FR2452285A1 - Procede d'encapsulation d'un tissu viable ou d'une matiere biologiquement active a implanter, et capsules obtenues - Google Patents

Procede d'encapsulation d'un tissu viable ou d'une matiere biologiquement active a implanter, et capsules obtenues

Info

Publication number
FR2452285A1
FR2452285A1 FR8006875A FR8006875A FR2452285A1 FR 2452285 A1 FR2452285 A1 FR 2452285A1 FR 8006875 A FR8006875 A FR 8006875A FR 8006875 A FR8006875 A FR 8006875A FR 2452285 A1 FR2452285 A1 FR 2452285A1
Authority
FR
France
Prior art keywords
tissue
capsules
encapsulation
implanted
active material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8006875A
Other languages
English (en)
Other versions
FR2452285B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Damon Corp
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Corp filed Critical Damon Corp
Publication of FR2452285A1 publication Critical patent/FR2452285A1/fr
Application granted granted Critical
Publication of FR2452285B1 publication Critical patent/FR2452285B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/0231—Chemically defined matrices, e.g. alginate gels, for immobilising, holding or storing cells, tissue or organs for preservation purposes; Chemically altering or fixing cells, tissue or organs, e.g. by cross-linking, for preservation purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Sustainable Development (AREA)

Abstract

L'INVENTION CONCERNE L'ENCAPSULATION DE FRAGMENTS D'UN TISSU VIABLE OU D'UNE MATIERE BIOLOGIQUEMENT ACTIVE A IMPLANTER DANS UN CORPS DE MAMMIFERE, ET LES CAPSULES OBTENUES. ON MET LE TISSU VIVANT FINEMENT DIVISE EN SUSPENSION DANS UN MILIEU AQUEUX PHYSIOLOGIQUEMENT COMPATIBLE AVEC LUI ET QUI CONTIENT UNE GOMME OU SUBSTANCE HYDROSOLUBLE COMPATIBLE AVEC LE TISSU ET POUVANT ETRE GELIFIEE A; ON TRANSFORME LA SUSPENSION EN DES GOUTTELETTES DE DIMENSIONS SUFFISANTES POUR ENVELOPPER LE TISSU BC; ON GELIFIE LES GOUTTELETTES POUR FORMER DES CAPSULES TEMPORAIRES SEPAREES ET CONSERVANT LEUR FORME D, E; ET L'ON FORME A F UNE MEMBRANE PERMANENTE 24 AUTOUR DES CAPSULES TEMPORAIRES CONTENANT LE TISSU 26 ET SES CELLULES 28. INJECTEES A LA SERINGUE DANS LE CORPS D'UN MAMMIFERE, DES CAPSULES DE CELLULES DE FOIE OU DE PANCREAS PEUVENT Y JOUER LE ROLE D'UN ORGANE ARTIFICIEL.
FR8006875A 1979-03-28 1980-03-27 Procede d'encapsulation d'un tissu viable ou d'une matiere biologiquement active a implanter, et capsules obtenues Expired FR2452285B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,600 US4352883A (en) 1979-03-28 1979-03-28 Encapsulation of biological material

Publications (2)

Publication Number Publication Date
FR2452285A1 true FR2452285A1 (fr) 1980-10-24
FR2452285B1 FR2452285B1 (fr) 1986-12-05

Family

ID=21821422

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8006875A Expired FR2452285B1 (fr) 1979-03-28 1980-03-27 Procede d'encapsulation d'un tissu viable ou d'une matiere biologiquement active a implanter, et capsules obtenues
FR8020768A Expired FR2457688B1 (fr) 1979-03-28 1980-09-26 Organe artificiel, sous forme de microcapsules, convenant pour son implantation dans le corps d'un mammifere

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8020768A Expired FR2457688B1 (fr) 1979-03-28 1980-09-26 Organe artificiel, sous forme de microcapsules, convenant pour son implantation dans le corps d'un mammifere

Country Status (12)

Country Link
US (1) US4352883A (fr)
JP (2) JPS55157502A (fr)
BE (1) BE882476A (fr)
CA (1) CA1145258A (fr)
CH (2) CH653914A5 (fr)
DE (1) DE3012233A1 (fr)
DK (1) DK130580A (fr)
FR (2) FR2452285B1 (fr)
GB (1) GB2046209B (fr)
IT (1) IT1133081B (fr)
NO (1) NO160380C (fr)
SE (1) SE448060B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501715A1 (fr) * 1981-03-13 1982-09-17 Damon Corp Procede de culture de cellules necessitant une fixation pour la fabrication de substances therapeutiques
FR2503183A1 (fr) * 1981-03-13 1982-10-08 Damon Corp Procede et ensemble de production de substances formees par des cellules vivantes
DE3432923A1 (de) * 1984-09-07 1986-03-06 Joachim Prof. Dr. Klein Biokatalysator und verfahren zu seiner herstellung
FR3107901A1 (fr) 2020-03-09 2021-09-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé de perfusion micro-fluidique d'un sphéroïde et dispositif adapté pour mettre en œuvre ledit procédé

Families Citing this family (525)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4621053A (en) * 1980-07-30 1986-11-04 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for the production of human peptide hormones
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
FR2501229A1 (fr) * 1981-03-06 1982-09-10 Rhone Poulenc Ind Procede d'inclusion de micro-organismes du groupe des mycorhizes et des actinorhizes
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4418691A (en) * 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4659655A (en) * 1981-11-25 1987-04-21 Bio-Response, Inc. Method for isolating product-producing cells
FR2519022A1 (fr) * 1981-12-29 1983-07-01 Rhone Poulenc Sa Preparation d'inoculums a longue viabilite et resistance a la temperature amelioree et produits ainsi obtenus
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
US4886664A (en) * 1982-06-18 1989-12-12 Rhone-Poulenc, S.A. Low-water-activity inocula for biological control
US4530900A (en) * 1982-09-13 1985-07-23 Seragen Diagnostics Inc. Soluble insoluble polymers in enzymeimmunoassay
US4562663A (en) * 1982-10-12 1986-01-07 Plant Genetics, Inc. Analogs of botanic seed
AU567155B2 (en) * 1983-04-15 1987-11-12 Damon Biotech Inc. Capsules for releasing core material at constant rate
US4690682A (en) * 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
US4789516A (en) * 1983-04-15 1988-12-06 Damon Biotech, Inc Production of sustained released system
EP0127989A3 (fr) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Micro-encapsulation de tissu vivant et de cellules
CA1196862A (fr) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulement de cellules et de tissus vivants
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
JPS6025929A (ja) * 1983-07-20 1985-02-08 ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン カプセル化細胞、その製造方法および用途
IL72787A (en) * 1983-09-01 1987-12-31 Damon Biotech Inc Polyionic microencapsulation of viable cells
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
JPS60141281A (ja) * 1983-12-28 1985-07-26 Meiji Milk Prod Co Ltd 菌体顆粒の製造方法及び装置
US4715143A (en) * 1984-01-13 1987-12-29 Plant Genetics, Inc. Artificial seed coat for botanic seed analogs
US4724206A (en) * 1984-02-13 1988-02-09 Damon Biotech, Inc. Protein production using hypertonic media
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
NL8500351A (nl) * 1984-02-13 1985-09-02 Damon Biotech Inc Kweken van cellen met behulp van inborrelen van gas.
DE3575375D1 (de) * 1984-02-15 1990-02-22 Massachusetts Inst Technology Verfahren zur verkapselung und systeme mit verkapseltem aktivmaterial.
US4649109A (en) * 1984-02-16 1987-03-10 Brandeis University Methods for isolating mutant microorganisms from parental populations
MX163953B (es) * 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
JPS60237054A (ja) * 1984-05-10 1985-11-25 Nippon Kayaku Co Ltd アミノ酸の晶析法
SE8405105L (sv) * 1984-05-24 1985-11-25 Damon Biotech Inc Sett for screening av celler
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
US4956128A (en) * 1984-05-25 1990-09-11 Connaught Laboratories Limited Droplet generation
US5387522A (en) * 1984-06-01 1995-02-07 Schering Corporation Apparatus having a biphasic spray head for entrapping biological material in a hydrophilic gel
EP0185701A4 (fr) * 1984-06-01 1986-09-24 Karyon Technology Inc Culture et production de tissus dans des gels permeables.
US4778749A (en) * 1984-06-01 1988-10-18 Karyon Technology, Inc. Tissue culture and production in permeable gels
CA1241598A (fr) * 1984-07-11 1988-09-06 Connaught Laboratories Limited Generation de gouttelettes
AU567374B2 (en) * 1984-10-03 1987-11-19 Leonard B. Torobin Hollow inorganic microspheres
US5167811A (en) * 1984-11-28 1992-12-01 Trustees Of The University Of Pennsylvania Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
US5167812A (en) * 1984-11-28 1992-12-01 Trustees Of The Univ. Of Penna. Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
US4954443A (en) * 1984-12-27 1990-09-04 The Nisshin Oil Mills, Ltd. Method of immobilizing biochemically active substance with xanthan gum
NO166836C (no) * 1985-03-14 1991-09-11 Univ California Fremgangsmaate for behandling av et organtransplantat.
US4900556A (en) * 1985-04-26 1990-02-13 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4921757A (en) * 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
EP0199362A3 (fr) * 1985-04-26 1987-10-07 Massachusetts Institute Of Technology Système et dispositif pour la libération retardée et par à-coups de substances biologiquement actives
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
EP0233899A1 (fr) * 1985-06-24 1987-09-02 Karyon Technology, Incorporated Emprisonnement de cellules dependant de l'ancrage
US4774093A (en) * 1985-06-25 1988-09-27 Fmc Corporation Polysaccharide compositions, preparation and uses
JPH0659217B2 (ja) * 1985-08-06 1994-08-10 三井東圧化学株式会社 固定化酵素の製造方法及びその方法に用いるための装置
US4753799A (en) * 1985-10-23 1988-06-28 Plant Genetics, Inc. Production of hydrogel encapsulated nematodes
US4701326A (en) * 1985-10-23 1987-10-20 Plant Genetics, Inc. Membrane-coated hydrogel encapsulated nematodes
US4615883A (en) * 1985-10-23 1986-10-07 Plant Genetics, Inc. Hydrogel encapsulated nematodes
CH666131A5 (fr) * 1985-10-31 1988-06-30 Battelle Memorial Institute Support a phase solide muni d'un composant destine a participer a une reaction dans une phase liquide.
US4898733A (en) * 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
DE3545237A1 (de) * 1985-12-20 1987-06-25 Juergen Dr Med Schrezenmeir Vorrichtung fuer die aufnahme und zum einbringen von geweben in den menschlichen koerper sowie hierfuer verwendbares instrument
JPH0773491B2 (ja) * 1986-03-17 1995-08-09 森下仁丹株式会社 生細胞カプセル
US4673650A (en) * 1986-03-28 1987-06-16 Damon Biotech, Inc. Protein harvesting system
JPS62234005A (ja) * 1986-04-02 1987-10-14 Seikaken:Kk 農林水産業用微生物製剤
US4692284A (en) * 1986-04-30 1987-09-08 Damon Biotech, Inc. Method and apparatus for forming droplets and microcapsules
DE3615043A1 (de) * 1986-05-03 1987-11-05 Hoechst Ag Verfahren zur verkapselung von biologisch aktivem material
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
AU610083B2 (en) * 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US4840891A (en) * 1986-09-03 1989-06-20 Genetic Engineering, Inc. Encapsulation of sperm for artificial insemination
USRE34326E (en) * 1986-09-03 1993-07-27 British Technology Group, USA, Inc. Encapsulation of sperm for artificial insemination
US4933185A (en) * 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
SE8604684L (sv) * 1986-11-03 1988-05-04 Excorim Kommanditbolag Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
JPH07110182B2 (ja) * 1986-11-26 1995-11-29 ぺんてる株式会社 菌根菌の菌根形成法
JPH0763607B2 (ja) * 1987-02-13 1995-07-12 麒麟麦酒株式会社 ビ−ズ製造方法およびその装置
GB8705464D0 (en) * 1987-03-09 1987-04-15 Atomic Energy Authority Uk Composite material
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US4808707A (en) * 1987-06-08 1989-02-28 University Of Delaware Chitosan alginate capsules
US5427935A (en) * 1987-07-24 1995-06-27 The Regents Of The University Of Michigan Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes
EP0301777A1 (fr) * 1987-07-28 1989-02-01 Queen's University At Kingston Microencapsulation multiple à membrane
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5487739A (en) * 1987-11-17 1996-01-30 Brown University Research Foundation Implantable therapy systems and methods
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5156844A (en) * 1987-11-17 1992-10-20 Brown University Research Foundation Neurological therapy system
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5441878A (en) * 1987-12-08 1995-08-15 Thies Technology, Inc. Preparation of uniform droplets by using gas pressure to force liquid from a syringe and flowing gas to detach droplets
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US5264359A (en) * 1988-04-18 1993-11-23 Nitta Gelatin Inc. Methods for large-scale cultivation of animal cells and for making supporting substrata for the cultivation
AU4191989A (en) * 1988-08-24 1990-03-23 Marvin J. Slepian Biodegradable polymeric endoluminal sealing
US5055402A (en) * 1989-01-04 1991-10-08 Bio-Recovery Systems, Inc. Removal of metal ions with immobilized metal ion-binding microorganisms
JPH04505701A (ja) * 1989-02-21 1992-10-08 バイオシス 虫生線虫をパッケージ化するための方法および媒体
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
US5204111A (en) * 1989-04-07 1993-04-20 L'oreal Process for the preparation of alginate capsules, apparatus for producing said capsules and cosmetic compositions containing said capsules
FR2645439B1 (fr) * 1989-04-07 1991-06-21 Oreal Procede de preparation de capsules d'alginate(s) particulierement adaptees a un usage cosmetique, appareil pour sa mise en oeuvre et composition cosmetique contenant lesdites capsules
US5116747A (en) * 1989-08-11 1992-05-26 University Of Waterloo Immobilization of biologically active material in capsules prepared from a water-soluble polymer and chitosan acetate
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
JPH03504467A (ja) * 1989-10-18 1991-10-03 アメリカ合衆国 固定化金属抽出剤含有ポリマービーズ
US5093253A (en) * 1989-11-06 1992-03-03 Monsanto Company Method for microbial immobilization by entrapment in gellan gum
US5175093A (en) * 1989-11-07 1992-12-29 Lehigh University Bioactive cells immobilized in alginate beads containing voids formed with polyethylene glycol
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
WO1991007951A1 (fr) * 1989-12-05 1991-06-13 Trancel Corporation Composition de revêtement a base d'alginate comprenant de l'acide guluronique homologue destinee a etre appliquee et implantee in vivo et procede d'utilisation
WO1991009119A1 (fr) * 1989-12-13 1991-06-27 Trancel Corporation Microcapsules d'alginate ameliorees et procedes pour leur fabrication et leur utilisation
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6099856A (en) * 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US8067149B2 (en) * 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
FR2668081B1 (fr) * 1990-10-19 1994-11-18 Lvmh Rech Procede et appareil de fabrication de particules solides a partir d'un materiau solidifiable en presence d'un agent de solidification en de bons rendements.
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
ATE138256T1 (de) * 1990-10-31 1996-06-15 Baxter Int Vaskularisation erlaubendes implantatmaterial
CA2099617C (fr) * 1990-12-31 1995-11-28 William M. Rutherford Bacteries sechees microencapsulees avec des acides gras a l'aide d'un plateau rotatif
US5292657A (en) * 1990-12-31 1994-03-08 Pioneer Hi-Bred International, Inc. Process for preparing rotary disc fatty acid microspheres of microorganisms
FR2673122B1 (fr) * 1991-02-25 1994-09-09 Moet & Chandon Gel ionotrope deficient en entite ionique de gelification, procede de preparation d'un tel gel et utilisation de celui-ci notamment dans un procede d'elaboration de vin effervescent.
WO1992019195A1 (fr) * 1991-04-25 1992-11-12 Brown University Research Foundation Vehicule implantable immuno-isolateur et biocompatible servant a apporter des produits therapeutiques selectionnes
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
US5736371A (en) * 1991-06-04 1998-04-07 A Et S Biovecteurs Biodegradable particulate vector for transporting molecules having biological activity
US5232712A (en) * 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
US6773458B1 (en) * 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
JP3199405B2 (ja) * 1991-08-30 2001-08-20 生化学工業株式会社 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法
AU2572692A (en) 1991-09-09 1993-04-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and devices for treating hemophilia and aids
JP3252361B2 (ja) * 1991-10-02 2002-02-04 ミルトン・エイチ・リプスキー インビボにおける癌の治療のアッセイ
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5610753A (en) * 1991-12-12 1997-03-11 Eastman Kodak Company Optical design of laser scanner to reduce thermal sensitivity
US5170744A (en) * 1991-12-13 1992-12-15 Biosys Corporation Long-term storage of infective juvenile nematodes in pseudoplastic layers
US6340594B1 (en) 1991-12-19 2002-01-22 Cellfor, Inc. Production of desiccation-tolerant gymnosperm embryos
DE69231890T2 (de) 1991-12-19 2002-03-28 Univ Saskatchewan Saskatchewan Desikkation von gymnosperm somatischen embryonen
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
DE69327281T2 (de) * 1992-02-24 2000-08-10 Encelle, Inc. Künstliche endokrine vorrichtung
PT627911E (pt) 1992-02-28 2001-04-30 Univ Texas Hidrogeis biodegradaveis fotopolimerizaveis como materiais de contacto de tecidos e veiculos de libertacao controlada
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5453270A (en) * 1992-03-30 1995-09-26 Hypermetabolic Therapies, Inc. Pharmaceutical composition and method for hypermetabolic weight loss
DE69331108T2 (de) * 1992-04-01 2002-07-04 Baxter International Inc. (A Delaware Corporation), Deerfield Systeme zum einpflanzen von gefässbildendem gewebe
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5286495A (en) * 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
ATE207727T1 (de) * 1992-05-29 2001-11-15 Univ California Beschichtetes transplantat sowie herstellungsverfahren dafür
WO1994013266A1 (fr) * 1992-05-29 1994-06-23 The Regents Of The University Of California Nouveau procede electrostatique de realisation de transplants a revetement et produits ainsi realises
AU4397593A (en) * 1992-05-29 1993-12-30 Vivorx, Inc. Microencapsulation of cells
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5521079A (en) * 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
US6001387A (en) * 1992-05-29 1999-12-14 The Reguents Of The University Of California Spin disk encapsulation apparatus and method of use
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
WO1994003154A1 (fr) * 1992-07-29 1994-02-17 Washington University Utilisation d'une poche pour l'implantation de cellules vivantes
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
EP0762874A4 (fr) * 1992-12-30 1997-08-06 Clover Cons Ltd Systemes de conditionnement de substances biologiquement actives dans des macrocapsules recuperables, biocompatibles et cytoprotectrices
US6689608B1 (en) 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
FR2703927B1 (fr) * 1993-04-13 1995-07-13 Coletica Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées.
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
ATE298561T1 (de) * 1993-04-22 2005-07-15 Emisphere Tech Inc Orale dareichungsform
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
EP2025353A2 (fr) 1993-04-30 2009-02-18 Massachusetts Institute of Technology Compositions de cellules de polysaccharide injectables
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5698413A (en) * 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
EP0708670A4 (fr) * 1993-06-23 1998-07-01 Cytotherapeutics Inc Procede et appareil de fermeture hermetique de dispositifs d'encapsulage membranaire implantable
WO1995005452A2 (fr) * 1993-08-12 1995-02-23 Cytotherapeutics, Inc. Compositions et procedes ameliores pour l'administration de molecuiles a activite biologique a l'aide de cellules modifiees genetiquement comprises dans des capsules biocompatibles immuno-isolatrices
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5965149A (en) * 1993-08-13 1999-10-12 Thermo Trilogy Corporation Granular formulation of biological entities with improved storage stability
US5453368A (en) * 1993-08-27 1995-09-26 Brown University Research Foundation Method of encapsulating biological substances in microspheres
US5500161A (en) * 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
CA2148354A1 (fr) * 1993-09-24 1995-03-30 Laura A. Martinson Methodes pour accroitre la vascularisation des implants
WO1995018216A1 (fr) * 1993-12-30 1995-07-06 Nitta Gelatin Inc. Procedes permettant d'enrober des cultures de cellules animales
CA2180826A1 (fr) 1994-01-13 1995-07-20 Richard J. Ii Stoner Systeme organique de lutte contre les maladies
ATE320482T1 (de) * 1994-01-13 2006-04-15 Rogosin Inst Makroeingekapselte sekretorische zellen
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5459258A (en) * 1994-03-01 1995-10-17 Massachusetts Institute Of Technology Polysaccharide based biodegradable thermoplastic materials
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
JP2848515B2 (ja) * 1994-03-31 1999-01-20 矢崎総業株式会社 種子類似物作成装置
US5620883A (en) * 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5585183A (en) * 1994-04-13 1996-12-17 National Science Council Preparation of liquid-core microcapsules for cell cultures
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
DE69530227T2 (de) * 1994-04-15 2004-04-01 Temple University Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
US5651980A (en) * 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
US6531156B1 (en) 1994-04-15 2003-03-11 Temple University Aqueous solven encapsulation method, apparatus and microcapsules
US5602071A (en) * 1994-05-26 1997-02-11 Aero-Terra-Aqua Technologies Corporation Bead for removing dissolved metal contaminants
US5578547A (en) * 1994-05-26 1996-11-26 Aero-Terra-Aqua Technologies Corp. Bead for removing dissolved metal contaminants
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
US5531735A (en) * 1994-09-27 1996-07-02 Hercules Incorporated Medical devices containing triggerable disintegration agents
US6281015B1 (en) 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
CA2146098A1 (fr) * 1995-01-12 1996-07-13 Ray V. Rajotte Preservation cryogenique en vrac de substances biologiques et applications pour la cryopreservation et l'encapsulage de ces substances
JPH11501512A (ja) * 1995-03-03 1999-02-09 メタボレックス，インコーポレイティド ゲル化ポリマーによる新規の被包方法
US7008634B2 (en) 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
JP3830986B2 (ja) * 1995-03-07 2006-10-11 日本化学工業株式会社 ジ（１，１，３，３−テトラメチルブチル）ホスフィン及びその製造方法
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
BR9604880A (pt) * 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5795570A (en) * 1995-04-07 1998-08-18 Emory University Method of containing core material in microcapsules
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5827707A (en) * 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
JPH0928722A (ja) * 1995-07-19 1997-02-04 Kajiwara Hiroshi 長期保存可能な肝補助体及びその製造方法
DE19681560T1 (de) * 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
EP0822857A1 (fr) * 1996-02-23 1998-02-11 Circe Biomedical, Inc. Nouveau pancreas artificiel
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
CA2258264A1 (fr) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Parfums microencapsules et leur procede de production
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
HU220588B1 (hu) * 1996-09-05 2002-03-28 Bay Zoltán Alkalmazott Kutatási Alapítvány Biotechnológiai Intézet Eljárás és bioreaktortöltet L(-)-almasav előállítására fumársavból
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
DE19644343A1 (de) * 1996-10-25 1998-04-30 Privates Inst Bioserv Gmbh Geschmacksneutrale Mikrokapseln, Verfahren zu ihrer Herstellung sowie ihre Verwendung
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
ATE550429T1 (de) * 1996-11-20 2012-04-15 Crucell Holland Bv Adenovirus-zusammensetzungen erhältlich durch ein verbessertes produktions- und reinigungsverfahren
AU742316B2 (en) 1996-12-10 2001-12-20 Curis, Inc. Improved hydrogel for tissue engineering
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) * 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) * 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
GB2327074B (en) * 1997-07-07 2001-09-12 Norsk Hydro As Improvements in or relating to capsules
US6096303A (en) * 1997-07-31 2000-08-01 Medical College Of Georgia Research Institute, Inc. Method to enhance treatment of cystic tumors
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6368612B1 (en) 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US6958148B1 (en) * 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
DE19813011A1 (de) * 1998-03-25 1999-10-14 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von Mikrokapseln
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
AU1623300A (en) * 1998-11-13 2000-06-05 Sensor Technologies, Inc. Monodisperse preparations useful with implanted devices
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
WO2000054786A1 (fr) * 1999-03-15 2000-09-21 Modex Therapeutiques, S.A. Methodes et compositions destines a rendre des hotes tolerants a la survie a long terme de greffons de tissus
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
EP1208382B1 (fr) 1999-08-17 2006-04-26 Luminex Corporation Encapsulation de particules fluorescentes
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
CA2382821A1 (fr) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation de liberation a partir de formulations seches en poudre
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6395678B1 (en) 1999-09-01 2002-05-28 Aero-Terra-Aqua Technologies Corporation Bead and process for removing dissolved metal contaminants
US6878543B1 (en) * 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
IL134009A (en) 2000-01-12 2011-07-31 Bo2 Technologies Ltd Transplant device
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
US20030129248A1 (en) * 2000-02-29 2003-07-10 Rainer Pommersheim Microcapsule, in particular, for immobilizing organic or inorganic solids, liquids and/or gases
CA2403292C (fr) 2000-04-06 2011-02-08 Panacea Pharmaceuticals, Llc Systeme d'administration microbienne
DK1280521T3 (da) 2000-05-12 2005-08-08 Pharmacia & Upjohn Co Llc Vaccinesammensætning, fremgangsmåde til fremstilling deraf og fremgangsmåde til vaccination af hvirveldyr
US6991652B2 (en) * 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
AU2001273234A1 (en) * 2000-07-05 2002-01-14 Islet Technology, Inc. Method and system for consistent and effective encapsulation of biological material
WO2002026911A1 (fr) 2000-09-27 2002-04-04 Microtek Laboratories, Inc. Macrocapsules contenant des matieres a changement de phase microencapsulees
CA2428260A1 (fr) * 2000-11-09 2002-05-16 Kenneth Allan De Luca Extraction de graisse
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
JP2005504715A (ja) 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US20070082052A1 (en) * 2001-02-23 2007-04-12 Bonassar Lawrence J Tympanic membrane repair constructs
AU2002252025A1 (en) * 2001-02-23 2002-09-12 University Of Massachusetts Injection molding of living tissues
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US20040009160A1 (en) * 2001-06-22 2004-01-15 Villamar Daniel F Bioactive food complex, method for making bioactive food complex product and method for controlling disease
US7534774B2 (en) * 2001-10-03 2009-05-19 Tissue Repair Company Traversal of nucleic acid molecules through a fluid space and expression in repair cells
AU2002361601A1 (en) * 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
ES2415654T3 (es) * 2001-11-20 2013-07-26 Civitas Therapeutics, Inc. Composiciones particuladas mejoradas para suministro pulmonar
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US20030175410A1 (en) * 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
CA2483778A1 (fr) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Systemes de fixation et de confinement structurels de matrices biologiques et procedes d'utilisation de ceux-ci
EP1458853B1 (fr) * 2002-05-16 2009-11-25 Absorber AB Methodes d'essai de compatibilite croisee specifique du donneur
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
EP1585964A4 (fr) * 2002-08-28 2008-07-16 Introgen Therapeutics Inc Procedes chromatographiques de purification d'adenovirus
JPWO2004026457A1 (ja) * 2002-09-18 2006-06-15 中嶋　光敏 マイクロカプセルの製造方法
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
DE10254636A1 (de) * 2002-11-22 2004-06-09 Capsulution Nanoscience Ag Verfahren zum Modifizieren von Mikropartikeln sowie Vorrichtung zum Modifizieren von Mikropartikeln
CA2450650C (fr) * 2002-12-24 2007-08-28 An-Go-Gen Inc. Therapie a l'aide de cellules encapsulees
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
BRPI0407142A (pt) * 2003-02-14 2006-01-10 Depuy Spine Inc Dispositivo de fusão intervertebral formado in situ
WO2004075855A2 (fr) 2003-02-26 2004-09-10 Biomed Solutions, Llc Procede de traitement in vivo de cibles biologiques specifiques dans un fluide corporel
NZ543365A (en) 2003-04-18 2009-02-28 Biogen Idec Inc Polymer-conjugated glycosylated neublastin
US20040229335A1 (en) * 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
GB0311664D0 (en) * 2003-05-21 2003-06-25 Univ Manchester Polymeric hollow nanospheres
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
WO2006071794A2 (fr) 2004-12-23 2006-07-06 Ethicon Incorporated Cellules postnatales derivees de tissus du cordon ombilical, et procedes de production et d'utilisation de celles-ci
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
PL1641913T3 (pl) 2003-06-27 2016-06-30 Depuy Synthes Products Inc Komórki poporodowe pochodzące z tkanek pępowinowych i sposoby ich wytwarzania i zastosowania
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
DE10334237A1 (de) * 2003-07-28 2005-02-24 Robert Bosch Gmbh Aktiver Sensorkanal
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7927599B2 (en) * 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
WO2005033297A1 (fr) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methodes et kits relatifs a la reprogrammation de cellules differenciees adultes et production de cellules du type cellules souches embryonnaires
US20090325859A1 (en) * 2003-09-19 2009-12-31 Northwestern University Citric acid polymers
WO2005028631A2 (fr) 2003-09-19 2005-03-31 Northwestern University Nouvel echafaudage elastomere biodegradable pour genie tissulaire et procedes d'essai associes de cartographie peptidique de diffusion de lumiere
US20050067341A1 (en) * 2003-09-25 2005-03-31 Green Dennis H. Continuous production membrane water treatment plant and method for operating same
CA2548822C (fr) * 2003-12-08 2015-08-11 Gel-Del Technologies, Inc. Dispositifs d'administration de medicaments mucoadhesifs et procedes de fabrication et d'utilisation associes
ATE442195T1 (de) * 2004-02-23 2009-09-15 Novartis Pharma Gmbh Verfahren zur herstellung von mikrokugeln auf basis von ionisch vernetztem polysaccharid
US20050201990A1 (en) * 2004-03-09 2005-09-15 Suchitra Sumitran-Holgersson Endothelial progenitor cells and methods of use thereof
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
DE602005014354D1 (de) 2004-03-30 2009-06-18 Nsgene As Therapeutische verwendung des wachstumsfaktors nsg33
DE102004019241A1 (de) * 2004-04-16 2005-11-03 Cellmed Ag Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
JP5175092B2 (ja) 2004-06-01 2013-04-03 クワラタ トレーディング リミティド 幹細胞を用いるｉｎｖｉｔｒｏ技術
EP1786834B1 (fr) * 2004-07-14 2016-02-17 Glusense Ltd. Capteurs et sources électriques implantables
WO2006013462A2 (fr) * 2004-07-30 2006-02-09 Nsgene A/S Facteurs de croissance nsg28, nsg30, et nsg32
US8722862B2 (en) * 2004-08-19 2014-05-13 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
EA013565B1 (ru) * 2004-08-19 2010-06-30 Байоджен Айдек Ма Инк. Варианты полипептидов нейбластина, способы их получения и их применение
EP2361970A1 (fr) 2004-09-24 2011-08-31 Angioblast Systems Incorporated Procédé d'amélioration de la prolifération et/ou survie des cellules de précurseurs mesenchymataux (MPC)
CN101506355B (zh) 2004-09-24 2012-06-27 成血管细胞系统公司 多能扩增间充质前体细胞子代（memp）及其应用
EP1807506B1 (fr) * 2004-10-08 2013-04-17 Georgia Tech Research Corporation Microencapsulation de cellules dans des hydrogels a l'aide de potentiels electrostatiques
AU2005305347A1 (en) * 2004-11-03 2006-05-18 Introgen Therapeutics Inc. Method of producing and purifying of adenoviral vectors
DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
SI1835924T1 (sl) 2004-12-23 2013-12-31 Ethicon, Incorporated Zdravljenje Parkinsonove bolezni in sorodnih obolenj z uporabo celic, pridobljenih post partum
KR20070100908A (ko) * 2005-01-31 2007-10-12 코그네이트 세러퓨틱 인크. 내피 세포의 특성을 나타내는 지방 유래 성인 스트로마세포
WO2006089152A2 (fr) * 2005-02-18 2006-08-24 Maxcyte, Inc. Utilisation d'inhibiteurs de methyltransferase pour augmenter l'expression transgenique
US8431226B2 (en) * 2005-03-30 2013-04-30 Biomet Manufacturing Corp. Coated medical device
EP1869165B1 (fr) * 2005-04-12 2015-10-21 Mesoblast, Inc. Isolation de cellules multipotentielles adultes au moyen d'une phosphatase alcaline non spécifique de tissu
ES2699690T3 (es) * 2005-06-02 2019-02-12 Univ Arizona Dispositivos prevascularizados y métodos relacionados
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
EP2093256A3 (fr) 2005-07-28 2009-10-14 Carnegie Mellon University Polymères biocompatibles et procédés d'utilisation
US8357666B2 (en) * 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
ES2397289T3 (es) * 2005-09-22 2013-03-06 Biocompatibles Uk Ltd. Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada
US20070071790A1 (en) 2005-09-28 2007-03-29 Northwestern University Biodegradable nanocomposites with enhance mechanical properties for soft tissue
AU2006325710B2 (en) 2005-12-16 2012-05-17 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
WO2007073552A1 (fr) 2005-12-19 2007-06-28 Ethicon, Inc. Methode d'expansion in vitro de cellules derivees de tissus puerperaux mise en oeuvre dans des flacons pour agitateurs rotatifs
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
WO2007092583A2 (fr) * 2006-02-08 2007-08-16 Northwestern University Fonctionnalisation de dispositifs implantables avec un polymère de poly(diol-co-citrate)
CN100571779C (zh) * 2006-02-24 2009-12-23 沈炳谦 海藻酸盐纳米胶囊及其制备方法
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
EP1993590B1 (fr) * 2006-03-01 2013-12-25 Biogen Idec MA Inc. Compositions et procedes d'administration de proteines de la famille des ligands gdnf
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
EP1854455B1 (fr) * 2006-05-10 2009-10-07 Biocompatibles UK Limited Microcapsules sphériques contenant des peptides du type GLP-1, leur production et leur utilisation
WO2007143139A1 (fr) 2006-05-31 2007-12-13 The Brigham And Women's Hospital, Inc. Cellules souches mésenchymateuses positives abcb5 en tant qu'immunomodulateurs
US20080003205A1 (en) * 2006-06-26 2008-01-03 University Of Massachusetts Tympanic Membrane Repair Constructs
WO2008011006A2 (fr) 2006-07-18 2008-01-24 University Of Utah Research Foundation Procédé pour traiter la douleur et rechercher systématiquement des composés analgésiques
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2008127423A2 (fr) * 2006-11-14 2008-10-23 Cornell Research Foundation, Inc. Systèmes de catalyseur microencapsulé
WO2008062417A2 (fr) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protection d'algues vis-à-vis de fluides corporels
EP2104492B1 (fr) * 2006-11-28 2017-11-22 Beta O2 Technologies Ltd. Alimentation en oxygène pour greffe de cellules et vascularisation
WO2008070863A2 (fr) 2006-12-07 2008-06-12 Interventional Spine, Inc. Implant intervertébral
EP1972324A1 (fr) * 2007-03-21 2008-09-24 Cognis IP Management GmbH Liposomes encapsulés
EP1972349A1 (fr) * 2007-03-21 2008-09-24 Biocompatibles UK Limited Peptides à fusion GLP-1 associée à un/plusieurs polymères, leur production et utilisation
EP1975176A1 (fr) * 2007-03-27 2008-10-01 Biocompatibles UK Limited Nouveaux peptides à fusion GLP-1, leur production et utilisation
US8026083B2 (en) 2007-04-03 2011-09-27 Oxyrane Uk Limited Yarrowia lipolytica and Pichia pastoris HAC1 nucleic acids
TWI445544B (zh) 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US20080279833A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US20080281419A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Breast implants and compositions of extracellular matrix
US9034367B2 (en) * 2007-05-10 2015-05-19 Cormatrix Cardiovascular, Inc. Articles for tissue regeneration with biodegradable polymer
US20080318314A1 (en) * 2007-06-20 2008-12-25 Valentin Fulga Production from blood of cells of neural lineage
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
CA2691793A1 (fr) * 2007-06-29 2009-01-08 Cellular Dynamics International, Inc. Procede automatise et appareil permettant une culture de cellule souche embryonnaire
ES2923016T3 (es) 2007-08-06 2022-09-22 Mesoblast Inc Células precursoras mesenquimales TNAP+ para el tratamiento de enfermedades del tejido conectivo
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
JP2010536373A (ja) 2007-08-23 2010-12-02 イントレキソン コーポレーション 疾患を診断するための方法および組成物
US8821431B2 (en) * 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
CA2715080C (fr) 2007-09-28 2021-09-28 Intrexon Corporation Constructions et bioreacteurs de commutation de gene theapeutique destines a l'expression de molecules biotherapeutiques, et utilisation de ceux-ci
ES2525718T3 (es) 2007-10-05 2014-12-29 DePuy Synthes Products, LLC Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano
DE102007059939A1 (de) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen
AU2008343193B2 (en) * 2007-12-20 2014-04-24 Ethicon, Incorporated Encapsulated kidney tissue
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
EP2237770A4 (fr) 2007-12-26 2011-11-09 Gel Del Technologies Inc Particules de protéines biocompatibles, dispositifs à particules et leurs procédés
EP2237748B1 (fr) 2008-01-17 2012-09-05 Synthes GmbH Implant intervertébral extensible
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
CA2720580A1 (fr) 2008-04-05 2009-10-08 Synthes Usa, Llc Implant intervertebral extensible
JP2011516082A (ja) 2008-04-07 2011-05-26 ニューポテンシャル，インコーポレイテッド 小分子修飾因子の使用を通して多能性遺伝子を誘発することによる細胞の再プログラミング
EP2163243A1 (fr) * 2008-09-12 2010-03-17 Biocompatibles UK Limited Traitement de l'infarctus du myocarde (AMI) utilisant des cellules encapsulées codant et sécrétant des peptides GLP-1 ou analogues associés
WO2010032242A1 (fr) * 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimisation de l'encapsulation dans de l'alginate d'îlots à transplanter
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
US20100111919A1 (en) * 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
AU2009327384B2 (en) 2008-12-19 2014-07-10 DePuy Synthes Products, LLC Treatment of lung and pulmonary diseases and disorders
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
WO2010075500A1 (fr) 2008-12-23 2010-07-01 Stemcells California, Inc Populations cibles de cellules précurseurs d'oligodendrocytes et leurs méthodes de fabrication et d'utilisation
US20100160749A1 (en) * 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
US9511093B2 (en) * 2009-03-23 2016-12-06 The Texas A & M University System Compositions of mesenchymal stem cells to regenerate bone
BRPI1013409A2 (pt) 2009-03-26 2018-01-16 Advanced Tech And Regenerative Medicine Llc células de tecido de cordão umbilical humano como terapia para doença de alzheimer
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
BRPI0902039B8 (pt) 2009-06-09 2021-05-25 Anhanguera Educacional Ltda composição farmacêutica e uso de composição farmacêutica para o tratamento, profilaxia ou prevenção de doenças neoplásicas em humanos e animais
CA2775938C (fr) 2009-09-29 2021-08-10 Oxyrane Uk Limited Hydrolyse de la liaison du mannose-1-phospho-6-mannose au phospho-6-mannose
CA2778678A1 (fr) 2009-10-30 2011-05-05 Cns Therapeutics, Inc. Molecules de neurturine ameliorees
JP2013510577A (ja) 2009-11-12 2013-03-28 ブイビーアイ テクノロジーズ， エルエルシー 胞子様細胞の亜集団およびその用途
JP2013511272A (ja) 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合ｎ−グリカンを生成する酵母株
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US9517250B2 (en) 2010-04-28 2016-12-13 The J. David Gladstone Institutes Methods for generating cardiomyocytes
WO2011159726A2 (fr) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogrammation de cellules pour leur conférer un nouveau destin
US9282979B2 (en) 2010-06-24 2016-03-15 DePuy Synthes Products, Inc. Instruments and methods for non-parallel disc space preparation
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
JP5850930B2 (ja) 2010-06-29 2016-02-03 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 離反椎間インプラント
WO2012027494A1 (fr) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Réactifs bispécifiques de ciblage
CN103261432A (zh) 2010-09-29 2013-08-21 奥克西雷恩英国有限公司 磷酸化的n-聚糖的脱甘露糖基化
EP2622088A2 (fr) 2010-09-29 2013-08-07 Oxyrane UK Limited Mannosidases capables d'éliminer la coiffe des liaisons mannose-1-phospho- 6-mannose et de démannosyler les n-glycanes phosphorylés, et méthodes facilitant l'assimilation des glycoprotéines par des cellules de mammifères
CA2813013C (fr) 2010-10-01 2019-10-22 Nsgene A/S Traitement de l'allodynie, de l'hyperalgesie, de la douleur spontanee et de la douleur illusionnelle
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US9867781B2 (en) 2011-02-18 2018-01-16 Massachusetts Institute Of Technology Hydrogel encapsulated cells and anti-inflammatory drugs
GB2489320A (en) * 2011-03-21 2012-09-26 Univ Reading Transport of cells by encapsulating in a hydrogel
DK3354665T5 (da) 2011-06-02 2022-09-19 Massachusetts Inst Technology Modificerede alginater til celleindkapsling og celleterapi
RU2637085C2 (ru) 2011-06-06 2017-11-29 КИНЕТА УАН, ЭлЭлСи Фармацевтические композиции на основе shk и способы их получения и использования
JP2014520665A (ja) * 2011-06-29 2014-08-25 ザ ユニバーシティ オブ アクロン 封入および固定化の方法
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
US9393272B2 (en) 2011-08-09 2016-07-19 Wake Forest University Health Sciences Co-encapsulation of live cells with oxygen-generating particles
EP2793965B1 (fr) 2011-12-20 2019-02-20 LifeCell Corporation Produits de tissu fluides
AU2012355463C1 (en) 2011-12-20 2016-09-22 Lifecell Corporation Sheet tissue products
EP2794854B1 (fr) 2011-12-23 2018-06-20 DePuy Synthes Products, Inc. Détection de cellules extraites du tissu du cordon ombilical chez l'homme
EP3461508A1 (fr) 2012-01-24 2019-04-03 LifeCell Corporation Matrices tissulaires allongées
KR20190114003A (ko) 2012-03-15 2019-10-08 옥시레인 유케이 리미티드 폼페병의 치료를 위한 방법 및 물질
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
ES2749178T3 (es) 2012-04-24 2020-03-19 Lifecell Corp Matrices de tejido funcionalizado
DK2854883T3 (da) 2012-05-17 2019-07-15 Cartiheal 2009 Ltd Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf
WO2013188858A2 (fr) 2012-06-15 2013-12-19 Microvi Biotech Inc. Nouvelles compositions de biocatalyseurs et procédés d'utilisation
US9752164B2 (en) 2012-06-15 2017-09-05 Microvi Biotech, Inc. Enhanced efficiency ethanol and sugar conversion processes
US9334507B2 (en) 2012-06-15 2016-05-10 Microvi Biotech, Inc. Bioprocesses for making butanol
US9255281B2 (en) 2012-06-15 2016-02-09 Microvi Biotech Inc. Bioconversion processes using water-insoluble liquids
WO2014022373A1 (fr) 2012-08-01 2014-02-06 United Therapeutics Corporation Traitement de l'hypertension artérielle pulmonaire avec des cellules souches mésenchymateuses
CA2880811C (fr) 2012-08-01 2021-12-07 United Therapeutics Corporation Traitement de l'hypertension arterielle pulmonaire avec des cellules progenitrices endotheliales traitees a la prostacycline
EP3878452B1 (fr) 2013-01-09 2023-09-20 United Therapeutics Corporation Traitement de la vasculopathie au moyen de la prostacycline et de cellules souches mésenchymateuses
US9717601B2 (en) 2013-02-28 2017-08-01 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
WO2014136065A2 (fr) 2013-03-05 2014-09-12 Oxyrane Uk Limited Production de sulfatase de type i catalytiquement active
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10172791B2 (en) 2013-03-14 2019-01-08 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US9555007B2 (en) 2013-03-14 2017-01-31 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
EP2992076B1 (fr) * 2013-05-03 2018-10-24 Novozymes A/S Microencapsulation d'enzymes détergentes
KR20160019469A (ko) 2013-05-31 2016-02-19 더 유니버시티 오브 유타 리서치 파운데이션 코노톡신 펩티드, 제약 조성물 및 그의 용도
WO2014198994A1 (fr) 2013-06-13 2014-12-18 Biomedal, S.L. Procédé d'analyse rapide de l'activité cellulaire
WO2015042580A1 (fr) 2013-09-23 2015-03-26 Biogen Idec Ma Inc. Compositions et méthodes de traitement d'une douleur neuropathique
WO2016019391A1 (fr) * 2014-08-01 2016-02-04 Massachusetts Institute Of Technology Alginates modifiés pour matériaux anti-fibrotiques et applications associées
US10575765B2 (en) 2014-10-13 2020-03-03 Glusense Ltd. Analyte-sensing device
KR20170110574A (ko) 2014-12-05 2017-10-11 오거스타 유니버시티 리서치 인스티튜트, 인크. 조직 보강, 생의학 및 화장품 적용을 위한 유리 복합체
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US20180085496A1 (en) 2015-04-01 2018-03-29 Yale University Ferromagnetic particles bound to polymeric implants
US20180353643A1 (en) 2015-05-17 2018-12-13 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
RU2018120104A (ru) 2015-11-01 2019-12-02 Массачусетс Инститьют Оф Текнолоджи Модифицированные альгинаты в качестве противофиброзных материалов и их применения
EP3167911A1 (fr) 2015-11-10 2017-05-17 Oniris Cellules produisant de l'insuline encapsulée dans du si-hpmc- pour le traitement de diabètes de type1
KR20180086440A (ko) 2015-11-18 2018-07-31 유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 신경 세포 세포외 소포체
EP3445872A1 (fr) 2016-04-20 2019-02-27 Glusense Ltd. Molécules de détection de glucose par fret
JP6920681B2 (ja) * 2016-04-27 2021-08-18 株式会社クラレ 移植用デバイス及びその製造方法並びにバイオ人工臓器の製造方法
GB201610101D0 (en) * 2016-06-09 2016-07-27 Attenborough Dental Laboratories Ltd Multicellular lay-up process
CN109688980B (zh) 2016-06-28 2022-06-10 Eit 新兴移植技术股份有限公司 具有关节运动接头的可扩张和角度可调节的椎间笼
JP6995789B2 (ja) 2016-06-28 2022-01-17 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー 拡張可能かつ角度調節可能な椎間ケージ
JP2019528248A (ja) 2016-07-18 2019-10-10 ティシュージェン， インク． 生体分子の立体配座及び構造健全性を維持するための方法及び組成物
ES2927406T3 (es) 2016-10-24 2022-11-04 United Therapeutics Corp Potenciación de las propiedades inmunomoduladoras de las MSC mediante treprostinil
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
WO2019133828A1 (fr) * 2017-12-31 2019-07-04 Papazian Mihran Compositions de médicament dentaire sphérifié
EP3840874B1 (fr) 2018-08-20 2024-05-15 Immundiagnostik AG Composition de sorbant pour le traitement pré-analytique d'échantillons
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
CN114302749A (zh) 2019-06-28 2022-04-08 持田制药株式会社 使用了化学交联海藻酸的移植用器件
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
KR20230123959A (ko) 2020-12-22 2023-08-24 모찌다 세이야쿠 가부시끼가이샤 화학 가교 알긴산을 사용한 이식용 디바이스
CN116710110A (zh) * 2020-12-28 2023-09-05 持田制药株式会社 新型的多层聚合物涂层交联海藻酸凝胶纤维
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
KR20240006581A (ko) 2021-05-06 2024-01-15 호바 세라퓨틱스 에이피에스 화학요법-유도된 신경병성 통증의 예방 및 치료
CA3239550A1 (fr) 2021-12-10 2023-06-15 Kenneth Petersen Traitement de la douleur nociceptive
US12090064B2 (en) 2022-03-01 2024-09-17 Medos International Sarl Stabilization members for expandable intervertebral implants, and related systems and methods
CN114504561B (zh) * 2022-03-01 2023-08-11 陕西科技大学 一种用于制备药物渗透泵制剂的水性包衣方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1951M (fr) * 1962-01-19 1962-08-05 Rolland Lab A Extrait de pancréas.
GB931532A (en) * 1958-12-22 1963-07-17 Upjohn Co Injectable preparations comprising encapsulated medicaments and processes for making them
DD36655A3 (fr) * 1964-06-12 1965-11-05
GB1236885A (en) * 1968-09-28 1971-06-23 Fuji Photo Film Co Ltd Method of making multi-wall capsules
US3725113A (en) * 1970-12-17 1973-04-03 Research Corp Blood compatible microencapsulated detoxicants and method for making
FR2370510A1 (fr) * 1975-08-20 1978-06-09 Damon Corp Procede d'encapsulation d'une matiere biologique labile

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766478A (en) * 1951-10-15 1956-10-16 Gasoline Res Ind And Commercia Encapsulating method and apparatus
US3522346A (en) * 1968-05-31 1970-07-28 Research Corp Nonthrombogenic microcapsules
US3650900A (en) * 1968-09-27 1972-03-21 Yeda Res & Dev Insoluble polymer-enzyme products
US3734851A (en) * 1969-12-29 1973-05-22 K Matsumura Method and device for purifying blood
US3733205A (en) * 1970-08-07 1973-05-15 Pfizer Enzymatic removal of diacetyl from fermented beverages
US3730841A (en) * 1971-03-24 1973-05-01 American Cyanamid Co Encapsulated carrier bound enzymes
US3860490A (en) * 1972-02-11 1975-01-14 Nat Patent Dev Corp Process of subjecting a microorganism susceptible material to a microorganism
US3925157A (en) * 1972-07-12 1975-12-09 Pfizer Immobilized enzymes
JPS4930582A (fr) * 1972-07-17 1974-03-19
JPS5128589A (en) * 1974-09-04 1976-03-10 Matsushita Electric Ind Co Ltd Denbahatsukokeikotainoseizohoho
US4324683A (en) * 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
JPS6025117B2 (ja) * 1976-03-31 1985-06-17 北海道糖業株式会社 菌体酵素の固定化法
JPS5851758B2 (ja) * 1976-06-11 1983-11-18 日本ペイント株式会社 酵素もしくは菌体固定化物およびその製造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB931532A (en) * 1958-12-22 1963-07-17 Upjohn Co Injectable preparations comprising encapsulated medicaments and processes for making them
FR1951M (fr) * 1962-01-19 1962-08-05 Rolland Lab A Extrait de pancréas.
DD36655A3 (fr) * 1964-06-12 1965-11-05
GB1236885A (en) * 1968-09-28 1971-06-23 Fuji Photo Film Co Ltd Method of making multi-wall capsules
US3725113A (en) * 1970-12-17 1973-04-03 Research Corp Blood compatible microencapsulated detoxicants and method for making
CA982941A (en) * 1970-12-17 1976-02-03 Thomas M.S. Chang Blood compatible microencapsulated detoxicants
FR2370510A1 (fr) * 1975-08-20 1978-06-09 Damon Corp Procede d'encapsulation d'une matiere biologique labile

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1977 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501715A1 (fr) * 1981-03-13 1982-09-17 Damon Corp Procede de culture de cellules necessitant une fixation pour la fabrication de substances therapeutiques
FR2503183A1 (fr) * 1981-03-13 1982-10-08 Damon Corp Procede et ensemble de production de substances formees par des cellules vivantes
DE3432923A1 (de) * 1984-09-07 1986-03-06 Joachim Prof. Dr. Klein Biokatalysator und verfahren zu seiner herstellung
EP0173915A2 (fr) 1984-09-07 1986-03-12 Joachim Prof. Dr. Klein Biocatalyseur et son procédé de préparation
DE3448268C2 (en) * 1984-09-07 1990-02-22 Joachim Prof. Dr. Klein Process for the production of a biocatalyst
FR3107901A1 (fr) 2020-03-09 2021-09-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé de perfusion micro-fluidique d'un sphéroïde et dispositif adapté pour mettre en œuvre ledit procédé
EP3878942A1 (fr) 2020-03-09 2021-09-15 Commissariat à l'énergie atomique et aux énergies alternatives Procédé de perfusion micro-fluidique d'un sphéroïde et dispositif adapté pour mettre en oeuvre ledit procédé

Also Published As

Publication number Publication date
GB2046209A (en) 1980-11-12
CA1145258A (fr) 1983-04-26
CH657786A5 (de) 1986-09-30
CH653914A5 (de) 1986-01-31
IT1133081B (it) 1986-07-09
FR2457688B1 (fr) 1986-12-05
JPS61293919A (ja) 1986-12-24
FR2452285B1 (fr) 1986-12-05
JPS6242889B2 (fr) 1987-09-10
NO160380C (no) 1989-04-19
DE3012233A1 (de) 1980-11-20
NO800901L (no) 1980-09-29
NO160380B (no) 1989-01-02
JPS55157502A (en) 1980-12-08
IT8067472A0 (it) 1980-03-27
JPS6239131B2 (fr) 1987-08-21
DK130580A (da) 1980-09-29
US4352883A (en) 1982-10-05
DE3012233C2 (fr) 1988-03-31
SE8002357L (sv) 1980-09-29
SE448060B (sv) 1987-01-19
FR2457688A1 (fr) 1980-12-26
GB2046209B (en) 1983-09-14
BE882476A (fr) 1980-09-29

Similar Documents

Publication Publication Date Title
FR2452285A1 (fr) Procede d'encapsulation d'un tissu viable ou d'une matiere biologiquement active a implanter, et capsules obtenues
Tasaki et al. Stria vascularis as source of endocochlear potential
Hashimoto et al. Syringoma: Histochemical and electron microscopic studies
FR2450599B1 (fr) Element a implanter dans du tissu d'un corps, en particulier du tissu osseux
Dixit et al. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes
JPH06502080A (ja) 共培養細胞インプラントによる活性因子のイン・ビボ放出
Peters et al. THE AZOLLA‐ANABAENA AZOLLAE RELATIONSHIP: VI. MORPHOLOGICAL ASPECTS OF THE ASSOCIATION
ES2172986T3 (es) Implantes y proceso de preparacion.
Radanov et al. A unique case of naturally occurring mummification of human brain tissue
RU2223788C2 (ru) Трансдуцирующие цитохром p450 ретровирусные векторы
RU2002103465A (ru) Трансдуцирующие цитохром p450 ретровирусные векторы
Rixon et al. The histochemical localization of zinc in the dorsolateral prostate of the rat
Kwa Studies on the sparganum of Spirometra erinacei—III. The fine structure of the tegument in the scolex
Umphlett et al. Cytological and morphological studies of a new species of Phlyctochytrium
FAGERHOLM et al. Formation of after‐cataract by regeneration of human and rabbit lens epithelium in tissue culture
Bouland et al. Fine structure and presumed functions of the gastric hemal tufts of the Asteroid, Asterias rubens L.
Cifkova et al. Irritation effects of residual products derived from p (HEMA) gels: II. Compounds extracted from hydrogels
Merchan et al. Morphology of Hensen's cells.
Suddick et al. The microvascular architecture of the rat submaxillary gland: possible relationship to secretory mechanisms
Marchant An ultrastructural study of sexual reproduction in Pythium ultimum
Soskolne Phagocytosis of osteocytes by osteoclasts in femora of two week-old rabbits
Mhaskar et al. Development of the ascocarp in Epichloë cinerea (Clavicipitaceae)
Simon et al. Asteroid bodies in foreign-body reaction to amalgam
Peters et al. The Azolla-Anabaena azollae relationship.
Comb et al. Callis Wold round barrow, Humberside

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse