实施例6: 组合的 TNF 和 IL-17 抗体在小鼠胶原诱导的关节炎模型中的治疗功效
抗IL-17、抗TNF和组合的抗IL-17/抗TNF的治疗作用在本领域众所周知的胶原诱导的关节炎小鼠模型中进行评估。简言之,雄性DBA-1小鼠在尾的基部用在CFA中的牛II型胶原进行免疫接种。小鼠在第21天时用酵母聚糖进行腹膜内(i.p)加强。在(第24-27天时)疾病发作后,选择小鼠且分成各12只小鼠的分开组。对照组和抗细胞因子组的平均关节炎得分与治疗开始时是可比较的。小鼠用抗IL-17 mAb MAB421(12 mg/kg)、抗TNF抗体8C11(12 mg/kg)、或抗IL-17/抗TNF mAbs的组合(各12 mg/kg)进行i.p.注射,每周2次。小鼠就外周关节中关节炎的视觉出现对于第一周每天和随后每周3次进行监控,并且测定疾病活性的得分。通过非参数Mann-Whitney检验测定统计学差异,并且< 0.05的p值被视为显著的。
如下表中所示,用抗IL-17或抗TNF抗体单独处理小鼠使平均关节炎得分(MAS)分别减少43和36%。用抗IL-17和抗TNF单克隆抗体两者处理小鼠使MAS得分进一步减少至60%(p<0.05),从而证实与单独的任一单克隆抗体的处理比较更佳的功效。
表46. 通过抗IL-17和TNF抗体的关节炎得分的抑制。
引入作为参考
本发明将分子生物学、药物递送、免疫学、分子生物学和细胞生物学领域中众所周知的技术整体并入作为参考。这些技术包括,但不限于,在下述出版物中描述的技术:
。
进一步地,可能在本申请自始至终引用的所有引用的参考文献(包括文献参考、专利、专利申请和网站)的内容都为了所有目的在此明确地整体引入作为参考,其中引用的参考文献也如此。
等同方案
本发明在不背离其精神或基本特征的情况下可以以其他具体形式具体化。前述实施方案因此在所有方面被视为是示例性的,而不是限制此处所述的本发明。本发明的范围因而由所附的权利要求而不是由前述说明书指出,且在权利要求的等价含义和范围内的所有改变因而预期包含在其中。
序列表
<110> Abbott Laboratories
Hsieh, Chung-Ming
<120> IL-17结合蛋白
<130> ABT-113.1 PCT(9831.WO.O1)
<140> PCT/US10/26424
<141> 2010-03-05
<150> US 61/209,272
<151> 2009-03-05
<160> 933
<170> PatentIn version 3.5
<210> 1
<211> 132
<212> PRT
<213> 智人(Homo
sapiens)
<400> 1
Gly Ile Thr
Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys
1 5 10 15
Asn Phe Pro
Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn
20 25 30
Thr Asn Thr
Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr
35 40 45
Ser Pro Trp
Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser
50 55 60
Val Ile Trp
Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp
65 70 75 80
Gly Asn Val
Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile
85 90 95
Leu Val Leu
Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu
100 105 110
Glu Lys Ile
Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val
115 120 125
His His Val
Ala
130
<210> 2
<211> 133
<212> PRT
<213> 智人(Homo
sapiens)
<400> 2
Arg Lys Ile
Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser
1 5 10 15
Cys Pro Pro
Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile
20 25 30
Asn Glu Asn
Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser
35 40 45
Thr Ser Pro
Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro
50 55 60
Ser Glu Val
Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala
65 70 75 80
Gln Gly Lys
Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu
85 90 95
Thr Leu Val
Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln
100 105 110
Leu Glu Lys
Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val
115 120 125
Ile His His
Val Gln
130
<210> 3
<211> 330
<212> PRT
<213> 智人(Homo
sapiens)
<400> 3
Ala Ser Thr
Lys Gly Pro Ser Val Phe Phe Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225 230 235 240
Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 4
<211> 330
<212> PRT
<213> 智人(Homo
sapiens)
<400> 4
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225 230 235 240
Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 5
<211> 106
<212> PRT
<213> 智人(Homo
sapiens)
<400> 5
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 6
<211> 105
<212> PRT
<213> 智人(Homo
sapiens)
<400> 6
Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu
1 5 10 15
Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
20 25 30
Tyr Pro Gly
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val
35 40 45
Lys Ala Gly
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys
50 55 60
Tyr Ala Ala
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
65 70 75 80
His Arg Ser
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
85 90 95
Lys Thr Val
Ala Pro Thr Glu Cys Ser
100 105
<210> 7
<211> 30
<212> PRT
<213> 智人(Homo
sapiens)
<400> 7
Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser
20 25 30
<210> 8
<211> 14
<212> PRT
<213> 智人(Homo
sapiens)
<400> 8
Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10
<210> 9
<211> 32
<212> PRT
<213> 智人(Homo
sapiens)
<400> 9
Arg Val Thr
Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu
1 5 10 15
Leu Ser Ser
Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
20 25 30
<210> 10
<211> 11
<212> PRT
<213> 智人(Homo
sapiens)
<400> 10
Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 11
<211> 11
<212> PRT
<213> 智人(Homo
sapiens)
<400> 11
Trp Gly Gln
Gly Thr Met Val Thr Val Ser Ser
1 5 10
<210> 12
<211> 11
<212> PRT
<213> 智人(Homo
sapiens)
<400> 12
Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 13
<211> 23
<212> PRT
<213> 智人(Homo
sapiens)
<400> 13
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys
20
<210> 14
<211> 15
<212> PRT
<213> 智人(Homo
sapiens)
<400> 14
Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr
1 5 10 15
<210> 15
<211> 32
<212> PRT
<213> 智人(Homo
sapiens)
<400> 15
Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr
1 5 10 15
Leu Thr Ile
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
20 25 30
<210> 16
<211> 23
<212> PRT
<213> 智人(Homo
sapiens)
<400> 16
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys
20
<210> 17
<211> 15
<212> PRT
<213> 智人(Homo
sapiens)
<400> 17
Trp Tyr Gln
Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
1 5 10 15
<210> 18
<211> 32
<212> PRT
<213> 智人(Homo
sapiens)
<400> 18
Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
1 5 10 15
Leu Thr Ile
Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
20 25 30
<210> 19
<211> 15
<212> PRT
<213> 智人(Homo
sapiens)
<400> 19
Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
1 5 10 15
<210> 20
<211> 32
<212> PRT
<213> 智人(Homo
sapiens)
<400> 20
Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
1 5 10 15
Phe Thr Ile
Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys
20 25 30
<210> 21
<211> 23
<212> PRT
<213> 智人(Homo sapiens)
<400> 21
Glu Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys
20
<210> 22
<211> 15
<212> PRT
<213> 智人(Homo
sapiens)
<400> 22
Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
1 5 10 15
<210> 23
<211> 32
<212> PRT
<213> 智人(Homo
sapiens)
<400> 23
Gly Ile Pro
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr
1 5 10 15
Leu Thr Ile
Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys
20 25 30
<210> 24
<211> 11
<212> PRT
<213> 智人(Homo
sapiens)
<400> 24
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
1 5 10
<210> 25
<211> 11
<212> PRT
<213> 智人(Homo
sapiens)
<400> 25
Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys Arg
1 5 10
<210> 26
<211> 121
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 26
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Thr
Leu Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Ile Lys Gln Thr Pro Ala Gln Val Leu Glu Trp Ile
35 40 45
Gly Val Thr
Asp Pro Glu Ser Gly Gly Thr Leu His Asn Pro Lys Phe
50 55 60
Asp Gly Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Tyr
Tyr Lys Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Ser Val Thr Val Ser Ser
115 120
<210> 27
<211> 107
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 27
Gln Ile Val
Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly
1 5 10 15
Glu Lys Val
Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met
20 25 30
Cys Trp Tyr
Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Cys
35 40 45
Asp Thr Ser
Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Thr Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 28
<211> 119
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 28
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Ile His
Trp Val Lys Gln Thr Pro Val His Gly Leu Ala Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu
Thr Val Ser Ser
115
<210> 29
<211> 108
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 29
Ser Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp
20 25 30
Val Ala Trp
Tyr Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Asn Tyr Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu
Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 30
<211> 119
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 30
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Met His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Arg Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ile Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu
Thr Val Ser Ser
115
<210> 31
<211> 108
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 31
Ser Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp
20 25 30
Val Ala Trp
Phe Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Asn Tyr Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ser
65 70 75 80
Glu Asp Leu
Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Thr Leu Glu Ile Lys Arg
100 105
<210> 32
<211> 120
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 32
Gln Val Gln
Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser
Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Gly Val His
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Val Val Ile
Trp Ser Asp Gly Thr Thr Thr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu
Ser Ile Thr Arg Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Asp Ser
Thr Trp Asp Tyr Tyr Tyr Thr Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Pro
Val Thr Val Ser Ser
115 120
<210> 33
<211> 112
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 33
Asp Val Val
Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala
Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn
Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu
Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val
Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105 110
<210> 34
<211> 121
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 34
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Thr
Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Asp Gly Lys
Ala Glu Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys
85 90 95
Thr Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Ser Ile Thr Val Ser Ser
115 120
<210> 35
<211> 107
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 35
Gln Ile Val
Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val
Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe
Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50
55 60
Gly Ser Gly
Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly
Gly Ser Lys Leu Glu Ile Lys Arg
100 105
<210> 36
<211> 119
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 36
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys
85 90 95
Thr Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ala Leu
Thr Val Ser Ser
115
<210> 37
<211> 108
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 37
Asn Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Pro Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Val Asn Thr Val Gln Ala
65 70 75 80
Glu Asp Leu
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Leu Glu Leu Lys Arg
100 105
<210> 38
<211> 118
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 38
Gln Val Gln
Leu Lys Glu Ser Gly Pro Ala Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser
Phe Thr Cys Thr Ile Ser Gly Phe Ser Leu Ser Ser Tyr
20 25 30
Gly Val His
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Val Val Ile
Trp Ser Asp Gly Thr Thr Thr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu
Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn
Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Gly
Tyr Tyr Ile Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr
Val Ser Ser
115
<210> 39
<211> 113
<212> PRT
<213> 小鼠(Mus
musculus)
<400> 39
Asp Val Val
Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala
Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn
Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Leu
Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val
Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Gly
85 90 95
Thr His Ala
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Asn
100 105 110
Arg
<210> 40
<211> 124
<212> PRT
<213> 智人(Homo
sapiens)
<400> 40
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 41
<211> 111
<212> PRT
<213> 智人(Homo
sapiens)
<400> 41
Gln Ser Gly
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 42
<211> 124
<212> PRT
<213> 智人(Homo
sapiens)
<400> 42
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr
1 5 10 15
Phe Leu Arg
Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ala Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ala Val Thr
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 43
<211> 111
<212> PRT
<213> 智人(Homo
sapiens)
<400> 43
Gln Ser Gly
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 44
<211> 122
<212> PRT
<213> 智人(Homo
sapiens)
<400> 44
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Phe
20 25 30
Asp Ile Asp
Trp Val Arg Gln Ala Thr Gly Leu Gly Leu Glu Trp Met
35 40 45
Gly Trp Met
Asn Pro Asn Ser Gly Asn Thr Gly Val Ala Pro Lys Phe
50 55 60
Arg Gly Arg
Val Ser Met Thr Phe Asn Thr Ala Ile Arg Thr Ala Tyr
65 70 75 80
Leu Glu Leu
Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser
Ser Glu Ser Glu Gly Ile Thr Ile Gly Phe Asp Asn Trp
100 105 110
Gly Gln Gly
Thr Leu Val Thr Val Ser Ser
115 120
<210> 45
<211> 109
<212> PRT
<213> 智人(Homo
sapiens)
<400> 45
Ser Tyr Glu
Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser
Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Arg Tyr Ala
20 25 30
Cys Trp Tyr
Lys Gln Lys Pro Gly Gln Pro Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Asn
Lys Arg Pro Ser Gly Ile Ser Glu Arg Tyr Ser Gly Ser
50
55 60
Asn Tyr Gly
Asp Thr Ala Thr Leu Thr Ile Thr Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala
Asp Tyr Tyr Cys Gln Thr Trp Asp Ser Thr Thr Gly Ser
85 90 95
Tyr Val Phe
Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105
<210> 46
<211> 126
<212> PRT
<213> 智人(Homo
sapiens)
<400> 46
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser
115 120 125
<210> 47
<211> 108
<212> PRT
<213> 智人(Homo
sapiens)
<400> 47
Asp Val Val
Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Asp Ile Lys Arg
100 105
<210> 48
<211> 122
<212> PRT
<213> 智人(Homo
sapiens)
<400> 48
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Val Ser Gly Ser Arg Leu Ser Asp Leu
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Met
35 40 45
Gly Gly Phe
Asp Pro Asp Glu Gly Glu Thr Val Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg
Val Ser Met Thr Glu Asp Thr Ser Ser Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu
Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ile
Arg Pro Trp Leu Gly Gly Ala Tyr Tyr Phe Asp Asn Trp
100 105 110
Gly Gln Gly
Thr Leu Val Thr Val Ser Ser
115 120
<210> 49
<211> 108
<212> PRT
<213> 智人(Homo
sapiens)
<400> 49
Glu Thr Thr
Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly
1 5 10 15
Asp Lys Val
Asn Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp
20 25 30
Met Asn Trp
Tyr Gln Gln Lys Pro Gly Glu Ala Ala Leu Phe Ile Ile
35 40 45
Gln Glu Ala
Thr Thr Leu Val Pro Gly Ile Pro Pro Arg Phe Ser Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Leu Thr Val Asn Asn Ile Gln Ser
65 70 75 80
Glu Asp Ala
Ala Tyr Tyr Phe Cys Leu Gln His Asp Ser Phe Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 50
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VH
<400> 50
Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr
20 25 30
Glu Ile His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Asp Gly Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Thr Val Thr Val Ser Ser
115 120
<210> 51
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 51
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 52
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 52
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Tyr
Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 53
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 53
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20
25 30
Tyr Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 54
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 54
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Tyr
Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 55
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VH
<400> 55
Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr
20
25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 56
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 56
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20
25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile
Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 57
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 57
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile
Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 58
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 58
Glu Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20
25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe
Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 59
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> CDR嫁接的抗体VL
<400> 59
Glu Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe
Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 60
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VH
<400> 60
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50
55 60
Asp Gly Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Thr Val Thr Val Ser Ser
115 120
<210> 61
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VH
<400> 61
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50
55 60
Asp Gly Arg
Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Thr Val Thr Val Ser Ser
115 120
<210> 62
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 62
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50
55 60
Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 63
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 63
Asp Ile Gln
Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe Gln
Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 64
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 64
Gln Ile Val
Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe
Gln Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50
55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 65
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 65
Glu Ile Val
Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe Gln
Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 66
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 66
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Tyr
Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50
55 60
Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 67
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 67
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe Gln
Gln Lys Pro Asp Gln Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 68
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 68
Gln Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe
Gln Gln Lys Pro Asp Gln Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50
55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 69
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VH
<400> 69
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 70
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VH
<400> 70
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50
55 60
Arg Asp Arg
Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 71
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 71
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50
55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 72
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 72
Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 73
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 73
Asn Ile Val
Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50
55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 74
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 74
Glu Ile Val Met
Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 75
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 75
Glu Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly
50
55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 76
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VL
<400> 76
Asn Ile Val Met
Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 77
<211> 124
<212> PRT
<213> 智人(Homo
sapiens)
<400> 77
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 78
<211> 111
<212> PRT
<213> 智人(Homo
sapiens)
<400> 78
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 79
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH(与亲本VH相同)
<400> 79
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 80
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#1)
<400> 80
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 81
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#2)
<400> 81
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Ala Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 82
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#2)
<400> 82
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 83
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#3)
<400> 83
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Pro Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 84
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#3)
<400> 84
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Glu Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Met Trp Asp Asp Ser Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 85
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#4)
<400> 85
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Arg Gln Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Leu Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 86
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#4)
<400> 86
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Met Trp Asp Asp Ser Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 87
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#5)
<400> 87
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn His
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Ser Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Arg Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 88
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#5)
<400> 88
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 89
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#6)
<400> 89
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu His
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 90
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#6)
<400> 90
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 91
<400> 91
000
<210> 92
<400> 92
000
<210> 93
<400> 93
000
<210> 94
<400> 94
000
<210> 95
<400> 95
000
<210> 96
<400> 96
000
<210> 97
<400> 97
000
<210> 98
<400> 98
000
<210> 99
<400> 99
000
<210> 100
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#7)
<400> 100
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 101
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#7)
<400> 101
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 102
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#8)
<400> 102
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Lys Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 103
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#8)
<400> 103
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 104
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#9)
<400> 104
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Pro Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115
120
<210> 105
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#9)
<400> 105
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Leu Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 106
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#10)
<400> 106
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Phe Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 107
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#10)
<400> 107
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 108
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#11)
<400> 108
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Glu Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 109
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#11)
<400> 109
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 110
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#12)
<400> 110
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Thr Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 111
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#12)
<400> 111
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 112
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#13)
<400> 112
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 113
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#13)
<400> 113
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 114
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#14)
<400> 114
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 115
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#14)
<400> 115
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 116
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#15)
<400> 116
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 117
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#15)
<400> 117
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 118
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#16)
<400> 118
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 119
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#16)
<400> 119
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Phe Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 120
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#17)
<400> 120
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 121
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#17)
<400> 121
Gln Ser Val
Leu Ser Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Arg His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 122
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#18)
<400> 122
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Arg Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Arg Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 123
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#18)
<400> 123
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Asn His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Val Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 124
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#19)
<400> 124
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Ser Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 125
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#19)
<400> 125
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Arg Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Arg Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 126
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#20)
<400> 126
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 127
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#20)
<400> 127
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Asn His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Val Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 128
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#21)
<400> 128
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 129
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#21)
<400> 129
Gln Ser Gly
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 130
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#22)
<400> 130
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 131
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#22)
<400> 131
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 132
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#23)
<400> 132
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 133
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#23)
<400> 133
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 134
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#24)
<400> 134
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 135
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#24)
<400> 135
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 136
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#25)
<400> 136
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn His
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Trp Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 137
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#25)
<400> 137
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 138
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#26)
<400> 138
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Gly Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Thr Ser Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 139
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#26)
<400> 139
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 140
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#27)
<400> 140
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Pro Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 141
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#27)
<400> 141
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 142
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#28)
<400> 142
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 143
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#28)
<400> 143
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Pro Ser Asn Ile Gly Ser His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp His Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 144
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#29)
<400> 144
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Cys Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asn Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 145
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#29)
<400> 145
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Tyr His
20 25 30
Thr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ser Val Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 146
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#30)
<400> 146
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 147
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#30)
<400> 147
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 148
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#31)
<400> 148
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 149
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#31)
<400> 149
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Gly Lys Ser Asn Ile Gly Ser His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Val Gly Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 150
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#32)
<400> 150
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 151
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#32)
<400> 151
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Thr Gly Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Glu Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 152
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#33)
<400> 152
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Ser Asp Gly Ser His Gly Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 153
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#33)
<400> 153
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Met Ser Asn Ile Gly Tyr His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Ile Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 154
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#34)
<400> 154
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 155
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#34)
<400> 155
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 156
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#35)
<400> 156
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn His
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Tyr Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 157
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#35)
<400> 157
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Cys His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Ser Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Ala Ala Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 158
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#36)
<400> 158
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 159
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#36)
<400> 159
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Ile Ser Asn Ile Gly Asn His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 160
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#37)
<400> 160
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Tyr His
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 161
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#37)
<400> 161
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Ser Val Tyr
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Glu
Ser Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Val Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 162
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#38)
<400> 162
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 163
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#38)
<400> 163
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Arg Ser Asn Ile Gly Tyr His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 164
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#39)
<400> 164
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 165
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#39)
<400> 165
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Ser Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 166
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#40)
<400> 166
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Arg Asp Gly Ser Gly Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 167
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#40)
<400> 167
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Asn His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Val Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 168
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#41)
<400> 168
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 169
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#41)
<400> 169
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asn Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 170
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#42)
<400> 170
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Lys Gln Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 171
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#42)
<400> 171
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asn Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 172
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#43)
<400> 172
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly His Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Gln Tyr Tyr Val Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 173
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#43)
<400> 173
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Thr Ser Asn Ile Gly Arg His
20 25 30
Phe Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Asp Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 174
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#44)
<400> 174
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Arg Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Leu Gly Asp Tyr Tyr Tyr Thr Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 175
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#44)
<400> 175
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ser Asp Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 176
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#45)
<400> 176
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Arg Gly Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 177
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#45)
<400> 177
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Arg His
20 25 30
Cys Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Phe
Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 178
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#46)
<400> 178
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Met Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 179
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#46)
<400> 179
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Phe
Thr Asp Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Leu Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 180
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#47)
<400> 180
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Met Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 181
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#47)
<400> 181
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Pro Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Phe
Thr Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Thr Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 182
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#48)
<400> 182
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Ser Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 183
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#48)
<400> 183
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 184
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#49)
<400> 184
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Trp Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 185
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#49)
<400> 185
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Ser His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 186
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#50)
<400> 186
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 187
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#50)
<400> 187
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Gly His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Ala Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 188
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#51)
<400> 188
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 189
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#51)
<400> 189
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 190
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#52)
<400> 190
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Ser Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 191
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#52)
<400> 191
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Arg Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn Asn Ser Asn Ile Gly Thr His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 192
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#53)
<400> 192
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Arg
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 193
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#53)
<400> 193
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Phe
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 194
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#54)
<400> 194
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 195
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#54)
<400> 195
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 196
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#55)
<400> 196
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Met Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Ala Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 197
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#55)
<400> 197
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Ser His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ser Val Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 198
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#56)
<400> 198
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 199
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#56)
<400> 199
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn His Ser Asn Ile Gly Asn His
20 25 30
Phe Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ser Trp Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 200
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#57)
<400> 200
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 201
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#57)
<400> 201
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 202
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#58)
<400> 202
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Ser Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Ser Gly Pro Tyr Tyr Tyr Thr Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 203
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#58)
<400> 203
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Thr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Thr Gly Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Lys Leu
85 90 95
Gly Gly Tyr
Asp Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 204
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#59)
<400> 204
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Arg Lys Tyr Tyr Glu Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 205
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#59)
<400> 205
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Lys Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Ser Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 206
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#60)
<400> 206
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Phe Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 207
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#60)
<400> 207
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Pro Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Phe Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 208
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#61)
<400> 208
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 209
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#61)
<400> 209
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Tyr Asp Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Tyr Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Leu Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 210
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#62)
<400> 210
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 211
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#62)
<400> 211
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Ile Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asn Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 212
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#63)
<400> 212
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Arg Asp Gly Ser His Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Gly Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser
115
120
<210> 213
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#63)
<400> 213
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Tyr Ser Asn Ile Gly Arg His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ile Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 214
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#64)
<400> 214
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly His Gly Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 215
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#64)
<400> 215
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ile Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 216
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#65)
<400> 216
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Phe Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 217
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#65)
<400> 217
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Thr Ser Asn Ile Gly Arg His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asn Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 218
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#66)
<400> 218
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Phe Asp Gly Ser Arg Lys Tyr Tyr Val Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 219
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#66)
<400> 219
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Lys Asn Ser Asn Ile Gly Asn His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 220
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#67)
<400> 220
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Ser Asp Gly Ser Lys Asn Tyr Tyr Val Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 221
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#67)
<400> 221
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Asn His
20 25 30
Phe Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Val Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 222
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#68)
<400> 222
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Gln Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Arg Glu Tyr Tyr Gly Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 223
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#68)
<400> 223
Gln Ser Met
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg His Ser Asn Ile Gly Ser His
20 25 30
Glu Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 224
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#69)
<400> 224
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Cys Asn Gln Tyr Tyr Pro Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 225
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#69)
<400> 225
Gln Ser Gly
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Thr Ser Asn Ile Gly Asn His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Phe Gly Val Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Ser Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 226
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#70)
<400> 226
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Thr Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 227
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#70)
<400> 227
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Lys Asn Ser Asn Ile Gly Arg His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Phe Gly Thr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 228
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#71)
<400> 228
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Leu Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 229
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#71)
<400> 229
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Tyr His
20 25 30
Pro Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp
Phe Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ser Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 230
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#72)
<400> 230
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser His Asp Gly Cys Asn Asn Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Ala Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 231
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#72)
<400> 231
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Arg His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 232
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#73)
<400> 232
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Gly Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 233
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#73)
<400> 233
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Ser His
20 25 30
Ala Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 234
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#74)
<400> 234
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 235
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#74)
<400> 235
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 236
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#75)
<400> 236
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 237
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#75)
<400> 237
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Met Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 238
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#76)
<400> 238
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 239
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#76)
<400> 239
Gln Ser Val
Leu Thr Gln Pro Pro Thr Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Ile Gly Phe Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 240
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#77)
<400> 240
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 241
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#77)
<400> 241
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 242
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#78)
<400> 242
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Cys Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 243
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#78)
<400> 243
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Phe Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Pro
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 244
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#79)
<400> 244
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Gly Ser Gly Glu Tyr Tyr Tyr Ser Pro Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 245
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#79)
<400> 245
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Arg
20 25 30
Ser Val Thr
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Phe Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Ala Glu Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 246
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#80)
<400> 246
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Lys Gln Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 247
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#80)
<400> 247
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Tyr His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Phe Gly Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 248
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#81)
<400> 248
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 249
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#81)
<400> 249
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp
Phe Gly Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 250
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#82)
<400> 250
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Arg Asn Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Tyr Gly Pro Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 251
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#82)
<400> 251
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Cys His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Met Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 252
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#83)
<400> 252
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Asn Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 253
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#83)
<400> 253
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Thr Asn Ser Asn Ile Gly Asn His
20 25 30
Ala Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Leu Gly Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Asp Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 254
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#84)
<400> 254
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 255
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#84)
<400> 255
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Ser His
20 25 30
Thr Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Glu
Ile Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Asp Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 256
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#85)
<400> 256
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 257
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#85)
<400> 257
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Asp Val Thr
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Met Trp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 258
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#86)
<400> 258
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Gln
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 259
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#86)
<400> 259
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Phe Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Glu
Tyr Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Ile Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 260
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#87)
<400> 260
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Gly Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 261
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#87)
<400> 261
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 262
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#88)
<400> 262
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Phe
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 263
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#88)
<400> 263
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Val His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 264
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#89)
<400> 264
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Glu Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 265
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#89)
<400> 265
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Ser
Ile Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 266
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#90)
<400> 266
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Ala Asp Gly Arg Lys Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Trp Gly Asp Tyr Tyr Tyr Thr Tyr Gly Leu Asp
100 105 110
Ser Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 267
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#90)
<400> 267
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Tyr Ser Asn Ile Gly Asn His
20 25 30
Ser Val His
Trp Tyr Arg Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Asp Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 268
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#91)
<400> 268
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Gly Tyr Asp Gly Tyr Arg Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 269
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#91)
<400> 269
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Arg Thr Pro Gly Gln
1 5 10 15
Thr Val Pro
Ile Ser Cys Ser Gly Arg His Ser Asn Ile Gly Asn His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 270
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#92)
<400> 270
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Arg Lys Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 271
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#92)
<400> 271
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Asn His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Thr Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Gly Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 272
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#93)
<400> 272
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 273
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#93)
<400> 273
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Lys Ser Asn Ile Gly Ser His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Tyr Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Met Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 274
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#94)
<400> 274
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 275
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#94)
<400> 275
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Ile Ser Asn Ile Gly Ser His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Leu Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 276
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#95)
<400> 276
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Lys Asp Gly Arg Asn Lys Tyr Tyr Gly Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 277
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#95)
<400> 277
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Cys Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 278
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#96)
<400> 278
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Arg Asp Gly Arg Arg Lys Tyr Tyr Ser Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Leu Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 279
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#96)
<400> 279
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 280
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#97)
<400> 280
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Asn Asp Gly Thr Asn Lys Tyr Tyr Thr Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 281
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#97)
<400> 281
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Arg His
20 25 30
Phe Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Ala
Asn Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 282
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#98)
<400> 282
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Asn
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Glu Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Phe Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 283
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#98)
<400> 283
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Ile Ser Asn Ile Gly Arg His
20 25 30
Ala Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Phe Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 284
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#99)
<400> 284
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu His Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 285
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#99)
<400> 285
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Arg His
20 25 30
His Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Tyr Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Ala Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 286
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH (#100)
<400> 286
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50
55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 287
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#100)
<400> 287
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn Arg Ser Asn Ile Gly His His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Ser Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 288
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#101)
<400> 288
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 289
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#101)
<400> 289
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ile Thr Ser Asn Ile Gly Arg His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Cys Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 290
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#102)
<400> 290
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ala Asn Arg Tyr Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 291
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#102)
<400> 291
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Arg His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Trp
Tyr Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 292
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#103)
<400> 292
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 293
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#103)
<400> 293
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Tyr Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Ser
Asn Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 294
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#104)
<400> 294
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
His Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 295
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#104)
<400> 295
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ile Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ala
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Ala Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 296
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#105)
<400> 296
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Gly Asn Gln Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 297
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#105)
<400> 297
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Phe
Asn Gly Val Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Asp Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 298
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#106)
<400> 298
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly His Asn Gln Tyr Tyr Gln Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 299
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#106)
<400> 299
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ala Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Gly Met Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Pro Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 300
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#107)
<400> 300
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser His Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 301
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#107)
<400> 301
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ile Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Gly Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Ser Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Val Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 302
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#108)
<400> 302
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 303
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#108)
<400> 303
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 304
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#109)
<400> 304
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val His Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser His Asp Gly Ser Lys Gln Tyr Tyr Ala Asp Ser Leu
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 305
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#109)
<400> 305
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 306
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#110)
<400> 306
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Gly Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 307
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#110)
<400> 307
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Ser Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Ile
35 40 45
Ile Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 308
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#111)
<400> 308
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Tyr Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Phe Trp Gly
Gln Gly Thr Thr Val Thr Val Ser
115
120
<210> 309
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#111)
<400> 309
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Val Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 310
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#112)
<400> 310
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ser
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 311
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#112)
<400> 311
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Ala Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Gly Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 312
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#113)
<400> 312
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser His Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Pro Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 313
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#113)
<400> 313
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Arg His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp
Val Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 314
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#114)
<400> 314
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 315
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#114)
<400> 315
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Ser Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 316
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#115)
<400> 316
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Phe Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 317
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#115)
<400> 317
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn Lys Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 318
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#116)
<400> 318
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Phe Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 319
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#116)
<400> 319
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Met His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Ser Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 320
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#117)
<400> 320
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Pro Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 321
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#117)
<400> 321
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Arg His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Tyr Phe Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 322
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#118)
<400> 322
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Gly Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 323
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#118)
<400> 323
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp
Phe Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 324
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#119)
<400> 324
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser His Asp Gly Trp Ser Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Ala Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 325
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#119)
<400> 325
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn Tyr Ser Asn Ile Gly Thr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp
Phe Gly His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 326
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#120)
<400> 326
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Leu Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 327
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#120)
<400> 327
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Tyr Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 328
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#121)
<400> 328
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Gly Asn Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 329
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#121)
<400> 329
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Trp
Gly Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Asp Asp Arg Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 330
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#122)
<400> 330
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Ser Leu Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Phe Asp
100 105 110
Gly Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 331
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#122)
<400> 331
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 332
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#123)
<400> 332
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Lys Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Leu Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 333
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#123)
<400> 333
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Asn Arg Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser
Met Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 334
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#124)
<400> 334
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 335
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#124)
<400> 335
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 336
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VH
(#125)
<400> 336
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20
25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 337
<211> 110
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的人IL-17抗体G9的VL
(#125)
<400> 337
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 338
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> CDR-H1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> N, D, Y或H
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Y,N,H,Q,或F
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<400> 338
Xaa Xaa Gly
Met His
1 5
<210> 339
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> CDR-H2共有序列
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> A, G,或S
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Y, N, S, H, R, F, C, M, K,或A
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> S, R, T, G, W, H, C, Y,或A
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> N, R, K, S, H, G,或Y
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> K, Q, T, R, N, A, G, S,或E
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> A, S, V, G, T, E, P, R, Q,或L
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> V或L
<400> 339
Val Ile Xaa
Xaa Asp Gly Xaa Xaa Xaa Tyr Tyr Xaa Asp Ser Xaa Lys
1 5 10 15
Gly
<210> 340
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> CDR-H3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> V或L
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> G或S
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> A, L,或G
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> S, Y, L, F, W, N,或K
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> D, P, N, E,或A
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> S或T
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Y, P,或F
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> L或F
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> V, L, Y, G, F, A, S,或E
<400> 340
Xaa Xaa Xaa
Xaa Gly Xaa Tyr Tyr Tyr Xaa Xaa Gly Xaa Asp Xaa
1 5 10 15
<210> 341
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> CDR-L1共有序列
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> R, S, T, N, H, I, Y, K, G,或A
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> N, Q, K, H, R, Y, T, I, P, S, M,或D
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> R, S, N, Y, T, C, V, M, H,或G
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> H或R
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Y, S, P, A, F, T, H, E, D,或C
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> D, H, N, T,或Y
<400> 341
Ser Gly Xaa
Xaa Ser Asn Ile Gly Xaa Xaa Xaa Val Xaa
1 5 10
<210> 342
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> CDR-L2共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Y, G, D, W, F, S, E,或A
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> D, I, F, T, S, N, G, Y, V, M,或L
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> G, S, D, V, W, C,或F
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Q, I, Y, E, L, H, W, M, V, T, S, N, F,或D
<400> 342
Xaa Xaa Xaa
Xaa Arg Pro Ser
1 5
<210> 343
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> CDR-L3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> A或G
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> T, S, M, L,或I
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> S, W, R, M,
L, K, H, G,或F
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> G, A,或V
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> G, A, E, D, V,或S
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> V或D
<400> 343
Xaa Xaa Trp
Asp Asp Xaa Leu Xaa Xaa Tyr Xaa
1 5 10
<210> 344
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-1的VH
<400> 344
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 345
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-1的VL
<400> 345
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 346
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-3的VH
<400> 346
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 347
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-3的VL
<400> 347
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Asn Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Met Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 348
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-4的VL
<400> 348
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 349
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M3的VH
<400> 349
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 350
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M2的VL
<400> 350
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu
Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 351
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VH
<400> 351
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 352
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VL
<400> 352
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 353
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-5的VH
<400> 353
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ala Tyr Asp Gly Ser Arg Gln Tyr Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Leu Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 354
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-5的VL
<400> 354
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Met Trp Asp Asp Ser Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 355
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-6的VH
<400> 355
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 356
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-6的VL
<400> 356
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Asn His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Val Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Trp Leu
85 90 95
Ala Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 357
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M1的VH
<400> 357
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu
Ser Leu Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Phe Asp
100 105 110
Gly Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 358
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M1的VL
<400> 358
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Lys Ser Asn Ile Gly Ser His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Asp
Phe Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 359
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 359
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 360
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 360
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 361
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 361
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 362
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 362
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Val Ser Tyr
20 25 30
Gly Ile Cys
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 363
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 363
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Val
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Ala Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 364
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 364
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Val
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Ala Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Ile
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 365
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 365
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Val
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Ala Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 366
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 366
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Lys Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Ile Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asn Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 367
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 367
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Leu Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 368
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 368
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 369
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 369
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 370
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 370
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Lys Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 371
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 371
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Lys Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 372
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 372
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Arg Thr Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr Asp Tyr
100 105 110
Phe Asp Asn
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 373
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 373
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Arg Thr Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 374
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 374
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 375
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 375
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr Gln Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 376
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 376
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr Asp Tyr
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 377
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 377
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 378
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 378
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Leu Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 379
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 379
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Leu Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 380
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 380
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Leu Phe Phe Gly Ile Ser Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 381
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 381
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ala
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 382
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 382
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Met Glu Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 383
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 383
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 384
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 384
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro His Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 385
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 385
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 386
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 386
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 387
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 387
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ile Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 388
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 388
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ile Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 389
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 389
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 390
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 390
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Cys
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Val
Thr Thr Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 391
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 391
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Val Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro His Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 392
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 392
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Met Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 393
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 393
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 394
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 394
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Val Glu Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 395
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 395
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ile Ser Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 396
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 396
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ile Arg Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 397
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体的VH
<400> 397
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Val Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr Gln Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 398
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 398
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Leu Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 399
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 399
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Met Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 400
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 400
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Met Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 401
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 401
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 402
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 402
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Phe Ala Thr Asn Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 403
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 403
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 404
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 404
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 405
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 405
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Val Phe Phe Gly His Val Tyr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 406
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 406
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Tyr Asn
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Glu Phe Trp Asn Gly Tyr Tyr Cys Thr Gln Asp
100 105 110
Phe Asp Leu
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 407
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 407
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Leu Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Glu Phe Trp Asn Gly Tyr Tyr Cys Thr Gln Asp
100 105 110
Phe Asp Leu
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 408
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 408
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Thr Tyr
20 25 30
Gly Met Asn
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Glu Phe Trp Asn Gly Tyr Tyr Cys Thr Gln Asp
100 105 110
Phe Asp Leu
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 409
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 409
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Phe Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Glu Phe Trp Asn Gly Tyr Tyr Val Thr Asn Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 410
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 410
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Asn Glu Phe Trp Asn Gly Tyr Tyr Pro Thr Leu Asp
100 105 110
Leu Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 411
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 411
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Asn Glu Phe Trp Asn Gly Tyr Tyr Pro Thr Gln Asp
100 105 110
Tyr Asp Phe
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 412
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 412
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Ala Phe Trp Asn Gly Tyr Tyr Asn Thr Asn Asp
100 105 110
Leu Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 413
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 413
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Thr Glu Phe Trp Asn Gly Tyr Tyr Asn Thr Asn Asp
100 105 110
Tyr Asp Asn
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 414
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 414
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr Asp Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 415
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 415
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr Asp Asp
100 105 110
Leu Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 416
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 416
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr Asp Asp
100 105 110
Phe Asp Cys
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 417
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 417
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Phe Pro Thr Gln Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 418
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 418
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Thr Asn Glu Phe Trp Asn Gly Tyr Phe Pro Thr Gln Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 419
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 419
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Phe Pro Thr Gln Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 420
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 420
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Phe Pro Thr Leu Asp
100 105 110
Phe Asp Cys
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 421
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 421
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Phe Ala Thr Asn Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 422
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 422
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Ala Thr Asp Asn
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 423
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 423
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Ser Thr Asp His
100 105 110
Phe Asp Cys
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 424
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 424
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Asp Phe Trp Asn Gly Tyr Phe Ala Thr Asp Tyr
100 105 110
Phe Asp Asp
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 425
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 425
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Phe Ala Thr Asp His
100 105 110
Phe Asp Phe
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 426
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 426
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr Asp His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 427
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 427
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp His
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 428
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 428
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr Asp His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Ile Thr Val Ser Ser
115 120 125
<210> 429
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 429
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Phe Phe Phe Gly Ala Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 430
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 430
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 431
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 431
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Cys Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 432
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 432
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Ser Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 433
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 433
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 434
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 434
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 435
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 435
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Leu Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 436
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 436
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Met Phe Ala Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 437
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 437
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Ala Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 438
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 438
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ile Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 439
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 439
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Val Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 440
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 440
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Val Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 441
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 441
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Thr Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Leu Gly Thr Val Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 442
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 442
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Val Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Leu Leu Gly Ile Ser Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 443
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 443
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Val Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Ile Leu Gly Thr Ser Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 444
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 444
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Phe Gly Thr Gly Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 445
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 445
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Trp Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Glu Ser Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 446
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 446
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Leu Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 447
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 447
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ser Ala Tyr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 448
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 448
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Val Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 449
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 449
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 450
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 450
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Ser Tyr
20 25 30
Val Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 451
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 451
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 452
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 452
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Ile Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 453
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 453
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Thr Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 454
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 454
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Tyr Asn
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 455
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 455
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 456
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 456
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Val Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 457
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 457
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Asp Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ile Val Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 458
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 458
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Ser Tyr
20 25 30
Asp Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Phe Gly Ala Ser Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 459
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 459
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe His Ser Tyr
20 25 30
Asp Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Ser Phe Phe Gly Thr Glu Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 460
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 460
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Gly Tyr
20 25 30
Val Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 461
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 461
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Thr Ala Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 462
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 462
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Glu Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 463
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 463
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Asp Tyr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Met Ser Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 464
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 464
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Thr Arg Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Thr Ser Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 465
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 465
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Phe Ser Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 466
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 466
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 467
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 467
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Thr Phe Leu Gly Thr Val Val Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 468
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 468
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr
20 25 30
Val Val Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Leu Gly Thr Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 469
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 469
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Asp Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 470
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 470
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Leu Gly Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 471
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 471
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Asp Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 472
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VH
<400> 472
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 473
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 473
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Tyr Asp Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 474
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 474
Glu Ile Val
Leu Thr Gln Pro Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Tyr Asp Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 475
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 475
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Tyr Trp Leu Pro Asn
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 476
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 476
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Tyr Asn Leu Pro Ile
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 477
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 477
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Tyr Asn Leu Pro Ile
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 478
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 478
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Leu Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Asn Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Met Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 479
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 479
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 480
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 480
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Pro Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 481
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 481
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Ala Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 482
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 482
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Gly Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 483
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 483
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Val
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 484
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 484
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 485
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 485
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 486
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 486
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Ala Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Gly Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 487
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 487
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Gly Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 488
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 488
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 489
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 489
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro His
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 490
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 490
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Gly Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro His
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 491
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 491
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ala Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Asn Pro Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro Gln
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 492
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 492
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ser
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Phe Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 493
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 493
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ser
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Pro Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 494
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 494
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Arg Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Asp Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 495
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 495
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Asn Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ser Trp Leu Pro His
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 496
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 496
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Met Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ser Leu Pro His Ser
85 90 95
Phe Gly Pro
Gly Thr Lys Val Asp Ile Lys
100 105
<210> 497
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 497
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Tyr Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ser Glu Leu Pro His
85 90 95
Thr Phe Gly
Arg Gly Thr Lys Val Asp Ile Lys
100 105
<210> 498
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 498
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Ser Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ser Cys Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Gly Ile Lys
100 105
<210> 499
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 499
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Phe Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Glu Glu Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 500
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 500
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ala Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Arg Leu Pro Tyr
85 90 95
Ser Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 501
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 501
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Phe Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 502
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 502
Asp Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 503
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 503
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Ser Asp Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 504
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 504
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Met Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Thr Asn Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 505
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 505
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Gly
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Met Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Thr Asp Trp Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 506
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 506
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Arg
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asn Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 507
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 507
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Phe Asn Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 508
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 508
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Asn Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Ala Tyr Leu Pro Gln
85 90 95
Thr Phe Gly
Pro Gly Thr Ile Val Asp Ile Lys
100 105
<210> 509
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 509
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Gly Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 510
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 510
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 511
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 511
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Thr Leu Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 512
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 512
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Gly Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Gly Phe Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 513
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 513
Glu Val Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Phe Cys Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 514
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 514
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Ser Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 515
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 515
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Ser Ser Leu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Tyr Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Ile Val Asp Ile Lys
100 105
<210> 516
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 516
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Glu Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Trp Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 517
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 517
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Ala Ser
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Gly Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 518
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 518
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Gly Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asn Asp Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 519
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 519
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu Thr Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Thr Tyr Gly Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 520
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 520
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Met Gly Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 521
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 521
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Tyr Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Phe Thr Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 522
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 522
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Thr Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Cys Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Glu Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 523
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 523
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Thr Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 524
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 524
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Thr Asn Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 525
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 525
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Ser Ile Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 526
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 526
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Thr Trp Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 527
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 527
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Ala Phe Leu Pro Tyr
85 90 95
Ile Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 528
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 528
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Ile Ser Leu Pro Gln
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 529
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 529
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Ala Ser Leu Pro Ile
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 530
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 530
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Gly
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ala Tyr Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 531
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 531
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ala Val Leu Pro Asp
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 532
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 532
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Ala Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Ser Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ser Asp Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 533
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 533
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Ala Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Phe Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 534
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 534
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ala Phe Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 535
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 535
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Tyr Ser Leu Pro Phe
85 90 95
Asn Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 536
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 536
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Tyr Met Leu Pro Tyr
85 90 95
Ser Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 537
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 537
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Glu Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Ser Ser Pro Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Phe Ser Leu Pro Val
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 538
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 538
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Ala Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ile Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 539
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 亲和力成熟的全人IL-17抗体IL-17-TN-K7-B6的VL
<400> 539
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ala Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 540
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-H1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> S, G, T, V,或R
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> G, D, V, S, A, C,或I
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> I, F, T, Y, M,或V
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S, G, C, N, V,或H
<400> 540
Xaa Tyr Xaa
Xaa Xaa
1 5
<210> 541
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-H2共有序列
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> I或V
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> P, H, N, T, L, I, V, S,或F
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> F, I, M, V, S,或L
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> F或L
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> G, M, L, E,或A
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> T, I, S, W, A, F, L, M, V,或H
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> A, T, V, S, E, D, P, I, G,或R
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> D, N, Y, S, T, V,或I
<220>
<221> MISC_FEATURE
<222> (17)..(17)
<223> G或D
<400> 541
Gly Xaa Thr
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Gln Lys Phe Gln
1 5 10 15
Xaa
<210> 542
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-H3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> E, D,或V
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> P, S,或T
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> N, S, T,或H
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> E, D,或A
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Y或F
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> T, A, S, D, P, N, C,或V
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> H, D, Q, N,或L
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> D, H, Y,或N
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> F, L,或Y
<220>
<221> MISC_FEATURE
<222> (17)..(17)
<223> Y, S, L, N, F, C, I, H, A,或D
<400> 542
Xaa Xaa Xaa
Xaa Phe Trp Asn Gly Tyr Xaa Xaa Thr Xaa Xaa Xaa Asp
1 5 10 15
Xaa
<210> 543
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-L1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> R或W
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> A或V
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> N, D, E, A,或I
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> G, D,或E
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> S, Y, A, E, F, T,或G
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> A, E, D, S,或G
<400> 543
Xaa Xaa Ser
Gln Xaa Ile Xaa Xaa Xaa Leu His
1 5 10
<210> 544
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-L2共有序列
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> H, Q, Y, E, N, S,或W
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S, P,或C
<220>
<221> misc_feature
<222> (6)..(6)
<223> Xaa可为任何天然存在的氨基酸
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> S或P
<400> 544
Tyr Ala Ser
Xaa Xaa Xaa Xaa
1 5
<210> 545
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 来自抗体IL-17-TN-K7-B6的CDR-L3共有序列
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> S, T,或G
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> T, D, A, Y, S, F, N, I, E,或M
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S, D, N, G, I, T, F, Y, W, C, E, R, V, L,或M
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> H, Y, Q, F, I , V, D,或N
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> T, S, A, I, N,或L
<400> 545
His Gln Xaa
Xaa Xaa Leu Pro Xaa Xaa
1 5
<210> 546
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-5的VH区
<400> 546
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 547
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-5的Vk区
<400> 547
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Thr Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 548
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-15的VH区
<400> 548
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 549
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-15的Vk区
<400> 549
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ala Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Arg Leu Pro Tyr
85 90 95
Ser Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 550
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-16的VH区
<400> 550
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 551
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-16的Vk区
<400> 551
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro His
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 552
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-17的VH区
<400> 552
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 553
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-17的Vk区
<400> 553
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 554
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-18的VH区
<400> 554
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Arg Thr Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Asn Phe Phe Gly Trp Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr Asp Tyr
100 105 110
Phe Asp Asn
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 555
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-18的Vk区
<400> 555
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Ala Ser
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Gly Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 556
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-46的VH区
<400> 556
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ser Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Thr Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 557
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-46的Vk区
<400> 557
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Tyr Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Ala Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 558
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-44的VH区
<400> 558
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Leu Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Ser Ser Glu Phe Trp Asn Gly Tyr Tyr Cys Thr Gln Asp
100 105 110
Phe Asp Leu
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 559
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1-44的Vk区
<400> 559
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asp
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Asn Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Ala Tyr Leu Pro Gln
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 560
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.11的VH区
<400> 560
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 561
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.29的VH区
<400> 561
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ile Ser Tyr
20 25 30
Gly Tyr Asn
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 562
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-B6 DVD
<400> 562
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser
130 135 140
Leu Lys Ile
Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr Gly
145 150 155 160
Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Glu Pro
Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His Phe
225 230 235 240
Asp Tyr Trp
Gly Gln Gly Thr Pro Val Thr Val Ser Ser
245 250
<210> 563
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 563
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115
120
<210> 564
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH区的接头区段, D2-GS6-B6 DVD
<400> 564
Gly Gly Gly
Gly Ser Gly
1 5
<210> 565
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6的VH区
<400> 565
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser
115 120 125
<210> 566
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-B6 DVD
<400> 566
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 567
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-B6 DVD
<400> 567
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Asp Val
Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser
130 135 140
Ala Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro
195 200 205
His Thr Phe
Gly Gln Gly Thr Lys Leu Asp Ile Lys Arg
210 215 220
<210> 568
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 568
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 569
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头区段, E7-SL-B6 DVD
<400> 569
Gly Gly Ser
Gly Gly
1 5
<210> 570
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6的VL区
<400> 570
Asp Val Val
Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Asp Ile Lys Arg
100 105
<210> 571
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-B6 DVD
<400> 571
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 572
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-B6 DVD
<400> 572
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser
130 135 140
Leu Lys Ile
Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr Gly
145 150 155 160
Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Glu Pro
Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His Phe
225 230 235 240
Asp Tyr Trp
Gly Gln Gly Thr Pro Val Thr Val Ser Ser
245 250
<210> 573
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 573
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 574
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-B6 DVD
<400> 574
Ala Ser Thr
Lys Gly Pro
1 5
<210> 575
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6的VH区
<400> 575
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser
115 120 125
<210> 576
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-B6 DVD
<400> 576
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 577
<211> 252
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-G9 DVD
<400> 577
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
130 135 140
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
145 150 155 160
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
165 170 175
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
180 185 190
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
195 200 205
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
210 215 220
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
225 230 235 240
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 578
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 578
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115
120
<210> 579
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-G9 DVD
<400> 579
Gly Gly Gly
Gly Ser Gly
1 5
<210> 580
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9的VH区
<400> 580
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 581
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-G9 DVD
<400> 581
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 582
<211> 329
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-G9 DVD
<400> 582
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser
130 135 140
His Ser Val
Asn Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Gly Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Val Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu
225 230 235 240
Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
245 250 255
Tyr Pro Gly
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val
260 265 270
Lys Ala Gly
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys
275 280 285
Tyr Ala Ala
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
290 295 300
His Arg Ser
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
305 310 315 320
Lys Thr Val
Ala Pro Thr Glu Cys Ser
325
<210> 583
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 583
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 584
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-G9 DVD
<400> 584
Gly Gly Ser
Gly Gly
1 5
<210> 585
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9的VL区
<400> 585
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 586
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SG6-G9 DVD
<400> 586
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 587
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-G9 DVD
<400> 587
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser
130 135 140
His Ser Val
Asn Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Gly Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Val Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 588
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 588
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 589
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-G9 DVD
<400> 589
Thr Val Ala
Ala Pro
1 5
<210> 590
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9的VL区
<400> 590
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser His
20 25 30
Ser Val Asn
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Gly
Ile Gly Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Val Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 591
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-G9 DVD
<400> 591
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 592
<211> 251
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-G9 DVD
<400> 592
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu
115 120 125
Val Gln Leu
Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
130 135 140
Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly
145 150 155 160
Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
165 170 175
Val Ile Ser
Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys
180 185 190
Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
195 200 205
Glu Met Asn
Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Lys Val Gly
Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp Val
225 230 235 240
Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 593
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 593
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 594
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-G9 DVD
<400> 594
Ala Ser Thr
Lys Gly Pro
1 5
<210> 595
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9的VH区
<400> 595
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 596
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-G9 DVD
<400> 596
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 597
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-G9-1
<400> 597
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg
130 135 140
His Pro Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Tyr Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg
195 200 205
Leu Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 598
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 598
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 599
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-G9-1 DVD
<400> 599
Gly Gly Ser
Gly Gly
1 5
<210> 600
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-1的VL区
<400> 600
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 601
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-G9-1 DVD
<400> 601
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 602
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-G9-1 DVD
<400> 602
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg
130 135 140
His Pro Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Tyr Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg
195 200 205
Leu Val Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 603
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 603
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 604
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-G9-1 DVD
<400> 604
Thr Val Ala
Ala Pro
1 5
<210> 605
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-1的VL区
<400> 605
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser His Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Gly Gly Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu
85 90 95
Val Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 606
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-G9-1 DVD
<400> 606
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 607
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-G9-4 DVD
<400> 607
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg
130 135 140
His Tyr Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Tyr Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 608
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 608
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 609
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-G9-4 DVD
<400> 609
Gly Gly Ser
Gly Gly
1 5
<210> 610
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-4的VL区
<400> 610
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 611
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-G9-4 DVD
<400> 611
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 612
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-G9-4 DVD
<400> 612
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg
130 135 140
His Tyr Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Met Tyr
Tyr Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 613
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 613
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 614
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-G9-4 DVD
<400> 614
Thr Val Ala
Ala Pro
1 5
<210> 615
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-4的VH区
<400> 615
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Arg Gln Ser Asn Ile Gly Arg His
20 25 30
Tyr Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Met Tyr Tyr
Asp Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 616
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-G9-4 DVD
<400> 616
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 617
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-G9-M2 DVD
<400> 617
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr
130 135 140
His Tyr Val
His Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Ile Tyr
Gly Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 618
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 618
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 619
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-G9-M2 DVD
<400> 619
Gly Gly Ser
Gly Gly
1 5
<210> 620
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M2的VL区
<400> 620
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 621
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-G9-M2 DVD
<400> 621
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 622
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-G9-M2 DVD
<400> 622
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr
130 135 140
His Tyr Val
His Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Ile Tyr
Gly Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 623
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 623
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 624
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-G9-M2 DVD
<400> 624
Thr Val Ala
Ala Pro
1 5
<210> 625
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-M2的VL区
<400> 625
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly His Asn Ser Asn Ile Gly Tyr His
20 25 30
Tyr Val His
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly
Asp Gly Trp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Trp Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 626
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-G9-M2 DVD
<400> 626
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 627
<211> 255
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-G9-2 DVD
<400> 627
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln
130 135 140
Pro Gly Arg
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe
145 150 155 160
Arg Asn Tyr
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
165 170 175
Glu Trp Val
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala
180 185 190
Asp Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
195 200 205
Thr Leu Tyr
Leu Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Lys Val Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr
225 230 235 240
Gly Leu Asp
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250 255
<210> 628
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 628
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 629
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-G9-2 DVD
<400> 629
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 630
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VH区
<400> 630
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 631
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-G9-2 DVD
<400> 631
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 632
<211> 229
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-G9-2 DVD
<400> 632
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala
115 120 125
Ser Gly Thr
Pro Gly Gln Thr Val Ser Ile Ser Cys Ser Gly Ser Asn
130 135 140
Ser Asn Ile
Gly Arg His Pro Val Asp Trp Tyr Gln Gln Val Pro Gly
145 150 155 160
Ala Ala Pro
Lys Leu Leu Ile Tyr Tyr Asp Asp Gln Arg Pro Ser Gly
165 170 175
Val Pro Asp
Arg Phe Ser Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu
180 185 190
Ala Ile Ser
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala
195 200 205
Thr Trp Asp
Asp Ser Leu Gly Gly Tyr Val Phe Gly Ser Gly Thr Lys
210 215 220
Val Thr Val
Leu Gly
225
<210> 633
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 633
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 634
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-G9-2 DVD
<400> 634
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 635
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VL区
<400> 635
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 636
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-G9-2 DVD
<400> 636
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 637
<211> 251
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-G9-2 DVD
<400> 637
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Val Gln Leu
Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
130 135 140
Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr Gly
145 150 155 160
Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
165 170 175
Val Ile Ser
Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys
180 185 190
Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
195 200 205
Glu Met Asn
Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Lys Val Gly
Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp Val
225 230 235 240
Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 638
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 638
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 639
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-G9-2 DVD
<400> 639
Gly Gly Gly
Gly Ser Gly
1 5
<210> 640
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VH区
<400> 640
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 641
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-G9-2 DVD
<400> 641
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 642
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-G9-2 DVD
<400> 642
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg
130 135 140
His Pro Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Ile Tyr
Tyr Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 643
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 643
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 644
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-G9-2 DVD
<400> 644
Gly Gly Ser
Gly Gly
1 5
<210> 645
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VL区
<400> 645
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 646
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-G9-2 DVD
<400> 646
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 647
<211> 259
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS14-G9-2 DVD
<400> 647
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Gly Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly
130 135 140
Gly Val Val
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser
145 150 155 160
Gly Phe Ile
Phe Arg Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro
165 170 175
Gly Lys Gly
Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn
180 185 190
Lys Tyr Tyr
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
195 200 205
Asn Ser Lys
Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Arg Pro Glu
210 215 220
Asp Thr Ala
Val Tyr Tyr Cys Ala Lys Val Gly Ala Ser Gly Asp Tyr
225 230 235 240
Tyr Tyr Ser
Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr
245 250 255
Val Ser Ser
<210> 648
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 648
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 649
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS14-G9-2 DVD
<400> 649
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10
<210> 650
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VH区
<400> 650
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 651
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS14-G9-2 DVD
<400> 651
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser Gly
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 652
<211> 232
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS14-G9-2 DVD
<400> 652
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro
115 120 125
Pro Ser Ala
Ser Gly Thr Pro Gly Gln Thr Val Ser Ile Ser Cys Ser
130 135 140
Gly Ser Asn
Ser Asn Ile Gly Arg His Pro Val Asp Trp Tyr Gln Gln
145 150 155 160
Val Pro Gly
Ala Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Gln Arg
165 170 175
Pro Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser Gln Ser Gly Thr Ser
180 185 190
Ala Ser Leu
Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr
195 200 205
Tyr Cys Ala
Thr Trp Asp Asp Ser Leu Gly Gly Tyr Val Phe Gly Ser
210 215 220
Gly Thr Lys
Val Thr Val Leu Gly
225 230
<210> 653
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 653
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 654
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS14-G9-2 DVD
<400> 654
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 655
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VL区
<400> 655
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 656
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS14-G9-2 DVD
<400> 656
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 657
<211> 251
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-G9-2 DVD
<400> 657
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu
115 120 125
Val Gln Leu
Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
130 135 140
Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr Gly
145 150 155 160
Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
165 170 175
Val Ile Ser
Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys
180 185 190
Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
195 200 205
Glu Met Asn
Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Lys Val Gly
Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp Val
225 230 235 240
Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 658
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 658
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 659
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-G9-2 DVD
<400> 659
Ala Ser Thr
Lys Gly Pro
1 5
<210> 660
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VH区
<400> 660
Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr
20 25 30
Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met
Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Gly Ala Ser Gly Asp Tyr Tyr Tyr Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 661
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-G9-2 DVD
<400> 661
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 662
<211> 224
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-G9-2 DVD
<400> 662
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ser
Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly
115 120 125
Gln Thr Val
Ser Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg
130 135 140
His Pro Val
Asp Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu
145 150 155 160
Leu Ile Tyr
Tyr Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
165 170 175
Ser Gly Ser
Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
180 185 190
Gln Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser
195 200 205
Leu Gly Gly
Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
210 215 220
<210> 663
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 663
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 664
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-G9-2 DVD
<400> 664
Thr Val Ala
Ala Pro
1 5
<210> 665
<211> 111
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体G9-2的VL区
<400> 665
Gln Ser Val
Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Ser
Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Arg His
20 25 30
Pro Val Asp
Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gln
Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Gly Gly Tyr
Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly
100 105 110
<210> 666
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-G9-2 DVD
<400> 666
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 667
<211> 257
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-B6-17 DVD
<400> 667
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
130 135 140
Pro Gly Ser
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe
145 150 155 160
Gly Gly Tyr
Gly Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
165 170 175
Glu Trp Met
Gly Gly Ile Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala
180 185 190
Gln Lys Phe
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Arg Asp Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser
225 230 235 240
Thr His Asp
Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser
245 250 255
Ser
<210> 668
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 668
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 669
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-B6-17 DVD
<400> 669
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 670
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VH区
<400> 670
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 671
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-B6-17 DVD
<400> 671
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 672
<211> 226
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-B6-17 DVD
<400> 672
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Asp Phe
115 120 125
Gln Ser Val
Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser
130 135 140
Gln Asp Ile
Gly Ser Glu Leu His Trp Tyr Gln Gln Lys Pro Asp Gln
145 150 155 160
Pro Pro Lys
Leu Leu Ile Lys Tyr Ala Ser His Ser Thr Ser Gly Val
165 170 175
Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
180 185 190
Ile Asn Gly
Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr Cys His Gln
195 200 205
Thr Asp Ser
Leu Pro Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
210 215 220
Lys Arg
225
<210> 673
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 673
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 674
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-B6-17 DVD
<400> 674
Gly Gly Ser Gly
Gly Gly Gly Ser Gly Ser
1 5 10
<210> 675
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VL区
<400> 675
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 676
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-B6-17 DVD
<400> 676
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 677
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-B6-17 DVD
<400> 677
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val
Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr Gly
145 150 155 160
Ile Gly Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Asp Pro
Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp Phe
225 230 235 240
Asp Ser Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 678
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 678
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 679
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-B6-17 DVD
<400> 679
Gly Gly Gly
Gly Ser Gly
1 5
<210> 680
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VH区
<400> 680
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 681
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SG6-B6-17 DVD
<400> 681
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 682
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-B6-17 DVD
<400> 682
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser
130 135 140
Glu Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro
195 200 205
Tyr Thr Phe
Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 683
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 683
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 684
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SG6-B6-17 DVD
<400> 684
Gly Gly Ser
Gly Gly
1 5
<210> 685
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VL区
<400> 685
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 686
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-B6-17 DVD
<400> 686
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 687
<211> 261
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS14-B6-17 DVD
<400> 687
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala
130 135 140
Glu Val Lys
Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser
145 150 155 160
Gly Gly Ser
Phe Gly Gly Tyr Gly Ile Gly Trp Val Arg Gln Ala Pro
165 170 175
Gly Gln Gly
Leu Glu Trp Met Gly Gly Ile Thr Pro Phe Phe Gly Phe
180 185 190
Ala Asp Tyr
Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp
195 200 205
Glu Ser Thr
Thr Thr Ala Tyr Met Glu Leu Ser Gly Leu Thr Ser Asp
210 215 220
Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Asp Pro Asn Glu Phe Trp Asn
225 230 235 240
Gly Tyr Tyr
Ser Thr His Asp Phe Asp Ser Trp Gly Gln Gly Thr Thr
245 250 255
Val Thr Val
Ser Ser
260
<210> 688
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 688
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 689
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS14-B6-17 DVD
<400> 689
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10
<210> 690
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VH区
<400> 690
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 691
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS14-B6-17 DVD
<400> 691
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195
200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 692
<211> 229
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS14-B6-17 DVD
<400> 692
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser
115 120 125
Pro Asp Phe
Gln Ser Val Thr Pro Lys Glu Lys Val Thr Ile Thr Cys
130
135 140
Arg Ala Ser
Gln Asp Ile Gly Ser Glu Leu His Trp Tyr Gln Gln Lys
145 150 155 160
Pro Asp Gln
Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser His Ser Thr
165 170 175
Ser Gly Val
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
180 185 190
Thr Leu Thr
Ile Asn Gly Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr
195 200 205
Cys His Gln
Thr Asp Ser Leu Pro Tyr Thr Phe Gly Pro Gly Thr Lys
210 215 220
Val Asp Ile
Lys Arg
225
<210> 693
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 693
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 694
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS14-B6-17 DVD
<400> 694
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 695
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VL区
<400> 695
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 696
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS14-B6-17 DVD
<400> 696
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 697
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-B6-17 DVD
<400> 697
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val
Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr Gly
145 150 155 160
Ile Gly Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Asp Pro
Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp Phe
225 230 235 240
Asp Ser Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 698
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 698
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 699
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, D2-SL-B6-17 DVD
<400> 699
Ala Ser Thr
Lys Gly Pro
1 5
<210> 700
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VH区
<400> 700
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 701
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-B6-17 DVD
<400> 701
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 702
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-B6-17 DVD
<400> 702
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser
130 135 140
Glu Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro
195 200 205
Tyr Thr Phe
Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 703
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 703
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 704
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-B6-17 DVD
<400> 704
Thr Val Ala
Ala Pro
1 5
<210> 705
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VL区
<400> 705
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 706
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-B6-17 DVD
<400> 706
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 707
<211> 260
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-LL-B6-17 DVD
<400> 707
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
115 120 125
Val Phe Pro
Leu Ala Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu
130 135 140
Val Lys Lys
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly
145 150 155 160
Gly Ser Phe
Gly Gly Tyr Gly Ile Gly Trp Val Arg Gln Ala Pro Gly
165 170 175
Gln Gly Leu
Glu Trp Met Gly Gly Ile Thr Pro Phe Phe Gly Phe Ala
180 185 190
Asp Tyr Ala
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu
195 200 205
Ser Thr Thr
Thr Ala Tyr Met Glu Leu Ser Gly Leu Thr Ser Asp Asp
210 215 220
Thr Ala Val
Tyr Tyr Cys Ala Arg Asp Pro Asn Glu Phe Trp Asn Gly
225 230 235 240
Tyr Tyr Ser
Thr His Asp Phe Asp Ser Trp Gly Gln Gly Thr Thr Val
245 250 255
Thr Val Ser
Ser
260
<210> 708
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 708
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 709
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-LL-B6-17 DVD
<400> 709
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
1 5 10
<210> 710
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VH区
<400> 710
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Gly Gly Tyr
20 25 30
Gly Ile Gly
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ser Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 711
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-LL-B6-17 DVD
<400> 711
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 712
<211> 228
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-LL-B6-17 DVD
<400> 712
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Val
Phe Ile Phe Pro Pro Glu Ile Val Leu Thr Gln Ser Pro
115 120 125
Asp Phe Gln
Ser Val Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg
130 135 140
Ala Ser Gln
Asp Ile Gly Ser Glu Leu His Trp Tyr Gln Gln Lys Pro
145 150 155 160
Asp Gln Pro
Pro Lys Leu Leu Ile Lys Tyr Ala Ser His Ser Thr Ser
165 170 175
Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
180 185 190
Leu Thr Ile
Asn Gly Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr Cys
195
200 205
His Gln Thr
Asp Ser Leu Pro Tyr Thr Phe Gly Pro Gly Thr Lys Val
210 215 220
Asp Ile Lys
Arg
225
<210> 713
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 713
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 714
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-LL-B6-17 DVD
<400> 714
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro
1 5 10
<210> 715
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-17的VL区
<400> 715
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Pro Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Ser Leu Pro Tyr
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 716
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-LL-B6-17 DVD
<400> 716
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 717
<211> 257
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-B6-5 DVD
<400> 717
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
130 135 140
Pro Gly Glu
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe
145 150 155 160
Arg Ser Tyr
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
165 170 175
Glu Trp Met
Gly Gly Ile Thr His Phe Phe Gly Ile Thr Asp Tyr Ala
180 185 190
Gln Lys Phe
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Arg Glu Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp
225 230 235 240
Thr His Asp
Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser
245 250 255
Ser
<210> 718
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 718
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 719
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-B6-5 DVD
<400> 719
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 720
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-5的VH区
<400> 720
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 721
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-B6-5 DVD
<400> 721
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys Asn
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 722
<211> 226
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-B6-5 DVD
<400> 722
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Asp Phe
115 120 125
Gln Ser Val
Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser
130 135 140
Gln Asn Ile
Gly Ser Glu Leu His Trp Tyr Gln Gln Lys Pro Asp Gln
145 150 155 160
Ser Pro Lys
Leu Leu Ile Lys Tyr Ala Ser His Ser Ile Ser Gly Val
165 170 175
Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
180 185 190
Ile Asn Gly
Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln
195 200 205
Ser Asp Thr
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
210 215 220
Lys Arg
225
<210> 723
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 723
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 724
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-B6-5 DVD
<400> 724
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 725
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-5的VL区
<400> 725
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp Tyr
Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Thr Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 726
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-B6-5 DVD
<400> 726
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 727
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-B6-5 DVD
<400> 727
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser
130 135 140
Val Lys Ile
Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr Gly
145 150 155 160
Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
His Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Glu Pro
Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp Phe
225 230 235 240
Asp Ser Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 728
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 728
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 729
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-B6-5 DVD
<400> 729
Gly Gly Gly
Gly Ser Gly
1 5
<210> 730
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-5的VH区
<400> 730
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ile Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Asp Thr His Asp
100 105 110
Phe Asp Ser
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 731
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-B6-5 DVD
<400> 731
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 732
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-B6-5 DVD
<400> 732
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser
130 135 140
Glu Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Ala Thr Tyr Tyr Cys His Gln Ser Asp Thr Leu Pro
195 200 205
His Thr Phe
Gly Gln Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 733
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 733
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 734
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-B6-5 DVD
<400> 734
Thr Val Ala
Ala Pro
1 5
<210> 735
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-5的VL区
<400> 735
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Ser Asp Thr Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 736
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-B6-5 DVD
<400> 736
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 737
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-B6-15 DVD
<400> 737
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser
130 135 140
Leu Lys Ile
Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr Gly
145 150 155 160
Thr Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Asp Pro
Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp Phe
225 230 235 240
Asp Tyr Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 738
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 738
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 739
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-B6-15 DVD
<400> 739
Ala Ser Thr
Lys Gly Pro
1 5
<210> 740
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-15的VH区
<400> 740
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Gly Thr Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr His Phe Phe Gly Ala Val Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Ala Thr His Asp
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 741
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-B6-15 DVD
<400> 741
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 742
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-B6-15 DVD
<400> 742
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ala
130 135 140
Glu Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Thr Asp Arg Leu Pro
195 200 205
Tyr Ser Phe
Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 743
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 743
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 744
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, D2-GS6-B6-15 DVD
<400> 744
Gly Gly Ser
Gly Gly
1 5
<210> 745
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-15的VL区
<400> 745
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ala Glu
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Thr Asp Arg Leu Pro Tyr
85 90 95
Ser Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 746
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-B6-15 DVD
<400> 746
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 747
<211> 250
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-h5C5Vh1
DVD
<400> 747
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115
120 125
Gly Gly Ser
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
130 135 140
Pro Gly Ala
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145 150 155 160
Thr Asp Tyr
Glu Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
165 170 175
Glu Trp Met
Gly Val Ile His Pro Gly Asn Gly Gly Thr Ala Tyr Asn
180 185 190
Gln Asn Phe
Arg Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Arg Phe Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp
225 230 235 240
Gly Gln Gly
Thr Leu Val Thr Val Ser Ser
245 250
<210> 748
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 748
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 749
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-h5C5Vh1 DVD
<400> 749
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 750
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h5C5Vh1的VH区
<400> 750
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 751
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-h5C5Vh1 DVD
<400> 751
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 752
<211> 226
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-h5C5Vk3a
<400> 752
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr
115 120 125
Leu Ser Val
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser
130 135 140
Gln Ser Val
Ser Ile Asp Val Gly Trp Phe Gln Gln Lys Pro Gly Gln
145 150 155 160
Ser Pro Arg
Leu Leu Ile Tyr His Ala Ser Asn Arg Tyr Thr Gly Val
165 170 175
Pro Ala Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
180 185 190
Ile Ser Ser
Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln
195 200 205
Asp Tyr Ser
Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
210 215 220
Lys Arg
225
<210> 753
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 753
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 754
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-h5C5Vk3a DVD
<400> 754
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 755
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体H5C5
Vk3a的VL区
<400> 755
Glu Ile Val Met
Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 756
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-h5C5Vk3a DVD
<400> 756
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 757
<211> 250
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-6C6
DVD
<400> 757
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115
120 125
Gly Gly Ser
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
130 135 140
Pro Gly Ala
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145 150 155 160
Ser Asp Tyr
Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu
165 170 175
Ala Trp Ile
Gly Val Ile His Pro Gly Asn Gly Gly Thr Ala Tyr Asn
180 185 190
Gln Lys Phe
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
210 215 220
Tyr Tyr Cys
Glu Arg Phe Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp
225 230 235 240
Gly Gln Gly
Thr Thr Leu Thr Val Ser Ser
245 250
<210> 758
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 758
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 759
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-6C6 DVD
<400> 759
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 760
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体6C6的VH区
<400> 760
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Ile His
Trp Val Lys Gln Thr Pro Val His Gly Leu Ala Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu
Thr Val Ser Ser
115
<210> 761
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-6C6 DVD
<400> 761
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 762
<211> 252
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-h10F7Vh1a DVD
<400> 762
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
130 135 140
Pro Gly Ser
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145 150 155 160
Thr Asp Tyr
Glu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
165 170 175
Glu Trp Met
Gly Val Asn Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn
180 185 190
Gln Lys Phe
Asp Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Arg Tyr Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp
225 230 235 240
Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 763
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 763
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115
120
<210> 764
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-h10F7Vh1a DVD
<400> 764
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 765
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h10F7Vh1a的VH区
<400> 765
Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Asp Gly Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Thr Val Thr Val Ser Ser
115 120
<210> 766
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-h10F7Vh1a DVD
<400> 766
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 767
<211> 225
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-h10F7Vk1a DVD
<400> 767
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly Ser
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
115 120 125
Leu Ser Ala
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser
130 135 140
Ser Ser Ile
Ser Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ser
145 150 155 160
Pro Lys Arg
Trp Ile Tyr Ala Thr Phe Glu Leu Ala Ser Gly Val Pro
165 170 175
Ser Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
180 185 190
Ser Ser Leu
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg
195 200 205
Ser Ser Tyr
Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
210 215 220
Arg
225
<210> 768
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 768
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 769
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-h10F7Vk1a DVD
<400> 769
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 770
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h10F7Vk1a的VH区
<400> 770
Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe
Gln Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gln
Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 771
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-h10F7Vk1a
<400> 771
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 772
<211> 246
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-h5C5Vh1 DVD
<400> 772
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115
120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
130 135 140
Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu
145 150 155 160
Phe His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Val Ile His
Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe Arg
180 185 190
Asp Arg Val
Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Phe Leu
Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Leu Val Thr
Val Ser Ser
245
<210> 773
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 773
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 774
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-h5C5Vh1 DVD
<400> 774
Gly Gly Gly
Gly Ser Gly
1 5
<210> 775
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h5C5Vh1的VH区
<400> 775
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 776
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-h5C5Vh1 DVD
<400> 776
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 777
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-h5C5Vk1a DVD
<400> 777
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Asp Ile
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
115 120 125
Gly Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile
130 135 140
Asp Val Gly
Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu
145 150 155 160
Ile Tyr His
Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly
Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln
180 185 190
Pro Glu Asp
Phe Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro
195 200 205
Tyr Thr Phe
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
210 215 220
<210> 778
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 778
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 779
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-h5C5Vk1a DVD
<400> 779
Thr Val Ala
Ala Pro
1 5
<210> 780
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h5C5-Vk1a的VL区
<400> 780
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 781
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-h5C5Vk1a DVD
<400> 781
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 782
<211> 246
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-h5C5Vh1b
DVD
<400> 782
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115
120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
130 135 140
Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu
145 150 155 160
Phe His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
165 170 175
Val Ile His
Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe Arg
180 185 190
Asp Arg Ala
Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Arg Phe Leu
Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Leu Val Thr
Val Ser Ser
245
<210> 783
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 783
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 784
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, D2-GS6-h5C5Vh1b DVD
<400> 784
Gly Gly Gly
Gly Ser Gly
1 5
<210> 785
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h5C5Vh1b的VH区
<400> 785
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 786
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-h5C5Vh1b DVD
<400> 786
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 787
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-h5C5Vk3a DVD
<400> 787
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Glu Ile
Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro
115 120 125
Gly Glu Arg
Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile
130 135 140
Asp Val Gly
Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu
145 150 155 160
Ile Tyr His
Ala Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser
165 170 175
Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
180 185 190
Pro Glu Asp
Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro
195 200 205
Tyr Thr Phe
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
210 215 220
<210> 788
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 788
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 789
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-h5C5Vk3a DVD
<400> 789
Thr Val Ala
Ala Pro
1 5
<210> 790
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体h5C5Vk3a的VL区
<400> 790
Glu Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 791
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-h5C5Vk3a DVD
<400> 791
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 792
<211> 248
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-10F7 DVD
<400> 792
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gln
115 120 125
Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser
130 135 140
Val Thr Leu
Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr Glu
145 150 155 160
Ile His Trp
Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly
165 170 175
Val Asn Asp
Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe Asp
180 185 190
Gly Lys Ala
Glu Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met
195 200 205
Glu Leu Arg
Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys Thr
210 215 220
Arg Tyr Tyr
Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly Gln
225 230 235 240
Gly Thr Ser
Ile Thr Val Ser Ser
245
<210> 793
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 793
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr
Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 794
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-10F7 DVD
<400> 794
Gly Gly Gly
Gly Ser Gly
1 5
<210> 795
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体10F7的VH区
<400> 795
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Thr
Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr
20 25 30
Glu Ile His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Asn
Asp Pro Glu Ser Gly Gly Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Asp Gly Lys
Ala Glu Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys
85 90 95
Thr Arg Tyr
Tyr Arg Tyr Glu Ser Phe Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Ser Ile Thr Val Ser Ser
115 120
<210> 796
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-10F7 DVD
<400> 796
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 797
<211> 220
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-10F7 DVD
<400> 797
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Gln Ile
Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro
115 120 125
Gly Glu Lys
Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr
130 135 140
Ile Tyr Trp
Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile
145 150 155 160
Tyr Ala Thr
Phe Glu Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly
165 170 175
Ser Gly Ser
Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala
180 185 190
Glu Asp Ala
Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp
195 200 205
Thr Phe Gly
Gly Gly Ser Lys Leu Glu Ile Lys Arg
210 215 220
<210> 798
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 798
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 799
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-10F7 DVD
<400> 799
Thr Val Ala
Ala Pro
1 5
<210> 800
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体10F7的VL区
<400> 800
Gln Ile Val
Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val
Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile
20 25 30
Tyr Trp Phe
Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Ala Thr Phe
Glu Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly
Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly
Gly Ser Lys Leu Glu Ile Lys Arg
100 105
<210> 801
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-10F7 DVD
<400> 801
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 802
<211> 246
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-5C5 DVD
<400> 802
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gln
115 120 125
Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser
130 135 140
Val Lys Leu
Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr Glu
145 150 155 160
Phe His Trp
Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly
165 170 175
Val Ile His
Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe Arg
180 185 190
Asp Lys Ala
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys Thr
210 215 220
Arg Phe Leu
Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Ala Leu Thr
Val Ser Ser
245
<210> 803
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 803
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 804
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-5C5 DVD
<400> 804
Gly Gly Gly
Gly Ser Gly
1 5
<210> 805
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体5C5的VH区
<400> 805
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys
85 90 95
Thr Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ala Leu
Thr Val Ser Ser
115
<210> 806
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-5C5 DVD
<400> 806
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 807
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-5C5 DVD
<400> 807
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Asn Ile
Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Pro
115 120 125
Gly Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile
130 135 140
Asp Val Gly
Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Tyr His
Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr
165 170 175
Gly Ser Gly
Tyr Gly Thr Asp Phe Thr Phe Thr Val Asn Thr Val Gln
180 185 190
Ala Glu Asp
Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro
195 200 205
Tyr Thr Phe
Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg
210 215 220
<210> 808
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 808
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 809
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-5C5 DVD
<400> 809
Thr Val Ala
Ala Pro
1 5
<210> 810
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体5C5的VL区
<400> 810
Asn Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Pro Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Val Asn Thr Val Gln Ala
65 70 75 80
Glu Asp Leu
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Leu Glu Leu Lys Arg
100 105
<210> 811
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-5C5 DVD
<400> 811
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 812
<211> 246
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-1D8 DVD
<400> 812
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gln
115 120 125
Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser
130 135 140
Val Lys Leu
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu
145 150 155 160
Met His Trp
Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly
165 170 175
Val Ile His
Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe Arg
180 185 190
Asp Lys Ala
Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ile
210 215 220
Arg Phe Leu
Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr
Val Ser Ser
245
<210> 813
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 813
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 814
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-1D8
DVD
<400> 814
Gly Gly Gly
Gly Ser Gly
1 5
<210> 815
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体1DH的VH区
<400> 815
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Met His
Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Arg Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ile Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu
Thr Val Ser Ser
115
<210> 816
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-1D8 DVD
<400> 816
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 817
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-1D8 DVD
<400> 817
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Ile
Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala
115 120 125
Gly Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn
130 135 140
Asp Val Ala
Trp Phe Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Asn Tyr
Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr
165 170 175
Gly Ser Gly
Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln
180 185 190
Ser Glu Asp
Leu Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro
195 200 205
Tyr Thr Phe
Gly Gly Gly Thr Thr Leu Glu Ile Lys Arg
210 215 220
<210> 818
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 818
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 819
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-1D8 DVD
<400> 819
Thr Val Ala
Ala Pro
1 5
<210> 820
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体1D8的VL区
<400> 820
Ser Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp
20 25 30
Val Ala Trp
Phe Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Asn Tyr Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ser
65 70 75 80
Glu Asp Leu
Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Thr Leu Glu Ile Lys Arg
100 105
<210> 821
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-1D8 DVD
<400> 821
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 822
<211> 246
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-6C6 DVD
<400> 822
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gln
115 120 125
Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser
130 135 140
Val Lys Leu
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu
145 150 155 160
Ile His Trp
Val Lys Gln Thr Pro Val His Gly Leu Ala Trp Ile Gly
165 170 175
Val Ile His
Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Asp Lys Ala
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Glu
210 215 220
Arg Phe Leu
Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr
Val Ser Ser
245
<210> 823
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 823
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 824
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-6C6 DVD
<400> 824
Gly Gly Gly
Gly Ser Gly
1 5
<210> 825
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体6C6的VH区
<400> 825
Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Ile His
Trp Val Lys Gln Thr Pro Val His Gly Leu Ala Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu
Thr Val Ser Ser
115
<210> 826
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-6C6 DVD
<400> 826
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 827
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-6C6 DVD
<400> 827
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Ile
Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala
115 120 125
Gly Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn
130 135 140
Asp Val Ala
Trp Tyr Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Asn Tyr
Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr
165 170 175
Gly Ser Gly
Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln
180 185 190
Ala Glu Asp
Leu Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro
195 200 205
Tyr Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
210 215 220
<210> 828
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 828
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 829
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-6C6 DVD
<400> 829
Thr Val Ala
Ala Pro
1 5
<210> 830
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体6C6的VH区
<400> 830
Ser Ile Val
Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp
20 25 30
Val Ala Trp
Tyr Gln His Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Asn Tyr Ala
Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu
Ala Ile Tyr Phe Cys Gln Gln Asp Tyr Gly Ser Pro Tyr
85 90 95
Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 831
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-6C6 DVD
<400> 831
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 832
<211> 247
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-8B12 DVD
<400> 832
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gln
115 120 125
Val Gln Leu
Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
130 135 140
Leu Ser Ile
Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr Gly
145 150 155 160
Val His Trp
Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Val
165 170 175
Val Ile Trp
Ser Asp Gly Thr Thr Thr Tyr Asn Ser Ala Leu Lys Ser
180 185 190
Arg Leu Ser
Ile Thr Arg Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
195 200 205
Met Asn Ser
Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg
210 215 220
Asp Ser Thr
Trp Asp Tyr Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly
225 230 235 240
Thr Pro Val
Thr Val Ser Ser
245
<210> 833
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 833
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 834
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-8B12 DVD
<400> 834
Gly Gly Gly
Gly Ser Gly
1 5
<210> 835
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体8B12的VH区
<400> 835
Gln Val Gln
Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser
Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Gly Val His
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Val Val Ile
Trp Ser Asp Gly Thr Thr Thr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu
Ser Ile Thr Arg Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Asp Ser
Thr Trp Asp Tyr Tyr Tyr Thr Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Pro
Val Thr Val Ser Ser
115 120
<210> 836
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-8B12 DVD
<400> 836
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 837
<211> 225
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-SL-8B12 DVD
<400> 837
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Asp Val
Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
115 120 125
Gly Asp Gln
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His
130 135 140
Ser Asn Gly
Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln
145 150 155 160
Ser Pro Lys
Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val
165 170 175
Pro Asp Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
180 185 190
Ile Ser Arg
Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln
195 200 205
Ser Thr His
Val Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
210 215 220
Arg
225
<210> 838
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 838
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 839
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-SL-8B12 DVD
<400> 839
Thr Val Ala
Ala Pro
1 5
<210> 840
<211> 112
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体8B12的VL区
<400> 840
Asp Val Val
Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala
Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn
Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu
Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val
Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105 110
<210> 841
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-SL-8B12 DVD
<400> 841
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 842
<211> 257
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS10-B6-11 DVD
<400> 842
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
130 135 140
Pro Gly Ser
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe
145 150 155 160
Leu Ser Tyr
Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
165 170 175
Glu Trp Met
Gly Gly Ile Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala
180 185 190
Gln Lys Phe
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr
195 200 205
Thr Ala Tyr
Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val
210 215 220
Tyr Tyr Cys
Ala Arg Glu Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr
225 230 235 240
Thr His His
Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
245 250 255
Ser
<210> 843
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 843
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 844
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS10-B6-11
DVD
<400> 844
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 845
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-11的VH区
<400> 845
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 846
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS10-B6-11 DVD
<400> 846
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 847
<211> 226
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS10-B6.1 DVD
<400> 847
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Gly Gly
Ser Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Asp Phe
115 120 125
Gln Ser Val
Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser
130 135 140
Gln Asn Ile
Gly Ser Ala Leu His Trp Tyr Gln Gln Lys Pro Asp Gln
145 150 155 160
Ser Pro Lys
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val
165 170 175
Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
180 185 190
Ile Asn Gly
Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr Cys His Gln
195 200 205
Ser Thr Ser
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
210 215 220
Lys Arg
225
<210> 848
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 848
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 849
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS10-B6.1 DVD
<400> 849
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 850
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1的VL区
<400> 850
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 851
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS10-B6.1 DVD
<400> 851
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 852
<211> 260
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-LL-B6-11 DVD
<400> 852
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
115 120 125
Val Phe Pro
Leu Ala Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu
130 135 140
Val Lys Lys
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly
145 150 155 160
Gly Ser Phe
Leu Ser Tyr Gly Phe Ser Trp Val Arg Gln Ala Pro Gly
165 170 175
Gln Gly Leu
Glu Trp Met Gly Gly Ile Thr Pro Phe Phe Gly Phe Ala
180 185 190
Asp Tyr Ala
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu
195 200 205
Ser Thr Thr
Thr Ala Tyr Met Glu Leu Ser Gly Leu Thr Ser Asp Asp
210 215 220
Thr Ala Val
Tyr Tyr Cys Ala Arg Glu Pro Asn Asp Phe Trp Asn Gly
225 230 235 240
Tyr Tyr Thr
Thr His His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val
245 250 255
Thr Val Ser
Ser
260
<210> 853
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 853
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 854
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-LL-B6-11 DVD
<400> 854
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
1 5 10
<210> 855
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-11的VH区
<400> 855
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 856
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-LL-B6-11 DVD
<400> 856
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 857
<211> 228
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-LL-B6.1 DVD
<400> 857
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Val
Phe Ile Phe Pro Pro Glu Ile Val Leu Thr Gln Ser Pro
115 120 125
Asp Phe Gln
Ser Val Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg
130 135 140
Ala Ser Gln
Asn Ile Gly Ser Ala Leu His Trp Tyr Gln Gln Lys Pro
145 150 155 160
Asp Gln Ser
Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser
165 170 175
Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
180 185 190
Leu Thr Ile
Asn Gly Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr Cys
195
200 205
His Gln Ser
Thr Ser Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val
210 215 220
Asp Ile Lys
Arg
225
<210> 858
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 858
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 859
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-LL-B6.1 DVD
<400> 859
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro
1 5 10
<210> 860
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1的VL区
<400> 860
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 861
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-LL-B6.1 DVD
<400> 861
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 862
<211> 252
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-B6-11 DVD
<400> 862
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Thr Val Ala Ala Pro Glu Val
115 120 125
Gln Leu Val
Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val
130 135 140
Lys Val Ser
Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr Gly Phe
145 150 155 160
Ser Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly
165 170 175
Ile Thr Pro
Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe Gln Gly
180 185 190
Arg Val Thr
Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met Glu
195 200 205
Leu Ser Gly
Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg
210 215 220
Glu Pro Asn
Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His Phe Asp
225 230 235 240
Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 863
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 863
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 864
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-B6-11 DVD
<400> 864
Thr Val Ala
Ala Pro
1 5
<210> 865
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-11的VH区
<400> 865
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Leu Ser Tyr
20 25 30
Gly Phe Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Phe Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu
Pro Asn Asp Phe Trp Asn Gly Tyr Tyr Thr Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 866
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-B6-11 DVD
<400> 866
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 867
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-B6.1 DVD
<400> 867
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser
130 135 140
Ala Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro
195 200 205
His Thr Phe
Gly Gln Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 868
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 868
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 869
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-B6.1 DVD
<400> 869
Gly Gly Ser
Gly Gly
1 5
<210> 870
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6.1的VL区
<400> 870
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Thr Ser Leu Pro His
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 871
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-B6.1 DVD
<400> 871
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 872
<211> 252
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-SL-B6-16DVD
<400> 872
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Thr Val Ala Ala Pro Glu Val
115 120 125
Gln Leu Val
Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser Ser Leu
130 135 140
Lys Ile Ser
Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr Gly Ile
145 150 155 160
Ser Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly
165 170 175
Ile Thr Pro
Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe Gln Gly
180 185 190
Arg Val Thr
Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met Glu
195 200 205
Leu Ser Gly
Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg
210 215 220
Asp Pro Asn
Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His Phe Asp
225 230 235 240
Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 873
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 873
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 874
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-SL-B6-16DVD
<400> 874
Thr Val Ala
Ala Pro
1 5
<210> 875
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-16的VH区
<400> 875
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 876
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-SL-B6-16DVD
<400> 876
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 877
<211> 221
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VL区, E7-GS6-B6-16 DVD
<400> 877
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly
100 105 110
Gly Glu Ile
Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro
115 120 125
Lys Glu Lys
Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser
130 135 140
Ala Leu His
Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu
145 150 155 160
Ile Lys Tyr
Ala Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser
165 170 175
Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu
180 185 190
Ala Glu Asp
Ala Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro
195 200 205
His Thr Phe
Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
210 215 220
<210> 878
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VL区
<400> 878
Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
20 25 30
Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val
Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 879
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VL接头, E7-GS6-B6-16 DVD
<400> 879
Gly Gly Ser
Gly Gly
1 5
<210> 880
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-16的VL区
<400> 880
Glu Ile Val
Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val
Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala
20 25 30
Leu His Trp
Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Lys Tyr Ala
Ser His Ser Val Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala
65 70 75 80
Glu Asp Ala
Gly Thr Tyr Tyr Cys His Gln Ser Asp Ile Leu Pro His
85 90 95
Thr Phe Gly
Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 881
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CL区, E7-GS6-B6-16 DVD
<400> 881
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
1 5 10 15
Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
20 25 30
Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
35 40 45
Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
50 55 60
Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65 70 75 80
His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
85 90 95
Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 882
<211> 253
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的双重VH区, D2-GS6-B6-16 DVD
<400> 882
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Glu
115 120 125
Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser Ser
130 135 140
Leu Lys Ile
Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr Gly
145 150 155 160
Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Gly Ile Thr
Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe Gln
180 185 190
Gly Arg Val
Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr Met
195 200 205
Glu Leu Ser
Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
210 215 220
Arg Asp Pro
Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His Phe
225 230 235 240
Asp Tyr Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
245 250
<210> 883
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> TNF抗体D2E7的VH区
<400> 883
Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile
Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val
Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr
Leu Val Thr Val Ser Ser
115 120
<210> 884
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的VH接头, D2-GS6-B6-16DVD
<400> 884
Gly Gly Gly
Gly Ser Gly
1 5
<210> 885
<211> 126
<212> PRT
<213> 人工序列
<220>
<223> IL-17抗体B6-16的VH区
<400> 885
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Leu Lys
Ile Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Gly Tyr
20 25 30
Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile
Thr Pro Phe Phe Gly Trp Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg
Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp
Pro Asn Glu Phe Trp Asn Gly Tyr Tyr Asp Thr His His
100 105 110
Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 886
<211> 330
<212> PRT
<213> 人工序列
<220>
<223> DVD-Ig的CH区, D2-GS6-B6-16 DVD
<400> 886
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15
Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80
Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys
325 330
<210> 887
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 887
Gly Gly Gly
Gly Ser Gly
1 5
<210> 888
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 888
Gly Gly Ser
Gly Gly
1 5
<210> 889
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 889
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 890
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 890
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Ser
1 5 10
<210> 891
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 891
Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 892
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 892
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10
<210> 893
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 893
Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10 15
<210> 894
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 894
Ala Ser Thr
Lys Gly Pro
1 5
<210> 895
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 895
Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
1 5 10
<210> 896
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 896
Thr Val Ala
Ala Pro
1 5
<210> 897
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 897
Thr Val Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro
1 5 10
<210> 898
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 898
Ala Lys Thr
Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg
1 5 10 15
<210> 899
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 899
Ala Lys Thr
Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg
1 5 10 15
Val
<210> 900
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 900
Ala Lys Thr
Thr Pro Lys Leu Gly Gly
1 5
<210> 901
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 901
Ser Ala Lys
Thr Thr Pro Lys Leu Gly Gly
1 5 10
<210> 902
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 902
Ser Ala Lys
Thr Thr Pro
1 5
<210> 903
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 903
Arg Ala Asp
Ala Ala Pro
1 5
<210> 904
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 904
Arg Ala Asp
Ala Ala Pro Thr Val Ser
1 5
<210> 905
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 905
Arg Ala Asp
Ala Ala Ala Ala Gly Gly Pro Gly Ser
1 5 10
<210> 906
<211> 27
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 906
Arg Ala Asp
Ala Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10 15
Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser
20 25
<210> 907
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 907
Ser Ala Lys
Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala
1 5 10 15
Arg Val
<210> 908
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 908
Ala Asp Ala
Ala Pro
1 5
<210> 909
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 909
Ala Asp Ala
Ala Pro Thr Val Ser Ile Phe Pro Pro
1 5 10
<210> 910
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 910
Gln Pro Lys
Ala Ala Pro
1 5
<210> 911
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 911
Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
1 5 10
<210> 912
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 912
Ala Lys Thr
Thr Pro Pro
1 5
<210> 913
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 913
Ala Lys Thr
Thr Pro Pro Ser Val Thr Pro Leu Ala Pro
1 5 10
<210> 914
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 914
Ala Lys Thr
Thr Ala Pro
1 5
<210> 915
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 915
Ala Lys Thr
Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro
1 5 10
<210> 916
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 916
Gly Glu Asn
Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser
1 5 10 15
<210> 917
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 917
Gly Pro Ala
Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser
1 5 10 15
<210> 918
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 寡肽接头
<400> 918
Gly His Glu
Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser
1 5 10 15
<210> 919
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> CDR-H1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> D或S
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> E或G
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> I, M, V,或F
<400> 919
Xaa Tyr Xaa
Xaa His
1 5
<210> 920
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> CDR-H2共有序列
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> T, I,或N
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> D, H,或W
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> P,或不存在
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> E, G,或S
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> S, N,或D
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> G或T
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> L, A, T,或F
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> H或Y
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> P, Q,或S
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> K, A,或N
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> F或L
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> D, K,或R
<220>
<221> MISC_FEATURE
<222> (17)..(17)
<223> G, D,或S
<400> 920
Val Xaa Xaa
Xaa Xaa Xaa Gly Xaa Thr Xaa Xaa Asn Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 921
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> CDR-H3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Y, F,或D
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Y, L, S,或G
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> K, T, R,或Y
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Y或W
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> E, D,或I
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> S, G,或Y
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> F, Y,或T
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Y, F,或M
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> G, T,或不存在
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> M,或不存在
<400> 921
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Tyr
1 5 10
<210> 922
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> CDR-L1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> S, K,或R
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> A或S
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> S或Q
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S,或不存在
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> L,或不存在
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> V,或不存在
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> H,或不存在
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> S,或不存在
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> S, N,或不存在
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> S, V,或G
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> I, N,或S
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> S, N, T,或I
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Y或D
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> M, V, L,或I
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> C, A, H, Y,或G
<400> 922
Xaa Xaa Ser
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
<210> 923
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> CDR-L2共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> D, Y, K, A,或H
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> T, A,或V
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> S或F
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> K, N,或E
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> L或R
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> A, Y,或F
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> S或T
<400> 923
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa
1 5
<210> 924
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> CDR-L3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Q, S,或H
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> R, D, S,或G
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> S, Y,或T
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S, G,或H
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> Y, S, V,或A
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> P,或不存在
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> W, Y,或L
<400> 924
Xaa Gln Xaa
Xaa Xaa Xaa Xaa Xaa Thr
1 5
<210> 925
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> CDR-H1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> N, A, D,或S
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Y, F,或L
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> G, D,或A
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> M或I
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> H, D,或S
<400> 925
Xaa Xaa Xaa
Xaa Xaa
1 5
<210> 926
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> CDR-H2共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> V, M,或G
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> I, T, M,或F
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> S, N, T,或D
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Y或P
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> D, N,或I
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> G, S, L,或E
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> S或G
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> N, T,或E
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> K, T,或A
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Y, G, N,或V
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Y或V
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> D, P,或Q
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> S, K,或N
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> V或F
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> K, R,或Q
<400> 926
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa
1 5 10 15
Gly
<210> 927
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> CDR-H3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> V, S, E,或I
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> G, S, P,或R
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> A, E, N,或P
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> S, D,或W
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> G, E, F,或L
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> D, G,或W
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Y, I, N,或G
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Y, T, G,或A
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Y或I
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> S, G,或Y
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Y, F,或T
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> G, T,或不存在
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> L, H,或不存在
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> H,或不存在
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> F,或不存在
<220>
<221> MISC_FEATURE
<222> (17)..(17)
<223> V, N,或Y
<400> 927
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp
1 5 10 15
Xaa
<210> 928
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> CDR-L1共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> S, R,或K
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> G或A
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> S或D
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> N, K,或Q
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> S,或不存在
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> N,或不存在
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> I, L, N,或D
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> G或I
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> S, N, G,或D
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> H, R, S,或D
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> S, Y, A,或D
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> V, A, L,或M
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> N, C,或H
<400> 928
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10
<210> 929
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> CDR-L2共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> G, Q, Y,或E
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> I, D,或A
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> G, N, S,或T
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Q, K,或T
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> R, S,或L
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> P, I,或V
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Sor P
<400> 929
Xaa Xaa Xaa
Xaa Xaa Xaa Xaa
1 5
<210> 930
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> CDR-L3共有序列
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> A, Q, H,或L
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> T或Q
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> W, S,或H
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> D或T
<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> D或S
<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> S, T, L,或F
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> L, T,或P
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> G, H,或Y
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> G, S,或T
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Y,或不存在
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> V,或不存在
<400> 930
Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10
<210> 931
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体VH
<400> 931
Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Phe His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile
His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Asn Phe
50 55 60
Arg Asp Arg
Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Phe
Leu Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val
Thr Val Ser Ser
115
<210> 932
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体Vk
<400> 932
Asn Ile Val
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
50
55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 933
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 人源化的抗体Vk
<400> 933
Asn Ile Val
Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala
Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ile Asp
20 25 30
Val Gly Trp
Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile
35 40 45
Tyr His Ala
Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 105