CN1168440C - 左旋多巴/卡比多巴/恩他卡朋药物制剂 - Google Patents

左旋多巴/卡比多巴/恩他卡朋药物制剂 Download PDF

Info

Publication number
CN1168440C
CN1168440C CNB008095868A CN00809586A CN1168440C CN 1168440 C CN1168440 C CN 1168440C CN B008095868 A CNB008095868 A CN B008095868A CN 00809586 A CN00809586 A CN 00809586A CN 1168440 C CN1168440 C CN 1168440C
Authority
CN
China
Prior art keywords
entacapone
levodopa
carbidopa
composition
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB008095868A
Other languages
English (en)
Chinese (zh)
Other versions
CN1358090A (zh
Inventor
S���¶�
S·卡里奥恩
L·科维恩
�������ɭ
M·拉克森
J·林图拉克索
M·尼斯卡恩
M·帕坦恩
M·里塔拉
K·瓦赫沃
M·沃凯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8554988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1168440(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of CN1358090A publication Critical patent/CN1358090A/zh
Application granted granted Critical
Publication of CN1168440C publication Critical patent/CN1168440C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CNB008095868A 1999-06-30 2000-06-29 左旋多巴/卡比多巴/恩他卡朋药物制剂 Expired - Lifetime CN1168440C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991485 1999-06-30
FI991485A FI109453B (fi) 1999-06-30 1999-06-30 Farmaseuttinen koostumus

Publications (2)

Publication Number Publication Date
CN1358090A CN1358090A (zh) 2002-07-10
CN1168440C true CN1168440C (zh) 2004-09-29

Family

ID=8554988

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008095868A Expired - Lifetime CN1168440C (zh) 1999-06-30 2000-06-29 左旋多巴/卡比多巴/恩他卡朋药物制剂

Country Status (42)

Country Link
US (2) US6500867B1 (enExample)
EP (1) EP1189608B1 (enExample)
JP (2) JP4204783B2 (enExample)
KR (1) KR100905428B1 (enExample)
CN (1) CN1168440C (enExample)
AR (1) AR033796A1 (enExample)
AT (1) ATE245417T1 (enExample)
AU (1) AU765932B2 (enExample)
BG (1) BG65364B1 (enExample)
BR (2) BR0011867A (enExample)
CA (1) CA2378469C (enExample)
CO (1) CO5180579A1 (enExample)
CZ (2) CZ304416B6 (enExample)
DE (1) DE60004052T2 (enExample)
DK (1) DK1189608T3 (enExample)
EA (1) EA004503B1 (enExample)
EE (1) EE05473B1 (enExample)
ES (1) ES2203495T3 (enExample)
FI (1) FI109453B (enExample)
FR (1) FR2797587A1 (enExample)
GE (1) GEP20043314B (enExample)
HK (1) HK1047040B (enExample)
HR (1) HRP20020088B1 (enExample)
HU (1) HU230395B1 (enExample)
IL (1) IL146807A (enExample)
IT (1) ITMI20001450A1 (enExample)
ME (1) ME00520B (enExample)
MX (1) MXPA01013167A (enExample)
MY (1) MY127685A (enExample)
NO (2) NO330260B1 (enExample)
NZ (1) NZ515780A (enExample)
PE (1) PE20010399A1 (enExample)
PL (1) PL197818B1 (enExample)
PT (1) PT1189608E (enExample)
RS (1) RS50368B (enExample)
SI (1) SI1189608T1 (enExample)
SK (1) SK286451B6 (enExample)
TR (1) TR200103763T2 (enExample)
TW (1) TWI241187B (enExample)
UA (1) UA75047C2 (enExample)
WO (1) WO2001001984A1 (enExample)
ZA (1) ZA200109868B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384411C (zh) * 2006-03-17 2008-04-30 北京科信必成医药科技发展有限公司 卡左双多巴口腔崩解片

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109453B (fi) 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus
US20050147670A1 (en) * 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
US20040166159A1 (en) * 2002-05-29 2004-08-26 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
US20030224045A1 (en) * 2002-05-29 2003-12-04 Chien-Hsuan Han Combination immediate release sustained release levodopa/carbidopa dosage forms
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US20040006072A1 (en) * 2002-06-25 2004-01-08 Franz Robert M. Sustained-release alprazolam composition
CA2501345A1 (en) * 2002-10-11 2004-04-22 Depomed Development, Ltd. Gastro-retentive levodopa delivery form
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
SE0401842D0 (sv) * 2004-07-12 2004-07-12 Dizlin Medical Design Ab Infusion and injection solution of levodopa
WO2006037061A2 (en) * 2004-09-28 2006-04-06 Farouk Karoum Compositions and methods of using d-dopa to treat parkinson's disease
US20060173074A1 (en) 2004-11-10 2006-08-03 Juha Ellmen Treatment of restless legs syndrome
AU2012216377C1 (en) * 2005-06-08 2013-10-10 Orion Corporation Oral dosage form
KR101617990B1 (ko) * 2005-06-08 2016-05-03 오리온 코포레이션 경구 용량 형태
AU2006261893A1 (en) * 2005-06-23 2007-01-04 Combinatorx, Incorporated Improved dosage forms for movement disorder treatment
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
SI1907382T1 (sl) * 2005-07-26 2015-10-30 Bial-Portela & Ca S.A., Nitrokateholni derivati kot inhibitorji COMT
WO2007016190A2 (en) * 2005-07-28 2007-02-08 Duke University Antiparkinsonian action of phenylisopropylamines
EP1948153A2 (en) * 2005-09-21 2008-07-30 Orion Corporation Treatment of symptoms of parkinson`s disease
US20070178149A1 (en) * 2005-11-07 2007-08-02 Moshe Flashner-Barak Levodopa compositions
EP1954256A2 (en) * 2005-11-09 2008-08-13 Torrent Pharmaceuticals Ltd Pharmaceutical composition comprising a compound having a catechol moiety and an alkalising agent
GB2429645A (en) * 2006-03-10 2007-03-07 Sekhsaria Chemicals Ltd Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent
WO2007113371A1 (en) * 2006-03-31 2007-10-11 Iprbox Oy Pharmaceutical composition and preparation method thereof
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
US8106056B2 (en) * 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
US8741342B2 (en) * 2006-10-30 2014-06-03 Wockhardt Research Centre Pharmaceutical compositions comprising entacapone, levodopa, and carbidopa
AU2007338631A1 (en) * 2006-12-22 2008-07-03 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
EP2114374A4 (en) * 2006-12-27 2011-03-23 Wockhardt Research Center PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE
EP1946756A1 (en) * 2007-01-17 2008-07-23 Revotar Biopharmaceuticals AG Use of entacapone in cosmetic, dermatological and pharmaceutical compositions
ES2597705T3 (es) 2007-01-31 2017-01-20 Bial - Portela & Ca., S.A. Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico
US20110171275A1 (en) * 2007-08-20 2011-07-14 Team Academy Of Pharmaceutical Science Gastroretentive drug delivery system, preparation method and use thereof
JP5651478B2 (ja) * 2008-02-06 2015-01-14 ウォックハート リサーチ センター 糖アルコールと共微粒子化されたエンタカポンの医薬組成物
EP2252284B1 (en) * 2008-02-06 2011-05-25 Wockhardt Research Centre Pharmaceutical compositions of entacapone, levodopa and carbidopa with improved bioavailability
EP2276758B1 (en) 2008-03-17 2016-01-06 Bial-Portela & CA, S.A. Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,4] oxadiazol-5-yl]-3-nit robenzene-1, 2-diol
KR101667762B1 (ko) * 2008-08-22 2016-10-20 욱크하르트 리미티드 엔타카폰 또는 이의 염의 서방형 약학 조성물
UA102111C2 (uk) 2008-08-22 2013-06-10 Вокхардт Рісерч Сентер Фармацевтична композиція у вигляді разової пероральної дози, що містить леводопу, карбідопу і ентакапон або їх солі
TR200806646A2 (tr) * 2008-09-03 2009-06-22 Dr. F. Fri̇k İlaç San. Ve Ti̇c. A.Ş. Entakapon, levodopa ve karbidoba içeren farmasötik kombinasyonlar
EP2233131A1 (en) 2009-03-23 2010-09-29 Laboratorios Lesvi, S.L. Pharmaceutical composition containing levodopa, entacapone and carbidopa
KR102329271B1 (ko) 2009-04-01 2021-11-22 바이알 - 포르텔라 앤드 씨에이 에스에이 니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법
ES2627655T3 (es) * 2009-05-19 2017-07-31 Neuroderm Ltd Composiciones para la administración continua de inhibidores de DOPA descarboxilasa
JP5718937B2 (ja) 2009-12-25 2015-05-13 イノファーマックス インコーポレイテッド パーキンソン病を治療するための医薬組成物及びその調製方法
WO2011107653A2 (en) 2010-03-04 2011-09-09 Orion Corporation Method for treating parkinson's disease
DE102010023828A1 (de) 2010-06-15 2011-12-15 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält
JP5902705B2 (ja) * 2010-11-15 2016-04-13 ニューロダーム リミテッドNeuroderm Ltd L−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−o−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
EP2508174A1 (en) 2011-04-06 2012-10-10 Ljiljana Sovic Brkicic Pharmaceutical composition
WO2012147099A1 (en) 2011-04-25 2012-11-01 Suven Nishtaa Pharma Pvt. Ltd. Pharmaceutical compositions of levodopa, carbidopa and entacapone
MX2013012429A (es) * 2011-04-26 2013-12-06 Innopharmax Inc Una composicion de entacopone.
PL2791134T3 (pl) 2011-12-13 2020-03-31 BIAL - PORTELA & Cª S.A. Związek chemiczny użyteczny jako związek pośredni do wytwarzania inhibitora katechol-o-metylotransferazy
TR201204839A2 (tr) * 2012-04-25 2012-12-21 Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. Uzatılmış salım sağlayan levodopa karbıdopa entakapon içeren tablet formülasyonu.
WO2013183055A1 (en) 2012-06-05 2013-12-12 Neuroderm Ltd Compositions comprising apomorphine and organic acids and uses thereof
JP6472391B2 (ja) * 2013-03-13 2019-02-20 ニューロダーム リミテッドNeuroderm Ltd パーキンソン病の治療方法
EP2799065A1 (en) * 2013-04-30 2014-11-05 Deva Holding Anonim Sirketi Levodopa carbidopa entacapone pharmaceutical formulations
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
ES2823000T3 (es) 2013-10-07 2021-05-05 Impax Laboratories Llc Formulaciones muco-adhesivas de liberación controlada de levodopa y/o ésteres de levodopa y usos de las mismas
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
PT3116475T (pt) 2014-03-13 2020-12-15 Neuroderm Ltd Composições de inibidores de dopa-descarboxilase
ES2973289T3 (es) * 2014-09-04 2024-06-19 Lobsor Pharmaceuticals Ab Composiciones farmacéuticas en gel que comprenden levodopa, carbidopa y entacapona
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
EP3236957A1 (en) 2014-12-23 2017-11-01 Pharmathen S.A. Levodopa/carbidopa/entacapone pharmaceutical preparation and method for preparing the same
US10555922B2 (en) 2015-09-04 2020-02-11 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
WO2018011181A1 (en) * 2016-07-11 2018-01-18 Contera Pharma Aps Pulsatile drug delivery system for treating morning akinesia
EA036784B1 (ru) 2016-08-18 2020-12-21 Илько Илач Санайи Ве Тиджарет Аноним Ширкети Таблетированный состав с улучшенным профилем растворения для лечения болезни паркинсона
WO2019145773A1 (en) 2017-12-15 2019-08-01 Nos Life Sciences Corporation Liposomal-encapsulated formulations
CN118121710A (zh) 2018-03-23 2024-06-04 劳波索尔制药有限公司 用于治疗神经退行性疾病的药物组合物的连续施用
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
JP2024501235A (ja) 2020-12-22 2024-01-11 アムニール ファーマスーティカルズ エルエルシー レボドパ投薬レジメン
US11986449B2 (en) 2020-12-22 2024-05-21 Amneal Pharmaceuticals Llc Levodopa dosing regimen
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190672A (en) 1978-09-01 1980-02-26 Stanley Fahn Method and compositions of treating Parkinsonisms with levodopa and 3',4'-dihydroxy-2-methylisopropiophenone
GB8521350D0 (en) * 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
US5236952A (en) 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
NZ220599A (en) * 1986-06-16 1990-10-26 Merck & Co Inc Controlled release oral dosage formulation of carbidopa and levodopa
US5283352A (en) 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
DE4101873C2 (de) 1991-01-23 1993-12-09 Isis Pharma Gmbh Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände
US5888534A (en) 1995-06-13 1999-03-30 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
GB2321190B (en) * 1997-01-16 2000-09-20 Britannia Pharmaceuticals Ltd Pharmaceutical composition
US6599530B2 (en) 1998-09-14 2003-07-29 Orion Corporation Oral compacted composition comprising catechol derivatives
FI109453B (fi) * 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384411C (zh) * 2006-03-17 2008-04-30 北京科信必成医药科技发展有限公司 卡左双多巴口腔崩解片

Also Published As

Publication number Publication date
IL146807A (en) 2006-10-05
RS50368B (sr) 2009-11-10
ITMI20001450A1 (it) 2001-12-28
JP4204783B2 (ja) 2009-01-07
AR033796A1 (es) 2004-01-07
BRPI0011867B8 (pt) 2021-05-25
DK1189608T3 (da) 2003-11-10
CZ303010B6 (cs) 2012-02-29
BG106251A (en) 2002-08-30
EP1189608B1 (en) 2003-07-23
NO330260B1 (no) 2011-03-14
FR2797587A1 (fr) 2001-02-23
MY127685A (en) 2006-12-29
BR0011867A (pt) 2002-03-05
HRP20020088B1 (hr) 2007-05-31
HU230395B1 (hu) 2016-04-28
AU765932B2 (en) 2003-10-02
CN1358090A (zh) 2002-07-10
CA2378469C (en) 2009-10-06
ATE245417T1 (de) 2003-08-15
BG65364B1 (bg) 2008-04-30
PT1189608E (pt) 2003-12-31
PL197818B1 (pl) 2008-04-30
CZ304416B6 (cs) 2014-04-23
NO20016203D0 (no) 2001-12-18
FI991485A0 (fi) 1999-06-30
US20030017201A1 (en) 2003-01-23
HUP0202273A2 (en) 2002-10-28
ME00520B (me) 2011-10-10
PL352775A1 (en) 2003-09-08
CA2378469A1 (en) 2001-01-11
BRPI0011867B1 (pt) 2019-01-08
DE60004052D1 (de) 2003-08-28
WO2001001984A1 (en) 2001-01-11
NZ515780A (en) 2004-06-25
EE200100716A (et) 2003-02-17
JP2003503454A (ja) 2003-01-28
EE05473B1 (et) 2011-10-17
MXPA01013167A (es) 2002-07-02
EA200200106A1 (ru) 2002-06-27
EA004503B1 (ru) 2004-04-29
DE60004052T2 (de) 2004-04-15
YU92501A (sh) 2004-09-03
NO20016203L (no) 2002-02-25
JP4885896B2 (ja) 2012-02-29
HK1047040A1 (en) 2003-02-07
PE20010399A1 (es) 2001-04-10
US6500867B1 (en) 2002-12-31
SK19232001A3 (sk) 2002-06-04
EP1189608A1 (en) 2002-03-27
TWI241187B (en) 2005-10-11
GEP20043314B (en) 2004-02-10
SK286451B6 (sk) 2008-10-07
HRP20020088A2 (en) 2005-10-31
AU5830600A (en) 2001-01-22
CZ20014636A3 (cs) 2002-05-15
HUP0202273A3 (en) 2002-11-28
ES2203495T3 (es) 2004-04-16
UA75047C2 (en) 2006-03-15
CO5180579A1 (es) 2002-07-30
FI109453B (fi) 2002-08-15
JP2008156373A (ja) 2008-07-10
SI1189608T1 (en) 2004-04-30
US6797732B2 (en) 2004-09-28
FI991485L (fi) 2000-12-31
ZA200109868B (en) 2003-05-28
TR200103763T2 (tr) 2002-04-22
KR20020010155A (ko) 2002-02-02
NO20110090L (no) 2002-02-25
KR100905428B1 (ko) 2009-06-30
ITMI20001450A0 (it) 2000-06-28
HK1047040B (zh) 2005-04-29

Similar Documents

Publication Publication Date Title
CN1168440C (zh) 左旋多巴/卡比多巴/恩他卡朋药物制剂
CN102724970B (zh) 来那替尼马来酸盐的片剂制剂
EP3606511B1 (en) Pharmaceutical composition comprising lenvatinib mesylate
JP2008520655A (ja) 生体利用率を向上させた経口用製剤
CN105407925A (zh) 用于泡腾剂型的制造工艺
CA2450001A1 (en) Stable pharmaceutical compositions containing pravastatin
CN102159195A (zh) 阿利吉仑和氨氯地平的双层或单层片形式的固定剂量组合
CN103860550A (zh) 左旋多巴/卡比多巴/罗匹尼罗药物制剂
CN1330537A (zh) 含有普鲁芬的药物组合物
HK40081563B (en) Tablet formulations of neratinib maleate
RU19762U1 (ru) Таблетка
KR20060058415A (ko) 아목시실린 및 클라불란산 또는 그의 염의 혼합물 함유조성물 및 그의 제조방법
JP2004091373A (ja) 分解に対する安定性及び含量均一性に優れたメシル酸ペルゴリド含有製剤
JP2009542806A (ja) 感湿性薬物及び第2薬物の組合せを含んで成る安定製剤及びその製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1047040

Country of ref document: HK

CX01 Expiry of patent term

Granted publication date: 20040929

CX01 Expiry of patent term