GB931532A - Injectable preparations comprising encapsulated medicaments and processes for making them - Google Patents

Injectable preparations comprising encapsulated medicaments and processes for making them

Info

Publication number
GB931532A
GB931532A GB3793859A GB3793859A GB931532A GB 931532 A GB931532 A GB 931532A GB 3793859 A GB3793859 A GB 3793859A GB 3793859 A GB3793859 A GB 3793859A GB 931532 A GB931532 A GB 931532A
Authority
GB
United Kingdom
Prior art keywords
liquid
styrene
encapsulated
maleic acid
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3793859A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB931532A publication Critical patent/GB931532A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Abstract

Sterile, injectable therapeutic compositions comprise an injectable liquid carrier containing microscopic, medicament-containing capsules produced by liquid-liquid phase separation. Suitable encapsulating materials include gelable hydrophillic colloids e.g. gelatin, albumin, fibrinogen, casein, agar, sodium oleate, pectin and ichtlyocolla which may be used alone or together with other colloid materials of opposite charge e.g. gum acacia, sodium carboxymethylcellulose, sodium alginate and cellulose-, amylose- and starch acetate phthalates and "linear macromolecular synthetic polymers" i.e. materials whose structure comprises both lipophilic and hydrophilic units e.g. those derived from styrene, and an alkyl ring-substituted styrene or an ether- or ester-substituted ethylene and those derived from maleic, crotonic or acrylic acids or maleic acid or acrylic acid amides respectively. Examples of such polymers are styrene-maleic acid and styrene-maleic acid copolymers, sulphonated polystyrenes, polymethacrylic acid and vinyl ether-maleic acid copolymer. The particles to be encapsulated may be solid, liquid or emulsion particles having either hydrophilic or lipophilic surface characteristics and the encapsulation may be achieved by any suitable liquid/liquid phase separation process e.g. those disclosed in Specifications 751,600, 911,483, 929,402, 929,408 and 929,409. The capsules may be hardened by chemical or physical means e.g. irradiation and their components may be sterilized by conventional techniques e.g. by heat, disinfecting gases or irradiation and the encapsulation process may be carried out under aseptic conditions. Specific examples relate to medicaments comprising solutions of testosterone propionate and 6 - methyl - D 1 - hydrocortisone - 21 - acetate in cottonseed oil encapsulated in gelatin/acacia, and a cottonseed oil-in-water emulsion containing methyl salicylate in the aqueous phase and D 1-hydrocortisone acetate in the oil phase encapsulated in gelatin/styrenemaleic acid copolymer.
GB3793859A 1958-12-22 1959-11-09 Injectable preparations comprising encapsulated medicaments and processes for making them Expired GB931532A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78193458A 1958-12-22 1958-12-22

Publications (1)

Publication Number Publication Date
GB931532A true GB931532A (en) 1963-07-17

Family

ID=25124428

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3793859A Expired GB931532A (en) 1958-12-22 1959-11-09 Injectable preparations comprising encapsulated medicaments and processes for making them

Country Status (2)

Country Link
BR (1) BR5915735D0 (en)
GB (1) GB931532A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452285A1 (en) * 1979-03-28 1980-10-24 Damon Corp METHOD OF ENCAPSULATION OF A LIVABLE TISSUE OR OF A BIOLOGICALLY ACTIVE MATERIAL TO BE IMPLANTED, AND CAPSULES OBTAINED
US4612556A (en) * 1983-10-07 1986-09-16 The Wiggins Teape Group Limited Self-contained pressure sensitive copying material and its production
EP0313992A1 (en) * 1987-10-26 1989-05-03 Alza Corporation Plurality of tiny pills in liquid dosage form
AT392891B (en) * 1986-01-13 1991-06-25 Marpal Ag LOUNGE FURNITURE
US5030454A (en) * 1987-10-26 1991-07-09 Alza Corporation Method for delivering drug in tiny pills in liquid carrier

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452285A1 (en) * 1979-03-28 1980-10-24 Damon Corp METHOD OF ENCAPSULATION OF A LIVABLE TISSUE OR OF A BIOLOGICALLY ACTIVE MATERIAL TO BE IMPLANTED, AND CAPSULES OBTAINED
FR2457688A1 (en) * 1979-03-28 1980-12-26 Damon Corp ARTIFICIAL ORGAN, IN THE FORM OF MICROCAPSULES, SUITABLE FOR ITS IMPLANTATION IN THE BODY OF A MAMMAL
US4612556A (en) * 1983-10-07 1986-09-16 The Wiggins Teape Group Limited Self-contained pressure sensitive copying material and its production
AT392891B (en) * 1986-01-13 1991-06-25 Marpal Ag LOUNGE FURNITURE
EP0313992A1 (en) * 1987-10-26 1989-05-03 Alza Corporation Plurality of tiny pills in liquid dosage form
US5030454A (en) * 1987-10-26 1991-07-09 Alza Corporation Method for delivering drug in tiny pills in liquid carrier

Also Published As

Publication number Publication date
BR5915735D0 (en) 1973-05-24

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