GB929403A - Encapsulated emulsions and processes for their preparation - Google Patents

Encapsulated emulsions and processes for their preparation

Info

Publication number
GB929403A
GB929403A GB3794259A GB3794259A GB929403A GB 929403 A GB929403 A GB 929403A GB 3794259 A GB3794259 A GB 3794259A GB 3794259 A GB3794259 A GB 3794259A GB 929403 A GB929403 A GB 929403A
Authority
GB
United Kingdom
Prior art keywords
coacervating
oil
emulsion
agents
examples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3794259A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB929403A publication Critical patent/GB929403A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
    • G03C2001/0471—Isoelectric point of gelatine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Colloid Chemistry (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Particles of a hydrophilic liquid-in-oil emulsion are encapsulated by a process wherein the said emulsion containing an anti-inversion agent in the oil phase is dispersed in an aqueous dispersion of at least two coacervating colloids, at least one of which is gelable and at least one of which is an isoelectric colloid, at a temperature above the gel point of the gelable coacervating colloid and causing a coacervate to deposit on the emulsion particles to form a coating which may subsequently be hardened or plasticized, e.g. by treatment with aqueous formaldehyde. Conventional thickening agents, e.g. acacia, tragacanth, methyl cellulose, carboxymethylcellulose, magnesium aluminium silicate, polyglycols, glycerin, and syrups may be added to the coacervating medium and to the hydrophilic liquid of the primary emulsion and the latter may also contain conventional emulsifying agents, e.g. esters of polyhydric alcohols, sorbitan- and sorbitan polyoxyethylene derivatives. The anti-inversion agent may be any material capable of preventing the inversion of the primary emulsion on its dispersion in the coacervating medium, examples being surface-active agents (preferably non-ionic) e.g. sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, oil-thickening agents, e.g. natural and synthetic waxes, solid fats, sterols and other conventional oil-gelling or oil-thickening agents. Examples of coacervating colloids are gelatine, albumin, casein, fibrinogen, agar-agar, pectins, collagen, starch acetate phthalate, amylene acetate phthalate (all gellable), alginates, acacia, starch and cellulose acetate phthalate. Coacervation may be induced by dilution with water of an initial dispersion of the primary emulsion in the coacervating medium or by adjustment of pH. Examples of such processes are given. Either or both phases of the primary emulsion may contain dissolved or suspended materials which render the capsules of the invention useful as sustained-release fertilizers, plant-growth agents and pesticides, cosmetics, pharmaceuticals with sustained or delayed release for oral, topical or injectable use, additives for incorporation into foodstuffs, e.g. vitamins and ingredients which would normally be lost in a drying step. Specific examples relate inter alia to encapsulated emulsions comprising: (a) urea in the aqueous phase (fertilizer preparation) and, (b) caffeine in the aqueous phase. Specification 751,600 is referred to.
GB3794259A 1958-12-22 1959-11-09 Encapsulated emulsions and processes for their preparation Expired GB929403A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78192058A 1958-12-22 1958-12-22

Publications (1)

Publication Number Publication Date
GB929403A true GB929403A (en) 1963-06-19

Family

ID=25124375

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3794259A Expired GB929403A (en) 1958-12-22 1959-11-09 Encapsulated emulsions and processes for their preparation

Country Status (4)

Country Link
BR (1) BR5915721D0 (en)
CH (1) CH395939A (en)
DE (1) DE1180347B (en)
GB (1) GB929403A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399263A (en) * 1965-04-12 1968-08-27 American Cyanamid Co Stable adjuvant emulsion compositions comprising the hydrated reaction products of a methallic cation and a fatty acid
FR2201293A1 (en) * 1972-10-02 1974-04-26 Tavolek Laboratories
EP0107085A1 (en) * 1982-10-12 1984-05-02 Warner-Lambert Company Anhydrous emulsions and the use thereof
US4464434A (en) * 1978-03-13 1984-08-07 Celanese Corporation Microencapsulated alkaloidal material and method of producing same
EP0256856A2 (en) * 1986-08-14 1988-02-24 Synthetic Blood Corporation A parenterally administrable composition
US5071706A (en) * 1989-08-31 1991-12-10 Eurand America, Incorporated Oily, free-flowing, microcapsules
WO1999024159A1 (en) * 1997-11-10 1999-05-20 Quest International B.V. Encapsulate of active material in alginate matrix
FR2823137A1 (en) * 2001-04-06 2002-10-11 Godefroy Diffusion Method of producing capsules filled with an active principle, for use in cosmetic products such as shower gels, comprises adding calcium salt(s) to the alginate solution before coextrusion and gelling in an oil bath containing acetic acid
WO2005063016A1 (en) * 2003-12-19 2005-07-14 Bayer Technology Services Gmbh Multiphase active ingredient formulation
JP2013240787A (en) * 2007-05-21 2013-12-05 Firmenich Sa Large coacervated capsule
WO2017075681A1 (en) * 2015-11-06 2017-05-11 Oxiteno S.A. Indústria E Comércio Liquid thickener composition for cosmetic formulations for skin and hair cleansing, and for surface and fabric cleaners, and use of the liquid thickener composition
WO2017184606A2 (en) 2016-04-18 2017-10-26 Monosol, Llc Perfume microcapsules and related film and dtergent compositions

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103552011A (en) * 2013-09-30 2014-02-05 昆山振兴精密模具有限公司 Anti-inversion device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) * 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
NL95043C (en) * 1953-06-30

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399263A (en) * 1965-04-12 1968-08-27 American Cyanamid Co Stable adjuvant emulsion compositions comprising the hydrated reaction products of a methallic cation and a fatty acid
FR2201293A1 (en) * 1972-10-02 1974-04-26 Tavolek Laboratories
US4464434A (en) * 1978-03-13 1984-08-07 Celanese Corporation Microencapsulated alkaloidal material and method of producing same
EP0107085A1 (en) * 1982-10-12 1984-05-02 Warner-Lambert Company Anhydrous emulsions and the use thereof
EP0256856A2 (en) * 1986-08-14 1988-02-24 Synthetic Blood Corporation A parenterally administrable composition
EP0256856A3 (en) * 1986-08-14 1989-01-11 Synthetic Blood Corporation A parenterally administrable composition
US5071706A (en) * 1989-08-31 1991-12-10 Eurand America, Incorporated Oily, free-flowing, microcapsules
WO1999024159A1 (en) * 1997-11-10 1999-05-20 Quest International B.V. Encapsulate of active material in alginate matrix
FR2823137A1 (en) * 2001-04-06 2002-10-11 Godefroy Diffusion Method of producing capsules filled with an active principle, for use in cosmetic products such as shower gels, comprises adding calcium salt(s) to the alginate solution before coextrusion and gelling in an oil bath containing acetic acid
WO2005063016A1 (en) * 2003-12-19 2005-07-14 Bayer Technology Services Gmbh Multiphase active ingredient formulation
JP2013240787A (en) * 2007-05-21 2013-12-05 Firmenich Sa Large coacervated capsule
WO2017075681A1 (en) * 2015-11-06 2017-05-11 Oxiteno S.A. Indústria E Comércio Liquid thickener composition for cosmetic formulations for skin and hair cleansing, and for surface and fabric cleaners, and use of the liquid thickener composition
WO2017184606A2 (en) 2016-04-18 2017-10-26 Monosol, Llc Perfume microcapsules and related film and dtergent compositions
US11352468B2 (en) 2016-04-18 2022-06-07 Monosol, Llc Perfume microcapsules and related film and detergent compositions

Also Published As

Publication number Publication date
DE1180347B (en) 1964-10-29
BR5915721D0 (en) 1973-05-29
CH395939A (en) 1965-07-31

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