CN100345844C - 治疗肿瘤用的喹唑啉衍生物 - Google Patents

治疗肿瘤用的喹唑啉衍生物 Download PDF

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Publication number
CN100345844C
CN100345844C CNB01810830XA CN01810830A CN100345844C CN 100345844 C CN100345844 C CN 100345844C CN B01810830X A CNB01810830X A CN B01810830XA CN 01810830 A CN01810830 A CN 01810830A CN 100345844 C CN100345844 C CN 100345844C
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CN
China
Prior art keywords
group
alkyl
pyrrolidin
formula
ethoxy
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Expired - Lifetime
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CNB01810830XA
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English (en)
Chinese (zh)
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CN1434821A (zh
Inventor
L·F·A·亨尼奎恩
P·普莱
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB01810830XA 2000-06-06 2001-06-01 治疗肿瘤用的喹唑啉衍生物 Expired - Lifetime CN100345844C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP00401581.4 2000-06-06
EP00401581 2000-06-06
EP01400297.6 2001-02-07
EP01400297 2001-02-07
EP01400565.6 2001-03-05
EP01400565 2001-03-05

Publications (2)

Publication Number Publication Date
CN1434821A CN1434821A (zh) 2003-08-06
CN100345844C true CN100345844C (zh) 2007-10-31

Family

ID=27223613

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB01810830XA Expired - Lifetime CN100345844C (zh) 2000-06-06 2001-06-01 治疗肿瘤用的喹唑啉衍生物

Country Status (31)

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US (3) US7049438B2 (enExample)
EP (1) EP1292594B1 (enExample)
JP (1) JP3774438B2 (enExample)
KR (2) KR100807162B1 (enExample)
CN (1) CN100345844C (enExample)
AR (1) AR030937A1 (enExample)
AT (1) ATE275145T1 (enExample)
AU (2) AU2001260482B2 (enExample)
BG (1) BG65836B1 (enExample)
BR (1) BR0111335A (enExample)
CA (1) CA2407371C (enExample)
CO (1) CO5700751A2 (enExample)
CZ (1) CZ301987B6 (enExample)
DE (1) DE60105295T2 (enExample)
DK (1) DK1292594T3 (enExample)
EE (1) EE05481B1 (enExample)
ES (1) ES2225545T3 (enExample)
HU (1) HU229290B1 (enExample)
IL (2) IL152754A0 (enExample)
IS (1) IS2114B (enExample)
MX (1) MXPA02011765A (enExample)
MY (1) MY127369A (enExample)
NO (1) NO324838B1 (enExample)
NZ (1) NZ522204A (enExample)
PL (1) PL210852B1 (enExample)
PT (1) PT1292594E (enExample)
SI (1) SI1292594T1 (enExample)
SK (1) SK286748B6 (enExample)
TW (1) TWI288748B (enExample)
UA (1) UA73993C2 (enExample)
WO (1) WO2001094341A1 (enExample)

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EP1292594B1 (en) 2004-09-01
CZ20023961A3 (cs) 2003-03-12
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UA73993C2 (uk) 2005-10-17
JP3774438B2 (ja) 2006-05-17
KR20030007859A (ko) 2003-01-23
BR0111335A (pt) 2003-06-10
WO2001094341A9 (en) 2003-04-17
HUP0301046A2 (hu) 2003-08-28
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BG107332A (bg) 2003-07-31
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DE60105295T2 (de) 2005-09-15
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AU2001260482B2 (en) 2005-06-09
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