GB929409A - Encapsulated emulsions and processes for their preparation - Google Patents

Encapsulated emulsions and processes for their preparation

Info

Publication number
GB929409A
GB929409A GB4022759A GB4022759A GB929409A GB 929409 A GB929409 A GB 929409A GB 4022759 A GB4022759 A GB 4022759A GB 4022759 A GB4022759 A GB 4022759A GB 929409 A GB929409 A GB 929409A
Authority
GB
United Kingdom
Prior art keywords
hydrophilic
styrene
maleic acid
methyl
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4022759A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB929409A publication Critical patent/GB929409A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Particles of a (primary) oil-in-hydrophilic liquid emulsion containing a thickening agent in the hydrophilic liquid phase are encapsulated by forming a secondary emulsion comprising the said primary emulsion dispersed in a coacervating medium comprising an aqueous dispersion of at least two coacervating polymers, at least one of which is a hydrophilic colloid and at least one of which is a linear macromolecular synthetic polymer and causing the polymers to coacervate and thus coat the dispersed primary emulsion particles by altering the pH or by dilution with water. Suitable thickening agents are: acacia, tragacanth, methyl- and carboxymethyl-cellulose, magnesium aluminium silicate, polyglycols, glycerin and syrups. As hydrophilic colloids there are mentioned gelable and nongelable hydrophilic colloids e.g. gelatine, agar, albumen, alginates, deacetylated chitin, acacia, starch and fibrinogen. Suitable polymers are those whose structure comprises both lipophilic and hydrophilic units, e.g. styrene-maleic acid amide and methyl-vinyl ether-maleic acid copolymers, polymethacrylic acid, carbohydrate acetate phthalates and (preferably) hydrolysed styrene-maleic anhydride copolymers and modifications thereof, in particular those of general formula [-R-R1-]n, wherein R represents lipophilic polymer units of which more than 70% are styrene residues and R1 represents hydrophilic units of which more than 50% are maleic acid residues. Solubilizing agents may be added to increase the concentration of polymer, e.g. solvents and polysaccharides, e.g. alginates, pectins, methyl- and carboxymethyl-cellulose and Irish moss derivatives. Either or both phases of the primary emulsion may contain dissolved or suspended "active" ingredients which render the product of the invention useful as sustained release fertilizers, plant growth regulants, bactericides, and pesticides, as food additives, cosmetic ingredients and medicines. Specific examples include: (a) mineral oil-in-caffeine aqueous suspension in gelatine and styrene-maleic acid copolymer, and (b) corn oil-in-aqueous rotenone suspension in fibrinogen and cellulose acetate phthalate. Specification 751,600 is referred to.
GB4022759A 1958-12-22 1959-11-26 Encapsulated emulsions and processes for their preparation Expired GB929409A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78192758A 1958-12-22 1958-12-22

Publications (1)

Publication Number Publication Date
GB929409A true GB929409A (en) 1963-06-19

Family

ID=25124404

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4022759A Expired GB929409A (en) 1958-12-22 1959-11-26 Encapsulated emulsions and processes for their preparation

Country Status (3)

Country Link
CH (1) CH395942A (en)
DE (1) DE1249219B (en)
GB (1) GB929409A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3418656A (en) * 1965-10-23 1968-12-24 Us Plywood Champ Papers Inc Microcapsules, process for their formation and transfer sheet record material coated therewith
US3993831A (en) * 1968-12-17 1976-11-23 Champion International Corporation Microcapsules, process for their formation and transfer sheet record material coated therewith
FR2727632A1 (en) * 1994-12-06 1996-06-07 Godard Philippe Compsns. contg. perfume-filled microcapsules
US5700484A (en) * 1994-12-16 1997-12-23 Nestec S.A. Sustained release microparticulate caffeine formulation
WO2003032749A1 (en) * 2001-10-18 2003-04-24 Firmenich Sa Spray-dried compositions and method for their preparation
EP3775037A4 (en) * 2018-04-02 2021-12-01 Polygreen Ltd. Process for the production of biodegradable superabsorbent polymer with high absorbency under load based on styrene maleic acid copolymers and biopolymer
US12129419B2 (en) 2019-11-12 2024-10-29 Polygreen Ltd Polymeric composition for use as soil conditioner with improved water absorbency during watering of the agricultural crops

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3418656A (en) * 1965-10-23 1968-12-24 Us Plywood Champ Papers Inc Microcapsules, process for their formation and transfer sheet record material coated therewith
US3993831A (en) * 1968-12-17 1976-11-23 Champion International Corporation Microcapsules, process for their formation and transfer sheet record material coated therewith
FR2727632A1 (en) * 1994-12-06 1996-06-07 Godard Philippe Compsns. contg. perfume-filled microcapsules
US5700484A (en) * 1994-12-16 1997-12-23 Nestec S.A. Sustained release microparticulate caffeine formulation
US5744164A (en) * 1994-12-16 1998-04-28 Nestec S.A. Sustained release microparticulate caffeine formulation
WO2003032749A1 (en) * 2001-10-18 2003-04-24 Firmenich Sa Spray-dried compositions and method for their preparation
US6723359B2 (en) 2001-10-18 2004-04-20 Firmenich Sa Spray-dried compositions and method for their preparation
EP3775037A4 (en) * 2018-04-02 2021-12-01 Polygreen Ltd. Process for the production of biodegradable superabsorbent polymer with high absorbency under load based on styrene maleic acid copolymers and biopolymer
US12128144B2 (en) 2019-04-02 2024-10-29 Polygreen Ltd Process for the production of biodegradable superabsorbent polymer with high absorbency under load based on styrene maleic acid copolymers and biopolymer
US12129419B2 (en) 2019-11-12 2024-10-29 Polygreen Ltd Polymeric composition for use as soil conditioner with improved water absorbency during watering of the agricultural crops

Also Published As

Publication number Publication date
DE1249219B (en) 1967-09-07
CH395942A (en) 1965-07-31

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