CN1059445C - 红霉素的新型衍生物,其制备方法及作为药物的应用 - Google Patents

红霉素的新型衍生物,其制备方法及作为药物的应用 Download PDF

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Publication number
CN1059445C
CN1059445C CN95190283A CN95190283A CN1059445C CN 1059445 C CN1059445 C CN 1059445C CN 95190283 A CN95190283 A CN 95190283A CN 95190283 A CN95190283 A CN 95190283A CN 1059445 C CN1059445 C CN 1059445C
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China
Prior art keywords
formula
compound
methyl
oxygen
dideoxy
Prior art date
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Expired - Lifetime
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CN95190283A
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English (en)
Chinese (zh)
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CN1126997A (zh
Inventor
C·阿古里达斯
Ｙ·本尼迪蒂
J·F·尚托特
A·丹尼斯
O·勒马特雷特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharma SA
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Roussel Uclaf SA
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Publication of CN1126997A publication Critical patent/CN1126997A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN95190283A 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用 Expired - Lifetime CN1059445C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR94/04154 1994-04-08

Publications (2)

Publication Number Publication Date
CN1126997A CN1126997A (zh) 1996-07-17
CN1059445C true CN1059445C (zh) 2000-12-13

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CN95190283A Expired - Lifetime CN1059445C (zh) 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用

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FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DE69723848T2 (de) * 1996-05-07 2004-07-01 Abbott Laboratories, Abbott Park 3-descladinose-2,3-anhydroerythromycin-derivate
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
IL128681A0 (en) * 1996-09-04 2000-01-31 Abbott Lab 6-O substituted ketolides having antibacterial activity
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
WO1998040392A1 (fr) * 1997-03-10 1998-09-17 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
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FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
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FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
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ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
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FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
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CN105039464A (zh) 2002-07-01 2015-11-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
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HRP20160222T1 (hr) * 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
KR102006200B1 (ko) 2010-03-22 2019-08-01 셈프라 파마슈티컬스, 인크. 매크로라이드의 결정 형태들 및 그 용도들
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
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JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

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FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

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US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
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AU684939B2 (en) 1998-01-08
IL112954A0 (en) 1995-06-29
SV1995000018A (es) 1997-10-24
TW316908B (cg-RX-API-DMAC7.html) 1997-10-01
MD663F1 (ro) 1997-01-31
MD663G2 (ro) 1997-07-31
BG61916B1 (bg) 1998-09-30
NO954942L (no) 1996-02-07
YU49221B (sh) 2004-11-25
RO115634B1 (ro) 2000-04-28
DZ1869A1 (fr) 2002-02-17
KR100317148B1 (ko) 2002-06-22
EE9500080A (et) 1996-12-16
HRP950217A2 (en) 1997-08-31
SK154695A3 (en) 1996-10-02
US5656607A (en) 1997-08-12
AU2310795A (en) 1995-10-30
CN1126997A (zh) 1996-07-17
EE04498B1 (et) 2005-06-15
AP9500743A0 (en) 1995-07-31
DK0676409T3 (da) 2003-06-23
YU21695A (sh) 1997-12-05
LV11182B (en) 1997-04-20
PE2896A1 (es) 1996-02-12
PL180837B1 (pl) 2001-04-30
DE69529934T2 (de) 2003-09-04
PT676409E (pt) 2003-08-29
FR2718450A1 (fr) 1995-10-13
IS4309A (is) 1995-11-17
CA2164638C (fr) 2003-12-30
IL112954A (en) 2000-07-16
GB2288174A (en) 1995-10-11
CZ322395A3 (en) 1996-08-14
IS1865B (is) 2003-05-02
NO308361B1 (no) 2000-09-04
DE69529934D1 (de) 2003-04-24
HU215396B (hu) 1998-12-28
JP3000023B2 (ja) 2000-01-17
CO4370097A1 (es) 1996-10-07
ES2189820T3 (es) 2003-07-16
LV11182A (lv) 1996-04-20
GB9506856D0 (en) 1995-05-24
SI0676409T1 (en) 2003-06-30
HU9503505D0 (en) 1996-02-28
SK284079B6 (sk) 2004-09-08
NZ284498A (en) 1997-07-27
UA44705C2 (uk) 2002-03-15
ZA952059B (en) 1996-03-13
FI955913A7 (fi) 1995-12-08
RU2141965C1 (ru) 1999-11-27
CA2164638A1 (fr) 1995-10-19
AP587A (en) 1997-04-29
BR9506147A (pt) 1996-04-16
OA10200A (fr) 1996-12-18
GEP19991836B (en) 1999-11-05
HRP950217B1 (en) 2004-06-30
FR2718450B1 (fr) 1997-01-10
NO954942D0 (no) 1995-12-06
MY114672A (en) 2002-12-31
MA23501A1 (fr) 1995-12-31
PL311871A1 (en) 1996-03-18
US5760233A (en) 1998-06-02
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
BG100150A (bg) 1996-06-28
CZ296005B6 (cs) 2005-12-14
FI111264B (fi) 2003-06-30
TNSN95026A1 (fr) 1996-02-06
WO1995027720A1 (fr) 1995-10-19
FI955913A0 (fi) 1995-12-08
EP0676409A1 (fr) 1995-10-11
JPH07278177A (ja) 1995-10-24
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
SA97170757A (ar) 2005-12-03

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