BRPI0821777B8 - anticorpo biespecífico bivalente, método para a preparação do mesmo e composição - Google Patents

anticorpo biespecífico bivalente, método para a preparação do mesmo e composição

Info

Publication number
BRPI0821777B8
BRPI0821777B8 BRPI0821777A BRPI0821777A BRPI0821777B8 BR PI0821777 B8 BRPI0821777 B8 BR PI0821777B8 BR PI0821777 A BRPI0821777 A BR PI0821777A BR PI0821777 A BRPI0821777 A BR PI0821777A BR PI0821777 B8 BRPI0821777 B8 BR PI0821777B8
Authority
BR
Brazil
Prior art keywords
preparation
composition
bispecific antibody
bivalent bispecific
bivalent
Prior art date
Application number
BRPI0821777A
Other languages
English (en)
Inventor
Klein Christian
Schaefer Wolfgang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39682659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0821777(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0821777A2 publication Critical patent/BRPI0821777A2/pt
Publication of BRPI0821777B1 publication Critical patent/BRPI0821777B1/pt
Publication of BRPI0821777B8 publication Critical patent/BRPI0821777B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

anticorpos biespecíficos bivalentes, método para a preparação destes, célula hospedeira e composição. a presente invenção refere-se a novos anticorpos bivalentes biespecíficos com troca de domínio, sua fabricação e utilização.
BRPI0821777A 2007-12-21 2008-12-16 anticorpo biespecífico bivalente, método para a preparação do mesmo e composição BRPI0821777B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07024865.3 2007-12-21
EP07024865 2007-12-21
PCT/EP2008/010704 WO2009080253A1 (en) 2007-12-21 2008-12-16 Bivalent, bispecific antibodies

Publications (3)

Publication Number Publication Date
BRPI0821777A2 BRPI0821777A2 (pt) 2015-06-16
BRPI0821777B1 BRPI0821777B1 (pt) 2020-05-12
BRPI0821777B8 true BRPI0821777B8 (pt) 2021-05-25

Family

ID=39682659

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821777A BRPI0821777B8 (pt) 2007-12-21 2008-12-16 anticorpo biespecífico bivalente, método para a preparação do mesmo e composição

Country Status (30)

Country Link
US (1) US8242247B2 (pt)
EP (1) EP2225280B1 (pt)
JP (1) JP5281098B2 (pt)
KR (2) KR101265855B1 (pt)
CN (1) CN101903406B (pt)
AR (2) AR069775A1 (pt)
AU (1) AU2008340694B2 (pt)
BR (1) BRPI0821777B8 (pt)
CA (1) CA2709430C (pt)
CL (1) CL2008003778A1 (pt)
CO (1) CO6280543A2 (pt)
CR (1) CR11465A (pt)
CY (1) CY1115275T1 (pt)
DK (1) DK2225280T3 (pt)
EC (1) ECSP10010297A (pt)
ES (1) ES2471266T3 (pt)
HK (1) HK1145845A1 (pt)
HR (1) HRP20140727T1 (pt)
IL (1) IL206108A (pt)
MA (1) MA31925B1 (pt)
MY (1) MY160736A (pt)
NZ (1) NZ585774A (pt)
PE (1) PE20091169A1 (pt)
PL (1) PL2225280T3 (pt)
PT (1) PT2225280E (pt)
SI (1) SI2225280T1 (pt)
TW (1) TWI359028B (pt)
UA (1) UA100874C2 (pt)
WO (1) WO2009080253A1 (pt)
ZA (1) ZA201004300B (pt)

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