CH657786A5 - Verfahren zum einkapseln eines kernmaterials innerhalb einer semipermeablen membran. - Google Patents

Verfahren zum einkapseln eines kernmaterials innerhalb einer semipermeablen membran. Download PDF

Info

Publication number
CH657786A5
CH657786A5 CH187/84A CH18784A CH657786A5 CH 657786 A5 CH657786 A5 CH 657786A5 CH 187/84 A CH187/84 A CH 187/84A CH 18784 A CH18784 A CH 18784A CH 657786 A5 CH657786 A5 CH 657786A5
Authority
CH
Switzerland
Prior art keywords
capsules
tissue
membrane
solution
polymer
Prior art date
Application number
CH187/84A
Other languages
German (de)
English (en)
Inventor
Franklin Lim
Original Assignee
Damon Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc
Publication of CH657786A5 publication Critical patent/CH657786A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/128—Chemically defined matrices for immobilising, holding or storing living parts, e.g. alginate gels; Chemically altering living parts, e.g. by cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Physiology (AREA)
  • Sustainable Development (AREA)
  • Virology (AREA)
CH187/84A 1979-03-28 1980-03-27 Verfahren zum einkapseln eines kernmaterials innerhalb einer semipermeablen membran. CH657786A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,600 US4352883A (en) 1979-03-28 1979-03-28 Encapsulation of biological material

Publications (1)

Publication Number Publication Date
CH657786A5 true CH657786A5 (de) 1986-09-30

Family

ID=21821422

Family Applications (2)

Application Number Title Priority Date Filing Date
CH187/84A CH657786A5 (de) 1979-03-28 1980-03-27 Verfahren zum einkapseln eines kernmaterials innerhalb einer semipermeablen membran.
CH2423/80A CH653914A5 (de) 1979-03-28 1980-03-27 Verfahren zum einkapseln eines chemisch aktiven kernmaterials.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH2423/80A CH653914A5 (de) 1979-03-28 1980-03-27 Verfahren zum einkapseln eines chemisch aktiven kernmaterials.

Country Status (12)

Country Link
US (1) US4352883A (cg-RX-API-DMAC10.html)
JP (2) JPS55157502A (cg-RX-API-DMAC10.html)
BE (1) BE882476A (cg-RX-API-DMAC10.html)
CA (1) CA1145258A (cg-RX-API-DMAC10.html)
CH (2) CH657786A5 (cg-RX-API-DMAC10.html)
DE (1) DE3012233A1 (cg-RX-API-DMAC10.html)
DK (1) DK130580A (cg-RX-API-DMAC10.html)
FR (2) FR2452285B1 (cg-RX-API-DMAC10.html)
GB (1) GB2046209B (cg-RX-API-DMAC10.html)
IT (1) IT1133081B (cg-RX-API-DMAC10.html)
NO (1) NO160380C (cg-RX-API-DMAC10.html)
SE (1) SE448060B (cg-RX-API-DMAC10.html)

Families Citing this family (531)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4621053A (en) * 1980-07-30 1986-11-04 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for the production of human peptide hormones
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
FR2501229A1 (fr) * 1981-03-06 1982-09-10 Rhone Poulenc Ind Procede d'inclusion de micro-organismes du groupe des mycorhizes et des actinorhizes
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4418691A (en) * 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4659655A (en) * 1981-11-25 1987-04-21 Bio-Response, Inc. Method for isolating product-producing cells
FR2519022A1 (fr) * 1981-12-29 1983-07-01 Rhone Poulenc Sa Preparation d'inoculums a longue viabilite et resistance a la temperature amelioree et produits ainsi obtenus
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
US4886664A (en) * 1982-06-18 1989-12-12 Rhone-Poulenc, S.A. Low-water-activity inocula for biological control
US4530900A (en) * 1982-09-13 1985-07-23 Seragen Diagnostics Inc. Soluble insoluble polymers in enzymeimmunoassay
US4562663A (en) * 1982-10-12 1986-01-07 Plant Genetics, Inc. Analogs of botanic seed
AU567155B2 (en) * 1983-04-15 1987-11-12 Damon Biotech Inc. Capsules for releasing core material at constant rate
US4789516A (en) * 1983-04-15 1988-12-06 Damon Biotech, Inc Production of sustained released system
US4690682A (en) * 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
EP0127989A3 (en) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
JPS6025929A (ja) * 1983-07-20 1985-02-08 ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン カプセル化細胞、その製造方法および用途
IL72787A (en) * 1983-09-01 1987-12-31 Damon Biotech Inc Polyionic microencapsulation of viable cells
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
JPS60141281A (ja) * 1983-12-28 1985-07-26 Meiji Milk Prod Co Ltd 菌体顆粒の製造方法及び装置
US4715143A (en) * 1984-01-13 1987-12-29 Plant Genetics, Inc. Artificial seed coat for botanic seed analogs
NL8500351A (nl) * 1984-02-13 1985-09-02 Damon Biotech Inc Kweken van cellen met behulp van inborrelen van gas.
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4724206A (en) * 1984-02-13 1988-02-09 Damon Biotech, Inc. Protein production using hypertonic media
EP0152898B1 (en) * 1984-02-15 1990-01-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system(
US4649109A (en) * 1984-02-16 1987-03-10 Brandeis University Methods for isolating mutant microorganisms from parental populations
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
JPS60237054A (ja) * 1984-05-10 1985-11-25 Nippon Kayaku Co Ltd アミノ酸の晶析法
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
SE8405105L (sv) * 1984-05-24 1985-11-25 Damon Biotech Inc Sett for screening av celler
US4956128A (en) * 1984-05-25 1990-09-11 Connaught Laboratories Limited Droplet generation
US5387522A (en) * 1984-06-01 1995-02-07 Schering Corporation Apparatus having a biphasic spray head for entrapping biological material in a hydrophilic gel
US4778749A (en) * 1984-06-01 1988-10-18 Karyon Technology, Inc. Tissue culture and production in permeable gels
EP0185701A4 (en) * 1984-06-01 1986-09-24 Karyon Technology Inc Tissue culture and production in permeable gels.
CA1241598A (en) * 1984-07-11 1988-09-06 Connaught Laboratories Limited Droplet generation
DE3432923C2 (de) 1984-09-07 1992-07-02 Joachim Prof. Dr. Klein Biokatalysator und Verfahren zu seiner Herstellung
AU567374B2 (en) * 1984-10-03 1987-11-19 Leonard B. Torobin Hollow inorganic microspheres
US5167812A (en) * 1984-11-28 1992-12-01 Trustees Of The Univ. Of Penna. Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
US5167811A (en) * 1984-11-28 1992-12-01 Trustees Of The University Of Pennsylvania Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
US4954443A (en) * 1984-12-27 1990-09-04 The Nisshin Oil Mills, Ltd. Method of immobilizing biochemically active substance with xanthan gum
NO166836C (no) * 1985-03-14 1991-09-11 Univ California Fremgangsmaate for behandling av et organtransplantat.
US4921757A (en) * 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
EP0199362A3 (en) * 1985-04-26 1987-10-07 Massachusetts Institute Of Technology System and apparatus for delayed and pulsed release of biologically active substances
US4900556A (en) * 1985-04-26 1990-02-13 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
EP0233899A1 (en) * 1985-06-24 1987-09-02 Karyon Technology, Incorporated Entrapment of anchorage-dependent cells
US4774093A (en) * 1985-06-25 1988-09-27 Fmc Corporation Polysaccharide compositions, preparation and uses
JPH0659217B2 (ja) * 1985-08-06 1994-08-10 三井東圧化学株式会社 固定化酵素の製造方法及びその方法に用いるための装置
US4615883A (en) * 1985-10-23 1986-10-07 Plant Genetics, Inc. Hydrogel encapsulated nematodes
US4753799A (en) * 1985-10-23 1988-06-28 Plant Genetics, Inc. Production of hydrogel encapsulated nematodes
US4701326A (en) * 1985-10-23 1987-10-20 Plant Genetics, Inc. Membrane-coated hydrogel encapsulated nematodes
CH666131A5 (fr) * 1985-10-31 1988-06-30 Battelle Memorial Institute Support a phase solide muni d'un composant destine a participer a une reaction dans une phase liquide.
US4898733A (en) * 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
DE3545237A1 (de) * 1985-12-20 1987-06-25 Juergen Dr Med Schrezenmeir Vorrichtung fuer die aufnahme und zum einbringen von geweben in den menschlichen koerper sowie hierfuer verwendbares instrument
JPH0773491B2 (ja) * 1986-03-17 1995-08-09 森下仁丹株式会社 生細胞カプセル
US4673650A (en) * 1986-03-28 1987-06-16 Damon Biotech, Inc. Protein harvesting system
JPS62234005A (ja) * 1986-04-02 1987-10-14 Seikaken:Kk 農林水産業用微生物製剤
US4692284A (en) * 1986-04-30 1987-09-08 Damon Biotech, Inc. Method and apparatus for forming droplets and microcapsules
DE3615043A1 (de) * 1986-05-03 1987-11-05 Hoechst Ag Verfahren zur verkapselung von biologisch aktivem material
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
JP2876058B2 (ja) * 1986-08-18 1999-03-31 エミスフィア・テクノロジーズ・インコーポレイテッド 薬物送達システム
US4840891A (en) * 1986-09-03 1989-06-20 Genetic Engineering, Inc. Encapsulation of sperm for artificial insemination
USRE34326E (en) * 1986-09-03 1993-07-27 British Technology Group, USA, Inc. Encapsulation of sperm for artificial insemination
US4933185A (en) * 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
SE8604684L (sv) * 1986-11-03 1988-05-04 Excorim Kommanditbolag Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
JPH07110182B2 (ja) * 1986-11-26 1995-11-29 ぺんてる株式会社 菌根菌の菌根形成法
JPH0763607B2 (ja) * 1987-02-13 1995-07-12 麒麟麦酒株式会社 ビ−ズ製造方法およびその装置
GB8705464D0 (en) * 1987-03-09 1987-04-15 Atomic Energy Authority Uk Composite material
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US4808707A (en) * 1987-06-08 1989-02-28 University Of Delaware Chitosan alginate capsules
US5427935A (en) * 1987-07-24 1995-06-27 The Regents Of The University Of Michigan Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
EP0301777A1 (en) * 1987-07-28 1989-02-01 Queen's University At Kingston Multiple membrane microencapsulation
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5156844A (en) * 1987-11-17 1992-10-20 Brown University Research Foundation Neurological therapy system
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5487739A (en) * 1987-11-17 1996-01-30 Brown University Research Foundation Implantable therapy systems and methods
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5441878A (en) * 1987-12-08 1995-08-15 Thies Technology, Inc. Preparation of uniform droplets by using gas pressure to force liquid from a syringe and flowing gas to detach droplets
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
DE68913890T2 (de) * 1988-04-18 1994-08-04 Nitta Gelatin Kk Verfahren zur züchtung tierischer zellen in grossem massstab und verfahren zur herstellung von trägermaterial dafür.
ATE121954T1 (de) 1988-08-24 1995-05-15 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US5055402A (en) * 1989-01-04 1991-10-08 Bio-Recovery Systems, Inc. Removal of metal ions with immobilized metal ion-binding microorganisms
WO1990010063A1 (en) * 1989-02-21 1990-09-07 Biosys Method and medium for packaging entomogenous nematodes
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
FR2645439B1 (fr) * 1989-04-07 1991-06-21 Oreal Procede de preparation de capsules d'alginate(s) particulierement adaptees a un usage cosmetique, appareil pour sa mise en oeuvre et composition cosmetique contenant lesdites capsules
US5204111A (en) * 1989-04-07 1993-04-20 L'oreal Process for the preparation of alginate capsules, apparatus for producing said capsules and cosmetic compositions containing said capsules
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5116747A (en) * 1989-08-11 1992-05-26 University Of Waterloo Immobilization of biologically active material in capsules prepared from a water-soluble polymer and chitosan acetate
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
KR920701427A (ko) * 1989-10-18 1992-08-11 원본미기재 고정 금속 추출용제를 함유하는 폴리머 비이드
US5093253A (en) * 1989-11-06 1992-03-03 Monsanto Company Method for microbial immobilization by entrapment in gellan gum
US5175093A (en) * 1989-11-07 1992-12-29 Lehigh University Bioactive cells immobilized in alginate beads containing voids formed with polyethylene glycol
JPH05502863A (ja) * 1989-12-05 1993-05-20 トランセル・コーポレイション 生体内適用および埋め込み用コーティング組成物同種グルロン酸―アルギン酸塩およびその使用方法
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5269785A (en) 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) * 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US8067149B2 (en) * 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
FR2668081B1 (fr) * 1990-10-19 1994-11-18 Lvmh Rech Procede et appareil de fabrication de particules solides a partir d'un materiau solidifiable en presence d'un agent de solidification en de bons rendements.
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
DK0507933T3 (da) * 1990-10-31 1996-06-17 Baxter Int Nær-vaskulariserende implantationsmateriale
US5292657A (en) * 1990-12-31 1994-03-08 Pioneer Hi-Bred International, Inc. Process for preparing rotary disc fatty acid microspheres of microorganisms
JP2573892B2 (ja) * 1990-12-31 1997-01-22 パイオニア ハイ−ブレッド インターナショナル，インコーポレイテッド 回転ディスクミクロカプセル化法により得た、脂肪酸をカプセル化剤とする乾燥菌体
FR2673122B1 (fr) * 1991-02-25 1994-09-09 Moet & Chandon Gel ionotrope deficient en entite ionique de gelification, procede de preparation d'un tel gel et utilisation de celui-ci notamment dans un procede d'elaboration de vin effervescent.
WO1992019195A1 (en) 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
US5736371A (en) * 1991-06-04 1998-04-07 A Et S Biovecteurs Biodegradable particulate vector for transporting molecules having biological activity
US5232712A (en) * 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
US6773458B1 (en) * 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
JP3199405B2 (ja) * 1991-08-30 2001-08-20 生化学工業株式会社 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法
WO1993004732A1 (en) 1991-09-09 1993-03-18 The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Methods and devices for treating hemophilia and aids
JP3252361B2 (ja) * 1991-10-02 2002-02-04 ミルトン・エイチ・リプスキー インビボにおける癌の治療のアッセイ
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5610753A (en) * 1991-12-12 1997-03-11 Eastman Kodak Company Optical design of laser scanner to reduce thermal sensitivity
US5170744A (en) * 1991-12-13 1992-12-15 Biosys Corporation Long-term storage of infective juvenile nematodes in pseudoplastic layers
US6340594B1 (en) 1991-12-19 2002-01-22 Cellfor, Inc. Production of desiccation-tolerant gymnosperm embryos
AU679435B2 (en) 1991-12-19 1997-07-03 University Of Saskatchewan Maturation, desiccation and encapsulation of gymnosperm somatic embryos
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
CA2109065C (en) * 1992-02-24 2004-03-30 Anton-Lewis Usala Bioartificial endocrine device
EP0627911B1 (en) 1992-02-28 2000-10-25 Board Of Regents The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5453270A (en) * 1992-03-30 1995-09-26 Hypermetabolic Therapies, Inc. Pharmaceutical composition and method for hypermetabolic weight loss
WO1993019701A1 (en) * 1992-04-01 1993-10-14 Baxter International Inc. Angiogenic tissue implant systems and methods
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5286495A (en) * 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
US5521079A (en) * 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
AU4396893A (en) * 1992-05-29 1994-07-04 Regents Of The University Of California, The Novel electrostatic process for manufacturing coated transplants and products
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
CA2135769A1 (en) * 1992-05-29 1993-12-09 Kent C. Cochrum Coated transplant and method for making same
ATE204470T1 (de) * 1992-05-29 2001-09-15 Vivorx Inc Mikroverkapselung von zellen
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US6001387A (en) * 1992-05-29 1999-12-14 The Reguents Of The University Of California Spin disk encapsulation apparatus and method of use
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
JPH08500033A (ja) * 1992-07-29 1996-01-09 ワシントン・ユニバーシティ 生細胞移植のためのポーチの使用
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
JPH08507747A (ja) * 1992-12-30 1996-08-20 クローバー コンソリデイテッド，リミテッド 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム
US6689608B1 (en) 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
FR2703927B1 (fr) * 1993-04-13 1995-07-13 Coletica Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées.
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
ATE204467T1 (de) * 1993-04-22 2001-09-15 Emisphere Tech Inc Orale darreichungsform
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
EP2025353A2 (en) 1993-04-30 2009-02-18 Massachusetts Institute of Technology Injectable polysaccharide-cell compositions
US5698413A (en) * 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
AU688776B2 (en) * 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
US5908623A (en) 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
ATE218893T1 (de) * 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
US5965149A (en) * 1993-08-13 1999-10-12 Thermo Trilogy Corporation Granular formulation of biological entities with improved storage stability
US5453368A (en) * 1993-08-27 1995-09-26 Brown University Research Foundation Method of encapsulating biological substances in microspheres
US5500161A (en) * 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
EP0670738A1 (en) * 1993-09-24 1995-09-13 Baxter International Inc. Methods for enhancing vascularization of implant devices
DE69430054T2 (de) * 1993-12-30 2002-10-24 Nitta Gelatin Inc., Osaka Verfahren zum einbetten von tierkulturzellen
EP1418228B1 (en) * 1994-01-13 2006-03-15 The Rogosin Institute Macroencapsulated secretory cells
CA2180826A1 (en) 1994-01-13 1995-07-20 Richard J. Ii Stoner Organic disease control system
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5459258A (en) * 1994-03-01 1995-10-17 Massachusetts Institute Of Technology Polysaccharide based biodegradable thermoplastic materials
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
JP2848515B2 (ja) * 1994-03-31 1999-01-20 矢崎総業株式会社 種子類似物作成装置
US5620883A (en) * 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5585183A (en) * 1994-04-13 1996-12-17 National Science Council Preparation of liquid-core microcapsules for cell cultures
US6531156B1 (en) 1994-04-15 2003-03-11 Temple University Aqueous solven encapsulation method, apparatus and microcapsules
JPH10500889A (ja) * 1994-04-15 1998-01-27 テンプル・ユニバーシティ 水性溶媒封入法、装置およびマイクロカプセル
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5651980A (en) * 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
US5578547A (en) * 1994-05-26 1996-11-26 Aero-Terra-Aqua Technologies Corp. Bead for removing dissolved metal contaminants
US5602071A (en) * 1994-05-26 1997-02-11 Aero-Terra-Aqua Technologies Corporation Bead for removing dissolved metal contaminants
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
US5531735A (en) * 1994-09-27 1996-07-02 Hercules Incorporated Medical devices containing triggerable disintegration agents
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6281015B1 (en) 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
CA2146098A1 (en) * 1995-01-12 1996-07-13 Ray V. Rajotte Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
AU705108B2 (en) * 1995-03-03 1999-05-13 Metabolex, Inc. Novel encapsulation process by a gelling polymer
JP3830986B2 (ja) * 1995-03-07 2006-10-11 日本化学工業株式会社 ジ（１，１，３，３−テトラメチルブチル）ホスフィン及びその製造方法
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
BR9604880A (pt) * 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5795570A (en) * 1995-04-07 1998-08-18 Emory University Method of containing core material in microcapsules
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5827707A (en) * 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
JPH0928722A (ja) * 1995-07-19 1997-02-04 Kajiwara Hiroshi 長期保存可能な肝補助体及びその製造方法
DE19681560T1 (de) * 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
WO1997030778A1 (en) * 1996-02-23 1997-08-28 Circle Biomedical, Inc. Novel artificial pancreas
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
AU3828597A (en) 1996-06-14 1998-01-07 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
HU220588B1 (hu) * 1996-09-05 2002-03-28 Bay Zoltán Alkalmazott Kutatási Alapítvány Biotechnológiai Intézet Eljárás és bioreaktortöltet L(-)-almasav előállítására fumársavból
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
DE19644343A1 (de) * 1996-10-25 1998-04-30 Privates Inst Bioserv Gmbh Geschmacksneutrale Mikrokapseln, Verfahren zu ihrer Herstellung sowie ihre Verwendung
JP4492826B2 (ja) 1996-11-20 2010-06-30 イントロジェン セラピューティクス，インコーポレイテッド アデノウイルスベクターの産生および精製のための改良された方法
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
JP4002299B2 (ja) 1996-12-10 2007-10-31 セラマット・インコーポレーテッド 組織処理用の改善されたヒドロゲル
US5990166A (en) * 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) * 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
GB2327074B (en) * 1997-07-07 2001-09-12 Norsk Hydro As Improvements in or relating to capsules
US6096303A (en) * 1997-07-31 2000-08-01 Medical College Of Georgia Research Institute, Inc. Method to enhance treatment of cystic tumors
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6368612B1 (en) 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
DE19813011A1 (de) * 1998-03-25 1999-10-14 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von Mikrokapseln
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
AU1623300A (en) * 1998-11-13 2000-06-05 Sensor Technologies, Inc. Monodisperse preparations useful with implanted devices
US6689600B1 (en) * 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
WO2000054786A1 (en) * 1999-03-15 2000-09-21 Modex Therapeutiques, S.A. Methods and compositions for tolerizing hosts for long term survival of tissue transplants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
DE60027576T2 (de) * 1999-08-17 2007-05-03 Luminex Corp., Austin Verkapselung von fluoreszierenden partikeln
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
WO2001013891A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6395678B1 (en) 1999-09-01 2002-05-28 Aero-Terra-Aqua Technologies Corporation Bead and process for removing dissolved metal contaminants
US6878543B1 (en) * 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
IL134009A (en) * 2000-01-12 2011-07-31 Bo2 Technologies Ltd Transplant device
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
EP1261420A1 (de) * 2000-02-29 2002-12-04 Rainer Pommersheim Mikrokapsel insbesondere zur immobilisierung von organischen oder anorganischen feststoffen, flüssigkeiten und/oder gasen
CA2403292C (en) 2000-04-06 2011-02-08 Panacea Pharmaceuticals, Llc Microbial delivery system
DK1280521T3 (da) 2000-05-12 2005-08-08 Pharmacia & Upjohn Co Llc Vaccinesammensætning, fremgangsmåde til fremstilling deraf og fremgangsmåde til vaccination af hvirveldyr
US6991652B2 (en) * 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
WO2002002745A2 (en) 2000-07-05 2002-01-10 Islet Technology, Inc. Method and system for consistent and effective encapsulation of biological material
US6703127B2 (en) 2000-09-27 2004-03-09 Microtek Laboratories, Inc. Macrocapsules containing microencapsulated phase change materials
WO2002038202A1 (en) * 2000-11-09 2002-05-16 Kenneth Allan De Luca Fat extraction
CA2433335C (en) 2000-12-29 2010-04-20 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
WO2002067856A2 (en) * 2001-02-23 2002-09-06 University Of Massachusetts Injection molding of living tissues
US20070082052A1 (en) * 2001-02-23 2007-04-12 Bonassar Lawrence J Tympanic membrane repair constructs
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US20040009160A1 (en) * 2001-06-22 2004-01-15 Villamar Daniel F Bioactive food complex, method for making bioactive food complex product and method for controlling disease
US7534774B2 (en) * 2001-10-03 2009-05-19 Tissue Repair Company Traversal of nucleic acid molecules through a fluid space and expression in repair cells
US20050260179A1 (en) * 2001-11-06 2005-11-24 The General Hospital Corporation D/B/A Massachusetts General Hospital Stem and progenitor cell capture for tissue regeneration
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
JP4368198B2 (ja) * 2001-11-20 2009-11-18 アルカーメス，インコーポレイテッド 肺送達用の改良された粒状組成物
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
AU2003224710A1 (en) * 2002-03-18 2003-10-08 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US8529956B2 (en) * 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2003092468A2 (en) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
AU2003241107B2 (en) * 2002-05-16 2009-09-03 Absorber Ab Method of isolating an endothelial cell and method of donor specific crossmatching
US7299805B2 (en) * 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
CA2496918A1 (en) * 2002-08-28 2004-03-11 Introgen Therapeutics Inc. Chromatographic methods for adenovirus purification
WO2004026457A1 (ja) * 2002-09-18 2004-04-01 Koyama, Yuu マイクロカプセルの製造方法
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
DE10254636A1 (de) * 2002-11-22 2004-06-09 Capsulution Nanoscience Ag Verfahren zum Modifizieren von Mikropartikeln sowie Vorrichtung zum Modifizieren von Mikropartikeln
WO2004058305A2 (en) * 2002-12-24 2004-07-15 An-Go-Gen Inc. Encapsulated cell for therapy
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
WO2004073563A2 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
WO2004075855A2 (en) * 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
DK1897552T3 (da) 2003-04-18 2009-10-05 Biogen Idec Inc Polymer-konjugeret glycosyleret neublastin
US20040229335A1 (en) * 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
GB0311664D0 (en) * 2003-05-21 2003-06-25 Univ Manchester Polymeric hollow nanospheres
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
WO2006071794A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
ES2568463T3 (es) 2003-06-27 2016-04-29 DePuy Synthes Products, Inc. Regeneración y reparación de tejido neural usando células del postparto derivadas del cordon umbilical
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
DE10334237A1 (de) * 2003-07-28 2005-02-24 Robert Bosch Gmbh Aktiver Sensorkanal
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US7927599B2 (en) 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US20090325859A1 (en) * 2003-09-19 2009-12-31 Northwestern University Citric acid polymers
US20050063939A1 (en) * 2003-09-19 2005-03-24 Northwestern University Novel biodegradable elastomeric scaffold for tissue engineering and light scattering fingerprinting methods for testing the same
WO2005033297A1 (en) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
US20050067341A1 (en) * 2003-09-25 2005-03-31 Green Dennis H. Continuous production membrane water treatment plant and method for operating same
CA2548822C (en) * 2003-12-08 2015-08-11 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
WO2005079970A1 (en) * 2004-02-23 2005-09-01 Eyesense Ag Process for production of ionically crosslinked polysaccharide microspheres
ATE481477T1 (de) * 2004-03-09 2010-10-15 Absorber Ab Endothelvorläuferzellen und verfahren zur verwendung davon
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
CN1950397B (zh) 2004-03-30 2012-05-16 Ns基因公司 生长因子NsG33的治疗用途
DE102004019241A1 (de) * 2004-04-16 2005-11-03 Cellmed Ag Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
CA2567578C (en) 2004-06-01 2018-04-24 In Motion Investment, Ltd. In vitro techniques for obtaining stem cells from blood
EP2532356A1 (en) 2004-07-14 2012-12-12 Glusense Ltd. Implantable power sources and sensors
US20090136552A1 (en) * 2004-07-30 2009-05-28 Mette Gronborg Growth factors nsg28, nsg30, and nsg32
AU2005277227B2 (en) * 2004-08-19 2011-10-06 Biogen Ma Inc. Refolding transforming growth factor beta family proteins
EP2238983B1 (en) * 2004-08-19 2014-07-23 Biogen Idec MA Inc. Neublastin variants
WO2006032092A1 (en) 2004-09-24 2006-03-30 Angioblast Systems, Inc. Multipotential expanded mesenchymal precursor cell progeny (memp) and uses thereof
US20090029912A1 (en) 2004-09-24 2009-01-29 Stan Gronthos Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)
JP2008515434A (ja) * 2004-10-08 2008-05-15 ジョージア テック リサーチ コーポレイション 静電ポテンシャルを用いたヒドロゲル中の細胞のマイクロカプセル化
JP2008518632A (ja) * 2004-11-03 2008-06-05 イントロゲン セラピューティックス， インコーポレイテッド アデノウイルスベクターの製造および精製のための新規方法
DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
EP1833496B1 (en) 2004-12-23 2013-07-31 Ethicon, Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
US20060171932A1 (en) * 2005-01-31 2006-08-03 Cognate Therapeutics, Inc. Adipose derived stromal cells exhibiting characteristics of endothelial cells
US20060205081A1 (en) * 2005-02-18 2006-09-14 Linhong Li Use of methyltransferase inhibitors to enhance transgene expression
WO2006105161A2 (en) * 2005-03-30 2006-10-05 Cartilix, Inc. Coated medical device
KR101446634B1 (ko) 2005-04-12 2014-10-16 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체세포의 분리
JP4932832B2 (ja) * 2005-06-02 2012-05-16 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ 血管予形成デバイスおよび関連する方法
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
JP5475283B2 (ja) 2005-07-28 2014-04-16 カーネギー メロン ユニバーシティ 生体適合性ポリマーおよび使用方法
US8357666B2 (en) * 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
US20090253203A1 (en) 2005-08-01 2009-10-08 Nupotential, Inc. Reprogramming a Cell by Inducing a Pluripotent Gene Through Use of a Small Molecule Modulator
ES2397289T3 (es) * 2005-09-22 2013-03-06 Biocompatibles Uk Ltd. Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada
US20070071790A1 (en) 2005-09-28 2007-03-29 Northwestern University Biodegradable nanocomposites with enhance mechanical properties for soft tissue
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
EP1976975B1 (en) 2005-12-19 2012-08-01 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US20070208420A1 (en) * 2006-02-08 2007-09-06 Northwestern University Functionalizing implantable devices with a poly (diol co-citrate) polymer
CN100571779C (zh) * 2006-02-24 2009-12-23 沈炳谦 海藻酸盐纳米胶囊及其制备方法
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
US20100056440A1 (en) * 2006-03-01 2010-03-04 Biogen Idec Ma Inc. Compositions and methods for administering gdnf ligand family proteins
TW200734462A (en) * 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
EP1854455B1 (en) * 2006-05-10 2009-10-07 Biocompatibles UK Limited Spherical microcapsules comprising GLP-1 peptides, their production and use
EP2772535B1 (en) 2006-05-31 2022-04-06 Children's Medical Center Corporation ABC5 positive mesenchymal stem cells as immunomodulators
US20080003205A1 (en) * 2006-06-26 2008-01-03 University Of Massachusetts Tympanic Membrane Repair Constructs
EP2051726B1 (en) 2006-07-18 2018-04-18 University of Utah Research Foundation Methods for treating pain and screening analgesic compounds
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2008127423A2 (en) * 2006-11-14 2008-10-23 Cornell Research Foundation, Inc. Microencapsulated catalyst systems
WO2008062417A2 (en) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protecting algae from body fluids
EP2104492B1 (en) * 2006-11-28 2017-11-22 Beta O2 Technologies Ltd. Oxygen supply for cell transplant and vascularization
US8105382B2 (en) 2006-12-07 2012-01-31 Interventional Spine, Inc. Intervertebral implant
EP1972349A1 (en) * 2007-03-21 2008-09-24 Biocompatibles UK Limited GLP-1 fusion peptides conjugated to polymer(s), their production and use
EP1972324A1 (en) * 2007-03-21 2008-09-24 Cognis IP Management GmbH Encapsulated liposomes
EP1975176A1 (en) * 2007-03-27 2008-10-01 Biocompatibles UK Limited Novel glp-1 fusion peptides, their production and use
CA3069431A1 (en) 2007-04-03 2008-10-09 Oxyrane Uk Limited Glycosylation of molecules
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
US20080281419A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Breast implants and compositions of extracellular matrix
US9034367B2 (en) * 2007-05-10 2015-05-19 Cormatrix Cardiovascular, Inc. Articles for tissue regeneration with biodegradable polymer
US20080279833A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US20080318314A1 (en) * 2007-06-20 2008-12-25 Valentin Fulga Production from blood of cells of neural lineage
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
EP2173863B1 (en) * 2007-06-29 2018-10-10 FUJIFILM Cellular Dynamics, Inc. Automated method and apparatus for embryonic stem cell culture
KR20150021587A (ko) 2007-08-06 2015-03-02 메소블라스트, 아이엔씨. 생체 내에서 결합 조직을 생성, 복구 및/또는 유지하는 방법
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
EP2185730A4 (en) 2007-08-23 2010-10-27 Intrexon Corp METHOD AND COMPOSITIONS FOR SICKNESS DIAGNOSIS
US8821431B2 (en) * 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
US20090136465A1 (en) 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
ES2525718T3 (es) 2007-10-05 2014-12-29 DePuy Synthes Products, LLC Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano
DE102007059939A1 (de) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen
WO2009085850A2 (en) * 2007-12-20 2009-07-09 Ethicon, Incorporated Encapsulated kidney tissue
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
AU2008345047A1 (en) 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
WO2009092102A1 (en) 2008-01-17 2009-07-23 Synthes Usa, Llc An expandable intervertebral implant and associated method of manufacturing the same
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
BRPI0910325A8 (pt) 2008-04-05 2019-01-29 Synthes Gmbh implante intervertebral expansível
EP2163243A1 (en) * 2008-09-12 2010-03-17 Biocompatibles UK Limited Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
US20100111919A1 (en) * 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
WO2010075500A1 (en) 2008-12-23 2010-07-01 Stemcells California, Inc Target populations of oligodendrocyte precursor cells and methods of making and using same
US20100160749A1 (en) * 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
US9511093B2 (en) * 2009-03-23 2016-12-06 The Texas A & M University System Compositions of mesenchymal stem cells to regenerate bone
CN102498204B (zh) 2009-03-26 2015-02-04 德普伊新特斯产品有限责任公司 人脐带组织细胞作为用于阿尔茨海默病的疗法
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
BRPI0902039B8 (pt) 2009-06-09 2021-05-25 Anhanguera Educacional Ltda composição farmacêutica e uso de composição farmacêutica para o tratamento, profilaxia ou prevenção de doenças neoplásicas em humanos e animais
CN102712914A (zh) 2009-09-29 2012-10-03 根特大学 水解甘露糖-1-磷酸-6-甘露糖连接为磷酸-6-甘露糖
JP2013509422A (ja) 2009-10-30 2013-03-14 シーエヌエス セラピューティクス，インク． 改良されたニュールツリン分子
WO2011060135A1 (en) 2009-11-12 2011-05-19 Vbi Technologies, Llc Subpopulations of spore-like cells and uses thereof
DK2501805T3 (en) 2009-11-19 2019-04-15 Oxyrane Uk Ltd Yeast strains producing mammalian-like complex N-Glycans
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
EP2563907B1 (en) 2010-04-28 2019-06-19 The J. David Gladstone Institutes Methods for generating cardiomyocytes
WO2011154941A2 (en) 2010-06-07 2011-12-15 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
ES2986590T3 (es) 2010-06-14 2024-11-12 Scripps Research Inst Reprogramación de células hacia un nuevo destino
US9592063B2 (en) 2010-06-24 2017-03-14 DePuy Synthes Products, Inc. Universal trial for lateral cages
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
AU2011271465B2 (en) 2010-06-29 2015-03-19 Synthes Gmbh Distractible intervertebral implant
WO2012027494A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Bispecific targeting reagents
CN103328646B (zh) 2010-09-29 2021-06-18 奥克西雷恩英国有限公司 能够使甘露糖-1-磷酸-6-甘露糖连接脱帽并使磷酸化的n-聚糖脱甘露糖基化的甘露糖苷酶及促进糖蛋白的哺乳动物细胞摄取的方法
CN103261432A (zh) 2010-09-29 2013-08-21 奥克西雷恩英国有限公司 磷酸化的n-聚糖的脱甘露糖基化
CN103269708A (zh) 2010-10-01 2013-08-28 Ns基因公司 镍纹蛋白用于治疗异常性疼痛、痛觉过敏、自发性疼痛和幻痛的用途
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US9867781B2 (en) 2011-02-18 2018-01-16 Massachusetts Institute Of Technology Hydrogel encapsulated cells and anti-inflammatory drugs
GB2489320A (en) * 2011-03-21 2012-09-26 Univ Reading Transport of cells by encapsulating in a hydrogel
WO2012167223A1 (en) 2011-06-02 2012-12-06 Massachusetts Institute Of Technology Modified alginates for cell encapsulation and cell therapy
JP6250536B2 (ja) 2011-06-06 2017-12-20 ケイ・ブイ・１．３・セラピューティクス・インコーポレイテッド Ｓｈｋベースの薬学的組成物とその製造方法および使用方法
US20140113138A1 (en) * 2011-06-29 2014-04-24 The University Of Akron Method of encapsulation and immobilization
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
WO2013023013A1 (en) 2011-08-09 2013-02-14 Wake Forest University Health Sciences Co-encapsulation of live cells with oxygen-generating particles
CA2860850C (en) 2011-12-20 2019-05-21 Lifecell Corporation Sheet tissue products
DK3501558T3 (da) 2011-12-20 2021-03-01 Lifecell Corp Flydbare vævsprodukter
CN104837987B (zh) 2011-12-23 2018-10-02 德普伊新特斯产品公司 人脐带组织来源的细胞的检测
AU2013212592B2 (en) 2012-01-24 2016-06-30 Lifecell Corporation Elongated tissue matrices
EP2825193B1 (en) 2012-03-15 2019-11-13 Oxyrane UK Limited Methods and materials for treatment of pompe's disease
WO2013151725A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US9999637B2 (en) 2012-04-24 2018-06-19 Lifecell Corporation Functionalized tissue matrices
US10342897B2 (en) 2012-05-17 2019-07-09 Cartiheal (2009) Ltd Biomatrix hydrogels and methods of use thereof
US9334507B2 (en) 2012-06-15 2016-05-10 Microvi Biotech, Inc. Bioprocesses for making butanol
SG11201408356VA (en) 2012-06-15 2015-03-30 Microvi Biotech Inc Novel biocatalyst compositions and processes for use
US9255281B2 (en) 2012-06-15 2016-02-09 Microvi Biotech Inc. Bioconversion processes using water-insoluble liquids
US9752164B2 (en) 2012-06-15 2017-09-05 Microvi Biotech, Inc. Enhanced efficiency ethanol and sugar conversion processes
IN2015DN00934A (cg-RX-API-DMAC10.html) 2012-08-01 2015-06-12 United Therapeutics Corp
CN104936603A (zh) 2012-08-01 2015-09-23 联合治疗公司 利用前列环素处理的内皮祖细胞的肺动脉高血压的治疗
WO2014110094A1 (en) 2013-01-09 2014-07-17 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US9717601B2 (en) 2013-02-28 2017-08-01 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
EP2964758B1 (en) 2013-03-05 2020-05-27 Oxyrane UK Limited Production of catalytically active type i sulfatase
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10172791B2 (en) 2013-03-14 2019-01-08 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US9555007B2 (en) 2013-03-14 2017-01-31 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US20160075976A1 (en) * 2013-05-03 2016-03-17 Novozymes A/S Microencapsulation of Detergent Enzymes
MX367858B (es) 2013-05-31 2019-09-09 Univ Utah Res Found Péptidos de conotoxina, composiciones farmacéuticas y usos de los mismos.
WO2014198994A1 (es) 2013-06-13 2014-12-18 Biomedal, S.L. Método para el análisis rápido de actividad celular
WO2015042580A1 (en) 2013-09-23 2015-03-26 Biogen Idec Ma Inc. Compositions and methods for treatment of neuropathic pain
ES3036749T3 (en) 2014-08-01 2025-09-23 Massachusetts Inst Technology Modified alginates for anti-fibrotic materials and applications
CN106999118B (zh) 2014-10-13 2020-07-17 葡萄糖传感器公司 分析物感测装置
US10201633B2 (en) 2014-12-05 2019-02-12 Augusta University Research Institute, Inc. Glass composites for tissue augmentation, biomedical and cosmetic applications
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
EP3277328B1 (en) 2015-04-01 2023-06-07 Yale University Ferromagnetic particles bound to polymeric implants
WO2016187225A1 (en) 2015-05-17 2016-11-24 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
EP3368085B1 (en) 2015-11-01 2024-01-03 Massachusetts Institute Of Technology Modified alginates for anti-fibrotic materials and applications
EP3167911A1 (en) 2015-11-10 2017-05-17 Oniris Si-hpmc-encapsulated insulin-producing cells for the treatment of type 1 diabetes
SG11201804117XA (en) 2015-11-18 2018-06-28 Univ Georgia Neural cell extracellular vessicles
EP3445872A1 (en) 2016-04-20 2019-02-27 Glusense Ltd. Fret-based glucose-detection molecules
JP6920681B2 (ja) * 2016-04-27 2021-08-18 株式会社クラレ 移植用デバイス及びその製造方法並びにバイオ人工臓器の製造方法
GB201610101D0 (en) * 2016-06-09 2016-07-27 Attenborough Dental Laboratories Ltd Multicellular lay-up process
US11596522B2 (en) 2016-06-28 2023-03-07 Eit Emerging Implant Technologies Gmbh Expandable and angularly adjustable intervertebral cages with articulating joint
CN109688981A (zh) 2016-06-28 2019-04-26 Eit 新兴移植技术股份有限公司 可扩张的、角度可调整的椎间笼
CN109689029A (zh) 2016-07-18 2019-04-26 蒂舒金公司 用于保持生物分子的构象和结构完整性的方法和组合物
IL266175B2 (en) 2016-10-24 2024-01-01 United Therapeutics Corp Enhancement of msc immunomodulatory properties by treprostinil
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
US20210361537A1 (en) * 2017-12-31 2021-11-25 Mihran Papazian Spherificated dental medicament compositions
ES2984718T3 (es) 2018-08-20 2024-10-30 Immundiagnostik Ag Composición de sorbente para el tratamiento preanalítico de muestras
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US20220409773A1 (en) 2019-06-28 2022-12-29 Mochida Pharmaceutical Co., Ltd. Transplantation device using chemically crosslinked alginic acid
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
FR3107901A1 (fr) 2020-03-09 2021-09-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé de perfusion micro-fluidique d'un sphéroïde et dispositif adapté pour mettre en œuvre ledit procédé
CA3175322A1 (en) 2020-03-17 2021-09-23 Ohio State Innovation Foundation Designer extracellular vesicles for treating excitotoxicity
CN117042783A (zh) 2020-12-22 2023-11-10 持田制药株式会社 使用了化学交联海藻酸的移植用器件
CN116710110A (zh) 2020-12-28 2023-09-05 持田制药株式会社 新型的多层聚合物涂层交联海藻酸凝胶纤维
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
JP2024518433A (ja) 2021-05-06 2024-05-01 ホバ セラピューティクス エーピーエス 化学療法誘発性神経障害性疼痛の予防及び治療
CA3239550A1 (en) 2021-12-10 2023-06-15 Kenneth Petersen Treatment of nociceptive pain
US12090064B2 (en) 2022-03-01 2024-09-17 Medos International Sarl Stabilization members for expandable intervertebral implants, and related systems and methods
CN114504561B (zh) * 2022-03-01 2023-08-11 陕西科技大学 一种用于制备药物渗透泵制剂的水性包衣方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766478A (en) * 1951-10-15 1956-10-16 Gasoline Res Ind And Commercia Encapsulating method and apparatus
GB931532A (en) * 1958-12-22 1963-07-17 Upjohn Co Injectable preparations comprising encapsulated medicaments and processes for making them
FR1345565A (fr) * 1962-01-19 1963-12-13 Rolland Lab A Procédé pour l'obtention d'extraits totaux plus généralement orginaires de tissus viants
DD36655A3 (cg-RX-API-DMAC10.html) * 1964-06-12 1965-11-05
JPS5128589B1 (cg-RX-API-DMAC10.html) 1967-12-28 1976-08-20
US3522346A (en) * 1968-05-31 1970-07-28 Research Corp Nonthrombogenic microcapsules
US3650900A (en) * 1968-09-27 1972-03-21 Yeda Res & Dev Insoluble polymer-enzyme products
GB1236885A (en) * 1968-09-28 1971-06-23 Fuji Photo Film Co Ltd Method of making multi-wall capsules
US3734851A (en) * 1969-12-29 1973-05-22 K Matsumura Method and device for purifying blood
US3733205A (en) * 1970-08-07 1973-05-15 Pfizer Enzymatic removal of diacetyl from fermented beverages
US3725113A (en) * 1970-12-17 1973-04-03 Research Corp Blood compatible microencapsulated detoxicants and method for making
US3730841A (en) * 1971-03-24 1973-05-01 American Cyanamid Co Encapsulated carrier bound enzymes
US3860490A (en) * 1972-02-11 1975-01-14 Nat Patent Dev Corp Process of subjecting a microorganism susceptible material to a microorganism
US3925157A (en) * 1972-07-12 1975-12-09 Pfizer Immobilized enzymes
JPS4930582A (cg-RX-API-DMAC10.html) * 1972-07-17 1974-03-19
JPS5128589A (en) * 1974-09-04 1976-03-10 Matsushita Electric Industrial Co Ltd Denbahatsukokeikotainoseizohoho
US4324683A (en) * 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
GB1540461A (en) * 1975-08-20 1979-02-14 Damon Corp Chemical processes
JPS6025117B2 (ja) * 1976-03-31 1985-06-17 北海道糖業株式会社 菌体酵素の固定化法
JPS5851758B2 (ja) * 1976-06-11 1983-11-18 日本ペイント株式会社 酵素もしくは菌体固定化物およびその製造方法

Also Published As

Publication number Publication date
SE448060B (sv) 1987-01-19
FR2457688A1 (fr) 1980-12-26
FR2452285A1 (fr) 1980-10-24
IT8067472A0 (it) 1980-03-27
JPS6242889B2 (cg-RX-API-DMAC10.html) 1987-09-10
DK130580A (da) 1980-09-29
NO160380C (no) 1989-04-19
GB2046209A (en) 1980-11-12
GB2046209B (en) 1983-09-14
BE882476A (fr) 1980-09-29
DE3012233C2 (cg-RX-API-DMAC10.html) 1988-03-31
NO800901L (no) 1980-09-29
FR2452285B1 (fr) 1986-12-05
JPS61293919A (ja) 1986-12-24
JPS6239131B2 (cg-RX-API-DMAC10.html) 1987-08-21
NO160380B (no) 1989-01-02
CH653914A5 (de) 1986-01-31
CA1145258A (en) 1983-04-26
SE8002357L (sv) 1980-09-29
DE3012233A1 (de) 1980-11-20
FR2457688B1 (fr) 1986-12-05
JPS55157502A (en) 1980-12-08
US4352883A (en) 1982-10-05
IT1133081B (it) 1986-07-09

Similar Documents

Publication Publication Date Title
CH657786A5 (de) Verfahren zum einkapseln eines kernmaterials innerhalb einer semipermeablen membran.
DE69221484T2 (de) Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
DE69531821T2 (de) Mehrlagige alginatbeschichtungen von biologischen geweben für die transplantation
DE3209127C2 (cg-RX-API-DMAC10.html)
DE3209045C2 (de) Verfahren zum selektiven Aufbrechen permeabler Membranen
DE69330716T2 (de) Nicht faserige, mit alginat beschichtete transplantate sowie herstellungs- und anwendungssvefahren dafür
DE69634828T2 (de) Auffindbare künstliche bioimplantate
DE69119748T2 (de) Vaskularisation erlaubendes implantatmaterial
DE69001672T2 (de) Neurologisches therapiesystem.
DE69533437T2 (de) Makroeingekapselte sekretorische zellen
US4391909A (en) Microcapsules containing viable tissue cells
DE69221837T2 (de) In vivo sekretion von aktiven faktoren durch ko-kultivierte zellimplantate
DE69635940T2 (de) Hydrogelmatrix für Zellgewebelagerung
DE60002231T2 (de) Verfahren zur herstellung eines gels von autologen blutplättchen
DE69331997T2 (de) Chitozanmatrizes für eingekapselte zellen
DE102004017473A1 (de) Verfahren zur Differenzierung von Stammzellen in Zellen, die ein pankreatisches Hormon produzieren
DE2811372A1 (de) Vorrichtung zur verwendung als kuenstliches pankreas
CH629251A5 (de) Verfahren zur fixierung einer biologisch aktiven substanz auf einem poroesen traegermaterial.
DE3209098A1 (de) Verfahren zur kultivierung verankerungsabhaengiger zellen
DE10307925A1 (de) Träger für eine Zellkultur und Verfahren zur Kultivierung von Zellen
EP0173915A2 (de) Biokatalysator und Verfahren zu seiner Herstellung
DE3414083A1 (de) Verfahren zur gewinnung von durch lebende zellen produzierten, nicht sekretierten substanzen
DE69738170T2 (de) Konditioniertes Medium und diffusionsfähiges biologisches Material gewonnen durch Inkubierung von eingeschlossenen Zellen
WO2005001073A1 (de) Verfahren zur differenzierung von stammzellen in zellen, die ein pankreatisches hormon produzieren
Helander Morphology of animal secretory gland cells

Legal Events

Date Code Title Description
PL Patent ceased