO2004050054A1 (ja) | 2006-03-30 |
US8183283B2 (en) | 2012-05-22 |
AU2003284491A1 (en) | 2004-06-23 |
KR101156970B1 (ko) | 2012-06-20 |
US20060147398A1 (en) | 2006-07-06 |
CN1324021C (zh) | 2007-07-04 |
ES2427142T3 (es) | 2013-10-29 |
EP1570838B1 (en) | 2013-06-12 |
KR20050085266A (ko) | 2005-08-29 |
WO2004050054A1 (ja) | 2004-06-17 |
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