HK1258218A1 - T細胞受體(tcr)結合抗體及其應用 - Google Patents
T細胞受體(tcr)結合抗體及其應用Info
- Publication number
- HK1258218A1 HK1258218A1 HK19100576.1A HK19100576A HK1258218A1 HK 1258218 A1 HK1258218 A1 HK 1258218A1 HK 19100576 A HK19100576 A HK 19100576A HK 1258218 A1 HK1258218 A1 HK 1258218A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tcr
- cell receptor
- binding antibodies
- antibodies
- binding
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562218990P | 2015-09-15 | 2015-09-15 | |
PCT/US2016/051847 WO2017048902A1 (en) | 2015-09-15 | 2016-09-15 | T-cell receptor (tcr)-binding antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1258218A1 true HK1258218A1 (zh) | 2019-11-08 |
Family
ID=56990993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK19100576.1A HK1258218A1 (zh) | 2015-09-15 | 2019-01-14 | T細胞受體(tcr)結合抗體及其應用 |
Country Status (11)
Country | Link |
---|---|
US (2) | US10633445B2 (zh) |
EP (1) | EP3349791A1 (zh) |
JP (1) | JP7020687B2 (zh) |
KR (1) | KR20180042449A (zh) |
CN (1) | CN108430506A (zh) |
AU (2) | AU2016323153B2 (zh) |
CA (1) | CA2997673A1 (zh) |
HK (1) | HK1258218A1 (zh) |
IL (1) | IL258009B2 (zh) |
WO (1) | WO2017048902A1 (zh) |
ZA (1) | ZA202002966B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105408473B9 (zh) | 2013-05-14 | 2021-09-17 | 得克萨斯州大学系统董事会 | 工程化嵌合抗原受体(car)t细胞的人应用 |
CA2938887C (en) | 2014-02-14 | 2023-04-11 | Laurence J. N. Cooper | Chimeric antigen receptors and methods of making |
WO2016073629A1 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
JP6947647B2 (ja) | 2015-02-24 | 2021-10-13 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 遺伝子改変t細胞の選択方法 |
RU2020127887A (ru) | 2015-03-11 | 2020-10-02 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Полипептиды транспозазы и их применение |
JP7020687B2 (ja) | 2015-09-15 | 2022-02-16 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | T細胞受容体(tcr)結合抗体及びその使用 |
US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
KR20190142775A (ko) * | 2017-04-19 | 2019-12-27 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 조작된 항원 수용체를 발현하는 면역 세포 |
US11820823B2 (en) * | 2017-10-27 | 2023-11-21 | Kite Pharma, Inc. | T cell receptor antigen binding molecules and methods of use thereof |
WO2020010229A1 (en) * | 2018-07-06 | 2020-01-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Car t cell therapy to target t cell specific cancers |
CN109136282A (zh) * | 2018-09-30 | 2019-01-04 | 北京鼎成肽源生物技术有限公司 | 一种hafft1细胞的构建方法 |
CN117624340B (zh) * | 2024-01-23 | 2024-04-30 | 北京臻知医学科技有限责任公司 | 识别人乙型肝炎病毒(hbv)抗原的t细胞受体(tcr)及其用途 |
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EP3004168A4 (en) | 2013-05-24 | 2017-03-01 | Board of Regents, The University of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
AU2014339926B2 (en) | 2013-10-25 | 2018-02-08 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta T cells for immunotherapy |
CA2938887C (en) | 2014-02-14 | 2023-04-11 | Laurence J. N. Cooper | Chimeric antigen receptors and methods of making |
CN106459924A (zh) | 2014-04-23 | 2017-02-22 | 得克萨斯州大学系统董事会 | 用于疗法中的嵌合抗原受体(car)及其制备方法 |
CA2945393C (en) | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
JP2017535284A (ja) | 2014-11-05 | 2017-11-30 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 |
WO2016073629A1 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
JP6947647B2 (ja) | 2015-02-24 | 2021-10-13 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 遺伝子改変t細胞の選択方法 |
RU2020127887A (ru) | 2015-03-11 | 2020-10-02 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Полипептиды транспозазы и их применение |
JP7020687B2 (ja) | 2015-09-15 | 2022-02-16 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | T細胞受容体(tcr)結合抗体及びその使用 |
US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
-
2016
- 2016-09-15 JP JP2018513633A patent/JP7020687B2/ja active Active
- 2016-09-15 EP EP16770634.0A patent/EP3349791A1/en not_active Withdrawn
- 2016-09-15 CN CN201680066388.2A patent/CN108430506A/zh active Pending
- 2016-09-15 WO PCT/US2016/051847 patent/WO2017048902A1/en active Application Filing
- 2016-09-15 US US15/759,148 patent/US10633445B2/en active Active
- 2016-09-15 AU AU2016323153A patent/AU2016323153B2/en active Active
- 2016-09-15 KR KR1020187010458A patent/KR20180042449A/ko not_active Application Discontinuation
- 2016-09-15 IL IL258009A patent/IL258009B2/en unknown
- 2016-09-15 CA CA2997673A patent/CA2997673A1/en active Pending
-
2019
- 2019-01-14 HK HK19100576.1A patent/HK1258218A1/zh unknown
-
2020
- 2020-03-30 US US16/834,562 patent/US11548945B2/en active Active
- 2020-05-14 ZA ZA2020/02966A patent/ZA202002966B/en unknown
-
2021
- 2021-06-30 AU AU2021204534A patent/AU2021204534A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN108430506A (zh) | 2018-08-21 |
EP3349791A1 (en) | 2018-07-25 |
US20180362648A1 (en) | 2018-12-20 |
AU2016323153B2 (en) | 2021-04-22 |
WO2017048902A1 (en) | 2017-03-23 |
JP2018528776A (ja) | 2018-10-04 |
IL258009B2 (en) | 2024-03-01 |
AU2016323153A1 (en) | 2018-03-29 |
ZA202002966B (en) | 2022-07-27 |
CA2997673A1 (en) | 2017-03-23 |
JP7020687B2 (ja) | 2022-02-16 |
US20200299386A1 (en) | 2020-09-24 |
AU2021204534A1 (en) | 2021-07-29 |
KR20180042449A (ko) | 2018-04-25 |
IL258009A (en) | 2018-05-31 |
US11548945B2 (en) | 2023-01-10 |
IL258009B1 (en) | 2023-11-01 |
US10633445B2 (en) | 2020-04-28 |
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