CA2849917C - Unitized reagent strip - Google Patents
Unitized reagent strip Download PDFInfo
- Publication number
- CA2849917C CA2849917C CA2849917A CA2849917A CA2849917C CA 2849917 C CA2849917 C CA 2849917C CA 2849917 A CA2849917 A CA 2849917A CA 2849917 A CA2849917 A CA 2849917A CA 2849917 C CA2849917 C CA 2849917C
- Authority
- CA
- Canada
- Prior art keywords
- pipette
- sheath
- pipette tip
- aperture
- pipette sheath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Rigid containers without fluid transport within
- B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
- B01L3/50853—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates with covers or lids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0609—Holders integrated in container to position an object
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
- B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/103—General features of the devices using disposable tips
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161541991P | 2011-09-30 | 2011-09-30 | |
| US61/541,991 | 2011-09-30 | ||
| PCT/US2012/058102 WO2013049706A1 (en) | 2011-09-30 | 2012-09-28 | Unitized reagent strip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2849917A1 CA2849917A1 (en) | 2013-04-04 |
| CA2849917C true CA2849917C (en) | 2020-03-31 |
Family
ID=47046870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2849917A Active CA2849917C (en) | 2011-09-30 | 2012-09-28 | Unitized reagent strip |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9222954B2 (enExample) |
| EP (2) | EP3273253B1 (enExample) |
| JP (2) | JP6117217B2 (enExample) |
| KR (1) | KR102121853B1 (enExample) |
| CN (2) | CN106996984B (enExample) |
| AU (3) | AU2012315595B2 (enExample) |
| BR (1) | BR112014007440B1 (enExample) |
| CA (1) | CA2849917C (enExample) |
| DK (2) | DK2761305T3 (enExample) |
| ES (2) | ES2645966T3 (enExample) |
| RU (1) | RU2622432C2 (enExample) |
| WO (1) | WO2013049706A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| EP1654066B1 (en) | 2003-07-31 | 2014-11-12 | Handylab, Inc. | Processing particle-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US9804179B2 (en) * | 2011-01-08 | 2017-10-31 | Access Medical Systems, Ltd. | Systems for immunoassay tests |
| CN106190806B (zh) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| DK2761305T3 (da) | 2011-09-30 | 2017-11-20 | Becton Dickinson Co | Forenet reagensstrimmel |
| WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
| DK2810080T3 (da) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests |
| AU2013246418B2 (en) | 2012-04-13 | 2017-02-23 | Becton, Dickinson And Company | Reflex testing of samples using residual materials from a prior test |
| EP3034169A1 (de) * | 2014-12-15 | 2016-06-22 | Euroimmun Medizinische Labordiagnostika AG | Vorratsbehälter für Flüssigkeiten |
| EP3680332B1 (en) * | 2015-12-04 | 2024-10-09 | Ttp Plc | Sample preparation system and cartridge |
| JP1565699S (enExample) * | 2016-01-12 | 2016-12-19 | ||
| USD789217S1 (en) * | 2016-01-12 | 2017-06-13 | Peter Antons | Prescription container tray |
| USD814652S1 (en) * | 2016-10-14 | 2018-04-03 | Spartan Bioscience In. | Cartridge |
| CN106367309B (zh) * | 2016-11-22 | 2019-01-04 | 安图实验仪器(郑州)有限公司 | 适于核酸诊断系统的单排核酸提取盒 |
| JP7165651B2 (ja) * | 2017-05-12 | 2022-11-04 | ユニバーサル・バイオ・リサーチ株式会社 | 核酸検出用カートリッジ |
| CN107557873A (zh) * | 2017-09-05 | 2018-01-09 | 苏州普川生物科技有限公司 | 一种单人份文库构建试剂盒 |
| US11883825B2 (en) | 2017-11-02 | 2024-01-30 | Memed Diagnostics Ltd. | Cartridge and system for analyzing body liquid |
| JP1606642S (enExample) * | 2017-12-14 | 2018-06-11 | ||
| CH714486A1 (de) * | 2017-12-21 | 2019-06-28 | Integra Biosciences Ag | Probenverteilsystem und Verfahren zum Verteilen von Proben. |
| CN107966580A (zh) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | 一种应用条式检测卡的快速自动生化检测系统及方法 |
| CN108196081A (zh) * | 2018-01-23 | 2018-06-22 | 深圳市国赛生物技术有限公司 | 一种poct特定蛋白分析系统 |
| CN109212237A (zh) * | 2018-08-31 | 2019-01-15 | 深圳市国赛生物技术有限公司 | 糖化血红蛋白检测用试剂盒组件 |
| USD951482S1 (en) | 2018-09-02 | 2022-05-10 | Memed Diagnostics Ltd. | Cartridge device |
| GB201905230D0 (en) * | 2019-04-12 | 2019-05-29 | Randox Laboratories Ltd | Pipette tip carrier assembly |
| CN110132845B (zh) * | 2019-05-15 | 2024-09-03 | 浙江拱东医疗器械股份有限公司 | Cv值改善后的检测试剂条 |
| JP2021012175A (ja) * | 2019-07-08 | 2021-02-04 | 一般社団法人白亜会 | スピッツ・タグ及びチューブ |
| CN114206743A (zh) * | 2019-08-01 | 2022-03-18 | 日本化学药品株式会社 | 试剂盒 |
| US12357996B2 (en) * | 2019-11-06 | 2025-07-15 | Life Corporation | Pipette tip tray |
| US20220288584A1 (en) * | 2019-12-31 | 2022-09-15 | Anatolia Tani Ve Biyoteknoloji Ürünleri Arastirma Gelistirme Sanayi Ve Ticaret Anonim Sirketi | A reactive cartridge carrying system |
| CN111334417A (zh) * | 2020-04-14 | 2020-06-26 | 无锡科智达科技有限公司 | 预分装磁珠法核酸提取装置 |
| EP3909681A1 (en) | 2020-05-13 | 2021-11-17 | Sartorius Biohit Liquid Handling Oy | A spacer plate, a stackable rack, a stacked assembly of at least two racks, and use of a spacer plate |
| USD998172S1 (en) * | 2021-03-12 | 2023-09-05 | Ultima Genomics, Inc. | Sample rack |
| DE102021111102A1 (de) * | 2021-04-29 | 2022-11-03 | Aeneas Gmbh & Co. Kg | Teststreifenanordnung mit Behältern |
| US20260063656A1 (en) | 2022-08-23 | 2026-03-05 | Xi'an Tianlong Science and Technology Co., Ltd. | All-in-one machine for sample testing and control method thereof |
| US12455227B2 (en) * | 2023-01-19 | 2025-10-28 | International Business Machines Corporation | Enclosed, multi-chamber metering and mixing system used for urinalysis |
Family Cites Families (912)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1434314A (en) | 1921-08-04 | 1922-10-31 | Raich Anthony | Lunch pail |
| US1616419A (en) | 1925-04-03 | 1927-02-01 | Everlasting Valve Co | Automatic shut-off device for gas in case of fire |
| US1733401A (en) | 1928-03-29 | 1929-10-29 | Christman Matthias | Journal box |
| NL109202C (enExample) | 1959-11-20 | |||
| GB1095429A (enExample) | 1965-05-17 | |||
| US3528449A (en) | 1968-02-27 | 1970-09-15 | Trw Inc | Fluid flow control apparatus |
| US3813316A (en) | 1972-06-07 | 1974-05-28 | Gen Electric | Microorganisms having multiple compatible degradative energy-generating plasmids and preparation thereof |
| US4038192A (en) | 1973-12-03 | 1977-07-26 | International Biomedical Laboratories, Inc. | Device for exchange between fluids suitable for treatment of blood |
| JPS5348Y2 (enExample) | 1974-01-19 | 1978-01-05 | ||
| US3985649A (en) | 1974-11-25 | 1976-10-12 | Eddelman Roy T | Ferromagnetic separation process and material |
| JPS5255578A (en) | 1975-10-31 | 1977-05-07 | Hitachi Ltd | Analyzing apparatus |
| US4018652A (en) | 1976-01-09 | 1977-04-19 | Mcdonnell Douglas Corporation | Process and apparatus for ascertaining the concentration of microorganism in a water specimen |
| US4018089A (en) | 1976-05-05 | 1977-04-19 | Beckman Instruments, Inc. | Fluid sampling apparatus |
| USD249706S (en) | 1976-12-17 | 1978-09-26 | Eastman Kodak Company | Sample cup tray for chemical analysis of biological fluids |
| USD252157S (en) | 1977-04-14 | 1979-06-19 | Warner-Lambert Company | Diagnostic device for measuring biochemical characteristics of microorganisms and the like |
| USD252341S (en) | 1977-05-12 | 1979-07-10 | Ryder International Corporation | Testing tray |
| JPS5416896A (en) | 1977-06-21 | 1979-02-07 | Asahi Medical Co | Blood dialyser |
| US4139005A (en) | 1977-09-01 | 1979-02-13 | Dickey Gilbert C | Safety release pipe cap |
| USD254687S (en) | 1979-01-25 | 1980-04-08 | Mcdonnell Douglas Corporation | Biochemical card for use with an automated microbial identification machine |
| USD261033S (en) | 1979-02-05 | 1981-09-29 | American Optical Corporation | Bilirubin concentration analyzer |
| USD261173S (en) | 1979-02-05 | 1981-10-06 | American Optical Corporation | Bilirubinometer |
| US4301412A (en) | 1979-10-29 | 1981-11-17 | United States Surgical Corporation | Liquid conductivity measuring system and sample cards therefor |
| JPS5766361A (en) | 1980-10-09 | 1982-04-22 | Olympus Optical Co Ltd | Plate-shaped apparatus for judging cohesion of particle |
| US4472357A (en) | 1981-11-18 | 1984-09-18 | Medical Laboratory Automation, Inc. | Blood bank cuvette cassette and label therefor |
| US4457329A (en) | 1981-12-04 | 1984-07-03 | Air Products And Chemicals, Inc. | Safety pressure regulator |
| JPS58212921A (ja) | 1982-06-04 | 1983-12-10 | Aron Kasei Co Ltd | プラスチツクス中空成形物の成形方法 |
| USD279817S (en) | 1982-07-19 | 1985-07-23 | Daryl Laboratories, Inc. | Immunoassay test slide |
| US4504582A (en) | 1982-07-20 | 1985-03-12 | Genex Corporation | Vermiculite as a carrier support for immobilized biological materials |
| US4439526A (en) | 1982-07-26 | 1984-03-27 | Eastman Kodak Company | Clustered ingress apertures for capillary transport devices and method of use |
| DE3376763D1 (en) | 1982-09-02 | 1988-06-30 | Hettich Andreas Fa | Centrifugation chambers for the cytodiagnostic preparation of epithelial cells and their application |
| US4647432A (en) | 1982-11-30 | 1987-03-03 | Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha | Automatic analysis apparatus |
| USD282208S (en) | 1983-02-07 | 1986-01-14 | Data Packaging Corporation | Pipetter tip cartridge |
| US4522786A (en) | 1983-08-10 | 1985-06-11 | E. I. Du Pont De Nemours And Company | Multilayered test device for detecting analytes in liquid test samples |
| US4673657A (en) | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system |
| US4599315A (en) | 1983-09-13 | 1986-07-08 | University Of California Regents | Microdroplet test apparatus |
| USD292735S (en) | 1983-11-02 | 1987-11-10 | A/S Nunc | Tube for the immunological adsorption analysis |
| US4724207A (en) | 1984-02-02 | 1988-02-09 | Cuno Incorporated | Modified siliceous chromatographic supports |
| US4654127A (en) | 1984-04-11 | 1987-03-31 | Sentech Medical Corporation | Self-calibrating single-use sensing device for clinical chemistry and method of use |
| JP2502961B2 (ja) | 1984-04-26 | 1996-05-29 | 日本碍子株式会社 | 電気化学的装置の製造方法 |
| USD288478S (en) | 1984-06-21 | 1987-02-24 | Sentech Medical Corporation | Clinical chemistry analyzer |
| EP0215849B1 (en) | 1985-03-13 | 1993-03-17 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Platelet collection system |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4612959A (en) | 1985-05-07 | 1986-09-23 | Mobil Oil Corporation | Valveless shut-off and transfer device |
| US4720374A (en) | 1985-07-22 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Container having a sonication compartment |
| US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US4678752A (en) | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
| US4871779A (en) | 1985-12-23 | 1989-10-03 | The Dow Chemical Company | Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities |
| JPS62119460U (enExample) | 1986-01-22 | 1987-07-29 | ||
| DE3614955C1 (de) | 1986-05-02 | 1987-08-06 | Schulz Peter | Proben-Verteiler-System |
| US4978622A (en) | 1986-06-23 | 1990-12-18 | Regents Of The University Of California | Cytophaga-derived immunopotentiator |
| US5763262A (en) | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
| USD302294S (en) | 1986-10-03 | 1989-07-18 | Biotrack, Inc. | Reagent cartridge for blood analysis |
| US4935342A (en) | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| US4978502A (en) | 1987-01-05 | 1990-12-18 | Dole Associates, Inc. | Immunoassay or diagnostic device and method of manufacture |
| US4946562A (en) | 1987-01-29 | 1990-08-07 | Medtest Systems, Inc. | Apparatus and methods for sensing fluid components |
| US5004583A (en) | 1987-01-29 | 1991-04-02 | Medtest Systems, Inc. | Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid |
| US5599667A (en) | 1987-03-02 | 1997-02-04 | Gen-Probe Incorporated | Polycationic supports and nucleic acid purification separation and hybridization |
| JP2862547B2 (ja) | 1987-03-02 | 1999-03-03 | ジエン―プローブ・インコーポレイテツド | 核酸精製、分離及びハイブリダイゼーション用ポリカチオン性支持体 |
| US4855110A (en) | 1987-05-06 | 1989-08-08 | Abbott Laboratories | Sample ring for clinical analyzer network |
| US5001417A (en) | 1987-06-01 | 1991-03-19 | Abbott Laboratories | Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes |
| US5192507A (en) | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
| JPH0354470Y2 (enExample) | 1987-07-15 | 1991-12-02 | ||
| EP0367795A4 (en) | 1987-07-16 | 1992-01-15 | E.I. Du Pont De Nemours And Company | Affinity separating using immobilized flocculating reagents |
| US4827944A (en) | 1987-07-22 | 1989-05-09 | Becton, Dickinson And Company | Body fluid sample collection tube composite |
| GB8720470D0 (en) | 1987-08-29 | 1987-10-07 | Emi Plc Thorn | Sensor arrangements |
| US4921809A (en) | 1987-09-29 | 1990-05-01 | Findley Adhesives, Inc. | Polymer coated solid matrices and use in immunoassays |
| USD312692S (en) | 1987-10-09 | 1990-12-04 | Bradley Marshall C | Pipette holder |
| USD310413S (en) | 1987-12-17 | 1990-09-04 | Miles Inc. | Sample processor |
| JPH0720010Y2 (ja) | 1988-02-25 | 1995-05-10 | 株式会社吉野工業所 | ブロー成型容器 |
| US4895650A (en) | 1988-02-25 | 1990-01-23 | Gen-Probe Incorporated | Magnetic separation rack for diagnostic assays |
| JPH01219669A (ja) * | 1988-02-29 | 1989-09-01 | Shimadzu Corp | 液体試料容器の類別検出方法 |
| US5503803A (en) | 1988-03-28 | 1996-04-02 | Conception Technologies, Inc. | Miniaturized biological assembly |
| DE3811713A1 (de) | 1988-04-08 | 1989-10-19 | Bosch Gmbh Robert | Planare polarographische sonde zur bestimmung des (lambda)-wertes von gasgemischen |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5096669A (en) | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis |
| US5060823A (en) | 1988-09-15 | 1991-10-29 | Brandeis University | Sterile transfer system |
| DE8813340U1 (de) | 1988-10-24 | 1988-12-08 | Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad | Probenrack für Probengefäße |
| JPH0814337B2 (ja) | 1988-11-11 | 1996-02-14 | 株式会社日立製作所 | 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US4919829A (en) | 1988-12-30 | 1990-04-24 | The United States Of America As Represented By The Secretary Of Commerce | Aluminum hydroxides as solid lubricants |
| US5229297A (en) | 1989-02-03 | 1993-07-20 | Eastman Kodak Company | Containment cuvette for PCR and method of use |
| US5053199A (en) | 1989-02-21 | 1991-10-01 | Boehringer Mannheim Corporation | Electronically readable information carrier |
| US5416000A (en) | 1989-03-16 | 1995-05-16 | Chemtrak, Inc. | Analyte immunoassay in self-contained apparatus |
| FI86229C (fi) | 1989-04-10 | 1992-07-27 | Niilo Kaartinen | Foerfarande foer formning av ett uppvaermbart och nedkylbart element vid ett system behandlande smao vaetskemaengder samt ett medelst foerfarandet framstaellt element. |
| US4949742A (en) | 1989-04-26 | 1990-08-21 | Spectra-Physics, Inc. | Temperature operated gas valve |
| US5135872A (en) | 1989-04-28 | 1992-08-04 | Sangstat Medical Corporation | Matrix controlled method of delayed fluid delivery for assays |
| US5061336A (en) | 1989-05-01 | 1991-10-29 | Soane Technologies, Inc. | Gel casting method and apparatus |
| US5071531A (en) | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels |
| AU109440S (en) | 1989-05-03 | 1990-10-31 | Bayer Diagnostic G M B H | Diagnostic working station evaluation device |
| USD325638S (en) | 1989-07-10 | 1992-04-21 | Hach Company | Microtester or the like |
| USD328794S (en) | 1989-07-19 | 1992-08-18 | Pb Diagnostic Systems, Inc. | Diagnostic instrument or similar article |
| AU635314B2 (en) | 1989-09-08 | 1993-03-18 | Terumo Kabushiki Kaisha | Measuring apparatus |
| DE69004652T2 (de) | 1989-09-29 | 1994-05-11 | Glory Kogyo Kk | Vorrichtung zum Bündeln von Papierblättern. |
| US5275787A (en) | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid |
| LU87601A1 (fr) | 1989-10-05 | 1990-02-07 | Ceodeux Sa | Robinet pour bouteille de gaz |
| USD324426S (en) | 1989-10-20 | 1992-03-03 | Pacific Biotech, Inc. | Reaction unit for use in analyzing biological fluids |
| US4967950A (en) | 1989-10-31 | 1990-11-06 | International Business Machines Corporation | Soldering method |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5091328A (en) | 1989-11-21 | 1992-02-25 | National Semiconductor Corporation | Method of late programming MOS devices |
| JP2731613B2 (ja) | 1989-12-12 | 1998-03-25 | 株式会社クラレ | 酵素免疫測定用カートリツジ、それを用いた測定方法及び測定装置 |
| US5279936A (en) | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
| USD328135S (en) | 1990-01-12 | 1992-07-21 | Pacific Biotech, Inc. | Reaction unit for use in analyzing biological fluids |
| US5935401A (en) | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
| US6054034A (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| GB9007791D0 (en) | 1990-04-06 | 1990-06-06 | Foss Richard C | High voltage boosted wordline supply charge pump and regulator for dram |
| ATE154981T1 (de) | 1990-04-06 | 1997-07-15 | Perkin Elmer Corp | Automatisiertes labor für molekularbiologie |
| AU639575B2 (en) | 1990-05-01 | 1993-07-29 | Enprotech Corporation | Integral biomolecule preparation device |
| US5667976A (en) | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
| DE4023194A1 (de) | 1990-07-20 | 1992-01-23 | Kodak Ag | Vorrichtung mit mehreren einreihig angeordneten aufnahmen fuer mit fluessigkeit gefuellte behaelter |
| US5147606A (en) | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device |
| US5208163A (en) | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device |
| JPH0734375Y2 (ja) | 1990-09-11 | 1995-08-02 | 株式会社シノテスト | 被検体物質の反応測定検出器具 |
| WO1992005443A1 (en) | 1990-09-15 | 1992-04-02 | Medical Research Council | Reagent separation |
| US5135627A (en) | 1990-10-15 | 1992-08-04 | Soane Technologies, Inc. | Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography |
| US5652141A (en) | 1990-10-26 | 1997-07-29 | Oiagen Gmbh | Device and process for isolating nucleic acids from cell suspension |
| US5141718A (en) | 1990-10-30 | 1992-08-25 | Millipore Corporation | Test plate apparatus |
| EP0484278B1 (de) | 1990-11-01 | 1995-04-12 | Ciba-Geigy Ag | Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse |
| EP0488947B1 (de) | 1990-11-26 | 1995-02-15 | Ciba-Geigy Ag | Detektorzelle |
| US6703236B2 (en) | 1990-11-29 | 2004-03-09 | Applera Corporation | Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control |
| FR2672301A1 (fr) | 1991-02-01 | 1992-08-07 | Larzul Daniel | Procede et dispositif pour amplifier le nombre d'une sequence definie d'acide nucleique dans un echantillon biologique. |
| US5327038A (en) | 1991-05-09 | 1994-07-05 | Rockwell International Corporation | Walking expansion actuator |
| JPH05345900A (ja) | 1991-07-08 | 1993-12-27 | Fuji Oil Co Ltd | 硬質油脂の製造法 |
| DE4123348A1 (de) | 1991-07-15 | 1993-01-21 | Boehringer Mannheim Gmbh | Elektrochemisches analysesystem |
| USD333522S (en) | 1991-07-23 | 1993-02-23 | P B Diagnostic Systems, Inc. | Sample tube holder |
| IT1249433B (it) | 1991-08-06 | 1995-02-23 | Pompeo Moscetta | Procedimento per il dosaggio di analiti in campioni liquidi e relativaapparecchiatura. |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5256376A (en) | 1991-09-12 | 1993-10-26 | Medical Laboratory Automation, Inc. | Agglutination detection apparatus |
| CA2118912C (en) | 1991-10-04 | 1999-04-06 | Melville Douglas Ball | Peelable laminated structures and process for production thereof |
| CA2074671A1 (en) | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
| USD347478S (en) | 1991-11-05 | 1994-05-31 | Hybaid Ltd. | Laboratory instrument for handling bimolecular samples |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| EP1067134B1 (en) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
| US5787032A (en) | 1991-11-07 | 1998-07-28 | Nanogen | Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group |
| US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| USD351475S (en) | 1992-01-30 | 1994-10-11 | Jan Gerber | Skin patch for testing allergic reactions |
| US5559432A (en) | 1992-02-27 | 1996-09-24 | Logue; Delmar L. | Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core |
| US5217694A (en) | 1992-03-25 | 1993-06-08 | Gibler W Brian | Holder for evacuated test tubes |
| US5646049A (en) | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
| JPH07505297A (ja) | 1992-04-06 | 1995-06-15 | アボツト・ラボラトリーズ | 内面全反射を使用して核酸または被分析物質を検出する方法及び装置 |
| US5223226A (en) | 1992-04-14 | 1993-06-29 | Millipore Corporation | Insulated needle for forming an electrospray |
| US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US5744366A (en) | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5486335A (en) | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US6953676B1 (en) | 1992-05-01 | 2005-10-11 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
| US5401465A (en) | 1992-05-05 | 1995-03-28 | Chiron Corporation | Luminometer with reduced sample crosstalk |
| US5364591A (en) | 1992-06-01 | 1994-11-15 | Eastman Kodak Company | Device for moving a target-bearing solid through a liquid for detection while being contained |
| US5414245A (en) | 1992-08-03 | 1995-05-09 | Hewlett-Packard Corporation | Thermal-ink heater array using rectifying material |
| US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
| DE4231966A1 (de) | 1992-09-24 | 1994-03-31 | Bosch Gmbh Robert | Planare polarograhische Sonde zur Bestimmung des Lambda-Wertes von Gasgemischen |
| US5422271A (en) | 1992-11-20 | 1995-06-06 | Eastman Kodak Company | Nucleic acid material amplification and detection without washing |
| US5885432A (en) | 1992-11-05 | 1999-03-23 | Soane Biosciences | Un-crosslinked polymeric media for electrophoresis |
| US5569364A (en) | 1992-11-05 | 1996-10-29 | Soane Biosciences, Inc. | Separation media for electrophoresis |
| GB9223334D0 (en) | 1992-11-06 | 1992-12-23 | Hybaid Ltd | Magnetic solid phase supports |
| US5500187A (en) | 1992-12-08 | 1996-03-19 | Westinghouse Electric Corporation | Disposable optical agglutination assay device and method for use |
| US5302348A (en) | 1992-12-10 | 1994-04-12 | Itc Corporation | Blood coagulation time test apparatus and method |
| US5311996A (en) | 1993-01-05 | 1994-05-17 | Duffy Thomas J | Edge protector |
| DE4334834A1 (de) | 1993-10-13 | 1995-04-20 | Andrzej Dr Ing Grzegorzewski | Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen |
| FI932866A0 (fi) | 1993-06-21 | 1993-06-21 | Labsystems Oy | Separeringsfoerfarande |
| JPH0664156U (ja) | 1993-02-16 | 1994-09-09 | 株式会社ニッテク | 血液容器の保持構造 |
| USD351913S (en) | 1993-02-25 | 1994-10-25 | Diametrics Medical, Inc. | Disposable electrochemical measurement cartridge for a portable medical analyzer |
| US5339486A (en) | 1993-03-10 | 1994-08-23 | Persic Jr William V | Golf ball cleaner |
| US5565171A (en) | 1993-05-28 | 1996-10-15 | Governors Of The University Of Alberta | Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules |
| JP3339650B2 (ja) | 1993-07-02 | 2002-10-28 | 和光純薬工業株式会社 | 液体分注装置 |
| DE69429038T2 (de) | 1993-07-28 | 2002-03-21 | Pe Corporation (Ny), Norwalk | Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung |
| USD356232S (en) | 1993-08-20 | 1995-03-14 | Flair Communications Agency, Inc. | Dual vesselled beverage container |
| US5397709A (en) | 1993-08-27 | 1995-03-14 | Becton Dickinson And Company | System for detecting bacterial growth in a plurality of culture vials |
| JP2948069B2 (ja) | 1993-09-20 | 1999-09-13 | 株式会社日立製作所 | 化学分析装置 |
| US5374395A (en) | 1993-10-14 | 1994-12-20 | Amoco Corporation | Diagnostics instrument |
| US5645801A (en) | 1993-10-21 | 1997-07-08 | Abbott Laboratories | Device and method for amplifying and detecting target nucleic acids |
| US5415839A (en) | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
| EP0653631B1 (de) | 1993-11-11 | 2003-05-14 | Aclara BioSciences, Inc. | Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen |
| DE4343089A1 (de) | 1993-12-17 | 1995-06-29 | Bosch Gmbh Robert | Planares Sensorelement auf Festelektrolytbasis |
| CA2143365A1 (en) | 1994-03-14 | 1995-09-15 | Hugh V. Cottingham | Nucleic acid amplification method and apparatus |
| US5725831A (en) | 1994-03-14 | 1998-03-10 | Becton Dickinson And Company | Nucleic acid amplification apparatus |
| DE4408361C2 (de) | 1994-03-14 | 1996-02-01 | Bosch Gmbh Robert | Elektrochemischer Sensor zur Bestimmung der Sauerstoffkonzentration in Gasgemischen |
| CA2186340A1 (en) | 1994-03-24 | 1995-09-28 | Gamera Bioscience Corporation | A dna meltometer and methods of use thereof |
| US5580523A (en) | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
| USD366116S (en) | 1994-05-03 | 1996-01-09 | Thomas Biskupski | Electrical box for storing dental wax |
| DE4420732A1 (de) | 1994-06-15 | 1995-12-21 | Boehringer Mannheim Gmbh | Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe |
| US5514343A (en) | 1994-06-22 | 1996-05-07 | Nunc, As | Microtitration system |
| FR2722294B1 (fr) | 1994-07-07 | 1996-10-04 | Lyon Ecole Centrale | Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede |
| CA2195004A1 (en) | 1994-07-14 | 1996-02-01 | Tonejet Corporation Pty Ltd. | Solid ink jet ink |
| US5639428A (en) | 1994-07-19 | 1997-06-17 | Becton Dickinson And Company | Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| CA2156226C (en) | 1994-08-25 | 1999-02-23 | Takayuki Taguchi | Biological fluid analyzing device and method |
| US5627041A (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
| US5582988A (en) | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
| JP3403839B2 (ja) | 1994-10-27 | 2003-05-06 | プレシジョン・システム・サイエンス株式会社 | カートリッジ容器 |
| JP3652424B2 (ja) | 1994-10-27 | 2005-05-25 | 日本政策投資銀行 | 自動分析装置及びその方法 |
| US5721136A (en) | 1994-11-09 | 1998-02-24 | Mj Research, Inc. | Sealing device for thermal cycling vessels |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
| KR100314996B1 (ko) | 1994-11-10 | 2002-01-15 | 윌리암 제이. 버크 | 액체분배시스템 |
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| US5731212A (en) | 1994-12-20 | 1998-03-24 | International Technidyne Corporation | Test apparatus and method for testing cuvette accommodated samples |
| US5846493A (en) | 1995-02-14 | 1998-12-08 | Promega Corporation | System for analyzing a substance from a solution following filtering of the substance from the solution |
| US6884357B2 (en) | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
| US5579928A (en) | 1995-03-06 | 1996-12-03 | Anukwuem; Chidi I. | Test tube holder with lock down clamp |
| US6967088B1 (en) | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| US5674394A (en) | 1995-03-24 | 1997-10-07 | Johnson & Johnson Medical, Inc. | Single use system for preparation of autologous plasma |
| US5578270A (en) | 1995-03-24 | 1996-11-26 | Becton Dickinson And Company | System for nucleic acid based diagnostic assay |
| DE19512368A1 (de) | 1995-04-01 | 1996-10-02 | Boehringer Mannheim Gmbh | System zur Freisetzung und Isolierung von Nukleinsäuren |
| US5700429A (en) | 1995-04-19 | 1997-12-23 | Roche Diagnostic Systems, Inc. | Vessel holder for automated analyzer |
| USD382346S (en) | 1995-04-19 | 1997-08-12 | Roche Diagnostic Systems, Inc. | Vessel holder |
| US5578818A (en) | 1995-05-10 | 1996-11-26 | Molecular Dynamics | LED point scanning system |
| DE19519015C1 (de) | 1995-05-24 | 1996-09-05 | Inst Physikalische Hochtech Ev | Miniaturisierter Mehrkammer-Thermocycler |
| KR19990022214A (ko) | 1995-06-06 | 1999-03-25 | 윌리암 제이. 버크 | 미세 전기도관 제조방법 |
| CA2222506C (en) | 1995-06-06 | 2007-07-24 | Quantic Biomedical Partners | Device and method for concentrating plasma |
| US6228635B1 (en) | 1995-06-07 | 2001-05-08 | Aastrom Bioscience, Inc. | Portable cell growth cassette for use in maintaining and growing biological cells |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| US5968745A (en) | 1995-06-27 | 1999-10-19 | The University Of North Carolina At Chapel Hill | Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof |
| US20020022261A1 (en) | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
| US6168948B1 (en) | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6158269A (en) | 1995-07-13 | 2000-12-12 | Bayer Corporation | Method and apparatus for aspirating and dispensing sample fluids |
| US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| JP3927570B2 (ja) | 1995-07-31 | 2007-06-13 | プレシジョン・システム・サイエンス株式会社 | 容器 |
| US6143250A (en) * | 1995-07-31 | 2000-11-07 | Precision System Science Co., Ltd. | Multi-vessel container for testing fluids |
| JP3923968B2 (ja) | 1995-07-31 | 2007-06-06 | プレシジョン・システム・サイエンス株式会社 | 容器使用方法 |
| US5849208A (en) | 1995-09-07 | 1998-12-15 | Microfab Technoologies, Inc. | Making apparatus for conducting biochemical analyses |
| EP1291441A3 (en) | 1995-09-12 | 2003-03-19 | Becton, Dickinson and Company | Device and method for DNA amplification and assay |
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6911183B1 (en) | 1995-09-15 | 2005-06-28 | The Regents Of The University Of Michigan | Moving microdroplets |
| US6057149A (en) | 1995-09-15 | 2000-05-02 | The University Of Michigan | Microscale devices and reactions in microscale devices |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| GB9519346D0 (en) | 1995-09-22 | 1995-11-22 | English Glass Company The Limi | Dispensing systems |
| US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
| US20020068357A1 (en) | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method |
| US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
| DE69513658T2 (de) | 1995-09-29 | 2000-05-31 | Stmicroelectronics S.R.L., Agrate Brianza | Spannungsregler für nichtflüchtige, elektrisch programmierbare Halbleiterspeicheranordnungen |
| US5651839A (en) | 1995-10-26 | 1997-07-29 | Queen's University At Kingston | Process for engineering coherent twin and coincident site lattice grain boundaries in polycrystalline materials |
| US5705813A (en) | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
| DE19540877C2 (de) | 1995-11-02 | 1998-02-26 | Byk Sangtec Diagnostica | Modulare Reagenzienkartusche |
| AU702403B2 (en) | 1995-12-05 | 1999-02-18 | Gamera Bioscience | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
| US20010055812A1 (en) | 1995-12-05 | 2001-12-27 | Alec Mian | Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
| USD382647S (en) | 1996-01-17 | 1997-08-19 | Biomerieux Vitek, Inc. | Biochemical test card |
| US5883211A (en) | 1996-01-19 | 1999-03-16 | Aclara Biosciences, Inc. | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis |
| US5631337A (en) | 1996-01-19 | 1997-05-20 | Soane Bioscience | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis |
| US5863502A (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
| US5726944A (en) | 1996-02-05 | 1998-03-10 | Motorola, Inc. | Voltage regulator for regulating an output voltage from a charge pump and method therefor |
| US5981735A (en) | 1996-02-12 | 1999-11-09 | Cobra Therapeutics Limited | Method of plasmid DNA production and purification |
| US5736102A (en) | 1996-02-21 | 1998-04-07 | Biomerieux Vitek, Inc. | Test sample positioning system |
| AU715627B2 (en) | 1996-02-21 | 2000-02-03 | Biomerieux Vitek, Inc. | Automatic sample testing machine |
| USD378782S (en) | 1996-03-01 | 1997-04-08 | Johnson & Johnson Clinical Diagnostics, Inc. | Processor for nucleic acid detection |
| US5849598A (en) | 1996-03-15 | 1998-12-15 | Washington University | Method for transferring micro quantities of liquid samples to discrete locations |
| BR9708250A (pt) | 1996-03-25 | 2000-01-04 | Diasys Corp | Aparelho e método para manuseio de amostras de fluido de materiais corpóreos |
| US6114122A (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
| US5844238A (en) | 1996-03-27 | 1998-12-01 | David Sarnoff Research Center, Inc. | Infrared imager using room temperature capacitance sensor |
| US7244622B2 (en) | 1996-04-03 | 2007-07-17 | Applera Corporation | Device and method for multiple analyte detection |
| US7235406B1 (en) | 1996-04-03 | 2007-06-26 | Applera Corporation | Nucleic acid analysis device |
| US5788814A (en) | 1996-04-09 | 1998-08-04 | David Sarnoff Research Center | Chucks and methods for positioning multiple objects on a substrate |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| US6399023B1 (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US5671303A (en) | 1996-04-17 | 1997-09-23 | Motorola, Inc. | Molecular detection apparatus and method using optical waveguide detection |
| US5948363A (en) | 1996-04-22 | 1999-09-07 | Gaillard; Patrick | Micro-well strip with print tabs |
| US6001307A (en) | 1996-04-26 | 1999-12-14 | Kyoto Daiichi Kagaku Co., Ltd. | Device for analyzing a sample |
| US6221672B1 (en) | 1996-04-30 | 2001-04-24 | Medtronic, Inc. | Method for determining platelet inhibitor response |
| US6054277A (en) | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
| US6180950B1 (en) | 1996-05-14 | 2001-01-30 | Don Olsen | Micro heating apparatus for synthetic fibers |
| AU738336B2 (en) | 1996-05-20 | 2001-09-13 | Precision System Science Co., Ltd. | Control method and apparatus for controlling magnetic particles by a sample distributor |
| US6083762A (en) | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
| US5726404A (en) | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch |
| US5939291A (en) | 1996-06-14 | 1999-08-17 | Sarnoff Corporation | Microfluidic method for nucleic acid amplification |
| US5863801A (en) | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation |
| US5912124A (en) | 1996-06-14 | 1999-06-15 | Sarnoff Corporation | Padlock probe detection |
| US5914229A (en) | 1996-06-14 | 1999-06-22 | Sarnoff Corporation | Method for amplifying a polynucleotide |
| JP3361530B2 (ja) | 1996-06-28 | 2003-01-07 | カリパー・テクノロジーズ・コープ． | 電子ピペッタおよび電気泳動バイアスのための補償手段 |
| CN1173776C (zh) | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
| US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5699157A (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US20020053399A1 (en) | 1996-07-30 | 2002-05-09 | Aclara Biosciences, Inc | Methods for fabricating enclosed microchannel structures |
| US6558916B2 (en) | 1996-08-02 | 2003-05-06 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time measurements of patient cellular responses |
| US6280967B1 (en) | 1996-08-02 | 2001-08-28 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time of cellular responses |
| US5804436A (en) | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
| FR2752226B1 (fr) | 1996-08-08 | 1998-10-02 | Tran Tho Dong Jean | Emballage pourvu d'une enveloppe souple interne et son procede de fabrication |
| US5872623A (en) | 1996-09-26 | 1999-02-16 | Sarnoff Corporation | Massively parallel detection |
| US5858187A (en) | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip |
| US6110343A (en) | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus |
| JP2001502319A (ja) | 1996-10-15 | 2001-02-20 | 藤沢薬品工業株式会社 | 成長ホルモンの放出を促進するベンズオキセピン誘導体 |
| US6500390B1 (en) | 1996-10-17 | 2002-12-31 | David A. Boulton | Method for sealing and venting a microplate assembly |
| US5874046A (en) | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| USD421653S (en) | 1996-11-18 | 2000-03-14 | Tekmar Company | Housing for a laboratory instrument |
| US6465257B1 (en) | 1996-11-19 | 2002-10-15 | Caliper Technologies Corp. | Microfluidic systems |
| US6447727B1 (en) | 1996-11-19 | 2002-09-10 | Caliper Technologies Corp. | Microfluidic systems |
| DE19749011A1 (de) | 1996-11-19 | 1998-05-20 | Lang Volker | Mikroventil |
| CA2276251A1 (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| USD399959S (en) | 1997-01-24 | 1998-10-20 | Abbott Laboratories | Housing for a device for measuring the concentration of an analyte in a sample of blood |
| US5772966A (en) | 1997-01-24 | 1998-06-30 | Maracas; George N. | Assay dispensing apparatus |
| USD414271S (en) | 1997-02-03 | 1999-09-21 | Eli Lilly And Company | Reaction vessel for combining chemicals |
| US5972694A (en) | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| DE19707226A1 (de) | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Lichtabtastvorrichtung |
| US5861563A (en) | 1997-03-20 | 1999-01-19 | Bayer Corporation | Automatic closed tube sampler |
| US5964997A (en) | 1997-03-21 | 1999-10-12 | Sarnoff Corporation | Balanced asymmetric electronic pulse patterns for operating electrode-based pumps |
| US5747666A (en) | 1997-03-26 | 1998-05-05 | Willis; John P. | Point-of-care analyzer module |
| US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US5964995A (en) | 1997-04-04 | 1999-10-12 | Caliper Technologies Corp. | Methods and systems for enhanced fluid transport |
| US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US5993750A (en) | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| AU727083B2 (en) | 1997-04-25 | 2000-11-30 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| US5976336A (en) | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
| US5997708A (en) | 1997-04-30 | 1999-12-07 | Hewlett-Packard Company | Multilayer integrated assembly having specialized intermediary substrate |
| JP2001524214A (ja) | 1997-05-02 | 2001-11-27 | ジェン−プロウブ インコーポレイテッド | 反応容器装置 |
| US6106685A (en) | 1997-05-13 | 2000-08-22 | Sarnoff Corporation | Electrode combinations for pumping fluids |
| US5980719A (en) | 1997-05-13 | 1999-11-09 | Sarnoff Corporation | Electrohydrodynamic receptor |
| AU7591998A (en) | 1997-05-23 | 1998-12-11 | Gamera Bioscience Corporation | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system |
| US6524790B1 (en) | 1997-06-09 | 2003-02-25 | Caliper Technologies Corp. | Apparatus and methods for correcting for variable velocity in microfluidic systems |
| US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
| ES2249818T3 (es) | 1997-06-09 | 2006-04-01 | F. Hoffmann-La Roche Ag | Dispositivo desechable despues de su uso en un proceso. |
| US6190619B1 (en) | 1997-06-11 | 2001-02-20 | Argonaut Technologies, Inc. | Systems and methods for parallel synthesis of compounds |
| US5882465A (en) | 1997-06-18 | 1999-03-16 | Caliper Technologies Corp. | Method of manufacturing microfluidic devices |
| US5900130A (en) | 1997-06-18 | 1999-05-04 | Alcara Biosciences, Inc. | Method for sample injection in microchannel device |
| US6425972B1 (en) | 1997-06-18 | 2002-07-30 | Calipher Technologies Corp. | Methods of manufacturing microfabricated substrates |
| US5959291A (en) | 1997-06-27 | 1999-09-28 | Caliper Technologies Corporation | Method and apparatus for measuring low power signals |
| JP3191150B2 (ja) | 1997-06-30 | 2001-07-23 | 株式会社アステックコーポレーション | 採血管ラック |
| US6001231A (en) | 1997-07-15 | 1999-12-14 | Caliper Technologies Corp. | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems |
| US5932799A (en) | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
| US5827481A (en) | 1997-07-31 | 1998-10-27 | Hewlett-Packard Company | Cartridge system for effecting sample acquisition and introduction |
| US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
| US5916522A (en) | 1997-08-07 | 1999-06-29 | Careside, Inc. | Electrochemical analytical cartridge |
| US5919711A (en) | 1997-08-07 | 1999-07-06 | Careside, Inc. | Analytical cartridge |
| US6156199A (en) | 1997-08-11 | 2000-12-05 | Zuk, Jr.; Peter | Centrifugal filtration apparatus |
| WO1999033559A1 (en) | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
| US6368871B1 (en) | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
| JP2001515216A (ja) | 1997-08-13 | 2001-09-18 | シーフィード | 流体試料を操作するための微小構造体 |
| US5916776A (en) | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| US5965410A (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| CA2300203A1 (en) | 1997-09-02 | 1999-03-11 | Caliper Technologies Corporation | Microfluidic system with electrofluidic and electrothermal controls |
| US6597450B1 (en) | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
| US6284113B1 (en) | 1997-09-19 | 2001-09-04 | Aclara Biosciences, Inc. | Apparatus and method for transferring liquids |
| US6902703B2 (en) | 1999-05-03 | 2005-06-07 | Ljl Biosystems, Inc. | Integrated sample-processing system |
| US5961925A (en) | 1997-09-22 | 1999-10-05 | Bristol-Myers Squibb Company | Apparatus for synthesis of multiple organic compounds with pinch valve block |
| US5993611A (en) | 1997-09-24 | 1999-11-30 | Sarnoff Corporation | Capacitive denaturation of nucleic acid |
| US6012902A (en) | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump |
| DE69839294T2 (de) | 1997-09-29 | 2009-04-09 | F. Hoffmann-La Roche Ag | Gerät zur Abscheidung magnetischer Teilchen |
| WO1999018438A1 (en) | 1997-10-02 | 1999-04-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| WO1999019717A1 (en) | 1997-10-15 | 1999-04-22 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
| US6132684A (en) | 1997-10-31 | 2000-10-17 | Becton Dickinson And Company | Sample tube holder |
| ATE446141T1 (de) | 1997-11-14 | 2009-11-15 | Gen Probe Inc | Arbeitsgerät zur analyse |
| EP1030912A4 (en) | 1997-11-14 | 2007-01-10 | California Inst Of Techn | DEVICE FOR PERFORMING LYSIS OF CELLS |
| DE59810859D1 (de) | 1997-11-19 | 2004-04-01 | Inoex Gmbh | Einrichtung zur fehlererfassung und/oder wanddickenmessung bei durchlaufenden bändern oder rohren aus kunststoff mit ultraschallsignalen |
| US5992820A (en) | 1997-11-19 | 1999-11-30 | Sarnoff Corporation | Flow control in microfluidics devices by controlled bubble formation |
| US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| US6123205A (en) | 1997-11-26 | 2000-09-26 | Bayer Corporation | Sample tube rack |
| US6197503B1 (en) | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens |
| USD413677S (en) | 1997-11-26 | 1999-09-07 | Bayer Corporation | Sample tube rack |
| US6258264B1 (en) | 1998-04-10 | 2001-07-10 | Transgenomic, Inc. | Non-polar media for polynucleotide separations |
| ES2177093T3 (es) | 1997-12-06 | 2002-12-01 | Dna Res Innovations Ltd | Aislamiento de acidos nucleicos. |
| US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| US6074725A (en) | 1997-12-10 | 2000-06-13 | Caliper Technologies Corp. | Fabrication of microfluidic circuits by printing techniques |
| US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
| EP1044370B1 (en) | 1997-12-30 | 2017-08-23 | Caliper Life Sciences, Inc. | Software for the display of chromatographic separation data |
| US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
| JP3551293B2 (ja) | 1998-02-02 | 2004-08-04 | 東洋紡績株式会社 | 核酸抽出装置 |
| USD413391S (en) | 1998-02-05 | 1999-08-31 | Bayer Corporation | Test tube sample rack |
| US6420143B1 (en) | 1998-02-13 | 2002-07-16 | Caliper Technologies Corp. | Methods and systems for performing superheated reactions in microscale fluidic systems |
| US6756019B1 (en) | 1998-02-24 | 2004-06-29 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
| US6100541A (en) | 1998-02-24 | 2000-08-08 | Caliper Technologies Corporation | Microfluidic devices and systems incorporating integrated optical elements |
| US6251343B1 (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
| US6861035B2 (en) | 1998-02-24 | 2005-03-01 | Aurora Discovery, Inc. | Multi-well platforms, caddies, lids and combinations thereof |
| USD417009S (en) | 1998-03-02 | 1999-11-23 | Bayer Corporation | Sample tube rack |
| USD428497S (en) | 1998-03-06 | 2000-07-18 | Bayer Corporation | Test tube sample rack |
| JPH11295323A (ja) * | 1998-04-13 | 1999-10-29 | Matsushita Electric Ind Co Ltd | 自動分注装置および分注方法 |
| US6024920A (en) | 1998-04-21 | 2000-02-15 | Bio-Rad Laboratories, Inc. | Microplate scanning read head |
| US7078224B1 (en) | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| DE69940647D1 (de) | 1998-05-01 | 2009-05-07 | Gen Probe Inc | Automatische diagnostische Analysevorrichtung |
| JPH11316226A (ja) | 1998-05-06 | 1999-11-16 | Olympus Optical Co Ltd | 自動測定用カートリッジ及び自動測定法 |
| US6123798A (en) | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements |
| US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
| EP0964555A1 (de) | 1998-06-04 | 1999-12-15 | Siemens Aktiengesellschaft | Pegelregelung und adaptive Filterung in CAP-Empfängern |
| US6306590B1 (en) | 1998-06-08 | 2001-10-23 | Caliper Technologies Corp. | Microfluidic matrix localization apparatus and methods |
| US6274089B1 (en) | 1998-06-08 | 2001-08-14 | Caliper Technologies Corp. | Microfluidic devices, systems and methods for performing integrated reactions and separations |
| US6149882A (en) | 1998-06-09 | 2000-11-21 | Symyx Technologies, Inc. | Parallel fixed bed reactor and fluid contacting apparatus |
| USD421130S (en) | 1998-06-15 | 2000-02-22 | Bayer Corporation | Sample tube rack |
| US7799521B2 (en) | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
| US6375901B1 (en) | 1998-06-29 | 2002-04-23 | Agilent Technologies, Inc. | Chemico-mechanical microvalve and devices comprising the same |
| US6787111B2 (en) | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
| USD420747S (en) | 1998-07-10 | 2000-02-15 | Bayer Corporation | Sample tube rack |
| DE19833087A1 (de) | 1998-07-23 | 2000-01-27 | Bosch Gmbh Robert | Gassensor und Verfahren zu dessen Herstellung |
| DE19833293C1 (de) | 1998-07-24 | 2000-01-20 | Gunther Botsch | Trennvorrichtung |
| US20020049694A1 (en) | 1998-07-27 | 2002-04-25 | J. Wallace Parce | Distributed database for analytical instruments |
| DE59912484D1 (de) | 1998-07-31 | 2005-10-06 | Tecan Trading Ag Maennedorf | Magnetseparator |
| US6540896B1 (en) | 1998-08-05 | 2003-04-01 | Caliper Technologies Corp. | Open-Field serial to parallel converter |
| US6236456B1 (en) | 1998-08-18 | 2001-05-22 | Molecular Devices Corporation | Optical system for a scanning fluorometer |
| US6316774B1 (en) | 1998-08-18 | 2001-11-13 | Molecular Devices Corporation | Optical system for a scanning fluorometer |
| US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| USD439673S1 (en) | 1998-10-06 | 2001-03-27 | Sorenson Bioscience | Multi-well microcentrifuge tube |
| US6958392B2 (en) | 1998-10-09 | 2005-10-25 | Whatman, Inc. | Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products |
| US6572830B1 (en) | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
| US6149787A (en) | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
| US6498497B1 (en) | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration |
| US6948843B2 (en) | 1998-10-28 | 2005-09-27 | Covaris, Inc. | Method and apparatus for acoustically controlling liquid solutions in microfluidic devices |
| US6086740A (en) | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
| US5973138A (en) | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
| WO2000034521A1 (en) | 1998-12-08 | 2000-06-15 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
| JP2000180455A (ja) | 1998-12-15 | 2000-06-30 | Sanuki Kogyo Kk | フローインジェクション自動分析装置 |
| US6062261A (en) | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
| US6261431B1 (en) | 1998-12-28 | 2001-07-17 | Affymetrix, Inc. | Process for microfabrication of an integrated PCR-CE device and products produced by the same |
| WO2000040334A1 (en) | 1999-01-08 | 2000-07-13 | Pe Corporation (Ny) | Fiber array for contacting chemical species and methods for using and making same |
| IT1306964B1 (it) | 1999-01-19 | 2001-10-11 | St Microelectronics Srl | Circuito a boosting capacitivo per la regolazione della tensione dilettura di riga in memorie non-volatili |
| US6150119A (en) | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
| US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US20020019059A1 (en) | 1999-01-28 | 2002-02-14 | Calvin Y.H. Chow | Devices, systems and methods for time domain multiplexing of reagents |
| CN1296703C (zh) | 1999-02-02 | 2007-01-24 | 卡钳生命科学股份有限公司 | 鉴定蛋白质的方法、装置和系统 |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| ATE508200T1 (de) | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | Sequenzierung durch inkorporation |
| US6749814B1 (en) | 1999-03-03 | 2004-06-15 | Symyx Technologies, Inc. | Chemical processing microsystems comprising parallel flow microreactors and methods for using same |
| US6171850B1 (en) | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
| US6558945B1 (en) | 1999-03-08 | 2003-05-06 | Aclara Biosciences, Inc. | Method and device for rapid color detection |
| US6326083B1 (en) | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety |
| US6148508A (en) | 1999-03-12 | 2000-11-21 | Caliper Technologies Corp. | Method of making a capillary for electrokinetic transport of materials |
| JP2000266760A (ja) | 1999-03-17 | 2000-09-29 | Hitachi Ltd | 分注装置 |
| JP3988306B2 (ja) | 1999-03-25 | 2007-10-10 | 東ソー株式会社 | 自動測定装置 |
| EP1041386B1 (en) | 1999-03-25 | 2007-10-17 | Tosoh Corporation | Analyzer |
| US6783962B1 (en) | 1999-03-26 | 2004-08-31 | Upfront Chromatography | Particulate material for purification of bio-macromolecules |
| US6500323B1 (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices |
| US6194563B1 (en) | 1999-03-26 | 2001-02-27 | Vysis, Inc. | Solid phase nucleic acid labeling by transamination |
| US6303343B1 (en) | 1999-04-06 | 2001-10-16 | Caliper Technologies Corp. | Inefficient fast PCR |
| US6306273B1 (en) | 1999-04-13 | 2001-10-23 | Aclara Biosciences, Inc. | Methods and compositions for conducting processes in microfluidic devices |
| US6322683B1 (en) | 1999-04-14 | 2001-11-27 | Caliper Technologies Corp. | Alignment of multicomponent microfabricated structures |
| US20040053290A1 (en) | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| CA2270106C (en) | 1999-04-23 | 2006-03-14 | Yousef Haj-Ahmad | Nucleic acid purification and process |
| US6773676B2 (en) | 1999-04-27 | 2004-08-10 | Agilent Technologies, Inc. | Devices for performing array hybridization assays and methods of using the same |
| JP4647792B2 (ja) | 1999-04-28 | 2011-03-09 | イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ | 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング |
| US6555389B1 (en) | 1999-05-11 | 2003-04-29 | Aclara Biosciences, Inc. | Sample evaporative control |
| US6458259B1 (en) | 1999-05-11 | 2002-10-01 | Caliper Technologies Corp. | Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow |
| US6838680B2 (en) | 1999-05-12 | 2005-01-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
| US6399952B1 (en) | 1999-05-12 | 2002-06-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
| US6326147B1 (en) | 1999-05-13 | 2001-12-04 | The Perkin-Elmer Corporation | Methods, apparatus, articles of manufacture, and user interfaces for performing automated biological assay preparation and macromolecule purification |
| US6310199B1 (en) | 1999-05-14 | 2001-10-30 | Promega Corporation | pH dependent ion exchange matrix and method of use in the isolation of nucleic acids |
| US6592821B1 (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| WO2000070080A1 (en) | 1999-05-17 | 2000-11-23 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| US6287774B1 (en) | 1999-05-21 | 2001-09-11 | Caliper Technologies Corp. | Assay methods and system |
| US6472141B2 (en) | 1999-05-21 | 2002-10-29 | Caliper Technologies Corp. | Kinase assays using polycations |
| US20040200909A1 (en) | 1999-05-28 | 2004-10-14 | Cepheid | Apparatus and method for cell disruption |
| WO2000072970A1 (en) | 1999-05-28 | 2000-12-07 | Cepheid | Cartridge for conducting a chemical reaction |
| WO2001012325A1 (en) | 1999-05-28 | 2001-02-22 | Bio/Data Corporation | Method and apparatus for directly sampling a fluid for microfiltration |
| US6391541B1 (en) | 1999-05-28 | 2002-05-21 | Kurt E. Petersen | Apparatus for analyzing a fluid sample |
| AU5291600A (en) | 1999-06-01 | 2000-12-18 | Caliper Technologies Corporation | Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities |
| DE29909529U1 (de) | 1999-06-01 | 1999-08-12 | Festo AG & Co, 73734 Esslingen | Fluidtechnisches Steuergerät |
| FR2795426A1 (fr) | 1999-06-22 | 2000-12-29 | Commissariat Energie Atomique | Support d'analyse biologique a amplification |
| US6706519B1 (en) | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays |
| US6811668B1 (en) | 1999-06-22 | 2004-11-02 | Caliper Life Sciences, Inc. | Apparatus for the operation of a microfluidic device |
| US6664104B2 (en) | 1999-06-25 | 2003-12-16 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
| CN100402850C (zh) | 1999-06-28 | 2008-07-16 | 加利福尼亚技术学院 | 微型制造的弹性体的阀和泵系统 |
| US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
| WO2001002850A1 (en) | 1999-07-06 | 2001-01-11 | Caliper Technologies Corp. | Microfluidic systems and methods for determining modulator kinetics |
| US6353475B1 (en) | 1999-07-12 | 2002-03-05 | Caliper Technologies Corp. | Light source power modulation for use with chemical and biochemical analysis |
| ATE411110T1 (de) | 1999-07-19 | 2008-10-15 | Biomerieux Bv | Verfahren zum mengen von magnetteilchen mit einer flüssigkeit |
| USD438311S1 (en) | 1999-07-28 | 2001-02-27 | Matsushita Electric Industrial Co.,Ltd. | Strip for blood test |
| US6337435B1 (en) | 1999-07-30 | 2002-01-08 | Bio-Rad Laboratories, Inc. | Temperature control for multi-vessel reaction apparatus |
| US6818060B2 (en) | 1999-08-02 | 2004-11-16 | Emerald Biostructures, Inc. | Robot for mixing crystallization trial matrices |
| US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6602206B1 (en) | 1999-08-18 | 2003-08-05 | Becton, Dickinson And Company | Stopper-shield assembly |
| US6495104B1 (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
| WO2001014931A1 (fr) | 1999-08-23 | 2001-03-01 | Mitsubishi Chemical Corporation | Composition photopolymerisable et plaque lithographique photopolymerisable |
| US6858185B1 (en) | 1999-08-25 | 2005-02-22 | Caliper Life Sciences, Inc. | Dilutions in high throughput systems with a single vacuum source |
| US6613581B1 (en) | 1999-08-26 | 2003-09-02 | Caliper Technologies Corp. | Microfluidic analytic detection assays, devices, and integrated systems |
| US6613211B1 (en) | 1999-08-27 | 2003-09-02 | Aclara Biosciences, Inc. | Capillary electrokinesis based cellular assays |
| US6824663B1 (en) | 1999-08-27 | 2004-11-30 | Aclara Biosciences, Inc. | Efficient compound distribution in microfluidic devices |
| US6633785B1 (en) | 1999-08-31 | 2003-10-14 | Kabushiki Kaisha Toshiba | Thermal cycler and DNA amplifier method |
| AU7101000A (en) | 1999-09-10 | 2001-04-10 | Caliper Technologies Corporation | Microfabrication methods and devices |
| USD466219S1 (en) | 1999-09-13 | 2002-11-26 | Micronic B.V. | Carrier for test-tubes |
| US6906797B1 (en) | 1999-09-13 | 2005-06-14 | Aclara Biosciences, Inc. | Side light activated microfluid channels |
| DE19945604A1 (de) | 1999-09-23 | 2003-08-07 | Aclara Biosciences Inc | Verfahren zur Verbindung von Werkstücken aus Kunststoff und seine Verwendung in der Mikro- und Nanostrukturtechnik |
| DE19948473A1 (de) | 1999-10-08 | 2001-04-12 | Nmi Univ Tuebingen | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
| WO2001027253A1 (en) | 1999-10-08 | 2001-04-19 | Caliper Technologies Corp. | Use of nernstein voltage sensitive dyes in measuring transmembrane voltage |
| US6221600B1 (en) | 1999-10-08 | 2001-04-24 | Board Of Regents, The University Of Texas System | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis |
| US6287254B1 (en) | 1999-11-02 | 2001-09-11 | W. Jean Dodds | Animal health diagnosis |
| US6232072B1 (en) | 1999-10-15 | 2001-05-15 | Agilent Technologies, Inc. | Biopolymer array inspection |
| US6272939B1 (en) | 1999-10-15 | 2001-08-14 | Applera Corporation | System and method for filling a substrate with a liquid sample |
| US6908594B1 (en) | 1999-10-22 | 2005-06-21 | Aclara Biosciences, Inc. | Efficient microfluidic sealing |
| USD461906S1 (en) | 1999-10-25 | 2002-08-20 | Tuan Hung Pham | Diagnostic test card |
| GB2355717A (en) | 1999-10-28 | 2001-05-02 | Amersham Pharm Biotech Uk Ltd | DNA isolation method |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| JP2003517591A (ja) | 1999-12-09 | 2003-05-27 | モトローラ・インコーポレイテッド | 分析試料の反応を行うための多層微量流体デバイス |
| USD438632S1 (en) | 1999-12-21 | 2001-03-06 | Compucyte Corporation | Multi-well reagent cartridge for treating a sample |
| USD438633S1 (en) | 1999-12-21 | 2001-03-06 | Compucyte Corporation | Reagent cartridge for treating a sample |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
| ATE340025T1 (de) | 2000-01-06 | 2006-10-15 | Caliper Life Sciences Inc | Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse |
| ATE386815T1 (de) | 2000-01-06 | 2008-03-15 | Caliper Life Sciences Inc | Methoden und syteme zur überwachung intrazellulärer bindereaktionen |
| US6468761B2 (en) | 2000-01-07 | 2002-10-22 | Caliper Technologies, Corp. | Microfluidic in-line labeling method for continuous-flow protease inhibition analysis |
| JP2004530860A (ja) | 2000-01-11 | 2004-10-07 | クリニカル・マイクロ・センサーズ・インコーポレイテッド | バイオチップ多重化デバイスおよび方法 |
| WO2001051918A1 (en) | 2000-01-12 | 2001-07-19 | Ut-Battelle, Llc | A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream |
| US7037416B2 (en) | 2000-01-14 | 2006-05-02 | Caliper Life Sciences, Inc. | Method for monitoring flow rate using fluorescent markers |
| JP3397737B2 (ja) | 2000-01-24 | 2003-04-21 | 倉敷紡績株式会社 | 核酸の抽出方法 |
| US6556923B2 (en) | 2000-01-26 | 2003-04-29 | Caliper Technologies Corp. | Software for high throughput microfluidic systems |
| US6589729B2 (en) | 2000-02-04 | 2003-07-08 | Caliper Technologies Corp. | Methods, devices, and systems for monitoring time dependent reactions |
| AU3499701A (en) | 2000-02-11 | 2001-08-20 | Aclara Biosciences Inc | Microfluidic device with sample injector and method |
| US6685813B2 (en) | 2000-02-11 | 2004-02-03 | Aclara Biosciences, Inc. | Tandem isotachophoresis/zone electrophoresis method and system |
| JP3750460B2 (ja) | 2000-02-18 | 2006-03-01 | 日立工機株式会社 | 分注装置及び分注方法 |
| US7332271B2 (en) | 2000-02-18 | 2008-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| MXPA02008290A (es) | 2000-02-23 | 2004-09-10 | Caliper Technologies Inc | Sistema de control de presion de multi-reserva-. |
| US6681616B2 (en) | 2000-02-23 | 2004-01-27 | Caliper Technologies Corp. | Microfluidic viscometer |
| US7040144B2 (en) | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer |
| US20020072060A1 (en) | 2000-07-19 | 2002-06-13 | Getts Robert C. | Methods for detecting and assaying nucleic acid sequences |
| EP1265709A2 (en) | 2000-03-17 | 2002-12-18 | Aclara BioSciences, Inc. | Microfluidic device and system with additional peripheral channels |
| US20020012971A1 (en) | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium |
| US6358387B1 (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods |
| US6927851B2 (en) | 2000-03-31 | 2005-08-09 | Neogen Corporation | Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods |
| US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
| US6401552B1 (en) | 2000-04-17 | 2002-06-11 | Carlos D. Elkins | Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples |
| US6733645B1 (en) | 2000-04-18 | 2004-05-11 | Caliper Technologies Corp. | Total analyte quantitation |
| USD446306S1 (en) | 2000-04-26 | 2001-08-07 | Matsushita Electric Industrial Co., Ltd. | Medical information communication apparatus |
| US6787016B2 (en) | 2000-05-01 | 2004-09-07 | Aclara Biosciences, Inc. | Dynamic coating with linear polymer mixture for electrophoresis |
| DE60144278D1 (de) | 2000-05-03 | 2011-05-05 | Caliper Life Sciences Inc | Herstellungsprozesse für substrate mit mehreren tiefen |
| WO2001086249A2 (en) | 2000-05-11 | 2001-11-15 | Caliper Technologies Corp. | Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers |
| AU6152301A (en) | 2000-05-12 | 2001-11-26 | Caliper Techn Corp | Detection of nucleic acid hybridization by fluorescence polarization |
| US6515753B2 (en) | 2000-05-19 | 2003-02-04 | Aclara Biosciences, Inc. | Optical alignment in capillary detection using capillary wall scatter |
| US6672458B2 (en) | 2000-05-19 | 2004-01-06 | Becton, Dickinson And Company | System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample |
| WO2001089705A2 (en) | 2000-05-19 | 2001-11-29 | Becton Dickinson And Company | System and method for manipulating magnetically responsive particles in fluid samples to collect dna or rna from a sample |
| JP2004508919A (ja) | 2000-05-24 | 2004-03-25 | セルラー プロセス ケミストリー インコーポレイテッド | マイクロリアクタを組み入れたモジュラ式化学生産システム |
| US6520197B2 (en) | 2000-06-02 | 2003-02-18 | The Regents Of The University Of California | Continuous laminar fluid mixing in micro-electromechanical systems |
| US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| US6790330B2 (en) | 2000-06-14 | 2004-09-14 | Board Of Regents, The University Of Texas System | Systems and methods for cell subpopulation analysis |
| WO2001097974A1 (en) | 2000-06-19 | 2001-12-27 | Caliper Technologies Corp. | Methods and devices for enhancing bonded substrate yields and regulating temperature |
| US6734401B2 (en) | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
| US6720187B2 (en) | 2000-06-28 | 2004-04-13 | 3M Innovative Properties Company | Multi-format sample processing devices |
| US7169618B2 (en) | 2000-06-28 | 2007-01-30 | Skold Technology | Magnetic particles and methods of producing coated magnetic particles |
| EP1305615B1 (en) | 2000-07-21 | 2004-09-29 | Aclara BioSciences, Inc. | Method and devices for capillary electrophoresis with a norbornene based surface coating |
| FR2812088B1 (fr) | 2000-07-21 | 2003-01-24 | Abx Sa | Dispositif de traitement d'echantillons de produits sanguins |
| US7004184B2 (en) | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
| WO2002010732A1 (en) | 2000-08-02 | 2002-02-07 | Caliper Technologies Corp. | High throughput separations based analysis systems |
| US20020142618A1 (en) | 2000-08-04 | 2002-10-03 | Caliper Technologies Corp. | Control of operation conditions within fluidic systems |
| FR2813207B1 (fr) | 2000-08-28 | 2002-10-11 | Bio Merieux | Carte reactionnelle et utilisation d'une telle carte |
| JP3993372B2 (ja) | 2000-09-13 | 2007-10-17 | 独立行政法人理化学研究所 | リアクタの製造方法 |
| ATE448875T1 (de) | 2000-09-14 | 2009-12-15 | Caliper Life Sciences Inc | Mikrofluidische vorrichtungen und methoden um temperatur-vermittelte reaktionen durchzuführen |
| US7294503B2 (en) | 2000-09-15 | 2007-11-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| US6939451B2 (en) | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
| US6623860B2 (en) | 2000-10-10 | 2003-09-23 | Aclara Biosciences, Inc. | Multilevel flow structures |
| USD463031S1 (en) | 2000-10-11 | 2002-09-17 | Aclara Biosciences, Inc. | Microvolume sample plate |
| AU2002213345A1 (en) | 2000-10-13 | 2002-04-22 | Irm, Llc | High throughput processing system and method of using |
| US6375185B1 (en) | 2000-10-20 | 2002-04-23 | Gamemax Corporation | Paper currency receiving control assembly for currency-coin exchange machine |
| WO2002037091A1 (en) | 2000-10-31 | 2002-05-10 | Caliper Technologies Corp. | Microfluidic methods, devices and systems for in situ material concentration |
| US7514046B2 (en) | 2000-10-31 | 2009-04-07 | Caliper Life Sciences, Inc. | Methods and systems for processing microscale devices for reuse |
| US7105304B1 (en) | 2000-11-07 | 2006-09-12 | Caliper Life Sciences, Inc. | Pressure-based mobility shift assays |
| US8900811B2 (en) | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device |
| US20050202470A1 (en) | 2000-11-16 | 2005-09-15 | Caliper Life Sciences, Inc. | Binding assays using molecular melt curves |
| CH695544A5 (de) | 2000-11-17 | 2006-06-30 | Tecan Trading Ag | Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben. |
| USD468437S1 (en) | 2000-11-21 | 2003-01-07 | Acon Laboratories, Inc. | Test platform |
| US6521188B1 (en) | 2000-11-22 | 2003-02-18 | Industrial Technology Research Institute | Microfluidic actuator |
| SE0004296D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| US7024281B1 (en) | 2000-12-11 | 2006-04-04 | Callper Life Sciences, Inc. | Software for the controlled sampling of arrayed materials |
| US6382254B1 (en) | 2000-12-12 | 2002-05-07 | Eastman Kodak Company | Microfluidic valve and method for controlling the flow of a liquid |
| US6453928B1 (en) | 2001-01-08 | 2002-09-24 | Nanolab Ltd. | Apparatus, and method for propelling fluids |
| JP4505776B2 (ja) | 2001-01-19 | 2010-07-21 | 凸版印刷株式会社 | 遺伝子検出システム、これを備えた遺伝子検出装置、検出方法、並びに遺伝子検出用チップ |
| JP3548858B2 (ja) | 2001-01-22 | 2004-07-28 | 独立行政法人産業技術総合研究所 | 流量の制御方法及びそれに用いるマイクロバルブ |
| US6878755B2 (en) | 2001-01-22 | 2005-04-12 | Microgen Systems, Inc. | Automated microfabrication-based biodetector |
| EP1355823A4 (en) | 2001-01-29 | 2005-04-20 | Caliper Life Sciences Inc | NON-MECHANICAL VALVES FOR FLUID SYSTEMS |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7670559B2 (en) | 2001-02-15 | 2010-03-02 | Caliper Life Sciences, Inc. | Microfluidic systems with enhanced detection systems |
| US6720148B1 (en) | 2001-02-22 | 2004-04-13 | Caliper Life Sciences, Inc. | Methods and systems for identifying nucleotides by primer extension |
| US7867776B2 (en) | 2001-03-02 | 2011-01-11 | Caliper Life Sciences, Inc. | Priming module for microfluidic chips |
| WO2002072264A1 (en) | 2001-03-09 | 2002-09-19 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
| US7150999B1 (en) | 2001-03-09 | 2006-12-19 | Califer Life Sciences, Inc. | Process for filling microfluidic channels |
| US6576459B2 (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents |
| US6575188B2 (en) | 2001-07-26 | 2003-06-10 | Handylab, Inc. | Methods and systems for fluid control in microfluidic devices |
| US20140227710A1 (en) | 2001-03-28 | 2014-08-14 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US7270786B2 (en) | 2001-03-28 | 2007-09-18 | Handylab, Inc. | Methods and systems for processing microfluidic samples of particle containing fluids |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US7192557B2 (en) | 2001-03-28 | 2007-03-20 | Handylab, Inc. | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids |
| US20020143297A1 (en) | 2001-03-30 | 2002-10-03 | Becton, Dickinson And Company | Adaptor for use with point-of-care testing cartridge |
| AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| USD470595S1 (en) | 2001-04-10 | 2003-02-18 | Andrea Crisanti | Assay device |
| USD500142S1 (en) | 2001-04-10 | 2004-12-21 | Andrea Crisanti | Assay device |
| US7440684B2 (en) | 2001-04-12 | 2008-10-21 | Spaid Michael A | Method and apparatus for improved temperature control in microfluidic devices |
| US20020155010A1 (en) | 2001-04-24 | 2002-10-24 | Karp Christoph D. | Microfluidic valve with partially restrained element |
| US6588625B2 (en) | 2001-04-24 | 2003-07-08 | Abbott Laboratories | Sample handling system |
| USD495805S1 (en) | 2001-05-25 | 2004-09-07 | Umedik, Inc. | Assay device |
| US7723123B1 (en) | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone |
| US20020187557A1 (en) | 2001-06-07 | 2002-12-12 | Hobbs Steven E. | Systems and methods for introducing samples into microfluidic devices |
| US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
| US6977163B1 (en) | 2001-06-13 | 2005-12-20 | Caliper Life Sciences, Inc. | Methods and systems for performing multiple reactions by interfacial mixing |
| US6859698B2 (en) | 2001-06-21 | 2005-02-22 | Snap-On Incorporated | Detachable cartridge unit and auxiliary unit for function expansion of a data processing system |
| US20030211517A1 (en) | 2001-06-22 | 2003-11-13 | Carulli John P. | Gp354 nucleic acids and polypeptides |
| US6709857B2 (en) | 2001-06-26 | 2004-03-23 | Becton, Dickinson And Company | System and method for optically monitoring the concentration of a gas in a sample vial using photothermal spectroscopy to detect sample growth |
| US6514750B2 (en) | 2001-07-03 | 2003-02-04 | Pe Corporation (Ny) | PCR sample handling device |
| AU2002316302A1 (en) | 2001-07-12 | 2003-01-29 | Aclara Biosciences, Inc. | Submersible light-directing member for material excitation in microfluidic devices |
| EP1415113B1 (en) | 2001-07-16 | 2011-08-31 | Idaho Technology, Inc. | Thermal cycling system and method of use |
| US7023007B2 (en) | 2001-07-17 | 2006-04-04 | Caliper Life Sciences, Inc. | Methods and systems for alignment of detection optics |
| US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
| US7270959B2 (en) | 2001-07-25 | 2007-09-18 | Oakville Hong Kong Company Limited | Specimen collection container |
| EP1439910A2 (en) | 2001-07-26 | 2004-07-28 | Motorola, Inc. | System and methods for mixing within a microfluidic device |
| EP1438567B1 (en) | 2001-07-26 | 2018-07-25 | Handylab, Inc. | Methods and systems for microfluidic processing |
| US20060062696A1 (en) | 2001-07-27 | 2006-03-23 | Caliper Life Sciences, Inc. | Optimized high throughput analytical systems |
| US7060171B1 (en) | 2001-07-31 | 2006-06-13 | Caliper Life Sciences, Inc. | Methods and systems for reducing background signal in assays |
| JP2003047839A (ja) | 2001-08-06 | 2003-02-18 | Yamatake Corp | マイクロリアクタ |
| JP2003047840A (ja) | 2001-08-06 | 2003-02-18 | Yamatake Corp | マイクロリアクタ |
| US6640981B2 (en) | 2001-08-14 | 2003-11-04 | 3088081 Canada Inc. | Modular test tube rack |
| USD482796S1 (en) | 2001-09-11 | 2003-11-25 | Sysmex Corporation | Sample analyzer |
| USD512155S1 (en) | 2001-09-12 | 2005-11-29 | Techno Medica Co., Ltd. | Automatic blood sampling tube preparation apparatus |
| US20030059823A1 (en) | 2001-09-21 | 2003-03-27 | Juki Corporation | Hybridization apparatus and method for detecting nucleic acid in sample using the same |
| JP3996416B2 (ja) | 2001-09-21 | 2007-10-24 | Ｊｕｋｉ株式会社 | 核酸ハイブリダイゼーションにおけるｂ／ｆ分離方法 |
| USD467349S1 (en) | 2001-09-28 | 2002-12-17 | Orasure Technologies, Inc. | Analyzer |
| USD467348S1 (en) | 2001-10-15 | 2002-12-17 | Kimberly-Clark Worldwide, Inc. | Diagnostic test carrier |
| WO2003047712A2 (en) | 2001-10-18 | 2003-06-12 | The Board Of Trustees Of The University Of Illinois | Hybrid microfluidic and nanofluidic system |
| US20030156991A1 (en) | 2001-10-23 | 2003-08-21 | William Marsh Rice University | Optomechanically-responsive materials for use as light-activated actuators and valves |
| US7338760B2 (en) | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip |
| US6750661B2 (en) | 2001-11-13 | 2004-06-15 | Caliper Life Sciences, Inc. | Method and apparatus for controllably effecting samples using two signals |
| US7247274B1 (en) | 2001-11-13 | 2007-07-24 | Caliper Technologies Corp. | Prevention of precipitate blockage in microfluidic channels |
| US7069952B1 (en) | 2001-11-14 | 2006-07-04 | Caliper Life Sciences, Inc. | Microfluidic devices and methods of their manufacture |
| DE10156790A1 (de) | 2001-11-19 | 2003-06-18 | Chemagen Biopolymer Technologi | Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln |
| US20030099954A1 (en) | 2001-11-26 | 2003-05-29 | Stefan Miltenyi | Apparatus and method for modification of magnetically immobilized biomolecules |
| US7635588B2 (en) | 2001-11-29 | 2009-12-22 | Applied Biosystems, Llc | Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength |
| EP1463796B1 (en) | 2001-11-30 | 2013-01-09 | Fluidigm Corporation | Microfluidic device and methods of using same |
| US6960235B2 (en) | 2001-12-05 | 2005-11-01 | The Regents Of The University Of California | Chemical microreactor and method thereof |
| JP2003185584A (ja) | 2001-12-18 | 2003-07-03 | Fuji Photo Film Co Ltd | スキャナ |
| DE10163476A1 (de) | 2001-12-21 | 2003-10-30 | Siemens Ag | Anordnung zur Trennung einer Komponente aus einem Fluid |
| US20030127327A1 (en) | 2002-01-04 | 2003-07-10 | Kurnik Ronald T. | Microfluidic device and method for improved sample handling |
| US7410615B2 (en) | 2002-01-24 | 2008-08-12 | Perkinelmer Las, Inc. | Precision liquid dispensing system |
| US7205154B2 (en) | 2002-01-31 | 2007-04-17 | Agilent Technologies, Inc. | Calibrating array scanners |
| US7288228B2 (en) | 2002-02-12 | 2007-10-30 | Gilson, Inc. | Sample injection system |
| US6819027B2 (en) | 2002-03-04 | 2004-11-16 | Cepheid | Method and apparatus for controlling ultrasonic transducer |
| US7101467B2 (en) | 2002-03-05 | 2006-09-05 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems |
| EP2497564B1 (en) | 2002-03-05 | 2014-05-14 | Caliper Life Sciences, Inc. | Electrophoretic separation in a microfluidic channel network |
| US7303727B1 (en) | 2002-03-06 | 2007-12-04 | Caliper Life Sciences, Inc | Microfluidic sample delivery devices, systems, and methods |
| US7195986B1 (en) | 2002-03-08 | 2007-03-27 | Caliper Life Sciences, Inc. | Microfluidic device with controlled substrate conductivity |
| KR100450818B1 (ko) | 2002-03-09 | 2004-10-01 | 삼성전자주식회사 | 다챔버 ｐｃｒ 칩 |
| US7252928B1 (en) | 2002-03-12 | 2007-08-07 | Caliper Life Sciences, Inc. | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels |
| EP1345026B1 (en) | 2002-03-15 | 2010-05-05 | Affymetrix, Inc. | System and method for scanning of biological materials |
| DE10212761B4 (de) | 2002-03-22 | 2009-12-31 | Eppendorf Ag | Mikrotiterplatte |
| US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US7419784B2 (en) | 2002-04-02 | 2008-09-02 | Dubrow Robert S | Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material |
| USD472324S1 (en) | 2002-04-05 | 2003-03-25 | Charles River Laboratories, Inc. | Cuvette |
| JP2003299485A (ja) | 2002-04-10 | 2003-10-21 | Sekisui Chem Co Ltd | 温度制御型マイクロリアクター及びマイクロリアクターシステム |
| US7364897B2 (en) | 2002-04-11 | 2008-04-29 | Sequenom, Inc. | Methods and devices for performing chemical reactions on a solid support |
| US8241883B2 (en) | 2002-04-24 | 2012-08-14 | Caliper Life Sciences, Inc. | High throughput mobility shift |
| US6905612B2 (en) | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
| JP3972189B2 (ja) | 2002-05-10 | 2007-09-05 | 日本パルスモーター株式会社 | 着脱自在なカートリッジラック構造を備える分注装置 |
| USD474279S1 (en) | 2002-05-15 | 2003-05-06 | Monogen, Inc. | Specimen processing instrument |
| JP3839349B2 (ja) | 2002-05-15 | 2006-11-01 | 株式会社堀場製作所 | 化学発光酵素免疫測定装置 |
| ATE375823T1 (de) | 2002-05-17 | 2007-11-15 | Gen Probe Inc | Probenträger mit lösbarer sperreinrichtung |
| RU2004137103A (ru) | 2002-05-17 | 2005-11-20 | Бектон, Дикинсон Энд Компани (Us) | Автоматизированная система для выделения, амплификации и выявления нуклеотидных последовательностей-мишеней |
| DE60307825T2 (de) | 2002-05-17 | 2007-03-01 | Gen-Probe Inc., San Diego | Probenträger mit feststelleinrichtung und zugehörige tropfschirmvorrichtung |
| WO2003099442A1 (de) | 2002-05-24 | 2003-12-04 | Epr Labautomation Ag | Verfahren und vorrichtung zum dosieren kleiner flüssigkeitsvolumen |
| US7161356B1 (en) | 2002-06-05 | 2007-01-09 | Caliper Life Sciences, Inc. | Voltage/current testing equipment for microfluidic devices |
| USD480814S1 (en) | 2002-06-11 | 2003-10-14 | Diversa Corporation | Gigamatrix holding tray |
| US7208125B1 (en) | 2002-06-28 | 2007-04-24 | Caliper Life Sciences, Inc | Methods and apparatus for minimizing evaporation of sample materials from multiwell plates |
| ATE529188T1 (de) | 2002-07-15 | 2011-11-15 | Phynexus Inc | Extraktionskolonnenvorrichtung |
| EP1539352B1 (en) | 2002-07-23 | 2009-12-23 | Protedyne Corporation | Liquid handling tool having hollow plunger |
| JP2005533652A (ja) | 2002-07-26 | 2005-11-10 | アプレラ コーポレイション | 微小流体サイズ排除デバイス、システム、および方法 |
| US7041258B2 (en) | 2002-07-26 | 2006-05-09 | Applera Corporation | Micro-channel design features that facilitate centripetal fluid transfer |
| US7214348B2 (en) | 2002-07-26 | 2007-05-08 | Applera Corporation | Microfluidic size-exclusion devices, systems, and methods |
| DE10236029A1 (de) | 2002-08-02 | 2004-02-19 | Cybio Systems Gmbh | Einrichtung zum Dispensieren und Beobachten der Lumineszenz von Einzelproben in Multiprobenanordnungen |
| US20040053315A1 (en) | 2002-08-12 | 2004-03-18 | Caliper Technologies Corp. | Methods and systems for monitoring molecular interactions |
| GB0219457D0 (en) | 2002-08-21 | 2002-09-25 | Amersham Biosciences Uk Ltd | Fluorescence reference plate |
| US7001853B1 (en) | 2002-08-30 | 2006-02-21 | Caliper Life Sciences, Inc. | Flow control of photo-polymerizable resin |
| USD516221S1 (en) | 2002-09-09 | 2006-02-28 | Meso Scale Technologies, Llc. | Diagnostic instrument |
| JP3756477B2 (ja) | 2002-09-17 | 2006-03-15 | 横河電機株式会社 | デンドリマーによる核酸またはタンパク質の抽出方法およびデンドリマー組成物 |
| ITTO20020808A1 (it) | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Dispositivo integrato di analisi del dna. |
| USD484989S1 (en) | 2002-09-20 | 2004-01-06 | Dade Behring Inc. | Multi-well liquid container |
| TW590982B (en) | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
| US6730883B2 (en) | 2002-10-02 | 2004-05-04 | Stratagene | Flexible heating cover assembly for thermal cycling of samples of biological material |
| AU2003284055A1 (en) | 2002-10-09 | 2004-05-04 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and components |
| US7932098B2 (en) | 2002-10-31 | 2011-04-26 | Hewlett-Packard Development Company, L.P. | Microfluidic system utilizing thin-film layers to route fluid |
| US7122384B2 (en) | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
| EP1567638A1 (en) | 2002-11-08 | 2005-08-31 | Irm, Llc | Apparatus and methods to process substrate surface features |
| JP2004170159A (ja) | 2002-11-18 | 2004-06-17 | Hitachi Koki Co Ltd | 自動分注装置 |
| WO2004048545A2 (en) | 2002-11-26 | 2004-06-10 | University Of Massachusetts | DELIVERY OF siRNAs______________________________________________ |
| USD491276S1 (en) | 2002-12-09 | 2004-06-08 | Babette Langille | Plastic diagnostic card |
| DK1570274T3 (da) * | 2002-12-13 | 2011-08-29 | Dhr Finland Oy | Analysator og analysefremgangsmåde og en væskekassette |
| USD491272S1 (en) | 2002-12-13 | 2004-06-08 | Immunivest Corporation | Autoprep instrument |
| WO2004055492A2 (en) | 2002-12-13 | 2004-07-01 | Aclara Biosciences, Inc. | Closed-loop control of electrokinetic processes in microfludic devices based on optical readings |
| SE0203781D0 (sv) | 2002-12-19 | 2002-12-19 | Alphahelix Ab | Holder and method for cooling or heating samples |
| USD491273S1 (en) | 2002-12-19 | 2004-06-08 | 3M Innovative Properties Company | Hybridization cartridge |
| JP4395133B2 (ja) | 2002-12-20 | 2010-01-06 | カリパー・ライフ・サイエンシズ・インク． | Ｄｎａの単一分子増幅および検出 |
| US20060094108A1 (en) | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
| US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
| US7850912B2 (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
| US20050042639A1 (en) | 2002-12-20 | 2005-02-24 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA length |
| US8676383B2 (en) | 2002-12-23 | 2014-03-18 | Applied Biosystems, Llc | Device for carrying out chemical or biological reactions |
| EP1583950B1 (en) | 2002-12-26 | 2017-04-05 | Meso Scale Technologies, LLC. | Assay cartridges and methods of using the same |
| US20060113190A1 (en) | 2002-12-27 | 2006-06-01 | Kurnik Ronald T | Microfluidic device and method for improved sample handling |
| JP2006512092A (ja) | 2002-12-30 | 2006-04-13 | ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア | 病原体の検出および分析のための方法および装置 |
| US20070269891A9 (en) | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| US7419638B2 (en) | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
| US6964747B2 (en) | 2003-01-21 | 2005-11-15 | Bioarray Solutions, Ltd. | Production of dyed polymer microparticles |
| US7049558B2 (en) | 2003-01-27 | 2006-05-23 | Arcturas Bioscience, Inc. | Apparatus and method for heating microfluidic volumes and moving fluids |
| JP4021335B2 (ja) | 2003-01-31 | 2007-12-12 | ユニバーサル・バイオ・リサーチ株式会社 | 監視機能付分注装置および分注装置の監視方法 |
| US7338637B2 (en) | 2003-01-31 | 2008-03-04 | Hewlett-Packard Development Company, L.P. | Microfluidic device with thin-film electronic devices |
| EP1603674B1 (en) | 2003-02-05 | 2016-01-06 | Iquum, Inc. | Sample processing |
| US20040157220A1 (en) | 2003-02-10 | 2004-08-12 | Purnima Kurnool | Methods and apparatus for sample tracking |
| KR100959101B1 (ko) | 2003-02-20 | 2010-05-25 | 삼성전자주식회사 | Ｐｃｒ 반응기 및 ｐｃｒ 반응기의 입구와 출구의 개폐를조절하는 방법 |
| US20050129580A1 (en) | 2003-02-26 | 2005-06-16 | Swinehart Philip R. | Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles |
| JP2004305009A (ja) | 2003-04-02 | 2004-11-04 | Hitachi Ltd | 核酸増幅装置及び核酸増幅方法 |
| CA2521539A1 (en) | 2003-04-08 | 2004-10-28 | Irm, Llc | Material removal and dispensing devices, systems, and methods |
| AU2004230592B2 (en) | 2003-04-14 | 2007-10-04 | Caliper Life Sciences, Inc. | Reduction of migration shift assay interference |
| US7820030B2 (en) | 2003-04-16 | 2010-10-26 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
| GB2401237A (en) | 2003-04-28 | 2004-11-03 | Hewlett Packard Development Co | Data transfer arrangement for disaster recovery |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| WO2004101152A1 (en) | 2003-05-09 | 2004-11-25 | Caliper Life Sciences, Inc. | Automated sample analysis |
| US7038472B1 (en) | 2003-05-12 | 2006-05-02 | Caliper Life Sciences, Inc. | Methods and systems for measuring internal dimensions of microscale structures |
| US7374949B2 (en) | 2003-05-29 | 2008-05-20 | Bayer Healthcare Llc | Diagnostic test strip for collecting and detecting an analyte in a fluid sample |
| US7055695B2 (en) | 2003-06-02 | 2006-06-06 | Caliper Life Sciencee, Inc. | Container providing a controlled hydrated environment |
| JP2005009870A (ja) | 2003-06-16 | 2005-01-13 | Fuji Photo Film Co Ltd | 分析装置の吸引方法 |
| WO2005008255A1 (ja) | 2003-07-17 | 2005-01-27 | Mitsubishi Kagaku Iatron, Inc. | 自動測定用カートリッジおよびそれを用いる測定装置 |
| US7381370B2 (en) | 2003-07-18 | 2008-06-03 | Dade Behring Inc. | Automated multi-detector analyzer |
| US20060177376A1 (en) | 2003-07-21 | 2006-08-10 | Dendritic Nanotechnologies, Inc. | Stabilized and chemically functionalized nanoparticles |
| USD500363S1 (en) | 2003-07-24 | 2004-12-28 | Biomerieux Inc. | Sample holder |
| USD508999S1 (en) | 2003-07-24 | 2005-08-30 | Biomerieux, Inc. | Sample testing machine |
| EP1654066B1 (en) | 2003-07-31 | 2014-11-12 | Handylab, Inc. | Processing particle-containing samples |
| US7744817B2 (en) | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
| US7413712B2 (en) | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
| US7347617B2 (en) | 2003-08-19 | 2008-03-25 | Siemens Healthcare Diagnostics Inc. | Mixing in microfluidic devices |
| USD499813S1 (en) | 2003-08-22 | 2004-12-14 | As.Pire Bioresearch Inc. | Assay testing device |
| JP2005065607A (ja) | 2003-08-26 | 2005-03-17 | Hitachi Ltd | 遺伝子処理チップおよび遺伝子処理装置 |
| USD515707S1 (en) | 2003-09-01 | 2006-02-21 | Matsushita Electric Industrial Co., Ltd. | Fluorescent reader |
| KR100852297B1 (ko) | 2003-09-05 | 2008-08-14 | 칼리퍼 라이프 사이언시즈, 인크. | 분석물 주입 시스템 |
| US7501094B2 (en) | 2003-09-15 | 2009-03-10 | Syngenta Limited | Preparation and characterization of formulations in a high throughput mode |
| US20050220675A1 (en) | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
| US20070218459A1 (en) | 2003-09-19 | 2007-09-20 | Miller Benjamin L | Diagnostic System For Otolaryngologic Pathogens And Use Thereof |
| US20050069898A1 (en) | 2003-09-25 | 2005-03-31 | Cepheid | Lyophilized beads containing mannitol |
| EP1664350A4 (en) | 2003-09-26 | 2007-10-10 | Datascope Investment Corp | PROCESS FOR SYNTHESIS OF NUCLEIC ACIDS IN SMALL VOLUME |
| DE10344700A1 (de) | 2003-09-26 | 2005-04-14 | Hirschmann Laborgeräte GmbH & Co. KG | Mehrkanal-Pipettiervorrichtung |
| WO2005031312A1 (en) | 2003-09-29 | 2005-04-07 | Vision Biosystems Limited | System and method for histological tissue specimen processing |
| USD528215S1 (en) | 2003-09-30 | 2006-09-12 | Biacore Ab | Chip carrier for biosensor |
| WO2005033672A1 (en) | 2003-10-01 | 2005-04-14 | Caliper Life Sciences, Inc. | Method for measuring diffusivities of compounds using microfluidic devices |
| NL1024578C2 (nl) | 2003-10-21 | 2005-04-22 | Univ Delft Tech | Inrichting voor het uitvoeren van een reactie. |
| JP2007510518A (ja) | 2003-11-12 | 2007-04-26 | ルー， ステファン ジェイ． バン | 医療／外科的手順のための磁気デバイスおよび装置ならびにそれらを使用するための方法 |
| US7754500B2 (en) | 2003-11-21 | 2010-07-13 | Anp Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| EP1541237A3 (en) | 2003-12-10 | 2006-02-01 | Samsung Electronics Co., Ltd. | Polymerase chain reaction (pcr) module and multiple pcr system using the same |
| JP4595446B2 (ja) | 2003-12-12 | 2010-12-08 | Ｄｉｃ株式会社 | 核酸増幅方法 |
| JP2005176613A (ja) | 2003-12-16 | 2005-07-07 | Yokogawa Electric Corp | デンドリマー利用のｄｎａ抽出方法およびバイオチップ |
| AU2004313572B2 (en) | 2003-12-23 | 2008-07-03 | Caliper Life Sciences, Inc. | Analyte injection system |
| JP4750412B2 (ja) | 2003-12-25 | 2011-08-17 | モレックス インコーポレイテド | 生体由来分子、ダイオキシン類及び内分泌撹乱物質検出装置及び当該装置を使用した検出方法 |
| KR100750586B1 (ko) | 2003-12-26 | 2007-08-20 | 한국전자통신연구원 | 미소유체 가열 시스템 |
| JP4732683B2 (ja) | 2003-12-29 | 2011-07-27 | ユニバーサル・バイオ・リサーチ株式会社 | 標的物質の検出方法 |
| US7099778B2 (en) | 2003-12-30 | 2006-08-29 | Caliper Life Sciences, Inc. | Method for determining diffusivity and molecular weight in a microfluidic device |
| CA2554240A1 (en) | 2004-01-25 | 2005-08-11 | Fluidigm Corporation | Crystal forming devices and systems and methods for making and using the same |
| US7618811B2 (en) | 2004-02-24 | 2009-11-17 | Thermal Gradient | Thermal cycling device |
| US20050196321A1 (en) | 2004-03-03 | 2005-09-08 | Zhili Huang | Fluidic programmable array devices and methods |
| TWD106277S1 (zh) | 2004-03-05 | 2005-09-01 | 精工愛普生股份有限公司 | 照相軟片掃描機 |
| KR100552706B1 (ko) | 2004-03-12 | 2006-02-20 | 삼성전자주식회사 | 핵산 증폭 방법 및 장치 |
| EP1768785A2 (en) | 2004-03-19 | 2007-04-04 | Espir Kahatt | Device for aspirating, manipulating, mixing and dispensing nano-volumes of liquids |
| JP3858029B2 (ja) * | 2004-03-22 | 2006-12-13 | 株式会社アイディエス | 試験管の検知装置 |
| JP2005291954A (ja) * | 2004-03-31 | 2005-10-20 | Olympus Corp | 使い捨て試薬パックとその試薬パックを用いる分析装置 |
| WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| WO2005102526A1 (en) | 2004-04-09 | 2005-11-03 | Research Think Tank, Inc. | Devices and methods for collection, storage and transportation of biological specimens |
| EP2345739B8 (en) | 2004-05-03 | 2016-12-07 | Handylab, Inc. | A microfluidic device for processing polynucleotide-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| WO2005108571A1 (ja) | 2004-05-07 | 2005-11-17 | Konica Minolta Medical & Graphic, Inc. | 検査用マイクロリアクタおよび遺伝子検査装置ならびに遺伝子検査方法 |
| GB2414059B (en) | 2004-05-10 | 2008-06-11 | E2V Tech Uk Ltd | Microfluidic device |
| JP3952036B2 (ja) | 2004-05-13 | 2007-08-01 | コニカミノルタセンシング株式会社 | マイクロ流体デバイス並びに試液の試験方法および試験システム |
| CA2567537A1 (en) | 2004-05-21 | 2005-12-01 | Caliper Life Sciences, Inc. | Automated system for handling microfluidic devices |
| US7553671B2 (en) | 2004-05-25 | 2009-06-30 | Vertex Pharmaceuticals, Inc. | Modular test tube rack |
| US20090317897A1 (en) | 2004-05-27 | 2009-12-24 | Universal Bio Research Co., Ltd. | Reaction vessel, reaction measuring device, and liquid rotating treatment device |
| US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
| AU2005252242A1 (en) | 2004-06-07 | 2005-12-22 | Irm Llc | Dispensing systems, software, and related methods |
| US7480042B1 (en) | 2004-06-30 | 2009-01-20 | Applied Biosystems Inc. | Luminescence reference standards |
| US8965710B2 (en) | 2004-07-02 | 2015-02-24 | The United States Of America, As Represented By The Secretary Of The Navy | Automated sample-to-microarray apparatus and method |
| JP4440020B2 (ja) | 2004-07-09 | 2010-03-24 | 株式会社神戸製鋼所 | マイクロ反応器及びその製造方法 |
| USD523153S1 (en) | 2004-07-23 | 2006-06-13 | Hitachi High-Technologies Corporation | Main part for immunity analysis machine |
| EP1621890A1 (en) | 2004-07-26 | 2006-02-01 | bioMerieux B.V. | Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods |
| WO2006032044A2 (en) | 2004-09-15 | 2006-03-23 | Microchip Biotechnologies, Inc. | Microfluidic devices |
| KR100668304B1 (ko) | 2004-09-16 | 2007-01-12 | 삼성전자주식회사 | Ｐｃｒ 혼합액을 ｐｃｒ 칩의 각 ｐｃｒ 채널에 주입하기위한 장치 및 상기 장치를 포함하는 ｐｃｒ 칩 유니트 |
| WO2006035800A1 (ja) | 2004-09-30 | 2006-04-06 | Arkray, Inc. | 薄膜ヒータおよび分析用具 |
| USD548841S1 (en) | 2004-10-15 | 2007-08-14 | Microsulis, Ltd | Electrical equipment for ablative treatment |
| WO2006043642A1 (ja) | 2004-10-20 | 2006-04-27 | Ebara Corporation | 流体反応装置 |
| JP2006145458A (ja) | 2004-11-24 | 2006-06-08 | Yaskawa Electric Corp | 分注装置 |
| US7727477B2 (en) | 2004-12-10 | 2010-06-01 | Bio-Rad Laboratories, Inc. | Apparatus for priming microfluidics devices with feedback control |
| JP4573243B2 (ja) | 2004-12-15 | 2010-11-04 | 小林クリエイト株式会社 | 試験管用トレイ |
| EP1836293A2 (en) | 2004-12-17 | 2007-09-26 | Nitto Denko Corporation | Immobilized degradable cationic polymer for transfecting eukaryotic cells |
| US20060165558A1 (en) | 2004-12-21 | 2006-07-27 | Thomas Witty | Cartridge for diagnostic assays |
| US20060183216A1 (en) | 2005-01-21 | 2006-08-17 | Kalyan Handique | Containers for liquid storage and delivery with application to microfluidic devices |
| US7964380B2 (en) | 2005-01-21 | 2011-06-21 | Argylia Technologies | Nanoparticles for manipulation of biopolymers and methods of thereof |
| DE102005004664B4 (de) | 2005-02-02 | 2007-06-21 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Vorrichtung und Verfahren und Verwendung zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit sowie deren Verwendungen |
| WO2006089252A2 (en) | 2005-02-16 | 2006-08-24 | Mcneely Michael R | Liquid valving using reactive or responsive materials |
| KR101544351B1 (ko) | 2005-02-18 | 2015-08-13 | 캐논 유.에스. 라이프 사이언시즈, 인크. | 유기체의 게놈 ｄｎａ를 확인하기 위한 장치 및 방법 |
| USD535403S1 (en) | 2005-02-25 | 2007-01-16 | Fuji Photo Film Co., Ltd. | Component extractor for biochemistry |
| EP1866653A4 (en) | 2005-03-07 | 2009-08-26 | Novx Systems Inc | ANALYSIS MACHINE |
| CA2599569A1 (en) | 2005-03-08 | 2006-09-14 | Authentix, Inc. | Microfluidic device for identification, quantification, and authentication of latent markers |
| US7794659B2 (en) | 2005-03-10 | 2010-09-14 | Gen-Probe Incorporated | Signal measuring system having a movable signal measuring device |
| US20060228734A1 (en) | 2005-03-18 | 2006-10-12 | Applera Corporation | Fluid processing device with captured reagent beads |
| JP4525427B2 (ja) | 2005-04-01 | 2010-08-18 | パナソニック株式会社 | 分析ディスク、並びに分析ディスクおよび分析装置の検査方法 |
| US9097723B2 (en) | 2005-04-01 | 2015-08-04 | Caliper Life Sciences, Inc. | Method and apparatus for performing peptide digestion on a microfluidic device |
| US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US20060246493A1 (en) | 2005-04-04 | 2006-11-02 | Caliper Life Sciences, Inc. | Method and apparatus for use in temperature controlled processing of microfluidic samples |
| CA112854S (en) | 2005-04-10 | 2007-03-27 | Akubio Ltd | Microbalance analyser cartridge |
| CN101663576B (zh) | 2005-04-12 | 2012-05-23 | 卡钳生命科学股份有限公司 | 用于微流体器件的紧凑型光检测系统 |
| US20060234251A1 (en) | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| US7300631B2 (en) | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
| WO2006119280A2 (en) | 2005-05-03 | 2006-11-09 | Handylab, Inc. | Lyophilized pellets |
| USD566291S1 (en) | 2005-05-03 | 2008-04-08 | Handylab, Inc. | Microfluidic cartridge |
| USD534280S1 (en) | 2005-05-04 | 2006-12-26 | Abbott Laboratories | Reagent carrier for use in an automated analyzer |
| CA2604422A1 (en) | 2005-05-06 | 2006-11-16 | Caliper Life Sciences, Inc. | Microtitre plate with a relieved perimeter |
| WO2006122312A2 (en) | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Methods of testing using a microfluidic cassette |
| US8273294B2 (en) | 2005-07-01 | 2012-09-25 | Honeywell International Inc. | Molded cartridge with 3-D hydrodynamic focusing |
| US7527763B2 (en) | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
| WO2007006315A2 (en) | 2005-07-07 | 2007-01-18 | Inverness Medical Switzerland Gmbh | A method of performing a test, a support instrument and a microliquid system comprising such support instrument |
| US20070020699A1 (en) | 2005-07-19 | 2007-01-25 | Idexx Laboratories, Inc. | Lateral flow assay and device using magnetic particles |
| US20070020764A1 (en) | 2005-07-20 | 2007-01-25 | Miller Kerry L | Method for processing chemistry and coagulation test samples in a laboratory workcell |
| US20070068573A1 (en) | 2005-08-22 | 2007-03-29 | Applera Corporation | Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible |
| JP2007074960A (ja) | 2005-09-13 | 2007-03-29 | Shimadzu Corp | 遺伝子増幅法 |
| USD549827S1 (en) | 2005-09-16 | 2007-08-28 | Horiba, Ltd. | Blood analyzer |
| EP1929269A2 (en) | 2005-09-30 | 2008-06-11 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads |
| JP4630786B2 (ja) | 2005-10-04 | 2011-02-09 | キヤノン株式会社 | 生化学処理装置、ｄｎａ増幅精製装置、該装置を含むｄｎａ検査装置 |
| JP4827483B2 (ja) | 2005-10-04 | 2011-11-30 | キヤノン株式会社 | 核酸試料処理装置 |
| US20070199821A1 (en) | 2005-10-05 | 2007-08-30 | Chow Andrea W | Automated two-dimensional gel electrophoresis |
| US7727371B2 (en) | 2005-10-07 | 2010-06-01 | Caliper Life Sciences, Inc. | Electrode apparatus for use with a microfluidic device |
| JP2009511059A (ja) | 2005-10-11 | 2009-03-19 | ハンディーラブ インコーポレイテッド | ポリヌクレオチドサンプル調製装置 |
| DE102005049920A1 (de) | 2005-10-17 | 2007-04-19 | Manz Automation Ag | Roboteranordnung |
| US20070092403A1 (en) | 2005-10-21 | 2007-04-26 | Alan Wirbisky | Compact apparatus, compositions and methods for purifying nucleic acids |
| USD537951S1 (en) | 2005-10-21 | 2007-03-06 | Sanyo Electric Co., Ltd. | Gene amplification apparatus |
| USD556914S1 (en) | 2005-10-21 | 2007-12-04 | Sanyo Electric Co., Ltd. | Gene amplification apparatus |
| DE102005051850A1 (de) | 2005-10-28 | 2007-05-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur Vervielfältigung und Detektion von Nukleinsäuren |
| US20070104617A1 (en) | 2005-11-04 | 2007-05-10 | Advanced Biotechnologies Limited | Capped tubes |
| US20070116613A1 (en) | 2005-11-23 | 2007-05-24 | Donat Elsener | Sample tube and system for storing and providing nucleic acid samples |
| WO2007064117A1 (en) | 2005-11-30 | 2007-06-07 | Electronics And Telecommunications Research Institute | Affinity chromatography microdevice and method for manufacturing the same |
| EP2283923A2 (en) | 2005-11-30 | 2011-02-16 | F. Hoffmann-La Roche AG | Linear cuvette array without positioning means |
| JP3899360B2 (ja) | 2005-12-19 | 2007-03-28 | オリンパス株式会社 | Ｄｎａ増幅装置 |
| JP2007178328A (ja) | 2005-12-28 | 2007-07-12 | Shimadzu Corp | 反応容器キット及び反応容器処理装置 |
| WO2007079257A2 (en) | 2005-12-30 | 2007-07-12 | Caliper Life Sciences, Inc. | Integrated dissolution processing and sample transfer system |
| US20070154895A1 (en) | 2005-12-30 | 2007-07-05 | Caliper Life Sciences, Inc. | Multi-assay microfluidic chips |
| SG134186A1 (en) | 2006-01-12 | 2007-08-29 | Nanyang Polytechnic | Smart nano-integrated system assembly |
| WO2007091530A1 (ja) | 2006-02-07 | 2007-08-16 | The Furukawa Electric Co., Ltd. | 光検出装置及び測定対象読取装置 |
| US8124033B2 (en) | 2006-02-17 | 2012-02-28 | Agency, Science, Technology and Research | Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same |
| USD538436S1 (en) | 2006-03-06 | 2007-03-13 | Steris Inc. | Reprocessor for decontaminating medical, dental and veterinary instruments and articles |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| USD559995S1 (en) | 2006-03-27 | 2008-01-15 | Handylab, Inc. | Controller cartridge for a diagnostic instrument |
| USD569526S1 (en) | 2006-03-27 | 2008-05-20 | Handylab, Inc. | Molecular diagnostic instrument |
| EP1839756A1 (en) | 2006-03-31 | 2007-10-03 | F.Hoffmann-La Roche Ag | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
| US8021531B2 (en) | 2006-04-14 | 2011-09-20 | Caliper Life Sciences, Inc. | Method for modifying the concentration of reactants in a microfluidic device |
| USD554070S1 (en) | 2006-05-03 | 2007-10-30 | Data I/O Corporation | Processing apparatus |
| USD554069S1 (en) | 2006-05-03 | 2007-10-30 | Data I/O Corporation | Processing apparatus |
| CN101522909A (zh) | 2006-05-17 | 2009-09-02 | 加利福尼亚技术学院 | 热循环系统 |
| US8232091B2 (en) | 2006-05-17 | 2012-07-31 | California Institute Of Technology | Thermal cycling system |
| CN101466848B (zh) | 2006-06-08 | 2017-08-25 | 皇家飞利浦电子股份有限公司 | 用于dna检测的微电子传感器装置 |
| US7629124B2 (en) | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
| WO2008030433A2 (en) | 2006-09-06 | 2008-03-13 | Canon U.S. Life Sciences, Inc. | Chip and cartridge design configuration for performing micro-fluidic assays |
| US8246919B2 (en) | 2006-09-21 | 2012-08-21 | Abbott Laboratories | Specimen sample rack |
| US20080095673A1 (en) | 2006-10-20 | 2008-04-24 | Lin Xu | Microplate with fewer peripheral artifacts |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
| KR101422467B1 (ko) | 2007-02-08 | 2014-07-24 | 삼성전자주식회사 | 미세유체 칩 내의 형광을 검출하기 위한 시스템 및 형광검출 방법 |
| US7985375B2 (en) | 2007-04-06 | 2011-07-26 | Qiagen Gaithersburg, Inc. | Sample preparation system and method for processing clinical specimens |
| JP2008267950A (ja) | 2007-04-19 | 2008-11-06 | Enplas Corp | 流体取扱装置 |
| US8133671B2 (en) * | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| GB0719193D0 (en) | 2007-10-02 | 2007-11-07 | Advanced Biotech Ltd | A Vessel |
| CN104777291B (zh) * | 2007-10-10 | 2017-09-12 | 普凯尔德诊断技术有限公司 | 用于鉴定尿中细菌的系统 |
| USD632799S1 (en) | 2008-05-15 | 2011-02-15 | The Automation Partnership | Cell dispenser |
| US8647593B2 (en) | 2008-06-09 | 2014-02-11 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
| USD596312S1 (en) | 2008-06-13 | 2009-07-14 | Csp Technologies, Inc. | Vial rack |
| USD595423S1 (en) | 2008-06-30 | 2009-06-30 | Ge Healthcare Bio-Sciences Ab | Magnetic rack |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| US20100009351A1 (en) | 2008-07-11 | 2010-01-14 | Handylab, Inc. | Polynucleotide Capture Materials, and Method of Using Same |
| USD598566S1 (en) | 2008-08-12 | 2009-08-18 | Diagenode Societe Anonyme | Medical instrument for laboratory use |
| WO2010025302A2 (en) | 2008-08-27 | 2010-03-04 | Life Technologies Corporation | Apparatus for and method of processing biological samples |
| BRPI1012522B1 (pt) | 2009-04-15 | 2019-11-26 | Biocartis N V | sistema ótico de multiplexação e método para detectar componentes de amostra em pelo menos duas câmaras de amostra diferentes |
| USD599234S1 (en) | 2009-04-28 | 2009-09-01 | Shiseido Co., Ltd. | Auto-sampler for chromatograph |
| USD638953S1 (en) | 2009-05-12 | 2011-05-31 | Invitrogen Dynal As | Laboratory apparatus |
| GB2473868A (en) | 2009-09-28 | 2011-03-30 | Invitrogen Dynal As | Apparatus and method of automated processing of biological samples |
| WO2010130310A1 (en) | 2009-05-15 | 2010-11-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pipette head with filter and flushing means |
| EP2263802A1 (en) | 2009-05-25 | 2010-12-22 | F. Hoffmann-La Roche AG | System and method for dispensing fluids |
| US9335339B2 (en) | 2009-06-04 | 2016-05-10 | Universal Bio Research Co., Ltd. | Specimen testing device and method thereof |
| USD628305S1 (en) | 2009-07-14 | 2010-11-30 | Medical Research Council | Sitting-drop microwell plate for crystalization |
| US8658417B2 (en) | 2009-09-15 | 2014-02-25 | Qiagen Gaithersburg, Inc. | Multiple-input analytical system |
| US20110097493A1 (en) | 2009-10-27 | 2011-04-28 | Kerr Roger S | Fluid distribution manifold including non-parallel non-perpendicular slots |
| EP2539073B1 (en) | 2010-02-22 | 2014-12-17 | 4titude Ltd. | Multiwell strips |
| EP2372367B1 (en) | 2010-04-01 | 2016-05-11 | F. Hoffmann-La Roche AG | A computer-implemented method for operating an automated sample workcell |
| US20110300033A1 (en) * | 2010-06-07 | 2011-12-08 | Chemence Medical, Inc. | Pipette Holder and Applicator Apparatus |
| KR20130029128A (ko) | 2010-07-23 | 2013-03-21 | 베크만 컬터, 인코포레이티드 | 실시간 pcr용 용기 |
| WO2012036296A1 (ja) | 2010-09-17 | 2012-03-22 | ユニバーサル・バイオ・リサーチ株式会社 | カートリッジおよび自動分析装置 |
| CN106190806B (zh) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| DK2761305T3 (da) | 2011-09-30 | 2017-11-20 | Becton Dickinson Co | Forenet reagensstrimmel |
| ES2660228T3 (es) | 2011-10-14 | 2018-03-21 | Becton Dickinson & Company | Ciclado térmico de onda cuadrada |
| WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
| DK2810080T3 (da) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests |
| USD686749S1 (en) | 2012-04-20 | 2013-07-23 | Stratec Biomedical Ag | Rack for holding sheaths |
| USD702854S1 (en) | 2012-05-18 | 2014-04-15 | Yoko Nakahana | Micro tube array container |
| USD687567S1 (en) | 2012-10-22 | 2013-08-06 | Qiagen Gaithersburg, Inc. | Tube strip for automated processing systems |
| USD710024S1 (en) | 2013-03-14 | 2014-07-29 | Bio-Rad Laboratories, Inc. | Microplate |
| WO2014149277A2 (en) | 2013-03-16 | 2014-09-25 | Roberts Leslie Don | Self-contained modular analytical cartridge and programmable reagent delivery system |
| CH709054A1 (de) | 2013-12-20 | 2015-06-30 | Tecan Trading Ag | Abstandhalter für übereinandergestapelte Pipettenspitzen-Träger. |
| USD729404S1 (en) | 2014-06-02 | 2015-05-12 | Seahorse Bioscience | Carrier |
| USD787008S1 (en) | 2015-06-29 | 2017-05-16 | David Hale | Shooting target |
-
2012
- 2012-09-28 DK DK12775396.0T patent/DK2761305T3/da active
- 2012-09-28 CA CA2849917A patent/CA2849917C/en active Active
- 2012-09-28 ES ES12775396.0T patent/ES2645966T3/es active Active
- 2012-09-28 DK DK17184677.7T patent/DK3273253T3/da active
- 2012-09-28 ES ES17184677T patent/ES2825905T3/es active Active
- 2012-09-28 WO PCT/US2012/058102 patent/WO2013049706A1/en not_active Ceased
- 2012-09-28 BR BR112014007440-2A patent/BR112014007440B1/pt active IP Right Grant
- 2012-09-28 RU RU2014112980A patent/RU2622432C2/ru active
- 2012-09-28 JP JP2014533437A patent/JP6117217B2/ja active Active
- 2012-09-28 EP EP17184677.7A patent/EP3273253B1/en active Active
- 2012-09-28 AU AU2012315595A patent/AU2012315595B2/en active Active
- 2012-09-28 EP EP12775396.0A patent/EP2761305B1/en active Active
- 2012-09-28 KR KR1020147011805A patent/KR102121853B1/ko active Active
- 2012-09-28 CN CN201710265204.1A patent/CN106996984B/zh active Active
- 2012-09-28 CN CN201280058922.7A patent/CN103959070B/zh active Active
-
2014
- 2014-03-27 US US14/227,883 patent/US9222954B2/en active Active
-
2015
- 2015-12-18 US US14/974,624 patent/US9480983B2/en active Active
-
2016
- 2016-01-21 AU AU2016200340A patent/AU2016200340A1/en not_active Abandoned
- 2016-03-11 AU AU2016201604A patent/AU2016201604B2/en active Active
- 2016-10-27 US US15/336,429 patent/US10076754B2/en active Active
-
2017
- 2017-03-21 JP JP2017054829A patent/JP6316473B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10076754B2 (en) | Unitized reagent strip | |
| US9701957B2 (en) | Reagent holder, and kits containing same | |
| JP6604980B2 (ja) | 自動化された試薬ベースの分析を行うためのシステム、方法、および装置 | |
| EP2279790B1 (en) | Sample Plate | |
| EP2188056B1 (en) | Thermal control apparatus for chemical and biochemical reactions | |
| EP2338600B1 (en) | Process head positioning | |
| JP6966375B2 (ja) | 自動分析システムのための容器キャリア | |
| EP1015551B1 (en) | New reaction vessel and methods for its use | |
| EP3359291B1 (en) | Reagent cartridge for detection of cells | |
| EP2094388B1 (en) | A well plate for holding a sample during analysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170925 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD Year of fee payment: 12 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240826 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20240826 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240826 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD Year of fee payment: 13 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250821 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250821 |