AR075798A1 - Proteinas de union a il-17 (interleuquina 17) - Google Patents

Proteinas de union a il-17 (interleuquina 17)

Info

Publication number
AR075798A1
AR075798A1 ARP100100680A ARP100100680A AR075798A1 AR 075798 A1 AR075798 A1 AR 075798A1 AR P100100680 A ARP100100680 A AR P100100680A AR P100100680 A ARP100100680 A AR P100100680A AR 075798 A1 AR075798 A1 AR 075798A1
Authority
AR
Argentina
Prior art keywords
present
cdr
seq
proteins
interleuquina
Prior art date
Application number
ARP100100680A
Other languages
English (en)
Inventor
Chung-Ming Hsieh
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42710240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR075798(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR075798A1 publication Critical patent/AR075798A1/es

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Proteínas de union a IL-17 y/o IL-17F, su uso en composiciones y métodos para el tratamiento, prevencion, y diagnostico de enfermedades relacionadas con IL-17 y para detectar IL-17 en células, tejidos, muestras y composiciones. Reivindicacion 1: Una proteína de union que comprende un dominio de union al antígeno capaz de unir IL-17 humana, caracterizada porque dicho dominio de union al antígeno comprende al menos una CDR que comprende una secuencia de aminoácidos seleccionada del grupo formado por: CDR-H 1. X1-X2-X3-X4-X5 (SEQ ID Ns:919), en donde; X1 es D o S; X2 es Y; X3 es E o G; X4.es l, M, V, o F; X5 es H; CDR-H2. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17 (SEQ ID Ns:920), en donde; X1 es V; X2 es T, 1, o N; X3 es D, H, o W; X4 es P o no está presente; X5 es E, G, o S; X6 es S, N, o D; X7 es G; X8 es G o T, X9 es T; X10 es L, A, T, o F; X11 es H o Y; X12 es N; X13 es P, Q, o S; X14 es K, A, o N; X15 es F o L; X16 es D, K, o R; y X17 es G, D, o S; CDR-H3. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12 (SEQ ID Ns:921), en donde; X1 es Y, F, o D; X2 es Y, L, S, o G; X3 es K, T, R, o Y; X4 es Y o W; X5 es E, D, o I; X6 es S, G, o Y; X7 es F, Y, o T; X8 es Y, F, o M; X9 es G, T, o no está presente; X10 es M o no está presente; X11 es D; y X12 es Y; CDR-L1. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16 (SEQ ID Ns:922), en donde; X1 es S, K, o R; X2 es A o S; X3 es S; X4 es S o Q; X5 es S o no está presente; X6 es L o no está presente; X7 es V o no está presente; X8 es H o no está presente; X9 es S o no está presente; X10 es S, N, o no está presente; X11 es S, V, o G; X12 es I, N, o S; X13 es S, N, T, o I; X14 es Y o D; X15 es M, V, L, o I; y X16 es C, A, H, Y, o G; CDR-L2. X1-X2-X3-X4-X5-X6-X7 (SEQ ID Ns:923), en donde; X1 es D, Y, K, A, o H; X2 es T, A, o V; X3 es S o F; X4 es K, N, o E; X5 es L o R; X6 es A, Y, o F; y X7 es S o T; y CDR-L3. X1-X2-X3-X4-X5-X6-X7-X8-X9 (SEQ ID Ns:924), en donde; X1 es Q, S, o H; X2 es Q; X3 es R, D, S, o G; X4 es S, Y, o T; X5 es S, G, o H; X6 es Y, S, V, o A; X7 es P o no está presente; X8 es W, Y, o L; y X9 es T.
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