NO20051359L - Innkapslede kollagensekretoriske celler og fremgangsmate til fremstilling derav - Google Patents

Innkapslede kollagensekretoriske celler og fremgangsmate til fremstilling derav

Info

Publication number
NO20051359L
NO20051359L NO20051359A NO20051359A NO20051359L NO 20051359 L NO20051359 L NO 20051359L NO 20051359 A NO20051359 A NO 20051359A NO 20051359 A NO20051359 A NO 20051359A NO 20051359 L NO20051359 L NO 20051359L
Authority
NO
Norway
Prior art keywords
preparation
secretory cells
collagen secretory
encapsulated collagen
agarose
Prior art date
Application number
NO20051359A
Other languages
English (en)
Other versions
NO324570B1 (no
Inventor
Albert L Rubin
Kanti Jain
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20051359L publication Critical patent/NO20051359L/no
Application filed by Rogosin Inst filed Critical Rogosin Inst
Publication of NO324570B1 publication Critical patent/NO324570B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20051359A 1994-01-13 2005-03-16 Agaroseovertrukket, agarosekollagensektretorisk celleperle og fremgangsmate til fremstilling derav samt fremgangsmate for konservering av sekretoriske celler. NO324570B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13
PCT/US1995/000400 WO1995019430A1 (en) 1994-01-13 1995-01-12 Macroencapsulated secretory cells

Publications (2)

Publication Number Publication Date
NO20051359L true NO20051359L (no) 1996-09-11
NO324570B1 NO324570B1 (no) 2007-11-26

Family

ID=22663563

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19962955A NO323228B1 (no) 1994-01-13 1996-07-15 En agaroseovertrukket, agarosesekretorisk celleperle, en fremgangsmate for fremstilling derav, samt en fremgangsmate for konservering av agarosesekretoriske celler.
NO20051359A NO324570B1 (no) 1994-01-13 2005-03-16 Agaroseovertrukket, agarosekollagensektretorisk celleperle og fremgangsmate til fremstilling derav samt fremgangsmate for konservering av sekretoriske celler.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19962955A NO323228B1 (no) 1994-01-13 1996-07-15 En agaroseovertrukket, agarosesekretorisk celleperle, en fremgangsmate for fremstilling derav, samt en fremgangsmate for konservering av agarosesekretoriske celler.

Country Status (19)

Country Link
US (3) US5643569A (no)
EP (3) EP0742818B1 (no)
JP (4) JP3948742B2 (no)
KR (1) KR100474803B1 (no)
CN (1) CN1087779C (no)
AT (3) ATE275194T1 (no)
AU (1) AU681240C (no)
CA (1) CA2181156C (no)
DE (3) DE69534865T2 (no)
DK (2) DK1418228T3 (no)
ES (3) ES2227544T3 (no)
FI (1) FI118853B (no)
HK (1) HK1084693A1 (no)
IL (1) IL112330A (no)
NO (2) NO323228B1 (no)
NZ (3) NZ509363A (no)
PT (3) PT1666585E (no)
RU (2) RU2177503C2 (no)
WO (1) WO1995019430A1 (no)

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US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
ATE275194T1 (de) * 1994-01-13 2004-09-15 Rogosin Inst Makroeingekapselte sekretorische zellen
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
AU6496996A (en) * 1996-02-23 1997-09-10 Circle Biomedical, Inc. Novel artificial pancreas
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
CN1119080C (zh) * 1996-04-03 2003-08-27 罗格森研究所 含有产生扩散性生物产物的细胞的可植入的琼脂糖－胶原珠及其应用
US7297331B2 (en) 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
KR100477296B1 (ko) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도
EP0935651B1 (en) 1996-09-13 2004-12-29 Transkaryotic Therapies, Inc. THERAPY FOR alpha-GALACTOSIDASE A DEFICIENCY
WO1999005502A2 (en) * 1997-07-22 1999-02-04 The General Hospital Corporation Modulation of multicellular aggregates by solid stress
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US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
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US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
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US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20060121077A1 (en) * 2004-11-11 2006-06-08 Lawrence Gazda Method for treating patients with implants of islets which have been kept in long term, in vitro culture
PL1928249T3 (pl) * 2005-09-26 2012-11-30 The Rogosin Inst Inc Makroperełki zawierające komórki wydzielnicze obejmujące agarozę Seakem Gold i ich zastosowanie
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
ES2386123T3 (es) * 2006-06-16 2012-08-09 Fmc Biopolymer As Dispositivo celular con una matriz de colágeno revestida de alginato, proceso para su formación y utilizaciones
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NZ583430A (en) 2007-08-23 2012-06-29 Intrexon Corp Methods and compositions for diagnosing disease via detecting reporter gene expression
CA2715080C (en) 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
EP2688397B1 (en) 2011-03-21 2016-07-20 University of Reading Transport of cells in alginate hydrogels
DE102011050024A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse
PL2809782T3 (pl) * 2012-01-31 2018-04-30 The Rogosin Institute, Inc. Ulepszony sposób wytwarzania makroperełek
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
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FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
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US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
DE69533437T2 (de) 2005-09-15
EP1666585B1 (en) 2008-09-10
IL112330A (en) 1999-01-26
JP3948742B2 (ja) 2007-07-25
USRE38027E1 (en) 2003-03-11
WO1995019430A1 (en) 1995-07-20
EP0742818A4 (en) 2002-01-09
US5643569A (en) 1997-07-01
CN1087779C (zh) 2002-07-17
JP4435134B2 (ja) 2010-03-17
DK1666585T3 (da) 2009-01-12
JP2005137376A (ja) 2005-06-02
ATE275194T1 (de) 2004-09-15
KR20050005235A (ko) 2005-01-13
RU2208636C2 (ru) 2003-07-20
AU1526795A (en) 1995-08-01
DE69535842D1 (de) 2008-10-23
ATE320482T1 (de) 2006-04-15
DE69534865D1 (de) 2006-05-11
FI118853B (fi) 2008-04-15
NZ509363A (en) 2006-02-24
JP3989492B2 (ja) 2007-10-10
NZ329619A (en) 1999-09-29
RU2177503C2 (ru) 2001-12-27
ES2227544T3 (es) 2005-04-01
AU681240C (en) 2006-12-07
USRE40555E1 (en) 2008-10-28
DE69534865T2 (de) 2006-08-17
KR100474803B1 (ko) 2005-03-10
NO324570B1 (no) 2007-11-26
EP0742818B1 (en) 2004-09-01
ES2309849T3 (es) 2008-12-16
NZ278809A (en) 1998-03-25
DE69533437D1 (de) 2004-10-07
JP2007020585A (ja) 2007-02-01
PT742818E (pt) 2004-12-31
CA2181156C (en) 2001-10-16
NO323228B1 (no) 2007-02-05
IL112330A0 (en) 1995-03-30
NO962955L (no) 1996-09-11
AU681240B2 (en) 1997-08-21
CA2181156A1 (en) 1995-07-20
EP0742818A1 (en) 1996-11-20
EP1666585A1 (en) 2006-06-07
NO962955D0 (no) 1996-07-15
ATE408005T1 (de) 2008-09-15
JPH09510868A (ja) 1997-11-04
FI962841A0 (fi) 1996-07-12
PT1418228E (pt) 2006-09-29
PT1666585E (pt) 2008-12-10
EP1418228A1 (en) 2004-05-12
DK1418228T3 (da) 2006-07-17
EP1418228B1 (en) 2006-03-15
FI962841A (fi) 1996-09-12
MX9602765A (es) 1998-06-30
JP2006345875A (ja) 2006-12-28
CN1141650A (zh) 1997-01-29
HK1084693A1 (en) 2006-08-04
ES2260568T3 (es) 2006-11-01

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