MX361350B - Compuestos heterocíclicos fusionados como moduladores del canal de sodio. - Google Patents

Compuestos heterocíclicos fusionados como moduladores del canal de sodio.

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Publication number
MX361350B
MX361350B MX2013012798A MX2013012798A MX361350B MX 361350 B MX361350 B MX 361350B MX 2013012798 A MX2013012798 A MX 2013012798A MX 2013012798 A MX2013012798 A MX 2013012798A MX 361350 B MX361350 B MX 361350B
Authority
MX
Mexico
Prior art keywords
sodium channel
heterocyclic compounds
fused heterocyclic
channel modulators
compounds
Prior art date
Application number
MX2013012798A
Other languages
English (en)
Other versions
MX2013012798A (es
Inventor
Kenneth Corkey Britton
Elzein Elfatih
h jiang Robert
V Kalla Rao
Kobayashi Tetsuya
Koltun Dmitry
Li Xiaofen
Martinez Ruben
Notte Gregory
Q Parkhill Eric
Perry Thao
Zablocki Jeff
Venkataramani Chandrasekar
Graupe Michael
Guerrero Juan
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2013012798A publication Critical patent/MX2013012798A/es
Publication of MX361350B publication Critical patent/MX361350B/es

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    • C07D253/04—1,2,3-Triazines
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  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención actual se refiere a compuestos que son inhibidores del canal de sodio y su uso en el tratamiento de varios estados de enfermedad, incluyendo enfermedades cardiovasculares y diabetes. En modalidades particulares, la estructura de los compuestos se da por la Fórmula (I), (ver Fórmula) en donde Q, R1, X1, X2, Y, y R2 son como se describe en la presente, a métodos para la preparación y uso de los compuestos y a composiciones farmacéuticas que contienen los mismos.
MX2013012798A 2011-05-10 2012-05-08 Compuestos heterocíclicos fusionados como moduladores del canal de sodio. MX361350B (es)

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