GB929406A - A process for the production of encapsulated material - Google Patents
A process for the production of encapsulated materialInfo
- Publication number
- GB929406A GB929406A GB3916259A GB3916259A GB929406A GB 929406 A GB929406 A GB 929406A GB 3916259 A GB3916259 A GB 3916259A GB 3916259 A GB3916259 A GB 3916259A GB 929406 A GB929406 A GB 929406A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gelatine
- treatment
- preparations
- membranes
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dentistry (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Colloid Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The walls of microcapsules comprised of at least one gelable hydrophilic colloid which contains amino groups and peptide linkages and produced by a coacervation process (see Group VI) are rendered opaque and their impermeability to fluids increased by successive treatment with (a) at least one watersoluble and ionizable ferric salt and, (b) an aqueous solution of one or more of tannic acid, gallic acid and di-gallic acid. Specified colloids of the above type are gelatin, fibrinogen, polylysine and polyrnithine. Specifications 751,600, 911,483, 929,401, 929,402, 929,403, 929,408 and 929,409 are referred to.ALSO:Membranes comprising at least one gelable hydrophilic colloid which contains amino groups and peptide linkages (e.g. proteins and polyamines) and produced by coacervation techniques are treated successively with: (1) at least one water-soluble and ionizable ferric salt and (2) an aqueous solution of one or more of tannic acid, gallic acid and digallic acid. The membranes may encapsulate solids, oils, oil-in-hydrophilic liquid and hydrophilic liquid-in-oil emulsions which may contain "active" ingredients which render the preparations of use as fertilizers, plant growth hormone preparations, bactericides, pesticides, vitamin preparations, pharmaceuticals and food-additives. In particular, the treatment renders the membranes opaque and therefore increases the stability of encapsulated preparations comprising photosensitive materials, e.g. reserpine, hyoscyamine, potassium iodide, silver salts and phenyl mercuric acetate. Specified colloids are gelatine, fibrinogen, polylysine and polyornithine. The coacervate must be gelled (e.g. by cooling) prior to the treatment with the ferric salt and may be present in the "spent" coacervating medium during the first or both steps of the treatment which preferably takes place at a pH of below 7. Specific examples refer to the treatment of: (a) aqueous potassium iodide-in-corn oil emulsion encapsulated in gelatine; (b) an ethanolic dispersion of silverbromide-in-silicone oil emulsion in gelatine; (c) aqueous epinephrine bitartrate-in-mineral oil emulsion in a complex coacervate of gelatine and styrene-maleic anhydride copolymer; (d) glyceryl monostearate coated yellow mercuric oxide in gelatine. Specifications 751,600, 911,483, 929,401, 929,402, 929,403, 929,408 and 929,409 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78193058A | 1958-12-22 | 1958-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB929406A true GB929406A (en) | 1963-06-19 |
Family
ID=25124414
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3916259A Expired GB929406A (en) | 1958-12-22 | 1959-11-18 | A process for the production of encapsulated material |
GB3916159A Expired GB929405A (en) | 1958-12-22 | 1959-11-18 | Processes for the encapsulation of particles |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3916159A Expired GB929405A (en) | 1958-12-22 | 1959-11-18 | Processes for the encapsulation of particles |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH396845A (en) |
DE (1) | DE1141263B (en) |
GB (2) | GB929406A (en) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808408A (en) * | 1983-05-11 | 1989-02-28 | Bend Research, Inc. | Microcapsules prepared by coacervation |
WO2001026627A1 (en) * | 1999-10-14 | 2001-04-19 | 1170535 Ontario Inc. | Liposome encapsulated silver salt compositions |
WO2013123492A2 (en) | 2012-02-17 | 2013-08-22 | Massachusetts Institute Of Technology | Glucose-responsive microgels for closed loop insulin delivery |
WO2013138343A1 (en) | 2012-03-16 | 2013-09-19 | The Johns Hopkins University | Controlled release formulations for the delivery of hif-1 inhibitors |
WO2013138346A1 (en) | 2012-03-16 | 2013-09-19 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
WO2014160404A1 (en) | 2013-03-13 | 2014-10-02 | The Regents Of The University Of California | Improved oral drug devices and drug formulations |
WO2015106106A1 (en) | 2014-01-10 | 2015-07-16 | Chamber Works, Llc | A personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof |
WO2015138951A1 (en) | 2014-03-14 | 2015-09-17 | Chamber Works, Llc | Articles of jewelry containing a personalizing additive such as dna and methods of making |
WO2016100380A1 (en) | 2014-12-15 | 2016-06-23 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
WO2016118506A1 (en) | 2015-01-20 | 2016-07-28 | The Johns Hopkins University | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
WO2017041053A1 (en) | 2015-09-04 | 2017-03-09 | Yale University | Polymeric bile acid nanocompositions targeting the pancreas and colon |
WO2017143042A2 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
WO2017143061A1 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions and methods for treatment of cystic fibrosis |
WO2017151879A1 (en) | 2016-03-02 | 2017-09-08 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
WO2018005552A1 (en) | 2016-06-27 | 2018-01-04 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
WO2018053010A1 (en) | 2016-09-13 | 2018-03-22 | North Carolina State University | Platelet compositions and methods for the delivery of therapeutic agents |
WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
US10441548B2 (en) | 2015-11-12 | 2019-10-15 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
WO2020028907A1 (en) | 2018-08-03 | 2020-02-06 | Brown University | Compositions and methods for improving the bioavailability of glp1 and analogues thereof |
WO2020033951A1 (en) | 2018-08-10 | 2020-02-13 | Yale University | Compositions and methods for embryonic gene editing in vitro |
US10722468B2 (en) | 2014-08-14 | 2020-07-28 | Brown University | Compositions for stabilizing and delivering proteins |
US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
WO2021258042A1 (en) | 2020-06-19 | 2021-12-23 | Yale University | Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance |
WO2022115474A1 (en) | 2020-11-27 | 2022-06-02 | General Nanotherapeutics Llc | Methods and composition for treatment of immune-mediated diseases |
EP4053117A1 (en) | 2015-08-26 | 2022-09-07 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3965033A (en) * | 1970-07-27 | 1976-06-22 | Fuji Photo Film Co., Ltd. | Process for the production of oil-containing microcapsules |
CA1044134A (en) * | 1975-04-09 | 1978-12-12 | Minnesota Mining And Manufacturing Company | Microcapsule insecticide composition |
FR2464093A1 (en) * | 1979-08-30 | 1981-03-06 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF SUSPENSIONS OR STABLE POWDERS OF STABLE MICROCAPSULES WITH VARIABLE POROSITY AND THE PRODUCTS OBTAINED THEREBY |
DE3016170A1 (en) | 1980-04-26 | 1981-10-29 | Bayer Ag, 5090 Leverkusen | MICROCAPSULES WITH A DEFINED OPENING TEMPERATURE, METHOD FOR THE PRODUCTION AND USE THEREOF |
FR2857592B1 (en) * | 2003-07-18 | 2006-02-24 | Sod Conseils Rech Applic | NEW PROCESS FOR THE PREPARATION OF MICROPARTICLES |
CN1997356A (en) | 2004-04-23 | 2007-07-11 | 安姆根有限公司 | Sustained release formulations |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
-
1959
- 1959-11-18 GB GB3916259A patent/GB929406A/en not_active Expired
- 1959-11-18 GB GB3916159A patent/GB929405A/en not_active Expired
- 1959-12-16 DE DEU6742A patent/DE1141263B/en active Pending
- 1959-12-19 CH CH8206059A patent/CH396845A/en unknown
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808408A (en) * | 1983-05-11 | 1989-02-28 | Bend Research, Inc. | Microcapsules prepared by coacervation |
WO2001026627A1 (en) * | 1999-10-14 | 2001-04-19 | 1170535 Ontario Inc. | Liposome encapsulated silver salt compositions |
US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
WO2013123492A2 (en) | 2012-02-17 | 2013-08-22 | Massachusetts Institute Of Technology | Glucose-responsive microgels for closed loop insulin delivery |
WO2013138343A1 (en) | 2012-03-16 | 2013-09-19 | The Johns Hopkins University | Controlled release formulations for the delivery of hif-1 inhibitors |
WO2013138346A1 (en) | 2012-03-16 | 2013-09-19 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
WO2014160404A1 (en) | 2013-03-13 | 2014-10-02 | The Regents Of The University Of California | Improved oral drug devices and drug formulations |
WO2015106106A1 (en) | 2014-01-10 | 2015-07-16 | Chamber Works, Llc | A personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof |
US9539186B2 (en) | 2014-01-10 | 2017-01-10 | Chamber Works, Llc | Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof |
US9539187B2 (en) | 2014-01-10 | 2017-01-10 | Chamber Works, Llc | Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof |
US9610229B2 (en) | 2014-01-10 | 2017-04-04 | Chamber Works, Llc | Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof |
WO2015138951A1 (en) | 2014-03-14 | 2015-09-17 | Chamber Works, Llc | Articles of jewelry containing a personalizing additive such as dna and methods of making |
US11504329B2 (en) | 2014-08-14 | 2022-11-22 | Brown University | Compositions for stabilizing and delivering proteins |
US10722468B2 (en) | 2014-08-14 | 2020-07-28 | Brown University | Compositions for stabilizing and delivering proteins |
WO2016100392A1 (en) | 2014-12-15 | 2016-06-23 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of ocular disorders |
US10525034B2 (en) | 2014-12-15 | 2020-01-07 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
WO2016100380A1 (en) | 2014-12-15 | 2016-06-23 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
US11013719B2 (en) | 2014-12-15 | 2021-05-25 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
WO2016118506A1 (en) | 2015-01-20 | 2016-07-28 | The Johns Hopkins University | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
EP4053117A1 (en) | 2015-08-26 | 2022-09-07 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders |
WO2017041053A1 (en) | 2015-09-04 | 2017-03-09 | Yale University | Polymeric bile acid nanocompositions targeting the pancreas and colon |
US10441548B2 (en) | 2015-11-12 | 2019-10-15 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
US11564890B2 (en) | 2015-11-12 | 2023-01-31 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
US11331276B2 (en) | 2015-11-12 | 2022-05-17 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
WO2017143061A1 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions and methods for treatment of cystic fibrosis |
WO2017143042A2 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
WO2017151879A1 (en) | 2016-03-02 | 2017-09-08 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
WO2018005552A1 (en) | 2016-06-27 | 2018-01-04 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
WO2018053010A1 (en) | 2016-09-13 | 2018-03-22 | North Carolina State University | Platelet compositions and methods for the delivery of therapeutic agents |
WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
WO2020028907A1 (en) | 2018-08-03 | 2020-02-06 | Brown University | Compositions and methods for improving the bioavailability of glp1 and analogues thereof |
WO2020033951A1 (en) | 2018-08-10 | 2020-02-13 | Yale University | Compositions and methods for embryonic gene editing in vitro |
WO2021258042A1 (en) | 2020-06-19 | 2021-12-23 | Yale University | Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance |
WO2022115474A1 (en) | 2020-11-27 | 2022-06-02 | General Nanotherapeutics Llc | Methods and composition for treatment of immune-mediated diseases |
Also Published As
Publication number | Publication date |
---|---|
GB929405A (en) | 1963-06-19 |
CH396845A (en) | 1965-08-15 |
DE1141263B (en) | 1962-12-20 |
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