CN111918661A - 用于活化和扩增自然杀伤细胞的方法及其用途 - Google Patents

用于活化和扩增自然杀伤细胞的方法及其用途 Download PDF

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CN111918661A
CN111918661A CN201980022341.XA CN201980022341A CN111918661A CN 111918661 A CN111918661 A CN 111918661A CN 201980022341 A CN201980022341 A CN 201980022341A CN 111918661 A CN111918661 A CN 111918661A
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cells
expanded
aapcs
disease
leukemia
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L·N·克宝
E·施帕尔
K·雷兹瓦尼
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University of Texas System
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CN201980022341.XA 2018-02-21 2019-02-21 用于活化和扩增自然杀伤细胞的方法及其用途 Pending CN111918661A (zh)

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US201862633592P 2018-02-21 2018-02-21
US62/633,592 2018-02-21
PCT/US2019/019019 WO2019165121A1 (en) 2018-02-21 2019-02-21 Methods for activation and expansion of natural killer cells and uses therof

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CN113786416A (zh) * 2021-09-22 2021-12-14 北京创世客生物技术有限公司 转基因的nk细胞在治疗癌症中的用途
CN115491355A (zh) * 2022-02-22 2022-12-20 北京景达生物科技有限公司 Nk细胞与pd1/pd-l1抑制剂的联合应用
CN116254230A (zh) * 2022-09-14 2023-06-13 卡瑞济(北京)生命科技有限公司 用于制备和扩增通用型人源化抗cd19 car-nk细胞的方法及其用途
CN119286778A (zh) * 2024-12-09 2025-01-10 天津迈默睿生物技术有限公司 一种利用外周血单个核细胞制备记忆性自然杀伤细胞的方法及记忆性自然杀伤细胞的应用
CN119367397A (zh) * 2024-11-11 2025-01-28 英百瑞(杭州)生物医药有限公司 Nk细胞在治疗白癜风和银屑病中的应用
WO2025222325A1 (zh) * 2024-04-22 2025-10-30 苏州艾凯利元生物科技有限公司 由iPSC诱导产生的iNK细胞群在治疗癌症中的应用

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
JP7273421B2 (ja) 2018-02-21 2023-05-15 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US20210077527A1 (en) * 2019-09-13 2021-03-18 The Research Institute At Nationwide Children's Hospital Universal donor selection method to identify nk-cell-donors
WO2021051088A1 (en) * 2019-09-13 2021-03-18 Ohio State Innovation Foundation Nk cell immunotherapy compositions, methods of making and methods of using same
US12195759B2 (en) 2020-02-21 2025-01-14 FullHope Biomedical Co., Ltd. Modified natural killer cells, pharmaceutical composition, manufacturing method thereof, and method of using the same
AU2021262835A1 (en) * 2020-04-30 2022-11-24 Fibrobiologics, Inc. Immunotherapeutic methods and compositions for targeting cancer fibroblasts
WO2021251708A1 (ko) * 2020-06-09 2021-12-16 사회복지법인 삼성생명공익재단 Nk 세포의 활성화 및 증폭을 위해 유전적으로 조작된 세포주, 및 그의 용도
EP4163366A4 (en) * 2020-06-09 2024-08-21 Samsung Life Public Welfare Foundation GENETICALLY MODIFIED CELL LINE FOR ACTIVATION AND AMPLIFICATION OF NK CELLS AND USE THEREOF
KR20230084470A (ko) 2020-08-14 2023-06-13 카이트 파마 인코포레이티드 면역 세포 기능의 향상
CN116568805A (zh) * 2020-09-02 2023-08-08 恩卡尔塔公司 工程化自然杀伤细胞的增强扩增和细胞毒性及其用途
US20240042028A1 (en) * 2020-12-07 2024-02-08 The Johns Hopkins University Methods of nk cell engineering to enhance tumor targeting
EP4079312A1 (en) * 2021-04-22 2022-10-26 Guizhou Sinorda Biotechnology CO., Ltd. New treatment of sepsis
CN116997346A (zh) * 2021-03-23 2023-11-03 贵州生诺生物科技有限公司 脓毒症的新的治疗
WO2022216992A1 (en) * 2021-04-08 2022-10-13 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and combinations with bispecific antibodies
US20250339528A1 (en) * 2021-07-28 2025-11-06 Nkarta, Inc. Selection of optimal cell donors and methods and compositions for enhanced expansion and cytotoxicity of donor cells
WO2023034758A1 (en) * 2021-08-30 2023-03-09 Cytoimmune Therapeutics, Inc. Methods and compositions for cell expansion
CN114058584B (zh) * 2022-01-07 2022-07-01 山东省齐鲁干细胞工程有限公司 一种临床用自然杀伤细胞的制备方法
WO2023163240A1 (ko) * 2022-02-22 2023-08-31 신동혁 자연살해세포 활성도 신속검사용 자극조성물 및 이를 이용한 자연살해세포 활성도 신속검사방법
US20260035424A1 (en) 2022-05-26 2026-02-05 Caribou Biosciences, Inc. Cytokine-receptor fusions for immune cell stimulation
EP4558152A2 (en) * 2022-07-22 2025-05-28 Board of Regents, The University of Texas System Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy
KR102566680B1 (ko) * 2022-09-28 2023-08-14 (주)포에버엔케이 면역세포 및 자연살해세포 배양을 위한 신규한 이중배양 제조방법 및 이의 용도
US20240279607A1 (en) * 2023-02-17 2024-08-22 FullHope Biomedical Co., Ltd. Pharmaceutical composition comprising modified natural killer cells and antigen-specific t cells, manufacturing method thereof, and method of using the same
CN120168514A (zh) * 2025-03-21 2025-06-20 英百瑞(杭州)生物医药有限公司 Nk细胞在治疗系统性红斑狼疮中的应用

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CN115491355A (zh) * 2022-02-22 2022-12-20 北京景达生物科技有限公司 Nk细胞与pd1/pd-l1抑制剂的联合应用
CN115521913A (zh) * 2022-02-22 2022-12-27 北京景达生物科技有限公司 NK细胞与CD20、CD38、Her2抗体联合应用
CN115491355B (zh) * 2022-02-22 2023-10-10 北京景达生物科技有限公司 Nk细胞与pd1/pd-l1抑制剂的联合应用
CN116254230A (zh) * 2022-09-14 2023-06-13 卡瑞济(北京)生命科技有限公司 用于制备和扩增通用型人源化抗cd19 car-nk细胞的方法及其用途
WO2024055339A1 (zh) * 2022-09-14 2024-03-21 卡瑞济(北京)生命科技有限公司 用于制备和扩增通用型人源化抗cd19 car-nk细胞的方法及其用途
WO2025222325A1 (zh) * 2024-04-22 2025-10-30 苏州艾凯利元生物科技有限公司 由iPSC诱导产生的iNK细胞群在治疗癌症中的应用
CN119367397A (zh) * 2024-11-11 2025-01-28 英百瑞(杭州)生物医药有限公司 Nk细胞在治疗白癜风和银屑病中的应用
CN119286778A (zh) * 2024-12-09 2025-01-10 天津迈默睿生物技术有限公司 一种利用外周血单个核细胞制备记忆性自然杀伤细胞的方法及记忆性自然杀伤细胞的应用

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