CN105693645B - 作为离子通道调节剂的稠合杂环化合物 - Google Patents
作为离子通道调节剂的稠合杂环化合物 Download PDFInfo
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- CN105693645B CN105693645B CN201610186640.5A CN201610186640A CN105693645B CN 105693645 B CN105693645 B CN 105693645B CN 201610186640 A CN201610186640 A CN 201610186640A CN 105693645 B CN105693645 B CN 105693645B
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- heteroaryl
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- phenyl
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- 0 **1C#CC=C(*c2ccc(CCN(*)*3)c3c2)*=C1 Chemical compound **1C#CC=C(*c2ccc(CCN(*)*3)c3c2)*=C1 0.000 description 8
- ZHQCEGDPANFHBB-UHFFFAOYSA-N CC(C)(C)CC(N(CC1)CCN1c1ncccn1)=O Chemical compound CC(C)(C)CC(N(CC1)CCN1c1ncccn1)=O ZHQCEGDPANFHBB-UHFFFAOYSA-N 0.000 description 1
- NAWUDZUUXXEXBD-PLNGDYQASA-N CC(C1)(CN1C(N(CC1)CC(C)=C1/C=C\C(c1ccc(C(F)(F)F)cc1)=C)=O)O Chemical compound CC(C1)(CN1C(N(CC1)CC(C)=C1/C=C\C(c1ccc(C(F)(F)F)cc1)=C)=O)O NAWUDZUUXXEXBD-PLNGDYQASA-N 0.000 description 1
- GRPPPTRYJSSDRJ-UHFFFAOYSA-N CC(CC1)CCN1c1ncccn1 Chemical compound CC(CC1)CCN1c1ncccn1 GRPPPTRYJSSDRJ-UHFFFAOYSA-N 0.000 description 1
- CFSVVKYPZDGOKQ-UHFFFAOYSA-N CC(NC(c1c2)=O)Oc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound CC(NC(c1c2)=O)Oc1ccc2-c(cc1)ccc1OC(F)(F)F CFSVVKYPZDGOKQ-UHFFFAOYSA-N 0.000 description 1
- XQDNOJORTIHTNK-UHFFFAOYSA-N CCOC(C[n]1nnc(C(N(CC2)Cc3c2ccc(-c2ccc(C(F)(F)F)cc2)c3)=O)c1)=O Chemical compound CCOC(C[n]1nnc(C(N(CC2)Cc3c2ccc(-c2ccc(C(F)(F)F)cc2)c3)=O)c1)=O XQDNOJORTIHTNK-UHFFFAOYSA-N 0.000 description 1
- BEJSXTRJVMOIMR-UHFFFAOYSA-N Cc1n[o]c(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2Oc2ccccc2)n1 Chemical compound Cc1n[o]c(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2Oc2ccccc2)n1 BEJSXTRJVMOIMR-UHFFFAOYSA-N 0.000 description 1
- NBRJCGZMFHTYQN-UHFFFAOYSA-N Cc1nc(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2OC(F)(F)F)c[o]1 Chemical compound Cc1nc(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2OC(F)(F)F)c[o]1 NBRJCGZMFHTYQN-UHFFFAOYSA-N 0.000 description 1
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- FBPYNRKZMQEMHM-UHFFFAOYSA-N O=C(CN1N=Nc(ccc(-c(cc2)ccc2Oc(cc2)ccc2Cl)c2)c2C1=O)N(CC1)CCN1c1ncccn1 Chemical compound O=C(CN1N=Nc(ccc(-c(cc2)ccc2Oc(cc2)ccc2Cl)c2)c2C1=O)N(CC1)CCN1c1ncccn1 FBPYNRKZMQEMHM-UHFFFAOYSA-N 0.000 description 1
- YQACCKXKBZZMLX-UHFFFAOYSA-N O=C(Cc1ncccc1)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(Cc1ncccc1)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 YQACCKXKBZZMLX-UHFFFAOYSA-N 0.000 description 1
- FPKUCEXGARYZEA-UHFFFAOYSA-N O=C(N(CC1)CC1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(N(CC1)CC1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 FPKUCEXGARYZEA-UHFFFAOYSA-N 0.000 description 1
- DPQBBWZRDOXZFQ-UHFFFAOYSA-N O=C(N1CCCC1)N(CC1)Cc2c1ccc(-c(cc1)ccc1OC(F)(F)F)c2 Chemical compound O=C(N1CCCC1)N(CC1)Cc2c1ccc(-c(cc1)ccc1OC(F)(F)F)c2 DPQBBWZRDOXZFQ-UHFFFAOYSA-N 0.000 description 1
- LTVIHCINJDCRMN-UHFFFAOYSA-N O=C(c([nH]cn1)c1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(c([nH]cn1)c1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 LTVIHCINJDCRMN-UHFFFAOYSA-N 0.000 description 1
- RMHUZTFIZINNOW-UHFFFAOYSA-N O=C(c1c2)N(Cc3ncccn3)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)N(Cc3ncccn3)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F RMHUZTFIZINNOW-UHFFFAOYSA-N 0.000 description 1
- CSUKHRGDGHLWNB-UHFFFAOYSA-N O=C(c1c2)NC3(COC3)Oc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)NC3(COC3)Oc1ccc2-c(cc1)ccc1OC(F)(F)F CSUKHRGDGHLWNB-UHFFFAOYSA-N 0.000 description 1
- DTBWRSXRFICCIP-UHFFFAOYSA-N O=C(c1c2)NN=Nc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)NN=Nc1ccc2-c(cc1)ccc1OC(F)(F)F DTBWRSXRFICCIP-UHFFFAOYSA-N 0.000 description 1
- JYWCWBAVDUJSAG-UHFFFAOYSA-N O=C(c1ncccn1)N1Cc2cc(-c(cc3)cc(F)c3Cl)ccc2CC1 Chemical compound O=C(c1ncccn1)N1Cc2cc(-c(cc3)cc(F)c3Cl)ccc2CC1 JYWCWBAVDUJSAG-UHFFFAOYSA-N 0.000 description 1
- OEOOFQZIUGTPKU-UHFFFAOYSA-N O=C1N(Cc2n[o]c(-c3cccc(C(F)(F)F)c3)n2)N=Cc(cc2)c1cc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C1N(Cc2n[o]c(-c3cccc(C(F)(F)F)c3)n2)N=Cc(cc2)c1cc2-c(cc1)ccc1OC(F)(F)F OEOOFQZIUGTPKU-UHFFFAOYSA-N 0.000 description 1
- XHEPANNURIQWRM-UHFFFAOYSA-N OC(CCl)c(ccc(Cl)c1)c1Cl Chemical compound OC(CCl)c(ccc(Cl)c1)c1Cl XHEPANNURIQWRM-UHFFFAOYSA-N 0.000 description 1
- VLUFTRQTDQIXBT-UHFFFAOYSA-N OC(CN(C(c1c2)=O)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F)c(ccc(Cl)c1)c1Cl Chemical compound OC(CN(C(c1c2)=O)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F)c(ccc(Cl)c1)c1Cl VLUFTRQTDQIXBT-UHFFFAOYSA-N 0.000 description 1
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
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Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ598942A (en) * | 2009-07-27 | 2014-02-28 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators |
| CN103096977B (zh) | 2010-07-02 | 2017-02-15 | 吉利德科学公司 | 作为离子通道调节剂的稠杂环化合物 |
| TWI577670B (zh) | 2011-05-10 | 2017-04-11 | 基利科學股份有限公司 | 充當離子通道調節劑之稠合雜環化合物 |
| TWI622583B (zh) | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
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| AU2013203252B2 (en) | 2012-01-27 | 2015-08-20 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PL3052485T3 (pl) | 2013-10-04 | 2022-02-28 | Infinity Pharmaceuticals, Inc. | Związki heterocykliczne i ich zastosowania |
| EP3083608B1 (en) | 2013-12-19 | 2018-07-18 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN104530037B (zh) * | 2015-01-21 | 2020-12-18 | 华东理工大学 | 一种具有杀线虫活性的三嗪杂环化合物及其制法和用途 |
| WO2017034997A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (pcsk9) modulators and their use |
| WO2017034994A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
| US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
| NZ740616A (en) | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| BR112018005637B1 (pt) | 2015-09-23 | 2023-11-28 | Janssen Pharmaceutica Nv | Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos |
| HRP20220012T1 (hr) | 2015-09-23 | 2022-04-01 | Janssen Pharmaceutica Nv | Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka |
| US10500205B2 (en) | 2015-12-09 | 2019-12-10 | Cadent Therapeutics, Inc. | Thienopyrimidinone NMDA receptor modulators and uses thereof |
| RS60834B1 (sr) | 2015-12-09 | 2020-10-30 | Cadent Therapeutics Inc | Modulatori heteroaromatskog nmda receptora i njihove upotrebe |
| WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| JP7105797B2 (ja) | 2016-11-28 | 2022-07-25 | プラクシス プレシジョン メディシンズ, インコーポレイテッド | 化合物及びその使用方法 |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| IL271149B2 (en) * | 2017-06-14 | 2024-05-01 | Trevena Inc | Compounds for modulating s1p1 activity and methods of using the same |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2019152419A1 (en) | 2018-01-31 | 2019-08-08 | Mirati Therapeutics, Inc | Prc2 inhibitors |
| CN108276352B (zh) * | 2018-03-13 | 2022-09-20 | 华东理工大学 | 一种具有杀线虫活性的含氮杂环化合物及其制法和用途 |
| TWI831786B (zh) | 2018-05-30 | 2024-02-11 | 美商普雷西斯精密藥品公司 | 離子通道調節劑 |
| EP4223760B1 (en) | 2018-08-03 | 2025-06-04 | Novartis AG | Heteroaromatic nmda receptor modulator and uses thereof |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| KR102288434B1 (ko) * | 2018-10-18 | 2021-08-12 | 에이치케이이노엔 주식회사 | 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도 |
| JP7624404B2 (ja) | 2019-04-22 | 2025-01-30 | ミラティ セラピューティクス,インク. | Prc2阻害剤としてのナフチリジン誘導体 |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| WO2020247475A1 (en) | 2019-06-05 | 2020-12-10 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
| WO2021026672A1 (en) | 2019-08-09 | 2021-02-18 | Novartis Ag | Heterocyclic wdr5 inhibitors as anti-cancer compounds |
| CN114585360B (zh) * | 2019-09-05 | 2025-04-29 | 特维娜有限公司 | 使用其治疗癫痫的方法 |
| CN114727977A (zh) | 2019-11-19 | 2022-07-08 | 特维娜有限公司 | 化合物和化合物s1p1调节剂的制备方法 |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| CN116368130A (zh) | 2020-08-28 | 2023-06-30 | 金橘生物科技公司 | 杂环化合物及其用途 |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| CN116265444B (zh) * | 2021-12-16 | 2025-09-05 | 华东理工大学 | 杀线虫活性的化合物及其制备方法和用途 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1182195A1 (en) * | 1999-05-07 | 2002-02-27 | Takeda Chemical Industries, Ltd. | Cyclic compounds and uses thereof |
| WO2004094371A2 (en) * | 2003-04-17 | 2004-11-04 | Merck & Co., Inc. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
| US6908917B2 (en) * | 2002-08-13 | 2005-06-21 | Warner-Lambert Company | Chromone derivatives as matrix metalloproteinase inhibitors |
| WO2006048727A1 (en) * | 2004-11-02 | 2006-05-11 | Pfizer Products Inc. | Piperazinylphenalkyl lactam/amine ligands for the 5ht1b receptor |
| WO2006095014A1 (en) * | 2005-03-11 | 2006-09-14 | N.V. Organon | 2- (4-0x0-4h-quinaz0lin-3-yl) acetamides and their use as vasopressin v3 antagonists |
| WO2008094909A2 (en) * | 2007-01-29 | 2008-08-07 | Xenon Pharmaceuticals Inc. | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions |
| US20090069300A1 (en) * | 2007-09-12 | 2009-03-12 | Wyeth | Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists |
| US20100099676A1 (en) * | 2006-11-02 | 2010-04-22 | Shionogi & Co., Ltd. | Sulfonylurea derivative capable of selectively inhibiting mmp-13 |
| CN103649056B (zh) * | 2011-05-10 | 2016-04-27 | 吉利德科学公司 | 作为离子通道调节剂的稠合杂环化合物 |
Family Cites Families (211)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2867616A (en) | 1950-05-17 | 1959-01-06 | Syntex Sa | 7-dehydro diosgenin compounds and process for making same |
| US2867618A (en) * | 1957-02-14 | 1959-01-06 | Dow Chemical Co | 3, 4-dihydro-2h-1, 3-benzoxazine |
| US2826575A (en) * | 1957-05-06 | 1958-03-11 | Dow Chemical Co | 3, 3'-alkylenebis |
| NL128591C (enExample) | 1965-07-02 | |||
| US3441649A (en) | 1966-08-18 | 1969-04-29 | Univ Minnesota | Suppression of cardiac ventricular fibrillation and cardiac arrhythmias with bretylium tosylate |
| US3594372A (en) | 1968-08-13 | 1971-07-20 | American Home Prod | Pyrimido(4,5-e)(1,4)oxazepin-5-ones and derivatives thereof |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4062881A (en) | 1974-07-26 | 1977-12-13 | Cincinnati Milacron Chemicals, Inc. | Sulfide containing tin stabilizers |
| US4230705A (en) | 1976-09-22 | 1980-10-28 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
| US4242515A (en) | 1979-03-28 | 1980-12-30 | American Cyanamid Company | Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines |
| US4244953A (en) | 1979-10-24 | 1981-01-13 | American Cyanamid Company | Substituted 6-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyridines |
| JPS5675428A (en) | 1979-11-21 | 1981-06-22 | Ayanori Takabe | Hypoglycemic agent containing procainamide hydrochloride |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US4812565A (en) | 1982-09-30 | 1989-03-14 | A. H. Robins Company, Incorporated | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US4665181A (en) * | 1984-05-17 | 1987-05-12 | Pennwalt Corporation | Anti-inflammatory phthalazinones |
| US4654343A (en) | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4746655A (en) | 1987-06-10 | 1988-05-24 | A. H. Robins Company, Incorporated | Fused aromatic-spiropiperidine oxazepinones(and thiones) |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| JPH061779Y2 (ja) | 1989-11-13 | 1994-01-19 | 株式会社新潟鐵工所 | 合成樹脂成形機におけるホッパー下部の冷却水装置 |
| DE4010488A1 (de) | 1990-03-31 | 1991-10-02 | Hoechst Ag | Benzoxazinderivate, verfahren zu ihrer herstellung und ihre verwendung zum behandeln oder zur prophylaxe von krankheiten |
| CA2044564A1 (en) | 1990-06-28 | 1991-12-29 | Quirico Branca | Amino acid derivatives |
| CN1060467A (zh) | 1990-09-25 | 1992-04-22 | 武田药品工业株式会社 | 1,3-苯并嗪衍生物、其生产方法和用途 |
| JPH04209692A (ja) | 1990-12-03 | 1992-07-31 | Asahi Glass Co Ltd | フォトクロミック材料 |
| ATE136296T1 (de) | 1991-05-10 | 1996-04-15 | Takeda Chemical Industries Ltd | Pyridinderivate, deren herstellung und anwendung |
| NZ243326A (en) | 1991-06-28 | 1995-10-26 | Smithkline Beecham Corp | Benzodiazepine, benzazepine; benzothiazepine and benzoxazepine derivatives; pharmaceutical compositions |
| US5939412A (en) | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
| US5565449A (en) | 1991-10-18 | 1996-10-15 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
| US5272158A (en) | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JPH061779A (ja) | 1992-02-06 | 1994-01-11 | Wakamoto Pharmaceut Co Ltd | ベンズオキサジノン誘導体 |
| JPH06107647A (ja) | 1992-08-12 | 1994-04-19 | Takeda Chem Ind Ltd | 1,3−ベンゾオキサジン誘導体の製造法 |
| US6011150A (en) | 1992-11-13 | 2000-01-04 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5442055A (en) | 1992-11-13 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| GB9225860D0 (en) | 1992-12-11 | 1993-02-03 | Smithkline Beecham Plc | Novel treatment |
| GB9226302D0 (en) | 1992-12-17 | 1993-02-10 | Smithkline Beecham Plc | Pharmaceuticals |
| US5550229A (en) | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| DE19526173A1 (de) | 1995-07-18 | 1997-01-30 | Hoechst Ag | Polyfullerenaddukte, Verfahren zu ihrer regioselektiven Herstellung und deren Verwendung |
| JPH09157262A (ja) | 1995-12-08 | 1997-06-17 | Tanabe Seiyaku Co Ltd | アゼチジノン誘導体及びその合成中間体の製法 |
| US5773186A (en) | 1996-02-19 | 1998-06-30 | Fuji Photo Film Co., Ltd. | Heat-sensitive recording material |
| GB9619492D0 (en) | 1996-09-18 | 1996-10-30 | Smithkline Beecham Plc | Novel treatment |
| WO1998047885A1 (en) | 1997-04-18 | 1998-10-29 | Smithkline Beecham Plc | A bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5ht1a, 5ht1b and 5ht1d receptor antagonistic activity |
| US6417362B1 (en) * | 1997-05-30 | 2002-07-09 | Meiji Seika Kaisha, Ltd. | Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same |
| JP3964053B2 (ja) | 1997-07-10 | 2007-08-22 | 三井化学株式会社 | 遷移金属化合物からなるオレフィン重合用触媒ならびに重合方法 |
| WO1999013038A1 (en) | 1997-09-08 | 1999-03-18 | Unilever N.V. | Method for enhancing the activity of an enzyme |
| HRP20000492A2 (en) | 1998-01-21 | 2000-12-31 | Merck Sharp & Dohme | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| AU2594799A (en) | 1998-02-11 | 1999-08-30 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| IL137720A0 (en) | 1998-02-18 | 2001-10-31 | Neurosearch As | Compounds and their use as positive ampa receptor modulators |
| US6479506B1 (en) | 1998-06-16 | 2002-11-12 | Merck Sharp & Dohme Ltd. | Triazolo-pyridine derivatives as ligands for GABA receptors |
| EP1123297A1 (en) | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
| AU779550B2 (en) | 1999-04-09 | 2005-01-27 | Meiji Seika Kaisha Ltd. | Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same |
| CA2381924A1 (en) | 1999-08-27 | 2001-03-08 | The Procter & Gamble Company | Color safe laundry methods employing zwitterionic formulation components |
| CN1384867A (zh) | 1999-08-27 | 2002-12-11 | 宝洁公司 | 稳定性提高的配制组分、使用该组分的组合物和洗衣方法 |
| CN1382207A (zh) | 1999-08-27 | 2002-11-27 | 宝洁公司 | 利用阳离子配制组分的颜色保护性洗衣方法 |
| EP1206513A2 (en) | 1999-08-27 | 2002-05-22 | The Procter & Gamble Company | Controlled availability of formulation components, compositions and laundry methods employing same |
| AU7072100A (en) | 1999-08-27 | 2001-03-26 | Procter & Gamble Company, The | Stable formulation components, compositions and laundry methods employing same |
| BR0013610A (pt) | 1999-08-27 | 2002-07-16 | Procter & Gamble | Componentes de formulções de ação rápida,composições e métodos para lavar roupa empregando os mesmos |
| JP2003510251A (ja) | 1999-08-27 | 2003-03-18 | ザ、プロクター、エンド、ギャンブル、カンパニー | ブリーチ増強成分、組成物および洗濯方法 |
| US6469020B2 (en) | 2000-05-15 | 2002-10-22 | Darwin Discovery, Ltd. | Hydroxamic and carboxylic acid derivatives |
| NZ523839A (en) | 2000-08-01 | 2005-07-29 | Ono Pharmaceutical Co | 3,4-dihydroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient |
| WO2002018377A1 (en) | 2000-08-29 | 2002-03-07 | Pharmacia Corporation | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
| JP2002205992A (ja) | 2000-11-08 | 2002-07-23 | Takeda Chem Ind Ltd | 二環式トリアゾロン誘導体およびそれを含有する除草剤 |
| DE60123665T2 (de) | 2000-12-26 | 2007-08-16 | Sankyo Co., Ltd. | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
| OA12552A (en) | 2001-03-09 | 2006-06-06 | Pfizer Prod Inc | Triazolopyridines as anti-inflammatory agents. |
| US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
| US20030114448A1 (en) | 2001-05-31 | 2003-06-19 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| JP2005089298A (ja) | 2001-09-18 | 2005-04-07 | Japan Tobacco Inc | ナフタレン化合物及びその医薬用途 |
| CN100509782C (zh) | 2001-11-13 | 2009-07-08 | 先灵公司 | Nk1拮抗剂 |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| JP2003277384A (ja) | 2002-03-26 | 2003-10-02 | Kyorin Pharmaceut Co Ltd | 縮合ニ環式ピリジン誘導体 |
| JP2003321461A (ja) | 2002-04-25 | 2003-11-11 | Kyorin Pharmaceut Co Ltd | 縮合ビフェニル誘導体 |
| WO2004014866A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US20040242572A1 (en) * | 2002-08-24 | 2004-12-02 | Boehringer Ingelheim International Gmbh | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture |
| PA8579601A1 (es) | 2002-08-30 | 2004-05-07 | Pfizer Prod Inc | Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas |
| US7005523B2 (en) | 2002-08-30 | 2006-02-28 | Pfizer Inc. | Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines |
| WO2004026292A1 (ja) | 2002-09-20 | 2004-04-01 | Tsumura & Co. | 鎮咳薬 |
| US20040204404A1 (en) | 2002-09-30 | 2004-10-14 | Robert Zelle | Human N-type calcium channel blockers |
| GB0223730D0 (en) | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
| AU2003294235A1 (en) | 2002-10-22 | 2004-05-13 | The Trustees Of The University Of Pennsylvania | Fragments and activity of rel protein in m. tuberculosis adn other uses thereof |
| CN100430386C (zh) | 2002-11-07 | 2008-11-05 | 默克公司 | 苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病 |
| RU2005117383A (ru) | 2002-11-07 | 2006-01-20 | Мерк энд Ко., Инк. (US) | Производные фенилаланина в качестве ингибиторов дипептидилпептидазы для лечения или профилактики диабета |
| WO2004062616A2 (en) | 2003-01-13 | 2004-07-29 | Cortex Pharmaceuticals, Inc. | Method of treating cognitive decline due to sleep deprivation and stress |
| JP4209692B2 (ja) | 2003-01-28 | 2009-01-14 | 株式会社日立製作所 | 図書管理システム及び書誌情報管理方法 |
| AR044503A1 (es) | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
| DE10317526A1 (de) | 2003-04-16 | 2004-11-04 | Degussa Ag | Verfahren zum Delignifizieren von ligninhaltigen Faserstoffen |
| US20060264496A1 (en) | 2003-04-25 | 2006-11-23 | H. Lundbeck A/S | Substituted indoline and indole derivatives |
| WO2004101509A2 (en) * | 2003-05-06 | 2004-11-25 | Case Western Reserve University | Functionalized benzoxazines, polymers and copolymers thereof |
| JP2007521296A (ja) | 2003-07-01 | 2007-08-02 | メルク エンド カムパニー インコーポレーテッド | 高眼圧の治療のための眼科用組成物 |
| CN1822833A (zh) | 2003-07-21 | 2006-08-23 | 索尔瓦药物有限公司 | 3,7-二氮杂双环[3,3,1]壬烷化合物在治疗和/或预防男性患者心律失常中的用途 |
| KR20060118398A (ko) | 2003-08-05 | 2006-11-23 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널 억제제로서의 축합 피라미딘 화합물 |
| US20050239767A1 (en) | 2003-10-28 | 2005-10-27 | Chan Michael K | Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands |
| KR20060120205A (ko) | 2003-12-18 | 2006-11-24 | 화이자 프로덕츠 인코포레이티드 | p38 MAP 키나제 억제제를 사용하여 동물의 급성 염증을치료하는 방법 |
| BRPI0508140B1 (pt) | 2004-03-05 | 2015-03-17 | Nissan Chemical Ind Ltd | Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo" |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| WO2006002470A1 (en) | 2004-06-30 | 2006-01-12 | Monash University | Chiral ligands for asymmetric catalysis |
| JP2006063064A (ja) | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| JP2007297283A (ja) | 2004-07-28 | 2007-11-15 | Santen Pharmaceut Co Ltd | 新規桂皮酸関連化合物 |
| WO2006020959A2 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| AU2005277283A1 (en) | 2004-08-23 | 2006-03-02 | Merck Sharp & Dohme Corp. | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| AU2005285083B2 (en) | 2004-09-13 | 2011-03-10 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantoin CGRP receptor antagonists |
| TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
| US7579348B2 (en) | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| CN101258134B (zh) * | 2005-03-11 | 2011-10-12 | 欧加农股份有限公司 | 2-(4-氧代-4h-喹唑啉-3-基)乙酰胺衍生物及其作为加压素v3拮抗剂的用途 |
| WO2006113432A2 (en) | 2005-04-14 | 2006-10-26 | Smithkline Beecham Corporation | Compounds, compositions and methods |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| CN101175488B (zh) | 2005-05-17 | 2012-04-18 | 萨可德公司 | 治疗眼病的组合物和方法 |
| TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| TW200726765A (en) | 2005-06-17 | 2007-07-16 | Bristol Myers Squibb Co | Triazolopyridine cannabinoid receptor 1 antagonists |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| EP1893617A1 (en) | 2005-06-17 | 2008-03-05 | Wyeth a Corporation of the State of Delaware | Tricyclic compounds useful as serotonin inhibitors and 5-ht1a agonists and antagonists |
| WO2007004028A2 (en) | 2005-06-30 | 2007-01-11 | Ranbaxy Laboratories Limited | Processes for the preparation of penems and its intermediate |
| EP1932549B1 (en) | 2005-08-26 | 2016-12-28 | AMNOS Co., Ltd. | Dried amnion and method for drying treatment of amnion |
| CA2621255A1 (en) | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| CA2623026A1 (en) | 2005-09-23 | 2007-04-05 | Schering Corporation | Fused tetracyclic mglur1 antagonists as therapeutic agents |
| WO2007047604A2 (en) | 2005-10-18 | 2007-04-26 | Elixir Pharmaceuticals, Inc. | Sirt1 inhibition |
| TW200804290A (en) | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
| JP2009515976A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロラクタム二環式cgrp受容体アンタゴニスト |
| CA2629409A1 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam aryl cgrp receptor antagonists |
| TW200734342A (en) | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
| BRPI0619966A2 (pt) | 2005-12-16 | 2011-10-25 | Alcon Inc | controle de pressão intra-ocular usando agentes de modulação de alk5 |
| US8013073B2 (en) | 2005-12-30 | 2011-09-06 | Chevron Oronite Company Llc | Method for preparing polyolefins containing vinylidine end groups using nonaromatic heterocyclic compounds |
| CA2644963A1 (en) | 2006-03-31 | 2007-10-11 | Novartis Ag | Organic compounds |
| WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
| US8883781B2 (en) | 2006-06-12 | 2014-11-11 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
| JP2009542673A (ja) | 2006-06-29 | 2009-12-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | ヒスタミンh3−受容体関連障害の治療に有用なヒスタミンh3−受容体モジュレータ |
| US8778977B2 (en) | 2006-06-30 | 2014-07-15 | Sunesis Pharmaceuticals, Inc. | Pyridinonyl PDK1 inhibitors |
| WO2008007661A1 (en) | 2006-07-11 | 2008-01-17 | Takeda Pharmaceutical Company Limited | Tricyclic heterocyclic compound and use thereof |
| EP2046788A1 (en) | 2006-07-12 | 2009-04-15 | Syngeta Participations AG | Triazolopyridine derivatives as herbicides |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| ES2397284T3 (es) * | 2006-08-22 | 2013-03-06 | Ranbaxy Laboratories Limited | Proceso para preparar inhibidores de la metaloproteinasa de la matriz y auxiliares quirales para los mismos |
| EP2068869A4 (en) | 2006-10-06 | 2011-05-25 | Abbott Lab | NEW IMIDAZOTHIAZOLE AND IMIDAZOXAZOLE |
| WO2008118141A2 (en) | 2006-10-17 | 2008-10-02 | Acadia Pharmaceuticals Inc. | Use of cannabinoid modulating compounds in combination with other therapeutic compounds for adjunctive therapy |
| ES2633318T3 (es) | 2006-10-23 | 2017-09-20 | Cephalon, Inc. | Derivados bicíclicos fusionados de 2,4-diaminopirimidina como inhibidores de ALK y c-Met |
| PL2343286T3 (pl) | 2006-10-28 | 2015-06-30 | Methylgene Inc | Pochodne dibenzo[b,f][1,4]oksazepiny jako inhibitory deacetylazy histonowej |
| CA2670651A1 (en) | 2006-12-21 | 2008-07-03 | Cv Therapeutics, Inc. | Reduction of cardiovascular symptoms |
| US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
| JP2010520237A (ja) | 2007-02-28 | 2010-06-10 | メルク・シャープ・エンド・ドーム・コーポレイション | ナトリウムチャネル遮断薬としての置換ベンゾジアゼピノン、ベンゾオキサアゼピノン及びベンゾチアゼピノン |
| US8247403B2 (en) | 2007-03-07 | 2012-08-21 | Takeda Pharmaceutical Company Limited | Benzoxazepine derivatives and use thereof |
| GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| JP2010523713A (ja) | 2007-04-12 | 2010-07-15 | ギリアード・パロ・アルト・インコーポレイテッド | インスリン分泌を増強するためのラノラジン |
| WO2008134553A1 (en) | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| WO2008144483A2 (en) | 2007-05-18 | 2008-11-27 | Armgo Pharma, Inc. | Agents for treating disorders involving modulation of ryanodine receptors |
| US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
| US20090012103A1 (en) | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| US20110263569A1 (en) | 2007-08-22 | 2011-10-27 | President And Fellows Of Harvard College | Ryanodine channel binders and uses thereof |
| US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| AU2008343062B2 (en) | 2007-12-19 | 2013-03-07 | Genentech, Inc. | 8-Anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents |
| PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| WO2009089027A1 (en) | 2008-01-09 | 2009-07-16 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Service, National Institutes Of Health | Phosphodiesterase inhibitors |
| KR20110013348A (ko) | 2008-02-06 | 2011-02-09 | 길리애드 사이언시즈, 인코포레이티드 | 통증 치료를 위한 라놀라진의 용도 |
| KR20100124262A (ko) | 2008-02-13 | 2010-11-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 비시클로아민 유도체 |
| JP2009286773A (ja) | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
| WO2009137499A1 (en) | 2008-05-05 | 2009-11-12 | Envivo Pharmaceuticals, Inc. | Inhibitors of histone deacetylase |
| US20110288070A1 (en) | 2008-05-05 | 2011-11-24 | ROGERS Kathryn | Methods for treating cognitive disorders using inhibitors of histone deacetylase |
| DE102008024182A1 (de) | 2008-05-19 | 2009-11-26 | Merck Patent Gmbh | Verbindungen für organische elektronische Vorrichtung |
| EP2297140A4 (en) | 2008-06-06 | 2012-05-02 | Abbott Lab | NOVEL 1,2,4-OXADIAZOLE COMPOUNDS AND METHODS OF USE |
| EA020807B1 (ru) | 2008-06-17 | 2015-01-30 | Астразенека Аб | Соединения пиридина |
| US8338477B2 (en) | 2008-07-11 | 2012-12-25 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
| KR101315628B1 (ko) | 2008-08-12 | 2013-10-08 | 닛뽕소다 가부시키가이샤 | 함질소 헤테로고리 유도체 및 농원예용 살균제 |
| WO2010022001A1 (en) | 2008-08-18 | 2010-02-25 | Im&T Research, Inc. | Methods for preparing fluoroalkyl arylsulfinyl compounds and fluorinated compounds thereto |
| US20100056536A1 (en) | 2008-09-04 | 2010-03-04 | Charles Antzelevitch | Method of treating atrial fibrillation |
| WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
| US8389500B2 (en) | 2008-10-30 | 2013-03-05 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
| WO2010056865A1 (en) | 2008-11-14 | 2010-05-20 | Gilead Palo Alto, Inc. | Quinoline derivatives as ion channel modulators |
| US20100130436A1 (en) | 2008-11-25 | 2010-05-27 | Gilead Palo Alto, Inc. | Co-administration of ranolazine and cardiac glycosides |
| MX2011006108A (es) | 2008-12-08 | 2011-11-18 | Vm Pharma Llc | Composiciones de inhibidores de los receptores tirosina quinasa. |
| AU2009333543A1 (en) | 2008-12-08 | 2011-07-07 | Sirtris Pharmaceuticals, Inc. | Isoindolinone and related analogs as sirtuin modulators |
| JP5271069B2 (ja) | 2008-12-24 | 2013-08-21 | 三和シヤッター工業株式会社 | 開閉装置 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| MX2011010132A (es) | 2009-03-27 | 2011-10-14 | Presidio Pharmaceuticals Inc | Inhibidores de anillo fusionado de hepatitis c. |
| WO2010118208A1 (en) | 2009-04-09 | 2010-10-14 | Exelixis, Inc. | Benzoxazepin-4- (5h) -yl derivatives and their use to treat cancer |
| NZ598942A (en) | 2009-07-27 | 2014-02-28 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators |
| PE20121025A1 (es) | 2009-09-28 | 2012-08-06 | Hoffmann La Roche | Compuestos de benzoxazepina como inhibidores de la p13k |
| US20120264636A1 (en) | 2009-10-07 | 2012-10-18 | Decode Genetics Ehf. | Genetic variants indicative of vascular conditions |
| WO2011056985A2 (en) | 2009-11-04 | 2011-05-12 | Gilead Sciences, Inc. | Substituted heterocyclic compounds |
| US20110152246A1 (en) | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
| CN103096977B (zh) | 2010-07-02 | 2017-02-15 | 吉利德科学公司 | 作为离子通道调节剂的稠杂环化合物 |
| WO2012019076A1 (en) | 2010-08-06 | 2012-02-09 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for preventing and treating cardiac ischemia/reperfusion injury |
| WO2012019071A1 (en) | 2010-08-06 | 2012-02-09 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating sarcopenia |
| WO2012037105A1 (en) | 2010-09-14 | 2012-03-22 | The Trustees Of Columbia University In The City Of New York | Methods of treating, ameliorating or preventing stress-induced neuronal disorders and diseases |
| WO2012036233A1 (ja) * | 2010-09-17 | 2012-03-22 | 塩野義製薬株式会社 | メラニン凝集ホルモン受容体アンタゴニスト活性を有する縮合へテロ環誘導体 |
| NZ609200A (en) | 2010-09-21 | 2015-01-30 | Purdue Pharma Lp | Buprenorphine analogs |
| US8999967B2 (en) | 2010-09-29 | 2015-04-07 | Presidio Pharmaceuticals, Inc. | Tricyclic fused ring inhibitors of hepatitis C |
| EP2643316A2 (en) | 2010-11-24 | 2013-10-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture |
| JP5675428B2 (ja) | 2011-02-25 | 2015-02-25 | サンドビック株式会社 | ベルトプレス装置 |
| CA2825966A1 (en) | 2011-03-21 | 2012-09-27 | F. Hoffmann-La Roche Ag | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
| CA2836904C (en) | 2011-06-03 | 2019-09-24 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| TWI622583B (zh) | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| AU2012312266A1 (en) | 2011-09-21 | 2013-05-02 | Gilead Sciences, Inc. | Sodium channel blockers reduce glucagon secretion |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| US8623860B2 (en) | 2011-12-30 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Azetidine derivatives, pharmaceutical compositions and uses thereof |
| AU2013203252B2 (en) | 2012-01-27 | 2015-08-20 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| BR112014000049A2 (pt) | 2012-03-27 | 2017-02-07 | Bayer Ip Gmbh | pirrolotriazinas substituídas com hidroximelilarilo e sua utilização |
| US8969588B2 (en) | 2012-06-05 | 2015-03-03 | Gilead Pharmasset Llc | Solid forms of an antiviral compound |
| ES2805341T3 (es) | 2012-06-13 | 2021-02-11 | Acesion Pharma Aps | Composiciones farmacéuticas para terapia de combinación |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
| TW201613908A (en) | 2014-02-13 | 2016-04-16 | Gilead Sciences Inc | Solid forms of an ion channel modulator |
| CN104844535A (zh) | 2014-02-13 | 2015-08-19 | 吉利德科学公司 | 用于制备稠合杂环离子通道调节剂的方法 |
-
2012
- 2012-05-08 TW TW104130125A patent/TWI577670B/zh not_active IP Right Cessation
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- 2012-05-09 UY UY34062A patent/UY34062A/es not_active Application Discontinuation
- 2012-05-09 AR ARP120101626 patent/AR086319A1/es unknown
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- 2013-10-24 IL IL229045A patent/IL229045A0/en unknown
-
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- 2015-07-24 US US14/808,296 patent/US9403782B2/en active Active
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- 2016-04-21 AU AU2016202535A patent/AU2016202535B2/en not_active Ceased
- 2016-06-21 US US15/188,701 patent/US9682998B2/en active Active
- 2016-12-19 HK HK16114404.3A patent/HK1238627A1/zh unknown
-
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- 2018-07-19 HK HK18109345.3A patent/HK1249902A1/en unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1182195A1 (en) * | 1999-05-07 | 2002-02-27 | Takeda Chemical Industries, Ltd. | Cyclic compounds and uses thereof |
| US6908917B2 (en) * | 2002-08-13 | 2005-06-21 | Warner-Lambert Company | Chromone derivatives as matrix metalloproteinase inhibitors |
| WO2004094371A2 (en) * | 2003-04-17 | 2004-11-04 | Merck & Co., Inc. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
| WO2006048727A1 (en) * | 2004-11-02 | 2006-05-11 | Pfizer Products Inc. | Piperazinylphenalkyl lactam/amine ligands for the 5ht1b receptor |
| WO2006095014A1 (en) * | 2005-03-11 | 2006-09-14 | N.V. Organon | 2- (4-0x0-4h-quinaz0lin-3-yl) acetamides and their use as vasopressin v3 antagonists |
| US20100099676A1 (en) * | 2006-11-02 | 2010-04-22 | Shionogi & Co., Ltd. | Sulfonylurea derivative capable of selectively inhibiting mmp-13 |
| WO2008094909A2 (en) * | 2007-01-29 | 2008-08-07 | Xenon Pharmaceuticals Inc. | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions |
| US20090069300A1 (en) * | 2007-09-12 | 2009-03-12 | Wyeth | Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists |
| CN103649056B (zh) * | 2011-05-10 | 2016-04-27 | 吉利德科学公司 | 作为离子通道调节剂的稠合杂环化合物 |
Non-Patent Citations (1)
| Title |
|---|
| Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity;Joachim Rudolph等;《J.Med.Chem.》;20070921;第50卷;5202-5216 * |
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Correction item: Inventor Correct: CORKEY BRITTON KENNETH|ELZEIN ELFATIH|JIANG ROBERT H.|KALLA RAO V.|Jeremy Lin|KOLTUN DMITRY|Li Xiaofen|MARTINEZ RUBEN|Notte Gregory|PARKHILL ERIC Q.|PERRY THAO|ZABLOCKI JEFF|VENKATARAMANI CHANDRASEKAR|Graupe Michael|GUERRERO JUAN False: CORKEY BRITTON KENNETH|ELZEIN ELFATIH|JIANG ROBERT H.|KALLA RAO V.|Jeremy Lin|KOLTUN DMITRY|Li Xiaofen|MARTINEZ RUBEN|Notte Gregory|PARKHILL ERIC Q.|PERRY THAO|ZABLOCKI JEFF|VENKATARAMANI CHANDRASEKAR|GUERRERO JUAN Number: 25 Volume: 32 |
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