ATE320482T1 - Makroeingekapselte sekretorische zellen - Google Patents

Makroeingekapselte sekretorische zellen

Info

Publication number
ATE320482T1
ATE320482T1 AT03028476T AT03028476T ATE320482T1 AT E320482 T1 ATE320482 T1 AT E320482T1 AT 03028476 T AT03028476 T AT 03028476T AT 03028476 T AT03028476 T AT 03028476T AT E320482 T1 ATE320482 T1 AT E320482T1
Authority
AT
Austria
Prior art keywords
macroenapsulated
secretory cells
agarose
coated
secretory cell
Prior art date
Application number
AT03028476T
Other languages
English (en)
Inventor
Kanti Jain
Albert L Rubin
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Application granted granted Critical
Publication of ATE320482T1 publication Critical patent/ATE320482T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03028476T 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen ATE320482T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13

Publications (1)

Publication Number Publication Date
ATE320482T1 true ATE320482T1 (de) 2006-04-15

Family

ID=22663563

Family Applications (3)

Application Number Title Priority Date Filing Date
AT06004970T ATE408005T1 (de) 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen
AT03028476T ATE320482T1 (de) 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen
AT95906814T ATE275194T1 (de) 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06004970T ATE408005T1 (de) 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95906814T ATE275194T1 (de) 1994-01-13 1995-01-12 Makroeingekapselte sekretorische zellen

Country Status (18)

Country Link
US (3) US5643569A (de)
EP (3) EP1666585B1 (de)
JP (4) JP3948742B2 (de)
KR (1) KR100474803B1 (de)
CN (1) CN1087779C (de)
AT (3) ATE408005T1 (de)
AU (1) AU681240C (de)
CA (1) CA2181156C (de)
DE (3) DE69535842D1 (de)
DK (2) DK1666585T3 (de)
ES (3) ES2309849T3 (de)
FI (1) FI118853B (de)
IL (1) IL112330A (de)
NO (2) NO323228B1 (de)
NZ (3) NZ509363A (de)
PT (3) PT1418228E (de)
RU (2) RU2208636C2 (de)
WO (1) WO1995019430A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
DK1666585T3 (da) * 1994-01-13 2009-01-12 Rogosin Inst Makroindkapslede sekretoriske celler
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
CA2218623A1 (en) * 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
ATE374034T1 (de) * 1996-04-03 2007-10-15 Rogosin Inst Konditioniertes medium und diffusionsfähiges biologisches material gewonnen durch inkubierung von eingeschlossenen zellen
KR100477296B1 (ko) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
MX340738B (es) 1996-09-13 2016-07-22 Shire Human Genetic Therapies Terapia para deficiencia de a-galactosidasa a.
WO1999005502A2 (en) * 1997-07-22 1999-02-04 The General Hospital Corporation Modulation of multicellular aggregates by solid stress
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
US6279656B1 (en) 1999-11-03 2001-08-28 Santrol, Inc. Downhole chemical delivery system for oil and gas wells
CA2410965C (en) 2000-05-31 2010-09-14 Encelle, Inc. Method of stimulating hair growth
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
WO2004075855A2 (en) * 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
WO2006053052A2 (en) * 2004-11-11 2006-05-18 The Rogosin Institute Method for treating patients with implants of islets which have been kept in long term, in vitro culture
RU2417090C2 (ru) * 2005-09-26 2011-04-27 Дзе Рогозин Инститьют, Инк. Макрогранулы агарозы seakem gold, содержащие секреторные клетки, и их применение
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
ES2386123T3 (es) 2006-06-16 2012-08-09 Fmc Biopolymer As Dispositivo celular con una matriz de colágeno revestida de alginato, proceso para su formación y utilizaciones
EP2126048B1 (de) * 2007-01-24 2012-06-20 Koninklijke Philips Electronics N.V. Verfahren zur behandlung kultivierter zellen
CA2698212A1 (en) 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
MX2010003371A (es) * 2007-09-28 2010-05-05 Intrexon Corp Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos.
RU2405561C2 (ru) * 2008-12-31 2010-12-10 Общество с ограниченной ответственностью "Медицинский научно-консультативный центр "Академическая больница" Способ лечения заболеваний щитовидной железы, сопровождаемых гипотиреозом
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
EP2688397B1 (de) 2011-03-21 2016-07-20 University of Reading Transport von zellen in alginat-hydrogelen
DE102011050024A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse
NZ624195A (en) 2012-01-31 2015-07-31 Rogosin Inst Improved method for manufacture of macrobeads
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
WO2024081309A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
JP2025534667A (ja) 2022-10-11 2025-10-17 シギロン セラピューティクス， インコーポレイテッド 疾患治療のための改変細胞及び移植可能エレメント

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
CA1196862A (en) * 1983-06-01 1985-11-19 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
SE8604684L (sv) * 1986-11-03 1988-05-04 Excorim Kommanditbolag Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar
US5053332A (en) * 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
SU1742330A1 (ru) * 1990-06-18 1992-06-23 Саратовский филиал Всесоюзного научно-исследовательского института генетики и селекции промышленных микроорганизмов Способ получени биокатализатора в полисахаридном носителе
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
AU4402793A (en) * 1992-05-29 1993-12-30 Regents Of The University Of California, The Coated transplant and method for making same
AU5728994A (en) * 1992-11-24 1994-06-22 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules
DK1666585T3 (da) * 1994-01-13 2009-01-12 Rogosin Inst Makroindkapslede sekretoriske celler
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
PT1666585E (pt) 2008-12-10
USRE40555E1 (en) 2008-10-28
USRE38027E1 (en) 2003-03-11
EP1418228B1 (de) 2006-03-15
RU2208636C2 (ru) 2003-07-20
AU1526795A (en) 1995-08-01
FI118853B (fi) 2008-04-15
ES2309849T3 (es) 2008-12-16
NO324570B1 (no) 2007-11-26
EP0742818B1 (de) 2004-09-01
NO962955L (no) 1996-09-11
HK1084693A1 (en) 2006-08-04
ATE408005T1 (de) 2008-09-15
JP4435134B2 (ja) 2010-03-17
DE69533437D1 (de) 2004-10-07
ES2227544T3 (es) 2005-04-01
JP3989492B2 (ja) 2007-10-10
NZ278809A (en) 1998-03-25
DK1418228T3 (da) 2006-07-17
DE69534865T2 (de) 2006-08-17
CN1141650A (zh) 1997-01-29
IL112330A0 (en) 1995-03-30
KR20050005235A (ko) 2005-01-13
AU681240B2 (en) 1997-08-21
DE69534865D1 (de) 2006-05-11
KR100474803B1 (ko) 2005-03-10
PT1418228E (pt) 2006-09-29
MX9602765A (es) 1998-06-30
CN1087779C (zh) 2002-07-17
DE69535842D1 (de) 2008-10-23
EP1418228A1 (de) 2004-05-12
PT742818E (pt) 2004-12-31
CA2181156C (en) 2001-10-16
JP2005137376A (ja) 2005-06-02
ATE275194T1 (de) 2004-09-15
EP1666585B1 (de) 2008-09-10
IL112330A (en) 1999-01-26
US5643569A (en) 1997-07-01
DK1666585T3 (da) 2009-01-12
AU681240C (en) 2006-12-07
CA2181156A1 (en) 1995-07-20
JP2006345875A (ja) 2006-12-28
EP1666585A1 (de) 2006-06-07
JP2007020585A (ja) 2007-02-01
JPH09510868A (ja) 1997-11-04
RU2177503C2 (ru) 2001-12-27
WO1995019430A1 (en) 1995-07-20
DE69533437T2 (de) 2005-09-15
NO20051359L (no) 1996-09-11
ES2260568T3 (es) 2006-11-01
NO323228B1 (no) 2007-02-05
NZ329619A (en) 1999-09-29
JP3948742B2 (ja) 2007-07-25
EP0742818A4 (de) 2002-01-09
NO962955D0 (no) 1996-07-15
EP0742818A1 (de) 1996-11-20
NZ509363A (en) 2006-02-24
FI962841A0 (fi) 1996-07-12
FI962841L (fi) 1996-09-12

Similar Documents

Publication Publication Date Title
ATE408005T1 (de) Makroeingekapselte sekretorische zellen
DE69734631D1 (de) Sonnenzelle, und Montage- und Herstellungsmethode dafür
DE69603416D1 (de) Elektrochemischer Immunobiosensor
NO982990L (no) Elektro-omformercelle
DE69709643D1 (de) Elektrochemische zelle
DE69718481D1 (de) Elektrolyt
DE69520862D1 (de) Detektorzelle für logarithmische Verstärker
DE59510541D1 (de) Elektrochemische Zelle
BR9607041A (pt) Célula eletroquímica primário
DE69613016D1 (de) Elektrochemische Zelle
BR9610196A (pt) Pilha eletroquímica
DE69608686D1 (de) Gewickelte elektrochemische zelle, herstellungsverfahren und verwendung der zelle
FI964014A7 (fi) Menetelmä sähkökemiallisen kennon valmistamiseksi
DE69508059D1 (de) Elektrode für elektrochemische bearbeitung
EP0685782A3 (de) Spannungsregler.
DE59602409D1 (de) Elektrolytzelle
ID18992A (id) Pelawan interleukin-4 selektif sel-t
DE69617383D1 (de) Stromspeicherzelle
FI961467L (fi) Sähkökemiallinen menetelmä
DE59604231D1 (de) Gasdurchlässige hochspannungsisolation
KR960009368U (ko) 정전압 충전기
NO961415D0 (no) Elektrolyttforsterker
NO912123D0 (no) Stroemtilfoerselsleder for en elektrode.
FI945329A0 (fi) Testanlaeggning foer en basstation i en utvidgad cell
KR950031467U (ko) 이온 주입 조절장치

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1418228

Country of ref document: EP