DK2854883T3 - Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf - Google Patents

Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK2854883T3
DK2854883T3 DK13728251.3T DK13728251T DK2854883T3 DK 2854883 T3 DK2854883 T3 DK 2854883T3 DK 13728251 T DK13728251 T DK 13728251T DK 2854883 T3 DK2854883 T3 DK 2854883T3
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Denmark
Prior art keywords
hydroges
biomatrix
procedures
biomatrix hydroges
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DK13728251.3T
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English (en)
Inventor
Nir Altschuler
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Cartiheal 2009 Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/365Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/3654Cartilage, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
DK13728251.3T 2012-05-17 2013-04-29 Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf DK2854883T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261648089P 2012-05-17 2012-05-17
US201261648087P 2012-05-17 2012-05-17
US201361764467P 2013-02-13 2013-02-13
US201361763985P 2013-02-13 2013-02-13
US201361764496P 2013-02-13 2013-02-13
US201361763981P 2013-02-13 2013-02-13
US201361773219P 2013-03-06 2013-03-06
US201361773228P 2013-03-06 2013-03-06
PCT/IL2013/050364 WO2013171736A1 (en) 2012-05-17 2013-04-29 Biomatrix hydrogels and methods of use thereof

Publications (1)

Publication Number Publication Date
DK2854883T3 true DK2854883T3 (da) 2019-07-15

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DK13728251.3T DK2854883T3 (da) 2012-05-17 2013-04-29 Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf

Country Status (6)

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US (1) US10342897B2 (da)
EP (1) EP2854883B1 (da)
DK (1) DK2854883T3 (da)
HU (1) HUE046178T2 (da)
SI (1) SI2854883T1 (da)
WO (1) WO2013171736A1 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180228621A1 (en) 2004-08-09 2018-08-16 Mark A. Reiley Apparatus, systems, and methods for the fixation or fusion of bone
EP2442750B1 (en) 2009-06-15 2019-05-01 Cartiheal (2009) Ltd Solid forms for tissue repair
US10363140B2 (en) 2012-03-09 2019-07-30 Si-Bone Inc. Systems, device, and methods for joint fusion
CN104334102A (zh) 2012-03-09 2015-02-04 西-博恩公司 整合种植体
EP2846705B1 (en) 2012-05-04 2018-12-26 SI-Bone, Inc. Fenestrated implant
AU2014217485B2 (en) 2013-02-13 2017-02-16 Cartiheal (2009) Ltd Solid substrates for mitigating or preventing cell and tissue adhesion and vascularization
US9936983B2 (en) 2013-03-15 2018-04-10 Si-Bone Inc. Implants for spinal fixation or fusion
US11147688B2 (en) 2013-10-15 2021-10-19 Si-Bone Inc. Implant placement
US10478309B2 (en) 2014-01-10 2019-11-19 Mbp (Mauritius) Ltd Method for producing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial
CN103877614A (zh) * 2014-02-26 2014-06-25 同济大学 一种组织工程骨软骨修复的双层复合支架及其制备方法
US10166033B2 (en) 2014-09-18 2019-01-01 Si-Bone Inc. Implants for bone fixation or fusion
US9662157B2 (en) 2014-09-18 2017-05-30 Si-Bone Inc. Matrix implant
MX2017011690A (es) * 2015-03-12 2018-02-09 Timplast Int Llc Composicion para la degradacion de materia plastica.
KR20180003587A (ko) * 2015-05-06 2018-01-09 카티힐 (2009) 엘티디. 세포 및 조직 성장을 촉진시키기 위한 최적화된 고체 기재, 그와 함께 사용하기 위한 공구 및 그의 용도
EP3291749B1 (en) * 2015-05-06 2019-09-11 Cartiheal (2009) Ltd Tools for use with optimized solid substrates
FR3037801B1 (fr) * 2015-06-23 2017-08-11 Jd Invest Materiau semi-synthetique pulverulent, obtenu par modification de la composition d'un biomateriau naturel marin, son procede de fabrication, ses applications
CN108136070B (zh) 2015-08-19 2021-11-23 爱荷华大学研究基金会 创伤后骨关节炎的预防性治疗
US11583613B2 (en) 2016-03-03 2023-02-21 University of Pittsburgh—of the Commonwealth System of Higher Education Hydrogel systems for skeletal interfacial tissue regeneration applied to epiphyseal growth plate repair
CN106046397A (zh) * 2016-06-28 2016-10-26 深圳市阳光之路生物材料科技有限公司 一种关节润滑材料及其制备方法
CN106267363B (zh) * 2016-09-18 2019-06-14 辽宁聚高智造科技有限公司 一种人造骨
CN114932679A (zh) * 2017-04-06 2022-08-23 卡内基梅隆大学 基于流体-流体界面的增材制造
CN111194204B (zh) * 2017-06-02 2022-09-30 海洋生物医药有限公司 制造钙化组织替代物的方法
WO2019067584A1 (en) 2017-09-26 2019-04-04 Si-Bone Inc. SYSTEMS AND METHODS FOR DECORTICATING SACROILITIC JOINT
RU2676478C1 (ru) * 2017-10-12 2018-12-29 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ приготовления пломбировочной массы для закрытия дефекта кости
CA3086956A1 (en) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
WO2019191505A1 (en) * 2018-03-28 2019-10-03 Si-Bone Inc. Threaded implants and methods of use across bone segments
WO2019241577A1 (en) * 2018-06-13 2019-12-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone regeneration in compromised wounds
US11369419B2 (en) 2019-02-14 2022-06-28 Si-Bone Inc. Implants for spinal fixation and or fusion
EP3923829A4 (en) 2019-02-14 2022-12-14 SI-Bone, Inc. IMPLANTS FOR SPINE FIXATION AND/OR FUSION
US20220047409A1 (en) * 2019-02-26 2022-02-17 Mirrorme3D Systems and methods for postoperative soft tissue care
CN110151362A (zh) * 2019-03-13 2019-08-23 上海交通大学医学院附属第九人民医院 一种3d打印的节段性骨缺损修复装置及其制备方法
US20220401617A1 (en) * 2019-11-04 2022-12-22 RevBio, Inc. Adhesive compositions comprising therapeutics
WO2021108590A1 (en) 2019-11-27 2021-06-03 Si-Bone, Inc. Bone stabilizing implants and methods of placement across si joints
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine
RU2729929C1 (ru) * 2020-02-18 2020-08-13 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Временный имплантат для пациентов с инфицированными дефектами в челюстно-лицевой области и способ их лечения с использованием такого имплантата
EP3896048A1 (en) * 2020-04-17 2021-10-20 Institut National De La Sante Et De La Recherche Medicale - Inserm Formulation comprising a phosphocalcic cement and a physical and/or covalent hydrogel of polysaccharides, printable and having ductile mechanical properties for bone regeneration/bone repair
TR202013434A2 (tr) * 2020-08-26 2020-10-21 Saadet Atsue Saglam %60 Osteoartrit tedavisinde hyaluronikasit- kollagenle enkapsülenen mezenkimal kök hücre-trombositten zengin plazma ve kondrosit içeren ürün-yöntem
JP2023553120A (ja) 2020-12-09 2023-12-20 エスアイ-ボーン・インコーポレイテッド 仙腸関節安定化インプラントおよびインプラント方法
EP4301340A1 (en) * 2021-03-05 2024-01-10 Georgia Tech Research Corporation Micelle releasing thermosensitive hydrogels as a therapeutic delivery system
CN113181430A (zh) * 2021-04-12 2021-07-30 北京冬曦既驾科技咨询有限公司 增材制造医用陶瓷浆料及其制成的医疗用品
WO2023099416A1 (en) * 2021-12-02 2023-06-08 Omya International Ag In situ mineralization of 3d printed metastable calcium species
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114452443A (zh) * 2021-12-24 2022-05-10 佛山科学技术学院 用于制备关节软骨支架的组合物及其制备方法与应用
CN115386544B (zh) * 2022-08-23 2024-01-05 广东唯泰生物科技有限公司 用于间充质干细胞培养的水凝胶、培养基及其制备方法
CN115554470B (zh) * 2022-08-30 2024-02-09 吉林大学 一种具有骨质疏松微环境调节功能的关节假体界面及其制备方法与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4440921A (en) 1982-06-21 1984-04-03 Research Corporation Coupling of polyorganophosphazenes to carboxylic acid
US4495174A (en) 1982-06-21 1985-01-22 Research Corporation Anesthetic polyorganophosphazenes
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4880622A (en) 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5902441A (en) 1996-09-04 1999-05-11 Z Corporation Method of three dimensional printing
US6506217B1 (en) * 1999-03-29 2003-01-14 Arnett Facial Reconstruction Courses, Inc. Moldable post-implantation bone filler and method
JP4315680B2 (ja) * 2000-12-29 2009-08-19 ビーエーエスエフ ソシエタス・ヨーロピア 吸収性組成物
GB0103754D0 (en) 2001-02-15 2001-04-04 Vantico Ltd Three-dimensional structured printing
US20030143283A1 (en) * 2002-01-28 2003-07-31 Andrew Tofe Bone repair material
AU2004285480B2 (en) * 2003-10-22 2010-12-16 Encelle, Inc. Bioactive hydrogel compositions for regenerating connective tissue
US20060198863A1 (en) * 2005-03-03 2006-09-07 Musculoskeletal Transplant Foundation Ceramic composition for filling bone defects
WO2008077257A1 (en) * 2006-12-22 2008-07-03 Mathys Ag Bettlach Precursor for the preparation of a pasty bone replacement material by admixture of a liquid
US8932581B2 (en) 2007-11-19 2015-01-13 Ben Gurion University Of The Negev Research And Development Authority Calcium-mediated effects of coral and methods of use thereof
ES2712891T3 (es) 2008-11-20 2019-05-16 Cartiheal 2009 Ltd Formas sólidas para reparación de tejidos
EP2442750B1 (en) 2009-06-15 2019-05-01 Cartiheal (2009) Ltd Solid forms for tissue repair
US10271938B2 (en) 2009-06-15 2019-04-30 Cartiheal (2009) Ltd Multi-phasic solid implants for tissue repair
SI2916779T1 (sl) 2012-11-12 2017-08-31 Cartiheal (2009) Ltd Orodja in sistemi za implantacijo trdne oblike in vsadka
AU2014217485B2 (en) 2013-02-13 2017-02-16 Cartiheal (2009) Ltd Solid substrates for mitigating or preventing cell and tissue adhesion and vascularization
KR20180003587A (ko) 2015-05-06 2018-01-09 카티힐 (2009) 엘티디. 세포 및 조직 성장을 촉진시키기 위한 최적화된 고체 기재, 그와 함께 사용하기 위한 공구 및 그의 용도

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SI2854883T1 (sl) 2019-08-30
HUE046178T2 (hu) 2020-02-28
EP2854883B1 (en) 2019-06-12
EP2854883A1 (en) 2015-04-08
US20150147397A1 (en) 2015-05-28
US10342897B2 (en) 2019-07-09
WO2013171736A1 (en) 2013-11-21

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