ATE207727T1 - Beschichtetes transplantat sowie herstellungsverfahren dafür - Google Patents

Beschichtetes transplantat sowie herstellungsverfahren dafür

Info

Publication number
ATE207727T1
ATE207727T1 AT93914321T AT93914321T ATE207727T1 AT E207727 T1 ATE207727 T1 AT E207727T1 AT 93914321 T AT93914321 T AT 93914321T AT 93914321 T AT93914321 T AT 93914321T AT E207727 T1 ATE207727 T1 AT E207727T1
Authority
AT
Austria
Prior art keywords
layer
acid polymer
amino acid
cytotoxic
membrane
Prior art date
Application number
AT93914321T
Other languages
English (en)
Inventor
Kent C Cochrum
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE207727T1 publication Critical patent/ATE207727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Fertilizers (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
AT93914321T 1992-05-29 1993-05-26 Beschichtetes transplantat sowie herstellungsverfahren dafür ATE207727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89089692A 1992-05-29 1992-05-29
PCT/US1993/005238 WO1993024076A1 (en) 1992-05-29 1993-05-26 Coated transplant and method for making same

Publications (1)

Publication Number Publication Date
ATE207727T1 true ATE207727T1 (de) 2001-11-15

Family

ID=25397300

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93914321T ATE207727T1 (de) 1992-05-29 1993-05-26 Beschichtetes transplantat sowie herstellungsverfahren dafür

Country Status (7)

Country Link
US (2) US5470731A (de)
EP (1) EP0641183B1 (de)
AT (1) ATE207727T1 (de)
AU (1) AU4402793A (de)
CA (1) CA2135769A1 (de)
DE (1) DE69331058D1 (de)
WO (1) WO1993024076A1 (de)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
EP1418228B1 (de) * 1994-01-13 2006-03-15 The Rogosin Institute Makroeingekapselte sekretorische Zellen
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
CA2146098A1 (en) * 1995-01-12 1996-07-13 Ray V. Rajotte Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials
US5540927A (en) * 1995-04-12 1996-07-30 Monsanto Company Microencapsulation process by coacervation
CA2218623A1 (en) * 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
US6051272A (en) * 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US6495195B2 (en) 1997-02-14 2002-12-17 Arcturus Engineering, Inc. Broadband absorbing film for laser capture microdissection
WO1998047948A1 (en) 1997-04-18 1998-10-29 California Institute Of Technology Multifunctional polymeric tissue coatings
DE19726282A1 (de) * 1997-06-20 1998-12-24 Inst Neue Mat Gemein Gmbh Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern
US7075640B2 (en) * 1997-10-01 2006-07-11 Arcturus Bioscience, Inc. Consumable for laser capture microdissection
DE69941498D1 (de) * 1998-11-12 2009-11-12 Internat Mfg Group Inc Hämostatische vernetzte Dextranperlen verwendbar zur schnellen Blutgerinnung und Hämostase
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6884628B2 (en) 1999-04-28 2005-04-26 Eidgenossische Technische Hochschule Zurich Multifunctional polymeric surface coatings in analytic and sensor devices
AU4812600A (en) 1999-04-29 2000-11-17 Arcturus Engineering, Inc. Processing technology for lcm samples
ATE356629T1 (de) * 1999-06-05 2007-04-15 Univ Leland Stanford Junior Methode und zusammensetzung zur inhibierung von kardiovaskulärer zellproliferation
AU7719300A (en) * 1999-09-27 2001-04-30 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US20020151055A1 (en) * 1999-11-02 2002-10-17 Stegemann Jan Philip Novel artificial pancreas
WO2001078906A1 (en) * 2000-04-14 2001-10-25 Virginia Tech Intellectual Properties, Inc. Self-assembled thin film coating to enhance the biocompatibility of materials
AU2001273234A1 (en) * 2000-07-05 2002-01-14 Islet Technology, Inc. Method and system for consistent and effective encapsulation of biological material
US20030211129A1 (en) * 2001-04-13 2003-11-13 Spillman William B Self-assembled thin film coating to enhance biocompatibility of materials
JP2003126125A (ja) * 2001-10-24 2003-05-07 Katsuko Sakai 人工血管及びその製造方法
US7252987B2 (en) * 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
AU2002361902A1 (en) * 2001-12-31 2003-07-24 Ares Medical, Inc. Hemostatic compositions and methods for controlling bleeding
US8263068B2 (en) * 2004-04-29 2012-09-11 Washington State University Research Foundation Modified cells expressing a protein that modulates activity of bHLH proteins, and uses thereof
US20070237749A1 (en) 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
US20070248653A1 (en) * 2006-04-20 2007-10-25 Cochrum Kent C Hemostatic compositions and methods for controlling bleeding
DE102008003615A1 (de) 2008-01-09 2009-07-16 Magforce Nanotechnologies Ag Magnetische Transducer
WO2013006683A2 (en) * 2011-07-05 2013-01-10 The Uab Research Foundation Bio-mimetic ultrathin hydrogel coatings for pancreatic islet transplantation
US9408912B2 (en) 2011-08-10 2016-08-09 Magforce Ag Agglomerating magnetic alkoxysilane-coated nanoparticles

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4749620A (en) * 1984-02-15 1988-06-07 Massachusetts Institute Of Technology Encapsulated active material system
US4744933A (en) * 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
US4778749A (en) * 1984-06-01 1988-10-18 Karyon Technology, Inc. Tissue culture and production in permeable gels
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CA2034641A1 (en) * 1990-11-27 1992-05-28 Gudmund Skjak-Braek Homologous guluronic acid alginate coating composition for in-vivo application and implatation and method of using same
IL103284A0 (en) * 1991-10-31 1993-02-21 Transtech Medical Inc Transplant protective coating

Also Published As

Publication number Publication date
DE69331058D1 (de) 2001-12-06
US5470731A (en) 1995-11-28
WO1993024076A1 (en) 1993-12-09
CA2135769A1 (en) 1993-12-09
AU4402793A (en) 1993-12-30
EP0641183A4 (de) 1997-01-29
US5531997A (en) 1996-07-02
EP0641183A1 (de) 1995-03-08
EP0641183B1 (de) 2001-10-31

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