BRPI0506125B8 - anticorpo anti - glipicano 3, seu método de produção, polinucleotídeo, vetor e inibidor do crescimento de células - Google Patents
anticorpo anti - glipicano 3, seu método de produção, polinucleotídeo, vetor e inibidor do crescimento de célulasInfo
- Publication number
- BRPI0506125B8 BRPI0506125B8 BRPI0506125A BRPI0506125A BRPI0506125B8 BR PI0506125 B8 BRPI0506125 B8 BR PI0506125B8 BR PI0506125 A BRPI0506125 A BR PI0506125A BR PI0506125 A BRPI0506125 A BR PI0506125A BR PI0506125 B8 BRPI0506125 B8 BR PI0506125B8
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- glypican
- cell growth
- growth inhibitor
- polynucleotide
- Prior art date
Links
- 102000010956 Glypican Human genes 0.000 title abstract 2
- 108050001154 Glypican Proteins 0.000 title abstract 2
- 108050007237 Glypican-3 Proteins 0.000 title abstract 2
- 230000010261 cell growth Effects 0.000 title abstract 2
- 239000003966 growth inhibitor Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
anticorpo antiglipicano 3. a presente invenção refere-se a um anticorpo capaz de ser ligar a uma região específica de glipicano 3, assim como um anticorpo humanizado criado com base neste anticorpo são descritos. o anticorpo antigpc3 da invenção apresenta atividade de adcc e atividade de cdc maiores comparadas com as de um anticorpo convencional. o anticorpo da presente invenção é utilizável como um inibidor do crescimento de células, um agente anticâncer e um agente para o diagnóstico de cânceres.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004203637 | 2004-07-09 | ||
JP2004-203637 | 2004-07-09 | ||
PCT/JP2005/013103 WO2006006693A1 (ja) | 2004-07-09 | 2005-07-08 | 抗グリピカン3抗体 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0506125A BRPI0506125A (pt) | 2006-10-24 |
BRPI0506125B1 BRPI0506125B1 (pt) | 2019-10-15 |
BRPI0506125B8 true BRPI0506125B8 (pt) | 2021-05-25 |
Family
ID=35784028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506125A BRPI0506125B8 (pt) | 2004-07-09 | 2005-07-08 | anticorpo anti - glipicano 3, seu método de produção, polinucleotídeo, vetor e inibidor do crescimento de células |
Country Status (26)
Country | Link |
---|---|
US (3) | US7919086B2 (pt) |
EP (4) | EP2898897A3 (pt) |
JP (3) | JP4011100B2 (pt) |
KR (2) | KR101413402B1 (pt) |
CN (4) | CN111925445A (pt) |
AT (1) | ATE486610T1 (pt) |
AU (1) | AU2005256113B2 (pt) |
BR (1) | BRPI0506125B8 (pt) |
CA (1) | CA2544692C (pt) |
CY (1) | CY1111649T1 (pt) |
DE (1) | DE602005024502D1 (pt) |
DK (1) | DK1674111T3 (pt) |
ES (1) | ES2353967T3 (pt) |
HK (1) | HK1092161A1 (pt) |
IL (1) | IL172938A (pt) |
MX (1) | MXPA06002890A (pt) |
MY (1) | MY145073A (pt) |
NO (1) | NO343105B1 (pt) |
NZ (2) | NZ579543A (pt) |
PL (1) | PL1674111T3 (pt) |
PT (1) | PT1674111E (pt) |
RU (2) | RU2427588C2 (pt) |
SI (1) | SI1674111T1 (pt) |
TW (1) | TWI455946B (pt) |
UA (1) | UA94019C2 (pt) |
WO (1) | WO2006006693A1 (pt) |
Families Citing this family (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7361336B1 (en) * | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
WO2004022597A1 (ja) * | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3の血中可溶化n端ペプチドに対する抗体 |
CN111925445A (zh) * | 2004-07-09 | 2020-11-13 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
WO2006022407A1 (ja) | 2004-08-24 | 2006-03-02 | Chugai Seiyaku Kabushiki Kaisha | 抗グリピカン3抗体を用いたアジュバント療法 |
UA93488C2 (uk) * | 2004-10-26 | 2011-02-25 | Чугаі Сейяку Кабусікі Кайся | Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг |
JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
US20070087005A1 (en) * | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
WO2007074880A1 (ja) | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | 抗体含有安定化製剤 |
EP1991274A4 (en) * | 2006-01-20 | 2009-06-10 | Women S And Children S Health | METHOD FOR THE TREATMENT, PROPHYLAXIS AND DIAGNOSIS OF BONE DISEASES |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
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EP2178921B1 (en) * | 2007-07-17 | 2016-01-06 | E. R. Squibb & Sons, L.L.C. | Monoclonal antibodies against glypican-3 |
RU2487168C2 (ru) | 2007-08-07 | 2013-07-10 | Чугаи Сейяку Кабусики Кайся | Способ получения гетерологичных белков |
DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
AR066172A1 (es) | 2007-09-28 | 2009-07-29 | Chugai Pharmaceutical Co Ltd | Metodo para la preparacion de un anticuerpo antiglipicano 3 con modulada cinetica plasmatica mediante variacion de la semivida plasmatica. |
PL2202307T5 (pl) * | 2007-10-15 | 2021-10-04 | Chugai Seiyaku Kabushiki Kaisha | Sposób wytwarzania przeciwciała |
JP5337043B2 (ja) * | 2007-10-15 | 2013-11-06 | 中外製薬株式会社 | 異種タンパク質を高生産する細胞の作製方法 |
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JO2913B1 (en) * | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
WO2009114335A2 (en) * | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
MX2010010136A (es) * | 2008-03-17 | 2011-02-23 | Univ Miyazaki | Metodo para detectar celulas de cancer de higado usando anticuerpo anti-glipicano 3. |
CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
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AU2010204576A1 (en) * | 2009-01-15 | 2011-09-01 | Laboratory Corporation Of America Holdings | Methods of determining patient response by measurement of HER-2 expression |
JP5715050B2 (ja) | 2009-04-22 | 2015-05-07 | 中外製薬株式会社 | 異種タンパク質を高生産する細胞の作製方法 |
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TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
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RU2658504C9 (ru) | 2010-11-30 | 2018-08-21 | Чугаи Сейяку Кабусики Кайся | Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул |
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AR087364A1 (es) * | 2011-07-29 | 2014-03-19 | Pf Medicament | Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres |
US10556949B2 (en) | 2011-09-30 | 2020-02-11 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
CA3186128A1 (en) | 2011-09-30 | 2013-04-04 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting elimination of antigens |
EP3617313A1 (en) | 2011-10-05 | 2020-03-04 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting clearance from plasma of antigen comprising saccharide chain receptor-binding domain |
WO2013065708A1 (ja) | 2011-10-31 | 2013-05-10 | 中外製薬株式会社 | 重鎖と軽鎖の会合が制御された抗原結合分子 |
US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
JP6118345B2 (ja) * | 2012-01-31 | 2017-04-19 | Sbiバイオテック株式会社 | 抗ホスホリパーゼd4抗体 |
EP3738980A1 (en) | 2012-02-24 | 2020-11-18 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via fc gamma riib |
JP6193275B2 (ja) | 2012-03-02 | 2017-09-06 | ヴァクシネックス, インコーポレイテッド | B細胞媒介炎症性疾患を治療するための方法 |
US20130280282A1 (en) * | 2012-04-24 | 2013-10-24 | Daiichi Sankyo Co., Ltd. | Dr5 ligand drug conjugates |
DK2857420T3 (da) | 2012-05-30 | 2020-11-23 | Chugai Pharmaceutical Co Ltd | Målvævsspecifikt antigenbindende molekyle |
WO2013181543A1 (en) * | 2012-06-01 | 2013-12-05 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | High-affinity monoclonal antibodies to glypican-3 and use thereof |
EP2921554B1 (en) | 2012-10-10 | 2019-12-04 | Chugai Seiyaku Kabushiki Kaisha | Method for establishing modified host cell |
CN103833852A (zh) * | 2012-11-23 | 2014-06-04 | 上海市肿瘤研究所 | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 |
EP4119947A1 (en) | 2012-12-21 | 2023-01-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy |
TWI693073B (zh) * | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑 |
WO2015097928A1 (ja) | 2013-12-24 | 2015-07-02 | 中外製薬株式会社 | 可溶性gpc3タンパク質の測定方法 |
WO2014121053A1 (en) | 2013-01-31 | 2014-08-07 | Vaccinex, Inc. | Methods for increasing immunoglobulin a levels |
US20160000946A1 (en) * | 2013-03-14 | 2016-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Radiolabeled anti-glypican-3 immunoconjugates for immuno-pet imaging of hepatocellular carcinoma |
CN104140974B (zh) * | 2013-05-08 | 2017-09-29 | 科济生物医药(上海)有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
JP6534615B2 (ja) | 2013-09-27 | 2019-06-26 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
AU2014358191B2 (en) | 2013-12-04 | 2020-12-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules |
TWI726842B (zh) | 2014-04-07 | 2021-05-11 | 日商中外製藥股份有限公司 | 免疫活化抗原結合分子 |
TWI735410B (zh) | 2014-05-08 | 2021-08-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投予的gpc3標的治療劑 |
TW201623333A (zh) | 2014-05-13 | 2016-07-01 | Chugai Pharmaceutical Co Ltd | 對具有免疫抑制機能之細胞的t細胞重定向抗原結合分子 |
WO2015172341A1 (zh) * | 2014-05-14 | 2015-11-19 | 上海市肿瘤研究所 | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 |
JP6858559B2 (ja) | 2014-08-20 | 2021-04-14 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
WO2016036973A1 (en) * | 2014-09-04 | 2016-03-10 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
SG11201701016WA (en) * | 2014-09-16 | 2017-03-30 | Ovascience Inc | Anti-vasa antibodies, and methods of production and use thereof |
WO2016049183A1 (en) * | 2014-09-24 | 2016-03-31 | Aerpio Therapeutics, Inc. | Ve-ptp extracellular domain antibodies delivered by a gene therapy vector |
MA40764A (fr) * | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
EP3223865A4 (en) | 2014-10-31 | 2018-10-03 | Jounce Therapeutics, Inc. | Methods of treating conditions with antibodies that bind b7-h4 |
AU2015376851B2 (en) * | 2015-01-16 | 2020-07-09 | Minomic International Ltd. | Glypican epitopes and uses thereof |
CN104610441B (zh) * | 2015-03-04 | 2018-02-13 | 首都医科大学 | 用于制备磷脂酰肌醇蛋白聚糖‑3(gpc3)单抗的人工半抗原、制备方法及获得的单克隆抗体 |
JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
US11376326B2 (en) | 2015-07-01 | 2022-07-05 | Chugai Seiyaku Kabushiki Kaisha | GPC3-targeting therapeutic agent which is administered to patient for whom the GPC3-targeting therapeutic agent is effective |
JP2018522564A (ja) * | 2015-08-03 | 2018-08-16 | カースゲン セラピューティクス リミテッドCarsgen Therapeutics Limited | 抗グリピカン3抗体およびその使用 |
CN105112046A (zh) * | 2015-09-29 | 2015-12-02 | 南通大学 | 核壳结构量子点的制备方法、靶向肿瘤标志物gpc-3的荧光纳米探针及其制备方法 |
CN105126123B (zh) * | 2015-09-29 | 2018-04-03 | 南通大学 | 纳米探针的制备方法、基于天然产物单体和纳米探针的纳米药物的制备方法及应用 |
KR101796688B1 (ko) * | 2015-10-29 | 2017-12-01 | 재단법인 목암생명과학연구소 | 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물 |
WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
CN108368166B (zh) | 2015-12-28 | 2023-03-28 | 中外制药株式会社 | 提高含fc区多肽纯化效率的方法 |
EP3428648B1 (en) * | 2016-03-10 | 2020-12-02 | National Cancer Center | Method for assisting prediction of recurrence risk in hepatocellular carcinoma patient, and use of a kit |
SG10202007025PA (en) | 2016-03-14 | 2020-08-28 | Chugai Pharmaceutical Co Ltd | Cell injury inducing therapeutic drug for use in cancer therapy |
TW202248213A (zh) * | 2016-03-15 | 2022-12-16 | 日商中外製藥股份有限公司 | 使用pd-1軸結合拮抗劑和抗gpc3抗體治療癌症的方法 |
JP6887613B2 (ja) * | 2016-03-31 | 2021-06-16 | 国立大学法人東北大学 | がん微小環境を標的とした抗ポドカリキシン抗体 |
CN109414512A (zh) | 2016-04-22 | 2019-03-01 | 科济生物医药(上海)有限公司 | 用于细胞免疫疗法的组合物和方法 |
JP2019530431A (ja) | 2016-07-26 | 2019-10-24 | テッサ・セラピューティクス・プライベート・リミテッド | キメラ抗原受容体 |
EP3502250B1 (en) | 2016-08-22 | 2024-04-24 | Chugai Seiyaku Kabushiki Kaisha | Gene-modified rodent expressing human gpc3 polypeptide |
JPWO2018097308A1 (ja) | 2016-11-28 | 2019-10-17 | 中外製薬株式会社 | リガンド結合活性が調整可能なリガンド結合分子 |
JP2018093823A (ja) | 2016-12-15 | 2018-06-21 | Heartseed株式会社 | 未分化幹細胞除去剤及び未分化幹細胞除去方法 |
EP3565596A4 (en) | 2017-01-05 | 2020-12-16 | Brown University | PROCESSES AND COMPOSITIONS RELATING TO ANTI-CHI3LI ANTIBODY REAGENTS |
CA3049189A1 (en) | 2017-01-10 | 2018-07-19 | Yamaguchi University | Anti-gpc3 antibody |
CA3060443A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
EP3615574A4 (en) * | 2017-04-26 | 2021-02-24 | Eureka Therapeutics, Inc. | CONSTRUCTIONS SPECIFICALLY RECOGNIZING GLYPICANE 3 AND USES OF SUCH LATEST |
US20200283510A1 (en) * | 2017-06-20 | 2020-09-10 | Savid Therapeutics Inc. | Antisulfataed glycosaminoglycan antibody |
US11214615B2 (en) | 2017-07-28 | 2022-01-04 | Phanes Therapeutics, Inc. | Anti-TIM-3 antibodies and uses thereof |
US10766968B2 (en) | 2017-08-23 | 2020-09-08 | Brown University | Methods and compositions relating to anti-CHI3L1 antibody reagents to treat cancer |
JP7382922B2 (ja) * | 2017-09-20 | 2023-11-17 | 中外製薬株式会社 | Pd-1系結合アンタゴニストおよびgpc3標的化剤を使用する併用療法のための投与レジメン |
RU2020120556A (ru) | 2017-11-28 | 2021-12-29 | Чугаи Сейяку Кабусики Кайся | Лигандсвязывающая молекула, обладающая регулируемой лигандсвязывающей активностью |
AR114112A1 (es) * | 2018-02-15 | 2020-07-22 | Seattle Genetics Inc | Anticuerpos de glipicano 3 y conjugados de los mismos |
KR20210010996A (ko) | 2018-05-21 | 2021-01-29 | 추가이 세이야쿠 가부시키가이샤 | 유리 용기에 봉입된 동결건조 제제 |
CN115649558A (zh) | 2018-05-28 | 2023-01-31 | 中外制药株式会社 | 填充喷嘴 |
WO2019230868A1 (ja) | 2018-05-30 | 2019-12-05 | 中外製薬株式会社 | 単ドメイン抗体含有リガンド結合分子 |
EP3825404A4 (en) | 2018-07-17 | 2022-04-13 | Noile-Immune Biotech, Inc. | CAR CONTAINING ANTI-GPC3 SINGLE STRAND ANTIBODY |
CN110760005A (zh) * | 2018-07-25 | 2020-02-07 | 上海细胞治疗集团有限公司 | 一种靶向Glypican-3抗原的嵌合抗原受体修饰T细胞及其用途 |
US20210388109A1 (en) | 2018-10-01 | 2021-12-16 | Adicet Bio, Inc. | Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of solid tumors |
JP2022505871A (ja) | 2018-10-23 | 2022-01-14 | ドラゴンフライ セラピューティクス, インコーポレイテッド | ヘテロ二量体fc融合タンパク質 |
EP3943108A4 (en) | 2019-03-19 | 2023-01-04 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE CONTAINING AN ANTIGEN-BINDING DOMAIN WHOSE ANTIGEN-BINDING ACTIVITY IS ALTERED DEPENDING ON THE MTA, AND BANK FOR OBTAINING SUCH ANTIGEN-BINDING DOMAIN |
WO2020190217A2 (en) * | 2019-03-21 | 2020-09-24 | Agency For Science, Technology And Research | Composition |
US20220220216A1 (en) | 2019-05-15 | 2022-07-14 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to cd40 and gpc3 |
US20220315909A1 (en) | 2019-06-05 | 2022-10-06 | Chugai Seiyaku Kabushiki Kaisha | Protease substrate, and polypeptide including protease cleavage sequence |
WO2020246563A1 (ja) | 2019-06-05 | 2020-12-10 | 中外製薬株式会社 | 抗体切断部位結合分子 |
JP2021176829A (ja) * | 2019-07-12 | 2021-11-11 | 国立大学法人京都大学 | 歯の再生治療のためのusag−1を標的分子とした中和抗体 |
EP4007604A4 (en) * | 2019-08-01 | 2023-07-19 | R.P. Scherer Technologies, LLC | ANTIBODY SPECIFIC TO GPC3 AND METHODS OF USE THEREOF |
CN116063528A (zh) * | 2019-08-16 | 2023-05-05 | 原启生物科技(上海)有限责任公司 | 一种分离的抗原结合蛋白及其用途 |
CN113227148B (zh) * | 2019-12-05 | 2022-11-01 | 上海翰森生物医药科技有限公司 | 抗gpc3抗体、其抗原结合片段及其医药用途 |
CN111116749B (zh) * | 2019-12-31 | 2023-02-17 | 南京拂晓生物科技有限公司 | 重组的人源化gpc3抗体及其制备和应用 |
AU2021260960A1 (en) | 2020-04-22 | 2022-11-24 | Dragonfly Therapeutics, Inc. | Formulation, dosage regimen, and manufacturing process for heterodimeric Fc-fused proteins |
CN111909902B (zh) * | 2020-06-24 | 2021-12-21 | 天津金虹生物科技开发有限公司 | 一种杂交瘤细胞株、单克隆抗体及其制备方法和应用、制备致敏胶乳原液的方法以及试剂盒 |
KR20230048059A (ko) | 2020-07-31 | 2023-04-10 | 추가이 세이야쿠 가부시키가이샤 | 키메라 수용체를 발현하는 세포를 포함하는 의약 조성물 |
EP4253423A1 (en) | 2020-09-17 | 2023-10-04 | Shanghai Lyn-Crest Enterprise Management Co., Ltd. | Bispecific recombinant protein and use thereof |
CN114478780A (zh) * | 2020-10-23 | 2022-05-13 | 华中农业大学 | 识别磷脂酰肌醇蛋白聚糖3多个不同表位的抗体及其应用 |
CN114478788A (zh) | 2020-11-11 | 2022-05-13 | 高新 | 一种同时靶向cd3和cd137的融合蛋白及其制备方法和用途 |
KR20220080381A (ko) * | 2020-12-07 | 2022-06-14 | (주)이노베이션바이오 | Gpc3에 특이적인 항체 및 이의 용도 |
WO2022129560A1 (en) * | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
CN112608907B (zh) * | 2020-12-18 | 2023-01-17 | 十堰市太和医院(湖北医药学院附属医院) | 磷脂酰肌醇蛋白聚糖3单克隆抗体,杂交瘤细胞株和应用 |
EP4274853A1 (en) * | 2021-01-05 | 2023-11-15 | National Institute Of Biological Sciences, Beijing | A bispecific antibody targeting gpc3 and cd47 |
WO2022166876A1 (zh) * | 2021-02-03 | 2022-08-11 | 江苏先声药业有限公司 | 特异性识别磷脂酰肌醇蛋白聚糖3的单克隆抗体及其应用 |
WO2022236049A1 (en) * | 2021-05-07 | 2022-11-10 | Senti Biosciences, Inc. | Chimeric antigen receptors and methods of use |
WO2022268196A1 (zh) * | 2021-06-25 | 2022-12-29 | 天辰生物医药(苏州)有限公司 | 靶向gpc3的抗原结合蛋白 |
WO2023283361A1 (en) * | 2021-07-07 | 2023-01-12 | Triumvira Immunologics Usa, Inc. | Gpc3 t cell-antigen couplers and uses thereof |
CN113248616B (zh) * | 2021-07-07 | 2022-04-12 | 北京艺妙神州医药科技有限公司 | 靶向gpc3的嵌合抗原受体及其用途 |
CN113354737B (zh) * | 2021-07-20 | 2022-11-18 | 广州爱思迈生物医药科技有限公司 | 一种磷脂酰肌醇蛋白聚糖3抗体及其应用 |
KR20240045278A (ko) | 2021-08-12 | 2024-04-05 | 상하이 티티엠-바이오 테크놀로지 컴퍼니 리미티드 | 이중특이적 재조합 단백질 및 이의 용도 |
WO2023034762A2 (en) * | 2021-08-30 | 2023-03-09 | Obi Pharma, Inc. | Bispecific dendritic cell engager and uses thereof |
CN117897410A (zh) * | 2021-09-06 | 2024-04-16 | 南京传奇生物科技有限公司 | 抗gpc3嵌合抗原受体及其使用方法 |
TW202323810A (zh) | 2021-10-08 | 2023-06-16 | 日商中外製藥股份有限公司 | 預填充式注射器製劑的調製方法 |
KR20230060546A (ko) | 2021-10-22 | 2023-05-04 | 상트네어바이오사이언스 주식회사 | 두개의 Fc 도메인을 포함하는 항원 결합 단백질 및 이의 용도 |
CA3237201A1 (en) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
CA3238167A1 (en) * | 2021-11-19 | 2023-05-25 | Maria Leia Smith | Gpc3 binding agents, conjugates thereof and methods of using the same |
WO2024076375A1 (en) * | 2022-10-07 | 2024-04-11 | Jecho Laboratories, Inc. | Glypican 3 antibody and related methods |
CN116444653B (zh) * | 2023-03-09 | 2024-03-15 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一株阻断性非洲猪瘟病毒单克隆抗体杂交瘤细胞株的制备与应用 |
CN116333172B (zh) * | 2023-05-04 | 2024-02-09 | 广州百暨基因科技有限公司 | 融合蛋白及其应用 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPH0242355A (ja) | 1988-08-02 | 1990-02-13 | Hitachi Constr Mach Co Ltd | 超音波検査装置 |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
JPH04336051A (ja) | 1991-05-10 | 1992-11-24 | Toshiba Corp | 超音波診断装置 |
EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
AU675661B2 (en) | 1992-07-24 | 1997-02-13 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
US5622701A (en) * | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
US5994524A (en) | 1994-07-13 | 1999-11-30 | Chugai Seiyaku Kabushiki Kaisha | Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same |
DE69534530T2 (de) * | 1994-08-12 | 2006-07-06 | Immunomedics, Inc. | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
AU744146B2 (en) | 1996-09-26 | 2002-02-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody against human parathormone related peptides |
WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
US6617156B1 (en) * | 1997-08-15 | 2003-09-09 | Lynn A. Doucette-Stamm | Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics |
US7361336B1 (en) * | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
BR9812846A (pt) * | 1997-10-03 | 2000-08-08 | Chugai Pharmaceutical Co Ltd | Anticorpo humanizado natural |
JPH11118775A (ja) | 1997-10-09 | 1999-04-30 | Canon Inc | 超音波検査装置 |
US6528624B1 (en) * | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
AU776790B2 (en) * | 1999-02-12 | 2004-09-23 | Lexigen Pharmaceuticals Corporation | Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies |
EP2264166B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
JP3606132B2 (ja) | 1999-10-14 | 2005-01-05 | Jfeエンジニアリング株式会社 | 超音波探傷方法およびその装置 |
JP2002048867A (ja) | 2000-08-07 | 2002-02-15 | Mitsubishi Heavy Ind Ltd | 音響探査装置 |
EP1319044B1 (en) | 2000-09-12 | 2007-06-06 | Union Carbide Chemicals & Plastics Technology Corporation | Polymer composites containing ethylene oxide copolymers |
DK2314686T4 (da) | 2000-10-06 | 2023-08-21 | Kyowa Kirin Co Ltd | Celler, der danner antistofsammensætninger |
JP4336051B2 (ja) | 2001-01-31 | 2009-09-30 | 株式会社エヌ・ティ・ティ・ドコモ | 無線通信端末、発呼制限方法及びプログラム |
AU2002307037B2 (en) | 2001-04-02 | 2008-08-07 | Biogen Idec Inc. | Recombinant antibodies coexpressed with GnTIII |
US20020194747A1 (en) * | 2001-06-21 | 2002-12-26 | Passke Joel L. | Footwear with bladder filter |
CN1314803C (zh) * | 2001-06-22 | 2007-05-09 | 中外制药株式会社 | 含有抗磷脂酰肌醇蛋白聚糖3抗体的细胞生长抑制剂 |
HUP0700103A3 (en) * | 2001-08-03 | 2012-09-28 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
JP3961359B2 (ja) | 2002-07-18 | 2007-08-22 | 株式会社東芝 | 超音波画像化装置 |
JP4087098B2 (ja) | 2001-11-14 | 2008-05-14 | 株式会社東芝 | 超音波検査装置 |
US7421900B2 (en) * | 2001-11-14 | 2008-09-09 | Kabushiki Kaisha Toshiba | Ultrasonograph, ultrasonic transducer, examining instrument, and ultrasonographing device |
EP1464702A4 (en) | 2001-12-28 | 2005-09-21 | Chugai Pharmaceutical Co Ltd | METHOD FOR PROTEIN STABILIZATION |
US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
US8093357B2 (en) * | 2002-03-01 | 2012-01-10 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
WO2003074679A2 (en) | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
EP1498491A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | METHOD FOR INCREASING THE ACTIVITY OF AN ANTIBODY COMPOSITION FOR BINDING TO THE FC GAMMA RECEPTOR IIIA |
WO2004022597A1 (ja) * | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3の血中可溶化n端ペプチドに対する抗体 |
ATE425461T1 (de) | 2002-05-23 | 2009-03-15 | Sunnybrook & Womens College | Diagnose von hepatozellulärem karzinom |
AU2003254950A1 (en) | 2002-08-26 | 2004-03-11 | Kirin Beer Kabushiki Kaisha | Peptides and drugs containing the same |
AU2002330482A1 (en) * | 2002-09-04 | 2004-03-29 | Perseus Proteomics Inc. | Method of diagnosing cancer by detecting gpc3 |
WO2004022595A1 (ja) * | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | MRL/lprマウスを用いた抗体の作製 |
JP4090345B2 (ja) | 2002-12-24 | 2008-05-28 | 株式会社グラノプト | 液相結晶成長法 |
US20090010920A1 (en) * | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
JPWO2005023301A1 (ja) | 2003-09-04 | 2006-11-02 | 中外製薬株式会社 | 胆管癌治療剤および検出薬 |
ITBO20040008U1 (it) | 2004-02-03 | 2004-05-03 | Tonazzi S R L | Macchina per il riempimento e la chiusura di tubetti |
CN111925445A (zh) * | 2004-07-09 | 2020-11-13 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
US20060040325A1 (en) * | 2004-08-16 | 2006-02-23 | Medimmune, Inc. | Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity |
WO2006022407A1 (ja) | 2004-08-24 | 2006-03-02 | Chugai Seiyaku Kabushiki Kaisha | 抗グリピカン3抗体を用いたアジュバント療法 |
UA93488C2 (uk) * | 2004-10-26 | 2011-02-25 | Чугаі Сейяку Кабусікі Кайся | Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг |
JPWO2006067847A1 (ja) * | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
WO2007137170A2 (en) * | 2006-05-20 | 2007-11-29 | Seattle Genetics, Inc. | Anti-glypican-3 antibody drug conjugates |
MX2010010136A (es) * | 2008-03-17 | 2011-02-23 | Univ Miyazaki | Metodo para detectar celulas de cancer de higado usando anticuerpo anti-glipicano 3. |
CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
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