ES2525718T3 - Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano - Google Patents
Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano Download PDFInfo
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- ES2525718T3 ES2525718T3 ES08835175.4T ES08835175T ES2525718T3 ES 2525718 T3 ES2525718 T3 ES 2525718T3 ES 08835175 T ES08835175 T ES 08835175T ES 2525718 T3 ES2525718 T3 ES 2525718T3
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract
Células obtenidas de tejido de cordón umbilical humano para su uso en el tratamiento de un paciente con lesión o insuficiencia renal aguda o enfermedad renal crónica, en el que el tejido de cordón umbilical está sustancialmente libre de sangre, y en el que las células son capaces de autorrenovarse y desarrollarse en cultivo y tienen el potencial de diferenciarse; necesitan L-valina para crecer; son capaces de crecer en atmósferas que contienen oxígeno del 5% al 20%; no producen CD117 ni HLA-DR; expresan alfa-actina de músculo liso; y expresan, en comparación con una célula madre mesenquimal, célula de médula ósea de cresta ilíaca o fibroblasto humano, mayores niveles de receptor 1 de lipoproteínas de baja densidad oxidadas, interleucina 8 o reticulón 1.
Description
E08835175
10-12-2014
Tabla 4
5
15
25
35
45
55
- Los genes demostraron tener una expresión disminuida en las células derivadas de tejido de cordón umbilical en comparación con otras líneas celulares ensayadas
- Genes disminuidos en las células derivadas de placenta y derivadas de tejido de cordón umbilical
- ID del conjunto de sondas
- Nombre el gen Número de registro del NCBI
- 210135_ s_at
- caja homeótica de la baja estatura 2 AF022654.1
- 205824_at
- proteína 2 de choque térmico de 27 kDa NM_001541.1
- 209687_at
- ligando 12 de quimiocina (motivo C-X-C ) (factor 1 derivado de células del estroma) U19495.1
- 203666_at
- ligando 12 de quimiocina (motivo C-X-C ) (factor 1 derivado de células del estroma) NM_000609.1
- 212670_at
- elastina (estenosis aórtica supravalvular, síndrome de Williams-Beuren) AA479278
- 213381_at
- ARNm de Homo sapiens; ADNc DKFZp586M2022 (del clon DKFZp586M2022) N91149
- 206201_s_at
- caja homeótica de mesénquima 2 (caja homeótica específica de la detención del crecimiento) NM_005924.1
- 205817_at
- homólogo 1 de caja homeótica de “sine oculis” (Drosophila) NM_005982.1
- 209283_at
- cristalino, alfa B AF007162.1
- 212793_at
- activador 2 de la morfogénesis asociado a “disheveled” BF513244
- 213488_at
- proteína DKFZP586B2420 AL050143.1
- 209763_at
- similar a neuralina 1 AL049176
- 205200_at
- tetranectina (proteína de unión a plasminógeno) NM_003278.1
- 205743_at
- de homología con src tres (SH3) y dominio rico en cisteína NM_003149.1
- 200921_s_at
- gen 1 de translocación de linfocitos B, anti-proliferativa NM_001731.1
- 206932_at
- colesterol 25-hidroxilasa NM_003956.1
- 204198_s_at
- factor de transcripción 3 relacionado con enanismo AA541630
- 219747_at
- proteína hipotética FLJ23191 NM_024574.1
- 204773_at
- receptor de interleucina 11, alfa NM_004512.1
- 202465_at
- potenciador de procolágeno C-endopeptidasa NM_002593.2
- 203706_s_at
- homólogo 7 de “frizzled“ (Drosophila) NM_003507.1
- 212736_at
- gen hipotético BC008967 BE299456
- 214587_at
- colágeno, tipo VIII, alfa 1 BE877796
- 201645_at
- tenascina C (hexabraquion) NM_002160.1
- 210239_at
- proteína 5 de la caja homeótica de “iroquois“ U90304.1
- 203903_s_at
- hepaestina NM_014799.1
- 205816_at
- integrina, beta 8 NM_002214.1
- 203069_at
- glicoproteína 2 de las vesículas sinápticas NM_014849.1
- 213909_at
- ADNc FLJ12280 fis de Homo sapiens, clon MAMMA1001744 AU147799
- 206315_at
- factor 1 similar a receptor de citocinas NM_004750.1
- 204401_at
- canal de potasio activado por calcio de conductancia intermedia/baja, subfamilia N, miembro 4 NM_002250.1
- 216331_at
- integrina, alfa 7 AK022548.1
- 209663_s_at
- integrina, alfa 7 AF072132.1
- 213125_at
- proteína DKFZP586L151 AW007573
- 202133_at
- coactivador de la transcripción con motivo de unión a PDZ (TAZ) AA081084
- 206511_s_at
- homólogo 2 de la caja homeótica de “sine oculis” (Drosophila) NM_016932.1
- 213435_at
- proteína KIAA1034 AB028957.1
- 206115_at
- de respuesta de crecimiento precoz 3 NM_004430.1
- 213707_s_at
- caja homeótica 5 de “distal-less” NM_005221.3
19
E08835175
10-12-2014
5
15
25
- 218181_s_at
- proteína hipotética FLJ20373 NM_017792.1
- 209160_ at
- familia 1 de aldo-ceto reductasa, miembro C3 (3-alfa hidroxiesteroide deshidrogenasa, tipo II) AB018580.1
- 213905_x_at
- biglicano AA845258
- 201261_x_at
- biglicano BC002416.1
- 202132_at
- coactivador de la transcripción con motivo de unión a PDZ (TAZ) AA081084
- 214701_s_at
- fibronectina 1 AJ276395.1
- 213791_at
- proencefalina NM_006211.1
- 205422_s_at
- integrina, similar a beta 1 (con dominios de repetición de tipo EGF) NM_004791.1
- 214927_at
- clon EUROIMAGE 1968422 de ADNc de inserto de longitud completa de ARNm de Homo sapiens AL359052.1
- 206070_s_at
- EphA3 AF213459.1
- 212805_at
- proteína KIAA0367 AB002365.1
- 219789_at
- receptor C del péptido natriurético/guanilato ciclasa C (receptor C del péptido atrial natriurético) AI628360
- 219054_at
- proteína hipotética FLJ14054 NM_024563.1
- 213429_at
- ARNm de Homo sapiens; ADNc DKFZp564B222 (del clon DKFZp564B222) AW025579
- 204929_s_at
- proteína 5 de membrana asociada a vesículas (miobrevina) NM_006634.1
- 201843_s_at
- proteína 1 de la matriz extracelular de tipo fibulina que contienen EGF NM_004105.2
- 221478_at
- similar a proteína 3 de interacción con BCL2/adenovirus E1B 19kDa AL132665.1
- 201792_at
- proteína 1 de unión a AE NM_001129.2
- 204570_at
- polipéptido 1 de la subunidad VIIa de la citocromo c oxidasa (músculo) NM_001864.1
- 201621_at
- neuroblastoma, supresión de tumorigenicidad 1 NM_005380.1
- 202718_at
- proteína 2 de unión al factor de crecimiento insulinoide, de 36kDa NM_000597.1
Las tablas 5, 6 y 7 muestran la expresión de genes aumentada en fibroblastos humanos (Tabla 5), células ICBM (Tabla 6) y MSC (Tabla 7).
Tabla 5
45
55
- Genes que demostraron tener una expresión aumentada en los fibroblastos en comparación con las demás líneas celulares ensayadas
- Genes aumentados en fibroblastos
- fosfatasa de doble especificidad 2
- proteína KIAA0527
- ADNc de Homo sapiens: FLJ23224 fis, clon ADSU02206
- dineína, citoplasmática, polipéptido intermedio 1
- anquirina 3, nódulo de Ranvier (anquirina G)
- inhibina, beta A (activina A, activina AB, polipéptido alfa)
- ectonucleótido pirofosfatasa/fosfodiesterasa 4 (función supuesta)
- proteína KIAA1053
- proteína asociada a microtúbulos 1A
- proteína con dedos de zinc 41
- proteína HSPC019
- ADNc de Homo sapiens: FLJ23564 fis, clon LNG10773
- ARNm de Homo sapiens; ADNc DKFZp564A072 (del clon DKFZp564A072)
- Proteína LIM (similar a enigma de unión a proteína quinasa C de rata)
- inhibidor del potenciador del gen del polipéptido de cadena ligera kappa en los linfocitos B, proteína asociada a complejo quinasa
- proteína hipotética FLJ22004
- Secuencia de ARNm humano (clon CTG-A4)
- EST, Moderadamente similares al factor 2 de tipo receptor de citocinas; precursor del receptor de citocinas CRL2 [Homo sapiens]
20
E08835175
10-12-2014
5
15
25
35
45
55
- IM042479 Medida inicial de la proliferación del receptor Control de autoestimulación (células autólogas tratadas con mitomicina C) Donante alogénico MLR IM04-2477 (tratado con mitomicina C) MLR con línea celular (célula tratada con mitomicina C, tipo A) SI (donante) SI (línea celular) IM042480 Medida inicial de la proliferación del receptor Control de autoestimulación (células autólogas tratadas con mitomicina C) Donante alogénico MLR IM04-2477 (tratado con mitomicina C) MLR con línea celular (célula tratada con mitomicina C, tipo A) SI (donante) SI (línea celular) IM042481 Medida inicial de la proliferación del receptor Control de autoestimulación (células autólogas tratadas con mitomicina C) Donante alogénico MLR IM04-2477 (tratado con mitomicina C) MLR con línea celular (célula tratada con mitomicina C, tipo A) SI (donante) SI (línea celular) Número de análisis Sistema de cultivo IM042482 Medida inicial de la proliferación del receptor Control de autoestimulación (células autólogas tratadas con mitomicina C) Donante alogénico MLR IM04-2477 (tratado con mitomicina C) MLR con línea celular (célula tratada con mitomicina C, tipo A) SI (donante) SI (línea celular)
- 530 508 701 567 25593 24732 5086 3932 1192 854 2963 993 25416 29721 2596 5076 695 451 738 1252 13177 24885 4495 3671 ID de placa: Placa 2 Repetic iones 1 2 432 533 1459 633 24286 30823 2762 1502 527 1111 22707 1497 1330 2197 23757 3426 555 464 15444 4674 3 274 598 31346 6723 521,7 793,0 24344,0 3505,0 47 7 1125,3 2051,0 26298,0 3699,3 23 3 567,0 818,0 17835,3 4280,0 31 8 Media 413.0 896.7 28818.3 3662.3 70 9 11,93 283,43 1481,61 1832,21 244,90 993,08 3078,27 1262,39 122,44 400,04 6209,52 534,95 DE 130.54 487.31 3933.82 2724.46 2,3 35,7 6,1 52,3 21,8 48,4 11,7 34,1 21,6 48,9 34,8 12,5 CV 31.6 54.3 13.7 74.4
27
E08835175
10-12-2014
- 17,45
- 25,46 269,38
- 18,56
- 78,26
- 18,41
- 17,30
- Promedio
- 17,33 54,25 97,28 114,4 3
- Est:
- 3,04 36,41 64,75 94,15
- EEM
- 0,81 10,51 19,52 54,36
La Tabla 20 y la Figura 4 muestran las mediciones de SCr de las muestras de suero del día 5. El tratamiento con HBSS y mMSC dio como resultado valores medios de creatinina de 0,74 mg/dl y 0,66 mg/dl, respectivamente. Se observó una reducción estadísticamente significativa en la SCr después del tratamiento con hMSC o hUTC a menor dosis (P < 0,03). El tratamiento con hMSC dio como resultado un valor medio de SCr de 0,47 mg/dl y el tratamiento con hUTC a menor dosis dio como resultado un valor medio de SCr de 0,57 mg/dl.
Tabla 20
25
35
45
- Creatinina sérica. La Crs se midió el día 5 después del trasplante de las células. Desviación estándar (est.). Error estándar de la media (EEM)
- Grupo de tratamiento
- Material de ensayo Creatinina mg/dl Media Est. EEM Valor de p
- 1
- HBSS HBSS HBSS HBSS HBSS 0,64 0,72 0,72 0,89 0,73 0,74 0,09 0,04 na
- 2
- mMSC mMSC mMSC mMSC mMSC 0,64 0,72 0,72 0,48 0,72 0,66 0,10 0,05 0,213
- 3
- hMSC hMSC hMSC hMSC 0,24 0,27 0,56 0,56 0,47 0,21 0,09 0,008
- 4
- hUTC hUTC hUTC hUTC 0,64 0,45 0,56 0,64 0,57 0,08 0,03 0,028
- 5
- hUTC hUTC hUTC hUTC 1,28 0,26 0,48 0,72 0,68 0,38 0,17 0,789
El día 7 después del trasplante de las células, se sacrificaron dos ratones por grupo de tratamiento y se fijaron los tejidos mediante perfusión transcardíaca con solución salina, seguido de perfusión e inmersión en paraformaldehído al 4%. Se extirparon los riñones de los ratones y se procesaron para la histología. A continuación se evaluaron los cortes teñidos con H&E para la lesión histológica. Dos patólogos entrenados realizaron
55 evaluaciones con enmascaramiento y puntuaron el grado de degeneración tubular renal.
Se midió cualitativamente la necrosis tubular en los cortes histológicos de animales tratados con HBSS, hMSC y hUTC a menor dosis. Se puntuó la degeneración tubular en una escala que iba de 1 a 4 (1 = daño mínimo, 2 = daño leve, 3 = daño moderado, 4 = daño grave). Como se muestra en la Tabla 21 y en la Figura 5, el tratamiento con vehículo y con hMSC dio como resultado una degeneración tubular leve, con una puntuación media de lesión de 2,5. Sin embargo, un tratamiento con hUTC a menor dosis dio como resultado daño tubular mínimo con una puntuación media de lesión de 1,9, que indicaba el potencial renoprotector de las hUTC.
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US97777507P | 2007-10-05 | 2007-10-05 | |
US977775P | 2007-10-05 | ||
PCT/US2008/078800 WO2009046335A1 (en) | 2007-10-05 | 2008-10-03 | Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells |
Publications (1)
Publication Number | Publication Date |
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ES2525718T3 true ES2525718T3 (es) | 2014-12-29 |
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ES08835175.4T Active ES2525718T3 (es) | 2007-10-05 | 2008-10-03 | Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano |
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US (1) | US8034329B2 (es) |
EP (1) | EP2203186B1 (es) |
JP (1) | JP5323845B2 (es) |
CN (1) | CN102036688B (es) |
AU (1) | AU2008308531B2 (es) |
BR (1) | BRPI0818183A2 (es) |
CA (1) | CA2701435C (es) |
ES (1) | ES2525718T3 (es) |
UA (1) | UA99152C2 (es) |
WO (1) | WO2009046335A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
AU2004252566B2 (en) | 2003-06-27 | 2011-09-15 | Ethicon, Incorporated | Postpartum cells derived from placental tissue, and methods of making and using the same |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
ES2621610T3 (es) * | 2007-12-27 | 2017-07-04 | DePuy Synthes Products, Inc. | Tratamiento de la degeneración de discos intervertebrales utilizando células derivadas de tejido cordón umbilical humano |
KR20240052847A (ko) | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
SI2331109T1 (sl) | 2008-08-22 | 2013-10-30 | Anthrogenesis Corporation | Postopki in sestavki za zdravljenje okvar kosti s populacijami placentarnih celic |
KR20110086176A (ko) | 2008-11-19 | 2011-07-27 | 안트로제네시스 코포레이션 | 양막 유래 부착성 세포 |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
US10557116B2 (en) | 2008-12-19 | 2020-02-11 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
EP2379089B1 (en) * | 2008-12-19 | 2019-04-17 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue following injury |
CA2756600C (en) | 2009-03-26 | 2019-08-20 | Advanced Technologies And Regenerative Medicine, Llc | Human umbilical cord tissue cells as therapy for alzheimer's disease |
US8796315B2 (en) | 2009-06-25 | 2014-08-05 | Darlene E. McCord | Methods for improved wound closure employing olivamine and human umbilical vein endothelial cells |
WO2011126833A2 (en) * | 2010-03-29 | 2011-10-13 | Massachusetts Institute Of Technology | Anti-inflammatory factors |
CA2795401A1 (en) | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
DK2576768T3 (en) | 2010-06-01 | 2017-08-28 | Auxocell Laboratories Inc | NATIVE WHARTONS JELLY STEM CELLS AND CLEANING THEREOF |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
EP3443968A1 (en) | 2011-06-01 | 2019-02-20 | Celularity, Inc. | Treatment of pain using placental stem cells |
KR101981450B1 (ko) * | 2011-12-23 | 2019-08-28 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | 인간 제대 조직-유래된 세포의 검출 |
WO2014066649A1 (en) * | 2012-10-26 | 2014-05-01 | The Regents Of The University Of California | A strategy for engineering various 3d tissues, organoids and vasculature |
US9144555B2 (en) | 2012-11-30 | 2015-09-29 | Darlene E. McCord | Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition |
DK2968420T3 (da) * | 2013-03-14 | 2019-01-02 | Celularity Inc | Anvendelse af placentastamceller til behandling af akut nyreskade |
US10480375B2 (en) | 2014-10-28 | 2019-11-19 | Cummins Emission Solutions Inc. | SCR conversion efficiency diagnostics |
US20200392465A1 (en) * | 2016-11-15 | 2020-12-17 | Regrow Biosciences Pvt. Ltd. | A process of preparing buccal epithelial cell suspension and its use |
JP7391327B2 (ja) | 2018-01-12 | 2023-12-05 | 国立大学法人大阪大学 | 重層扁平上皮細胞の正常分化・成熟促進剤、上皮疾患治療剤及び重層扁平上皮細胞の正常分化・成熟促進方法 |
CN112569408B (zh) * | 2020-12-01 | 2021-12-07 | 暨南大学 | 组织工程补片及其制备方法 |
Family Cites Families (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
CA1322262C (en) | 1987-06-26 | 1993-09-21 | Yoshito Ikada | Artificial skin |
NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
US20030032178A1 (en) * | 1988-08-04 | 2003-02-13 | Williams Robert Lindsay | In vitro propagation of embryonic stem cells |
US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5840580A (en) | 1990-05-01 | 1998-11-24 | Becton Dickinson And Company | Phenotypic characterization of the hematopoietic stem cell |
US5342761A (en) | 1990-10-01 | 1994-08-30 | Research Development Foundation | Oncofetal gene, gene product and uses therefor |
US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5286632A (en) * | 1991-01-09 | 1994-02-15 | Jones Douglas H | Method for in vivo recombination and mutagenesis |
US6399369B1 (en) * | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
US5320962A (en) * | 1992-07-22 | 1994-06-14 | Duke University | DNA encoding the human A1 adenosine receptor |
US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
WO1994010331A1 (en) | 1992-10-29 | 1994-05-11 | The Australian National University | Angiogenesis inhibitory antibodies |
US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
US6686198B1 (en) * | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
US6432711B1 (en) | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
US5698518A (en) | 1994-03-30 | 1997-12-16 | Oklahoma Medical Research Foundation | Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists |
US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US6703017B1 (en) * | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
US6413735B1 (en) | 1996-03-15 | 2002-07-02 | Munin Corporation | Method of screening for a modulator of angiogenesis |
AU2808397A (en) | 1996-04-26 | 1997-11-19 | Case Western Reserve University | Skin regeneration using mesenchymal stem cells |
US6787355B1 (en) * | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
US5919702A (en) * | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
JP4132089B2 (ja) * | 1997-05-30 | 2008-08-13 | オステオバイオロジックス,インコーポレイテッド | 繊維強化多孔性生体分解性移植デバイス |
US5902598A (en) * | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
WO1999028444A1 (en) * | 1997-12-02 | 1999-06-10 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
ATE286118T1 (de) * | 1998-03-13 | 2005-01-15 | Osiris Therapeutics Inc | Anwendungen für humane nicht autologe, mesenchymale stammzellen |
US6171610B1 (en) * | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
JP2002513545A (ja) * | 1998-05-07 | 2002-05-14 | ザ ユニヴァーシティー オブ サウス フロリダ | 脳および脊髄修復のためのニューロン源としての骨髄細胞 |
EP1082410B1 (en) * | 1998-05-29 | 2007-08-01 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
US6323188B1 (en) | 1998-07-01 | 2001-11-27 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins |
US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
US5958767A (en) * | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
US6284245B1 (en) | 1998-08-25 | 2001-09-04 | Diacrin, Inc. | Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders |
US6444205B2 (en) | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
MXPA01007810A (es) | 1999-02-04 | 2003-06-04 | Univ Mcgill | Plataforma para la diferenciacion de celulas. |
IL144654A0 (en) | 1999-02-10 | 2002-05-23 | Curis Inc | Pancreatic progenitor cells, methods and uses related thereto |
US20030007954A1 (en) * | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
WO2000062630A1 (en) * | 1999-04-16 | 2000-10-26 | Wm. Marsh Rice University | Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) |
US6287340B1 (en) * | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
US6355699B1 (en) * | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
US6333029B1 (en) * | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US6555374B1 (en) * | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US20030129745A1 (en) * | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
US20020164307A1 (en) | 1999-12-06 | 2002-11-07 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
EP1257282A4 (en) | 1999-12-06 | 2003-05-02 | Gen Hospital Corp | PANCREATIC STEM CELLS AND THEIR USE IN TRANSPLANTATION |
WO2001053503A1 (en) | 2000-01-18 | 2001-07-26 | Cornell Research Foundation, Inc. | Neural progenitor cells from hippocampal tissue and a method for isolating and purifying them |
US7544509B2 (en) * | 2000-01-24 | 2009-06-09 | Mcgill University | Method for preparing stem cell preparations |
US6610535B1 (en) | 2000-02-10 | 2003-08-26 | Es Cell International Pte Ltd. | Progenitor cells and methods and uses related thereto |
CA2399434C (en) | 2000-02-11 | 2010-10-19 | The Schepens Eye Research Institute, Inc. | Isolation and transplantation of retinal stem cells |
WO2001059072A1 (en) | 2000-02-11 | 2001-08-16 | Philadelphia Health And Education Corporation | Differentiation of bone marrow cells into neuronal cells and uses therefor |
AU2001243464B2 (en) * | 2000-03-09 | 2006-04-13 | Saneron Ccel Therapeutics, Inc. | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
US6673606B1 (en) * | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
AU2001264598B2 (en) | 2000-05-12 | 2006-07-06 | University Of Utah Research Foundation | Compositions and methods for tissue dedifferentiation and regeneration |
US8273570B2 (en) | 2000-05-16 | 2012-09-25 | Riken | Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells |
US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2002026941A2 (en) | 2000-09-29 | 2002-04-04 | Kooy Derek V D | Primitive neural stem cells and method for differentiation of stem cells to neural cells |
US20020098584A1 (en) * | 2000-11-06 | 2002-07-25 | Palmer Theo D. | Postmortem stem cells |
KR20030088022A (ko) | 2000-11-30 | 2003-11-15 | 스템론 인크. | 단리된 동종접합 간세포, 그로부터 유래된 분화 세포 및이들을 제조 및 사용하기 위한 물질 및 방법 |
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
AU2020902A (en) | 2000-12-06 | 2002-06-18 | Robert J Hariri | Method of collecting placental stem cells background of the invention |
US6599323B2 (en) * | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
US7449180B2 (en) | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
EP2336299A1 (en) * | 2001-02-14 | 2011-06-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
MX352687B (es) | 2001-02-14 | 2017-12-04 | Anthrogenesis Corp | Placenta de mamiferos postparto, su uso y celulas madres placentales extraidas de ella. |
CA2442177A1 (en) | 2001-03-29 | 2002-10-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
US20030211605A1 (en) | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
US20030022369A1 (en) * | 2001-05-18 | 2003-01-30 | Helen Fillmore | Differentiation of specialized dermal and epidermal cells into neuronal cells |
WO2002096203A1 (en) * | 2001-05-25 | 2002-12-05 | Cythera, Inc. | Stem cell differentiation |
CN1349845A (zh) * | 2001-06-22 | 2002-05-22 | 高大勇 | 分离脐血干细胞防冻剂的透析方法及透析装置 |
ATE443758T1 (de) * | 2001-08-08 | 2009-10-15 | Levesque Biosciences Inc | Zusammensetzungen und verfahren zur isolierung, vermehrung und differenzierung nicht-embryonale menschlicher stammzellen und deren verwendungen |
US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
WO2003018767A2 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
US20030104997A1 (en) * | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
WO2003033697A1 (en) * | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
US7129034B2 (en) * | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
WO2003039489A2 (en) * | 2001-11-09 | 2003-05-15 | Artecel Sciences, Inc. | Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof |
JP3728750B2 (ja) * | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
WO2003054171A1 (en) * | 2001-12-06 | 2003-07-03 | The Regents Of The University Of California | Method for differentiating islet precursor cells into beta cells |
EP1463798A4 (en) * | 2001-12-07 | 2005-01-19 | Geron Corp | ISLAND CELLS FROM HUMAN EMBRYONAL STEM CELLS |
JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
US20030113910A1 (en) * | 2001-12-18 | 2003-06-19 | Mike Levanduski | Pluripotent stem cells derived without the use of embryos or fetal tissue |
ATE464373T1 (de) * | 2001-12-21 | 2010-04-15 | Mount Sinai Hospital Corp | Zelluläre zusammensetzungen und verfahren zur deren bereitung und verwendung |
US7101546B2 (en) | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
EP1471918B1 (en) | 2002-01-14 | 2017-07-19 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
US20030162290A1 (en) * | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
US7576065B2 (en) | 2002-02-15 | 2009-08-18 | Cornell Research Foundation, Inc. | Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein |
US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
US7736892B2 (en) * | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
US7150990B2 (en) | 2002-03-06 | 2006-12-19 | Reprocell, Inc. | Self-renewing pluripotent hepatic stem cells |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
JP4136434B2 (ja) | 2002-04-17 | 2008-08-20 | 進 清野 | インスリン産生細胞の誘導 |
EP1497435A4 (en) | 2002-04-19 | 2005-07-27 | Univ Pittsburgh | PLACENTAL STEM CELLS AND USES |
AU2003239176A1 (en) | 2002-04-25 | 2003-11-10 | Wisconsin Alumni Research Foundation | Neurodegenerative disorder treatment using gdnf secreting neural cells |
US20040029269A1 (en) * | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
WO2003094965A2 (en) * | 2002-05-08 | 2003-11-20 | Neuronova Ab | Modulation of neural stem cells with s1p or lpa receptor agonists |
AU2003247514A1 (en) * | 2002-06-11 | 2003-12-22 | Roy Ogle | Meningeal-derived stem cells |
US7285415B2 (en) * | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
US7390659B2 (en) * | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
EP1551955A4 (en) | 2002-07-16 | 2006-11-29 | Yissum Res Dev Co | METHOD FOR IMPLANTING MESENCHYMAL STEM CELLS FOR TISSUE PAIRING AND FORMATION |
WO2004020601A2 (en) * | 2002-08-28 | 2004-03-11 | University Of Florida | Neurogenesis from hepatic stem cells |
US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
JP4571387B2 (ja) | 2003-02-07 | 2010-10-27 | 宣男 櫻川 | ヒト羊膜由来サイドポピュレーション細胞及びその用途 |
EP1594957B1 (en) * | 2003-02-11 | 2010-08-25 | John E. Davies | Progenitor cells from wharton's jelly of human umbilical cord |
US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
AU2004252566B2 (en) * | 2003-06-27 | 2011-09-15 | Ethicon, Incorporated | Postpartum cells derived from placental tissue, and methods of making and using the same |
US8039258B2 (en) * | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
WO2006101548A2 (en) | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
US20060153815A1 (en) * | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
WO2006083394A2 (en) | 2004-12-21 | 2006-08-10 | Ethicon, Inc. | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
CA2589063C (en) * | 2004-12-23 | 2016-08-09 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
EP1831356B1 (en) | 2004-12-23 | 2017-01-25 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
JP5179376B2 (ja) * | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
WO2007076522A2 (en) | 2005-12-28 | 2007-07-05 | Ethicon, Incorporated | Treatment of peripheral vascular disease using postpartum-derived cells |
ES2708933T3 (es) | 2005-12-29 | 2019-04-12 | Celularity Inc | Poblaciones de células madre placentarias |
AU2007308168B2 (en) * | 2006-10-12 | 2013-09-26 | Ethicon, Inc. | Kidney-derived cells and methods of use in tissue repair and regeneration |
JP5670053B2 (ja) | 2006-11-13 | 2015-02-18 | エシコン・インコーポレイテッドEthicon, Incorporated | マイクロキャリアを使用した、産褥由来の細胞の生体外での拡大 |
US20080305148A1 (en) | 2007-03-19 | 2008-12-11 | National Yang Ming University | Treatment of spinal injuries using human umbilical mesenchymal stem cells |
US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
ES2621610T3 (es) | 2007-12-27 | 2017-07-04 | DePuy Synthes Products, Inc. | Tratamiento de la degeneración de discos intervertebrales utilizando células derivadas de tejido cordón umbilical humano |
US10557116B2 (en) * | 2008-12-19 | 2020-02-11 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
US10179900B2 (en) * | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
EP2379089B1 (en) * | 2008-12-19 | 2019-04-17 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue following injury |
JP5646502B2 (ja) * | 2008-12-19 | 2014-12-24 | デピュイ・シンセス・プロダクツ・エルエルシーDePuy Synthes Products, LLC | 神経因性疼痛を治療するための臍帯組織由来細胞 |
CA2756600C (en) | 2009-03-26 | 2019-08-20 | Advanced Technologies And Regenerative Medicine, Llc | Human umbilical cord tissue cells as therapy for alzheimer's disease |
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EP2203186A1 (en) | 2010-07-07 |
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CN102036688A (zh) | 2011-04-27 |
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AU2008308531B2 (en) | 2014-04-24 |
CA2701435A1 (en) | 2009-04-09 |
UA99152C2 (ru) | 2012-07-25 |
AU2008308531A1 (en) | 2009-04-09 |
US8034329B2 (en) | 2011-10-11 |
JP5323845B2 (ja) | 2013-10-23 |
CA2701435C (en) | 2017-06-20 |
JP2010540662A (ja) | 2010-12-24 |
US20090092653A1 (en) | 2009-04-09 |
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