PT1418228E - Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos. - Google Patents

Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.

Info

Publication number
PT1418228E
PT1418228E PT03028476T PT03028476T PT1418228E PT 1418228 E PT1418228 E PT 1418228E PT 03028476 T PT03028476 T PT 03028476T PT 03028476 T PT03028476 T PT 03028476T PT 1418228 E PT1418228 E PT 1418228E
Authority
PT
Portugal
Prior art keywords
multicombinator
genes
antibodies
library
vectors
Prior art date
Application number
PT03028476T
Other languages
English (en)
Inventor
Kanti Jain
Albert L Rubin
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Publication of PT1418228E publication Critical patent/PT1418228E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT03028476T 1994-01-13 1995-01-12 Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos. PT1418228E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13

Publications (1)

Publication Number Publication Date
PT1418228E true PT1418228E (pt) 2006-09-29

Family

ID=22663563

Family Applications (3)

Application Number Title Priority Date Filing Date
PT95906814T PT742818E (pt) 1994-01-13 1995-01-12 Celulas secretoras macroencapsuladas
PT03028476T PT1418228E (pt) 1994-01-13 1995-01-12 Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.
PT06004970T PT1666585E (pt) 1994-01-13 1995-01-12 Células secretoras macroencapsuladas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT95906814T PT742818E (pt) 1994-01-13 1995-01-12 Celulas secretoras macroencapsuladas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT06004970T PT1666585E (pt) 1994-01-13 1995-01-12 Células secretoras macroencapsuladas

Country Status (19)

Country Link
US (3) US5643569A (pt)
EP (3) EP1418228B1 (pt)
JP (4) JP3948742B2 (pt)
KR (1) KR100474803B1 (pt)
CN (1) CN1087779C (pt)
AT (3) ATE408005T1 (pt)
AU (1) AU681240C (pt)
CA (1) CA2181156C (pt)
DE (3) DE69533437T2 (pt)
DK (2) DK1666585T3 (pt)
ES (3) ES2309849T3 (pt)
FI (1) FI118853B (pt)
HK (1) HK1084693A1 (pt)
IL (1) IL112330A (pt)
NO (2) NO323228B1 (pt)
NZ (3) NZ278809A (pt)
PT (3) PT742818E (pt)
RU (2) RU2177503C2 (pt)
WO (1) WO1995019430A1 (pt)

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US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
NZ278809A (en) * 1994-01-13 1998-03-25 Rogosin Inst Macroencapsulation of secretory cells in an agarose collagen gel material coated with agarose
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
CA2218623A1 (en) * 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
CN1296477C (zh) * 1996-04-03 2007-01-24 罗格森研究所 含有抑制癌细胞增殖的因子的条件培养基及其制备方法
KR100477296B1 (ko) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en) 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
ATE286120T1 (de) 1996-09-13 2005-01-15 Transkaryotic Therapies Inc Therapie für alpha galactosidase a insuffizienz
AU8577498A (en) * 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
US6279656B1 (en) 1999-11-03 2001-08-28 Santrol, Inc. Downhole chemical delivery system for oil and gas wells
WO2001091773A2 (en) 2000-05-31 2001-12-06 Encelle, Inc. Method of stimulating hair growth
US20040191246A1 (en) 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20060121077A1 (en) * 2004-11-11 2006-06-08 Lawrence Gazda Method for treating patients with implants of islets which have been kept in long term, in vitro culture
NZ566621A (en) * 2005-09-26 2010-07-30 Rogosin Inst Inc Agarose coated pancreas islets cells used for the treatment of insulin dependent diabetes
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
ATE552867T1 (de) 2006-06-16 2012-04-15 Fmc Biopolymer As Alginatbeschichtete collagenmatrix- zellvorrichtung, herstellungsverfahren dafür und verwendungen davon
CN101600792B (zh) * 2007-01-24 2012-03-21 皇家飞利浦电子股份有限公司 处理培养的细胞的方法
EP2185730A4 (en) 2007-08-23 2010-10-27 Intrexon Corp METHOD AND COMPOSITIONS FOR SICKNESS DIAGNOSIS
JP2010540534A (ja) * 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
US10655120B2 (en) 2011-03-21 2020-05-19 The University Of Newcastle Upon Tyne Transport of cells in hydrogels
DE102011050024A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse
RU2591518C2 (ru) 2012-01-31 2016-07-20 Де Рогозин Инститьют Инк. Усовершенствованный способ получения макрогранул
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
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US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
ATE207727T1 (de) * 1992-05-29 2001-11-15 Univ California Beschichtetes transplantat sowie herstellungsverfahren dafür
AU5728994A (en) * 1992-11-24 1994-06-22 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules
NZ278809A (en) * 1994-01-13 1998-03-25 Rogosin Inst Macroencapsulation of secretory cells in an agarose collagen gel material coated with agarose
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
RU2208636C2 (ru) 2003-07-20
NZ329619A (en) 1999-09-29
NO324570B1 (no) 2007-11-26
ATE320482T1 (de) 2006-04-15
NO962955L (no) 1996-09-11
DE69535842D1 (de) 2008-10-23
MX9602765A (es) 1998-06-30
EP1418228A1 (en) 2004-05-12
KR20050005235A (ko) 2005-01-13
WO1995019430A1 (en) 1995-07-20
FI962841A (fi) 1996-09-12
ES2227544T3 (es) 2005-04-01
CA2181156A1 (en) 1995-07-20
AU681240C (en) 2006-12-07
CA2181156C (en) 2001-10-16
AU681240B2 (en) 1997-08-21
NO323228B1 (no) 2007-02-05
IL112330A0 (en) 1995-03-30
DE69533437T2 (de) 2005-09-15
JP4435134B2 (ja) 2010-03-17
USRE40555E1 (en) 2008-10-28
JP2007020585A (ja) 2007-02-01
NZ278809A (en) 1998-03-25
CN1087779C (zh) 2002-07-17
CN1141650A (zh) 1997-01-29
JP3948742B2 (ja) 2007-07-25
JP2006345875A (ja) 2006-12-28
USRE38027E1 (en) 2003-03-11
JPH09510868A (ja) 1997-11-04
ES2260568T3 (es) 2006-11-01
KR100474803B1 (ko) 2005-03-10
NO962955D0 (no) 1996-07-15
EP1666585B1 (en) 2008-09-10
EP1666585A1 (en) 2006-06-07
IL112330A (en) 1999-01-26
DE69533437D1 (de) 2004-10-07
EP0742818A1 (en) 1996-11-20
RU2177503C2 (ru) 2001-12-27
PT742818E (pt) 2004-12-31
DK1666585T3 (da) 2009-01-12
ATE408005T1 (de) 2008-09-15
DE69534865D1 (de) 2006-05-11
AU1526795A (en) 1995-08-01
PT1666585E (pt) 2008-12-10
JP2005137376A (ja) 2005-06-02
ATE275194T1 (de) 2004-09-15
EP1418228B1 (en) 2006-03-15
US5643569A (en) 1997-07-01
JP3989492B2 (ja) 2007-10-10
FI118853B (fi) 2008-04-15
EP0742818A4 (en) 2002-01-09
NO20051359L (no) 1996-09-11
ES2309849T3 (es) 2008-12-16
EP0742818B1 (en) 2004-09-01
DK1418228T3 (da) 2006-07-17
FI962841A0 (fi) 1996-07-12
DE69534865T2 (de) 2006-08-17
HK1084693A1 (en) 2006-08-04
NZ509363A (en) 2006-02-24

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